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Chinese Journal of Cancer 2017年第11期36卷 533-536页

作者： Hali Hartmann Jie Zhao sujuan ba National Foundation for Cancer Research

The Szent-Gy?rgyi Prize for Progress in Cancer Research is a prestigious scientific award sponsored by the National Foundation for Cancer Research(NFCR)-a leading cancer research charitable organization in the United States that supports innovative cancer research globally with the ultimate goal to cure cancer. The coveted Szent-Gy?rgyi Prize annually honors a scientist whose seminal discovery or body of work has resulted in, or led toward, notable contributions to cancer prevention, diagnosis, or treatment; and the discovery has had a high direct impact of saving people's lives. In addition, the prize promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. In 2016, NFCR's Szent-Gy?rgyi Prize Selection Committee was unanimous in its decision to recognize an icon in human disease genetics, Dr. Mary-Claire King, for her pioneering research that demonstrated the first evidence of genetic predisposition to breast cancer. Her proof of existence of BRCA1 gene and its location has made genetic screening for breast and ovarian cancers possible, saving lives of many people who are at high risk with inherited BRCA1 mutations.

关键词： The National Foundation for Cancer Research The Szent-Gyorgyi Prize Mary-Claire King BRCA1 and genetic testing

Frederick *** received the 2015 Szent-Gyrgi Prize for Progress in Cancer Research

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Chinese Journal of Cancer 2016年第3期35卷 151-154页

作者： peter scully jie zhao sujuan ba national foundation for cancer research BethesdaMDUSA

The Szent-Gyorgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research(NFCR)—a leading cancer research charitable organization in the United States that is committed to supporting scientific research and public education relating to the prevention,early diagnosis,better treatments,and ultimately,a cure for *** year,the Szent-Gyorgyi Prize honors an outstanding researcher,nominated by colleagues or peers,who has contributed outstanding,significant research to the fight against cancer,and whose accomplishments have helped improve treatment options for cancer *** Prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer *** report highlights the pioneering work led by the 2015 Prize winner,*** ***'s work in the area of cancer genetics over four decades has helped to shape the very roots of modern cancer *** work continues to profoundly impact the approaches that doctors around the globe use to diagnose and treat *** particular,his seminal discoveries of gene amplification and his pioneering work on molecular mechanisms of DNA damage repair have helped to usher in the era of genetically targeted therapy and personalized medicine.

关键词： The National Foundation for Cancer Research, The Szent-Gyorgyi Prize, Frederick Alt, Gene amplification,Non-homologous end joining

James P. Allison received the 2014 Szent-Gyrgi Prize for Progress in Cancer Research

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Chinese Journal of Cancer 2014年第9期33卷 416-420页

作者： Jie Zhao Peter Scully sujuan ba National Foundation for Cancer Research

The Szent-Gyrgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research(NFCR)—a leading cancer research charitable organization in the United States that is committed to supporting innovative cancer research on the global scale that aims to cure cancer. Each year, the Szent-Gyrgyi Prize honors an outstanding researcher whose original discoveries have expanded our understanding of cancer and resulted in notable advances in cancer prevention, diagnosis, or treatment. The prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. This report highlights the history and mission of the Szent-Gyrgyi Prize, its role in promoting discovery-oriented cancer research, and the pioneering work led by the 2014 prize winner, Dr. James Allison. Dr. Allison's work in the area of cancer immunotherapy led to the successful development of immune checkpoint therapy, and the first drug approved by the United States Food and Drug Administration for the treatment of metastatic melanoma.

关键词：癌症治疗美国食品免疫治疗全球范围研究人员黑色素瘤基金会获奖者

Is the polydispersity exponent of the hyperbranched polymers the 3/2 or 5/2?

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Chinese Science Bulletin 2006年第12期51卷 1526-1528页

作者： ba Xinwu LIU Ying WANG sujuan WANG Haijun College of Chemistry and Environment Science Hebei University Baoding 071002 China Department of Chemistry Hebei Normal University of Science and Technology Qinhuangdao 066600 China

The number of the hyperbranched polymers in the system is investigated for the polymerization process to give the asymptotic form of the concentration of the n-mer. The polydispersity exponent is calculated, which coincides with that of the classical result. Finally, the asymptotic forms of the number, the weight and the z-average degrees of the polymerization were evaluated analytically to obtain polydispersity index, which is close to 1 as the reaction is quantitatively completed.

关键词：超分支聚合体多分散指数聚合过程渐近形式

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两亲性超支化聚合物的研究进展

化学通报 2011年第3期74卷 232-237页

作者：王素娟巴信武河北大学化学与环境科学学院保定071002

两亲性超支化聚合物作为一种新型功能性材料,近年来引起了人们的广泛关注。两亲性超支化聚合物的合成主要是利用不同亲水性的链段对超支化聚合物端基进行改性,或者首先在超支化聚合物末端产生活性位点,再利用超支化分子作为大分子引发... 详细信息

两亲性超支化聚合物作为一种新型功能性材料,近年来引起了人们的广泛关注。两亲性超支化聚合物的合成主要是利用不同亲水性的链段对超支化聚合物端基进行改性,或者首先在超支化聚合物末端产生活性位点,再利用超支化分子作为大分子引发剂引发烯类单体进行开环聚合、原子转移自由基聚合等得到以超支化聚合物为核的两亲性超支化共聚物;这些分子由于其内部超支化结构与外围链段的共价键连接,在溶液中可以形成不因外界条件(比如温度、浓度、pH等)发生变化而被破坏的单分子胶束、合适的外界条件下可以进一步组装成多分子胶束、球状胶束、聚合物囊泡、纳米纤维等不同的形态。本文主要介绍了近年来两亲性超支化聚合物的合成、在溶液中的聚集状态研究;并就超支化聚合物在相转移、作为制备纳米颗粒的模板和在聚合物共混方面的应用进行了详细概括。

关键词：两亲性超支化聚合物单分子胶束自组装相转移模板

Dietary bile acid supplementation in weaned piglets with intrauterine growth retardation improves colonic microbiota,metabolic activity,and epithelial function

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2578-2595页

作者： Yang Liu MdAbul Kalam Azad sujuan Ding Qian Zhu Francois Blachier Zugong Yu Haijun Gao Xiangfeng Kong Key Laboratory of Agro‑Ecological Process in Subtropical Region Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina. College of Veterinary Medicine Nanjing Agricultural UniversityNanjingJiangsu 210095China. Universite Paris-SaclayAgroParisTech INRAEUMR PNCA75005ParisFrance. College of Medicine Howard UniversityWashingtonDC 20059USA.

background Intrauterine growth retardation(IUGR)is one of the major constraints in animal *** previ-ous study showed that piglets with IUGR are associated with abnormal bile acid(ba)*** study explored whether dietary ba supplementation could improve growth performance and colonic development,function,micro-biota,and metabolites in the normal birth weight(NBW)and IUGR piglets.A total of 48 weaned piglets(24 IUGR and 24 NBW)were allocated to four groups(12 piglets per group):(i)NBW group,(ii)NBW+ba group,(iii)IUGR group,and(iv)IUGR+ba *** were collected after 28 days of *** The results showed that dietary ba supplementation increased the length and weight of the colon and colon weight to body weight ratio,while decreased the plasma diamine oxidase(DAO)concentration in the NBW pig-lets(Pba supplementation to IUGR piglets decreased(Pba supplementation to NBW and IUGR piglets increased Firmicutes abundance and decreased bacteroidetes abundance(Pbacillus was the dominant genus in the *** analysis revealed 65 and 51 differential metabolites in the colon of piglets fed a diet with/without ba,respectively,which was associated with the colonic function of IUGR ***,dietary ba supplementation to IUGR piglets upregulated the expressions of CAT,GPX,SOD,Nrf1,IL-2,and IFN-γin colonic mucosa(Pba supplementation could improve the colonic function of IUGR piglets,which was associated with increasing proportions of potentially beneficial bacteria and ***,ba shows a promising application prospect in improving the intestinal ecosystem and health of animals.

关键词： Bile acid Intrauterine growth retardation Metabolite Microbiota Piglet

碱性成纤维细胞生长因子脑脊液途径用药对听觉系统保护作用的实验研究

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中国耳鼻咽喉头颈外科 2010年第4期17卷 204-207页

作者：宋瑞彪李素娟张晓巴云鹏郑州大学第一附属医院耳鼻咽喉科河南郑州450052

目的探讨碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)脑脊液途径用药对硫酸丁胺卡那霉素诱导的豚鼠听觉损害的防治作用,为临床有效防治感音神经性聋提供理论依据。方法应用硫酸丁胺卡那霉素肌肉注射诱导豚鼠听觉损害,... 详细信息

目的探讨碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)脑脊液途径用药对硫酸丁胺卡那霉素诱导的豚鼠听觉损害的防治作用,为临床有效防治感音神经性聋提供理论依据。方法应用硫酸丁胺卡那霉素肌肉注射诱导豚鼠听觉损害,将bFGF采用脑脊液途径注入豚鼠体内。用药结束后测试听性脑干反应(auditory brainstem response,ABR)阈值,行耳蜗灌注琥珀酸脱氢酶(succinate dehydrogenase,SDH)组化染色,耳蜗铺片,观察染色强度及内、外毛细胞损伤程度,取脑干和双侧耳蜗行甲苯胺蓝染色,耳蜗螺旋神经节细胞计数,并测量相应的积分光密度(integral optical density,IOD)。结果用药后各组动物ABR阈值测试有显著性差异;耳蜗SDH染色和铺片内、外毛细胞损伤程度不同;耳蜗切片螺旋神经节细胞计数及IOD测定、耳蜗核切片IOD测试各组间比较有显著性差异。结论bFGF脑脊液途径用药对硫酸丁胺卡那霉素诱导的豚鼠听觉系统损害有防治作用。

关键词：动物,实验豚鼠听觉丧失,感音神经性成纤维细胞生长因子2 脑脊髓液

超支化聚(酰胺-酯)的端基光致变色改性研究

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功能高分子学报 2005年第2期18卷 180-184页

作者：丁海涛巴信武王素娟张书文河北大学化学与环境科学学院河北保定071002

采用丁二酸酐、三羟甲基氨基甲烷为主要原料,先在冰水浴条件下合成AB3型单体,然后进行熔融缩聚制得超支化聚(酰胺酯)(HBP),最后用4(4′二甲氨基苯基偶氮)苯甲酸对HBP的末端羟基进行功能化改性,得到了一种具有光致变色和酸碱变色性的HBP... 详细信息

采用丁二酸酐、三羟甲基氨基甲烷为主要原料,先在冰水浴条件下合成AB3型单体,然后进行熔融缩聚制得超支化聚(酰胺酯)(HBP),最后用4(4′二甲氨基苯基偶氮)苯甲酸对HBP的末端羟基进行功能化改性,得到了一种具有光致变色和酸碱变色性的HBP;用紫外光谱对改性超支化聚(酰胺酯)的变色性进行了研究。结果表明随紫外光照时间延长紫外吸收强度增加;随pH值增大紫外吸收波长向短波方向移动。

关键词：超支化聚(酰胺-酯) HBP 功能化改性光致变色酸碱变色性

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中原地区住宅建筑结构活荷载调查与统计分析

土木工程学报 2006年第5期39卷 29-34,64页

作者：陈淮葛素娟李静斌孙增寿郑州大学河南郑州450002

从调查中原地区城镇住宅楼面活荷载出发,建立了持久性及临时性活荷载概率模型。经检验,统计荷载均服从极值I型分布。从调查统计所得的活荷载统计参数出发,根据Turkstra荷载组合原则,得出中原地区城镇住宅建筑结构在设计基准使用期内活... 详细信息

从调查中原地区城镇住宅楼面活荷载出发,建立了持久性及临时性活荷载概率模型。经检验,统计荷载均服从极值I型分布。从调查统计所得的活荷载统计参数出发,根据Turkstra荷载组合原则,得出中原地区城镇住宅建筑结构在设计基准使用期内活荷载组合最大值的统计参数。针对不同使用功能的房间,分别按照79.1%分位值和97.4%分位值计算出代表各类型房间的楼面活荷载标准值,并与荷载规范中住宅楼面活荷载标准值的单一取值相比。计算结果表明,与原规范值(GBJ9-87)相比,不同使用功能房间的活荷载标准值是不同的,有高有低,且活荷载标准值应有所提高,这也是与新规范值(GB50009-2001)相一致的。结果反映了中原地区城镇住宅不同使用功能房间活荷载标准值的变化,可为荷载规范的进一步修订提供参考。

关键词：中原地区住宅活荷载调查统计分析

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板栗‘燕山早丰’雌花分化的解剖学研究

中南林业科技大学学报 2017年第1期37卷 43-47页

作者：王丽媛郭素娟北京林业大学省部共建森林培育与保护教育部重点实验室北京100083

为明确板栗雌花分化的解剖学特点,以河北迁西板栗‘燕山早丰’为研究对象,通过制作石蜡切片显微观察雌花的内部解剖构造,结合外部形态变化,研究了板栗的花芽分化过程。结果表明:板栗雌花在河北迁西地区从4月初开始分化,6月上旬雌花大量... 详细信息

为明确板栗雌花分化的解剖学特点,以河北迁西板栗‘燕山早丰’为研究对象,通过制作石蜡切片显微观察雌花的内部解剖构造,结合外部形态变化,研究了板栗的花芽分化过程。结果表明:板栗雌花在河北迁西地区从4月初开始分化,6月上旬雌花大量盛开,整个分化过程需70 d左右,分化过程可分为未分化期、分化前期、花序原基分化期、苞片原基分化期、雌花簇原基分化期、雌蕊原基分化期,板栗花芽分化温度在8.8℃至25.7℃间,雌蕊原基形成到雌花盛开温度在9.7℃至23.3℃间为宜。根据有效积温、芽体大小、形状、叶片颜色等方面,建立了板栗雌花分化过程中外部形态变化与内部解剖特点之间的关系。

关键词：板栗花芽分化外部形态内部解剖