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Natural therapeutics for cancer treatment:success,challenges,and prospect

Journal of Bio-X Research 2023年第2期6卷 61-72页

作者： Debasmita Dubey Shakti Rath Rajesh kumar Meher Sanghamitra Mishra Soumya Surath Panda Subhashree Ray Subrat kumar tripathy Medical Research Laboratory IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Central Research Laboratory Institute of Dental SciencesSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyotiviharBurlaSambalpurOdishaIndia Department of Critical Care Medicine IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Department of Oncology IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Department of Biochemistry IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia.

Cancer is a terrifying disease that has become one of the world’s most challenging health concerns,necessitating a proactive approach to its *** is a rich source of new chemical entities and a promising avenue for cancer *** of their different modes of action on target events in many ways,nature-derived chemicals are considered good possibilities for anticancer drug *** current review article highlights recent breakthroughs in cancer therapeutics,including natural therapeutic molecules and their mechanisms of action against cancer treatment,as well as their limits,challenges,and *** the review,article data have been collected from previously studied and published research reports,clinical evaluations,case studies,and clinical statistical data generated by scientific research organizations of *** chemical structures have been drawn using computational software(chemsketch).The development of promising candidates that can prevent or reduce the proliferation of cancer cells without causing adverse effects from these therapeutics is now ***,nature-derived products are a game-changer because they are simple,safer,environmentally friendly,low-cost,quick,and less toxic than traditional treatment ***,many bioactive chemicals and their analogs have been discovered as possible anticancer treatment *** the review,the potent therapeutics phytochemicals derived from nature with their tremendous anticancer effects with limitations and prospects have been studied and analyzed based on previously published articles and reports.

关键词： cancer treatment chemotherapy drug resistance natural therapy toxicity

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Morbidity Profile and Causes of Mortality in Type 2 Diabetes Patients: Data from a Tertiary Teaching Hospital from Eastern India

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Journal of Diabetes Mellitus 2017年第3期7卷 195-211页

作者： Soumya Ranjan Behera Manoranjan Behera Sidhartha Das Bhabani Prasad Panda Saroj kumar tripathy Purna Chandra Dash Department of Medicine VSS Institute of Medical Sciences and Research Burla Sambalpur Odisha India PG Department of Medicine Faculty of Medicine Sriram Chandra Bhanja Medical College Cuttack Odisha India PG Department of Medicine Sriram Chandra Bhanja Medical College Cuttack Odisha India

Background: Data regarding the prevalence of morbidity and mortality in patients of Type 2 Diabetes Mellitus (T2DM) is scanty in India. Objectives: To determine the prevalence of micro and macro vascular complications, acute metabolic complications, infections, Non Alcoholic Fatty Liver Disease (NAFLD) and cause of mortality in T2DM patients admitted to a tertiary care teaching hospital in Eastern India. Material and Methods: This was a hospital-based prospective study evaluating 150 T2DM patients admitted to a tertiary care institution in Eastern India. Diagnosis of micro and macro vascular complications, infections and NAFLD was made using standard protocols. In case of death, the most probable cause was noted. Results: Out of 150 patients, 14.7% of patients were newly diagnosed T2DM and out of them 41% of patients had vascular complications and 54.5% had infections. Of the total patients, 56% had nephropathy, 20% neuropathy, 17.3% retinopathy, 31.3% CVD, 11.3% CAD, 4.6% acute metabolic complications, 44% infections and 16.6% had NAFLD respectively. Macrovascular events occured earlier than microvascular complications. Multiple logistic regression analysis showed strong association of age, duration of diabetes, serum cholesterol, triglyceride, LDL-C with retinopathy (Regression coefficient β: -0.1086807, 0.4127152, -0.0513393, 0.0146429, 0.0587475;p < 0.05, < 0.001, < 0.05, < 0.05, < 0.05 respectively), while only duration of diabetes was strongly associated with nephropathy and neuropathy (Regression coefficient β: 0.2538751, 0.2261636;p < 0.001 for each). Increasing age was associated with CAD (Regression coefficient β: 0.055392;p β: 0.0055014;p 18.6% patients died due to diabetes related complications. Cardiovascular (CV)-related deaths (CVD+CAD) were most common cause (51.5%: CVD 36.4%, CAD 15.1%) to be followed by infections (27.3%) and then chronic kidney disease (12.1%). Conclusions: This study highlights the high prevalence of vascular complications and in

关键词： Type 2 Diabetes Mellitus Vascular Complications Infections NAFLD Mortality

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The keystone-design perforator-based flap for leg defects: a synthesis of philosophies

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Plastic and Aesthetic Research 2014年第1期1卷 70-74页

作者： Jerry R.John Jyoshid R.Balan Satyaswarup tripathy Ramesh kumar Sharma Chandan Jadhav Department of Plastic Surgery Post Graduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Plastic Surgery Sushruta Institute of Plastic SurgeryElite HospitalsThrissur 680007KeralaIndia.

Aim:The classical keystone-design flap,although elegantly employed for various trunk defects,has limited movement on the *** study aims to modify the keystone–design flaps for leg ***:A keystone-design flap,in which perforators are identified and dissected,is described specifically for elliptical defects overlying the ***:It retains the unique advantages of both the perforator island flap concept as well as the keystone-design ***:The technique as well as the possibilities of raising such flaps over various areas of the leg is outlined.

关键词： Flap keystone leg defect lower extremity reconstruction perforator island flap

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Methods for a blind analysis of isobar data collected by the STAR collaboration

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Nuclear Science and Techniques 2021年第5期32卷 43-50页

作者： J.Adam L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin E.C.Aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines M.Calderon de la Barca Sanchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.Chen J.H.Chen X.Chen Z.Chen J.Cheng M.Cherney M.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford M.Csanad M.Daugherity T.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop T.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng Y.Feng P.Filip E.Finch Y.Fisyak A.Francisco L.Fulek C.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal X.Gou D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He Y.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.Holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch Y.Ji J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey Y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.kumar S.kumar R.Kunnawalkam Elayavalli J.H.Kwasizur R.Lacey S.Lan J.M.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung C.Li C.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik T.Lin Y.Lin M.A.Lisa F.Liu H.Liu P.Liu P.Liu T.Liu X.Liu Y.Liu Z.Liu T.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.Ma L.Ma R.Ma Y.G.Ma N.Magdy R.Majka D.Mallick S.Margetis C.Markert H.S.Matis J.A.Mazer N.G.Minaev S.Mioduszewski B.Mohanty I.Mooney Z.Moravcova D.A.Morozov M.Nagy J.D.Nam Md.Nasim K.Nayak D.Neff J.M.Nelson D.B.Nemes M.Nie G.Nigmatkulov T.Niida L.V.Nogach T.Nonak Christian University AbileneTX 796992 AGH University of Science and Technology FPACSCracow 30-059Poland Alikhanov Institute for Theoretical and Experimental Physics NRC"Kurchatov Institute" MoscowRussia 117218 Argonne National Laboratory ArgonneIL 60439 American University of Cairo New CairoNew Cairo 11835Egypt Brookhaven National Laboratory UptonNY 11973 University of California BerkeleyCA 94720 University of California DavisCA 95616 University of California Los AngelesCA 90095 University of California RiversideCA 92521 Central China Normal University Wuhan 430079 University of Illinois at Chicago ChicagoIL 60607 Creighton University OmahaNE 68178 Czech Technical University in Prague FNSPEPrague 11519Czech Republic Technische Universitat Darmstadt Darmstadt 64289Germany ELTE Eotvos Lorand University Budapest 1117Hungary Frankfurt Institute for Advanced Studies FIAS Frankfurt 60438Germany Fudan University Shanghai 200433 University of Heidelberg 69120 HeidelbergGermany University of Houston HoustonTX 77204 Huzhou University Huzhou 313000 Indian Institute of Science Education and Research(IISER) Berhampur 760010India Indian Institute of Science Education and Research(IISER)Tirupati Tirupati 517507India Indian Institute Technology PatnaBihar 801106India Indiana University BloomingtonIN 47408 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 University of Jammu Jammu 180001India Joint Institute for Nuclear Research DubnaRussia 141980 Kent State University KentOH 44242 University of Kentucky LexingtonKY 40506-0055 Lawrence Berkeley National Laboratory BerkeleyCA 94720 Lehigh University BethlehemPA 18015 Max-Planck-Institut fur Physik 80805 MunichGermany Michigan State University East LansingMI 48824 National Research Nuclear University MEPhI MoscowRussia 115409 National Institute of Science Education and Research HBNIJatni 752050India National Cheng Kung University Tainan 70101 Nuclear Physics Institute of the CAS Rez 25068Czech Republic Ohio State University

In 2018,the STAR collaboration collected data from^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr at√^(S)NN=200 Ge V to search for the presence of the chiral magnetic effect in collisions of *** isobar collision species alternated frequently between 9644 Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)*** order to conduct blind analyses of studies related to the chiral magnetic effect in these isobar data,STAR developed a three-step blind analysis *** are initially provided a"reference sample"of data,comprised of a mix of events from the two species,the order of which respects time-dependent changes in run *** tuning analysis codes and performing time-dependent quality assurance on the reference sample,analysts are provided a species-blind sample suitable for calculating efficiencies and corrections for individual≈30-min data-taking *** this sample,species-specific information is disguised,but individual output files contain data from a single isobar *** run-by-run corrections and code alteration subsequent to these corrections are allowed at this *** these modifications,the"frozen"code is passed over the fully un-blind data,completing the blind *** a check of the feasibility of the blind analysis procedure,analysts completed a"mock data challenge,"analyzing data from Au+Au collisions at√^(S)NN=27 Ge V,collected in *** Au+Au data were prepared in the same manner intended for the isobar blind *** details of the blind analysis procedure and results from the mock data challenge are presented.

关键词： Blind analysis Chiral magnetic effect Heavy-ion collisions

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Measurement of away-side broadening with self-subtraction of flow in Au+Au collisions at √sNN=200 GeV

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Chinese Physics C 2020年第10期44卷 59-67页

作者： L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin E.C.Aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines M.Calderón de la Barca Sánchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.H.Chen X.Chen Z.Chen J.Cheng M.Cherney M.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford M.Csanád M.Daugherity T.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop T.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng Y.Feng P.Filip E.Finch Y.Fisyak A.Francisco L.Fulek C.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.Holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch Y.JI J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey Y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.kumar S.kumar R.Kunnawalkam Elayavalli J.H.Kwasizur R.Lacey S.Lan J.M.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung C.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik T.Lin Y.Lin M.A.Lisa F.Liu H.Liu P.Liu P.Liu T.Liu X.Liu Y.Liu Z.Liu T.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.Ma L.Ma R.Ma Y.G.Ma N.Magdy R.Majka D.Mallick S.Margetis C.Markert H.S.Matis J.A.Mazer N.G.Minaev S.Mioduszewski B.Mohanty I.Mooney Z.Moravcova D.A.Morozov M.Nagy J.D.Nam Nasim Md K.Nayak D.Neff J.M.Nelson D.B.Nemes M.Nie G.Nigmatkulov T.Niida L.V.Nogach T.Nonaka A.S.Nunes G.Odyniec A.Ogawa Abilene Christian University AbileneTexas 79699 AGH University of Science and Technology FPACSCracow 30-059Poland Alikhanov Institute for Theoretical and Experimental Physics NRC"Kurchatov Institute" Moscow 117218Russia Argonne National Laboratory ArgonneIllinois 60439 American University of Cairo New Cairo 11835New CairoEgypt Brookhaven National Laboratory UptonNew York 11973 University of California BerkeleyCalifornia 94720 University of California DavisCalifornia 95616 University of California Los AngelesCalifornia 90095 University of California RiversideCalifornia 92521 Central China Normal University WuhanHubei 430079 University of Illinois at Chicago ChicagoIllinois 60607 Creighton University OmahaNebraska 68178 Czech Technical University in Prague FNSPEPrague 11519Czech Republic Technische Universität Darmstadt Darmstadt 64289Germany ELTE Eötvös Loránd University BudapestHungary H-1117 Frankfurt Institute for Advanced Studies FIAS Frankfurt 60438Germany Fudan University Shanghai 200433 University of Heidelberg Heidelberg 69120Germany University of Houston HoustonTexas 77204 Huzhou University HuzhouZhejiang 313000 Indian Institute of Science Education and Research(IISER) Berhampur 760010India Indian Institute of Science Education and Research(IISER)Tirupati Tirupati 517507India Indian Institute Technology PatnaBihar 801106India Indiana University BloomingtonIndiana 47408 Institute of Modern Physics Chinese Academy of SciencesLanzhouGansu 730000 University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna 141980Russia Kent State University KentOhio 44242 University of Kentucky LexingtonKentucky 40506-0055 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Lehigh University BethlehemPennsylvania 18015 Max-Planck-Institut für Physik Munich 80805Germany Michigan State University East LansingMichigan 48824 National Research Nuclear University MEPhI Moscow 115409Russia National Institute of Science Education and Research HBNIJatni 752050Indi

High transverse momentum(pT)particle production is suppressed owing to the parton(jet)energy loss in the hot dense medium created in relativistic heavy-ion *** of energy at low-to-modest pT has been difficult to measure,owing to large anisotropic *** report a data-driven method for background evaluation and subtraction,exploiting the away-side pseudorapidity gaps,to measure the jetlike correlation shape in Au+Au collisions at √sNN=200 GeV in the STAR *** correlation shapes,for trigger particles pT>3GeV/c and various associated particle pT ranges within 0.5

关键词： di-hadron correlations jet heavy-ion

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