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Botulinum toxin type A for treating chronic low back pain:A double blinded randomized control study

World Journal of Methodology 2024年第3期14卷 119-125页

作者： Mantu Jain Shahnawaz Khan Paulson Varghese sujit kumar tripathy Manaswini Mangaraj Department of Orthopaedics All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Biochemistry All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia

BACKGROUND Low back pain(LBP)is a prevalent issue that orthopedic surgeons frequently address in the outpatient *** can arise from various causes,with stiffness in the paraspinal muscles being a notable *** administration of Botulinum toxin type A(BoNT-A)has been found to alleviate back pain by relaxing these stiff *** BoNT-A is approved for use in numerous conditions,a limited number of randomized clinical trials(RCTs)validate its efficacy specifically for treating *** To study the safety and the efficacy of BoNT-A in minimizing pain and improving functional outcomes in patients of chronic LBP(CLBP).METHODS In this RCT,adults aged 18-60 years with mechanical LBP persisting for at least six months were *** were allocated to either the Drug group,receiving 200 Ipsen Units(2 mL)of BoNT-A,or the Control group,which received a 2 mL *** a 2-month follow-up period,both groups were assessed using the Visual Analog Scale(VAS)for pain intensity and the Oswestry Disability Index(ODI)for disability at the start and conclusion of the study.A decrease in pain by 50%was deemed clinically *** The study followed 40 patients for two months,with 20 in each group.A clinically significant reduction in pain was observed in 36 *** was a statistically significant decrease in both VAS and ODI scores in the groups at the end of two ***,when comparing the mean score changes,only the reduction in ODI scores(15 in the placebo group vs 16.5 in the drug group,clinically insignificant)was statistically significant(P=0.012),whereas the change in mean VAS scores was not significant(P=0.45).CONCLUSION The study concludes that BoNT-A does not offer a short-term advantage over placebo in reducing pain or improving LBP scores in CLBP patients.

关键词： Botulinum toxin type A Chronic low back pain Randomized control study Double-blinded Pain management Therapeutic efficacy

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Analysis of causes for revision in unicompartmental knee arthroplasty

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World Journal of Clinical Cases 2024年第25期12卷 5642-5645页

作者： sujit kumar tripathy Siddharth Satyakam Pradhan Shahnawaz Khan Hursch Patel Department of Orthopaedics All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Orthopedics All India Institute of Medical SciencesBhubaneswar 751019India Department of Medicine Kansas City University of Medicine and BiosciencesKansas CityMO 64106United States

The study by Zhao et al identifies the factors leading to the failure of unicompartmental knee arthroplasty(UKA)in their *** factors include substandard suturing of the wound,the presence of osteophytes and intra-articular loose bodies causing impingement,premature loosening of the tibial component,choosing unsuitable patients for the procedure,dislocation of the movable insert,and damage to the anterior cruciate ligament and medial collateral *** findings suggest that employing the correct surgical techniques and indications is essential for successful outcomes in the UKA.

关键词： Unicompartmental knee arthroplasty Arthroplasty Knee Failure Conversion TKA

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Effect of osteoarthritic knee flexion deformity correction by total knee arthroplasty on sagittal spinopelvic alignment in Indian population

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World Journal of Clinical Cases 2022年第21期10卷 7348-7355页

作者： Lubaib Karaniveed Puthiyapura Mantu Jain sujit kumar tripathy Haridas Mundot Puliappadamb Department of Orthopaedics AIIMS BhubaneswarBhubaneswar 751019OdishaIndia Department of Pharmacology AIIMS BhubaneswarBhubaneswar 751019OdishaIndia

BACKGROUND Sagittal alignment of the spine,pelvis,and lower extremities is essential for maintaining a stable and efficient posture and *** in any element can result in compensatory changes in the other *** flexion is a compensatory mechanism for spinopelvic sagittal alignment and is markedly affected in severe knee osteoarthritis(OA).The correction of knee flexion deformity(KFD)by total knee arthroplasty(TKA)can lead to complementary changes in the sagittal spinopelvic parameters(SSPs).AIM To determine the SSP changes in patients with knee OA,with or without KFD undergoing *** The study was conducted in 32 patients who underwent TKA.A neutral standing whole-spine lateral radiograph was performed before surgery and 3 mo after surgery in these *** were divided into two groups(Group 1 obtained>10°corrections in KFD;group B obtained10°)in KFD.

关键词： Knee osteoarthritis Total knee replacement Spino-sagittal parameters Knee flexion deformity

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Perioperative mortality and morbidity of hip fractures among COVID-19 infected and non-infected patients: A systematic review and meta-analysis

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Chinese Journal of Traumatology 2023年第3期26卷 162-173页

作者： sujit kumar tripathy Paulson Varghese Sibasish Panigrahi Bijnya Birajita Panda Anand Srinivasan Ramesh kumar Sen Department of Orthopedics All India Institute of Medical SciencesBhubaneswar751019India Department of Ophthalmology Srirama Chandra Bhanja Medical College and HospitalCuttack753007India Department of Pharmacology All India Institute of Medical SciencesBhubaneswar751019India Department of Orthopaedics Max HospitalMohali160055India

Purpose:Hip fractures among elderly patients are surgical *** COVID-19 pandemic time,many such patients could not be operated at early time because of the limitation of the medical resources,the risk of infection and redirection of medical attention to a severe infective health ***:A search of electronic databases(PubMed,Medline,CINAHL,EMBASE and the Cochrane Central Register of Controlled Trials)with the keywords"COVID","COVID-19","SARS-COV-2","Corona","pandemic","hip fracture","trochanteric fracture"and"neck femur fracture"revealed 64 studies evaluating treatment of hip fracture in elderly patients during COVID-19 pandemic *** 30-day mortality rate,inpatient mortality rate,critical care/special care need,readmission rate and complications rate in both groups were *** were analyzed using Review Manager(RevMan)***:After screening,7 studies were identified that described the mortality and morbidity in hip fractures in both COVID-19 infected(COVID-19+)and non-infected(COVID-19-)*** were significantly increased risks of 30-day mortality(32.23%COVID-19+deathvs.8.85%COVID-19-death)and inpatient mortality(29.33%vs.2.62%)among COVID-19+patients with odds ratio(OR)of 4.84(95%CI:3.13-7.47,p<0.001)and 15.12(95%CI:6.12-37.37,p<0.001),*** COVID-19+patients needed more critical care admission(OR=5.08,95%CI:1.49-17.30,p<0.009)and they remain admitted for a longer time in hospital(mean difference=3.6,95% CI:1.74-5.45,p<0.001);but there was no difference in readmission rate between these 2 *** risks of overall complications(OR=17.22),development of pneumonia(OR=22.25),and acute respiratory distress syndrome/acute respiratory failure(OR=32.96)were significantly high among COVID-19+patients compared to ***:There are increased risks of the 30-day mortality,inpatient mortality and critical care admission among hip fracture patients who are COVID-19+.The chances of developing pn

关键词： Hip fracture Femur neck fracture Mortality COVID-19 Pandemic

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Nuclear medicine imaging in osteonecrosis of hip:Old and current concepts

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World Journal of Orthopedics 2017年第10期8卷 747-753页

作者： Kanhaiyalal Agrawal sujit kumar tripathy Ramesh kumar Sen S Santhosh Anish Bhattacharya Department of Nuclear Medicine All India Institute of Medical Sciences Department of Orthopedics All India Institute of Medical Sciences Department of Orthopedics Fortis Hospital Institute of Nuclear Imaging and Molecular Medicine Tamilnadu Government Multi Super Specialty Hospital Department of Nuclear Medicine PGI-MER

Osteonecrosis(ON) is caused by inadequate blood supply leading to bone death, which results in the collapse of the architectural bony structure. Femoral head is the most common site involved in ON. Magnetic resonance imaging(MRI) is a commonly used imaging modality to detect early ON. When MRI is inconclusive, bone scan is helpful in detecting ON during early phase of the disease. As newer nuclear medicine equipment, like single photon emission computed tomography/computed tomography(CT) and positron emission tomography/CT, are emerging in medical science, we review the role of these imaging modalities in ON of femoral head.

关键词： Osteonecrosis Avascular necrosis Bone scan Magnetic resonance imaging Photon emission computed tomography scan Single photon emission computed tomography/computed tomography

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Functional outcome of tibial fracture with acute compartment syndrome and correlation to deep posterior compartment pressure

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World Journal of Orthopedics 2017年第5期8卷 385-393页

作者： Saumitra Goyal Monappa A Naik sujit kumar tripathy Sharath K Rao Department of Orthopedics Kasturba Medical College Manipal University Department of Orthopedics All India Institute of Medical Sciences

AIM To measure single baseline deep posterior compartment pressure in tibial fracture complicated by acute compartment syndrome(ACS) and to correlate it with functional *** Thirty-two tibial fractures with ACS were evaluated clinically and the deep posterior compartment pressure was measured. Urgent fasciotomy was needed in 30 patients. Definite surgical fixation was performed either primarily or once fasciotomy wound was healthy. The patients were followed up at 3 mo, 6 mo and one year. At one year, the functional outcome [lower extremity functional scale(LEFS)] and complications were *** Three limbs were amputated. In remaining 29 patients, the average times for clinical and radiological union were 25.2 ± 10.9 wk(10 to 54 wk) and 23.8 ± 9.2 wk(12 to 52 wk) respectively. Nine patients had delayed union and 2 had nonunion who needed bone grafting to augment healing. Most common complaint at follow up was ankle stiffness(76%) that caused difficulty in walking,running and squatting. Of 21 patients who had paralysis at diagnosis, 13(62%) did not recover and additional five patients developed paralysis at follow-up. On LEFS evaluation, there were 14 patients(48.3%) with severe disability, 10 patients(34.5%) with moderate disability and 5 patients(17.2%) with minimal disability. The mean pressures in patients with minimal disability, moderate disability and severe disability were 37.8, 48.4 and 58.79 mmH g respectively(P < 0.001).CONCLUSION ACS in tibial fractures causes severe functional disability in majority of patients. These patients are prone for delayed union and nonunion; however, long term disability is mainly because of severe soft tissue contracture. Intracompartmental pressure(ICP) correlates with functional disability; patients with relatively high ICP are prone for poor functional outcome.

关键词： Compartment syndrome Leg Tibial fracture Deep posterior compartment Intracompartmental pressure Functional outcome

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Ipsilateral fracture dislocations of the hip and knee joints with contralateral open fracture of the leg： a rare case and its management principles

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Chinese Journal of Traumatology 2011年第3期14卷 183-187页

作者： Ramesh kumar Sen sujit kumar tripathy Vibhu Krishnan Tarun Goyal Vanyambadi Jagadeesh Department of Orthopedics Postgraduate Institute of Medical Education and Research Chandigarh 160012 India

这份报纸讨论了损害机制和有的伴随物 ipsilateral 臀部和膝脱臼和 contralateral 打开腿骨折的一个病人的管理。一个 32 岁的人与左臀部(小瓦锅的类型 IV ) 和关节和 contralateral 张开的膝(穆尔二世) 的 ipsilateral 破裂脱臼介绍了... 详细信息

这份报纸讨论了损害机制和有的伴随物 ipsilateral 臀部和膝脱臼和 contralateral 打开腿骨折的一个病人的管理。一个 32 岁的人与左臀部(小瓦锅的类型 IV ) 和关节和 contralateral 张开的膝(穆尔二世) 的 ipsilateral 破裂脱臼介绍了在一个汽车事故以后的腿骨头的骨折。在紧急情况以后使复生的措施，新潮的关节被减少，小瓦锅的破裂用 Ganz 途径被修理与落后螺丝钉；膝关节仔细被减少，胫骨的高原骨折与跨越 fixator 的侧面的撑墙板和 transarticular 被稳定。另外的腿上的开的破裂与外部 fixator 被清除并且修理。当他在麻醉下面被检查时，在在固定以后的两个关节没有不稳定性。破裂在 3 个月以后联合起来，病人没有臀部和膝的剩余不稳定性。没有在在 6 个月以后的新潮的关节的 osteonecrosis 的临床或放射学的证据。在一个年后续，他在两个关节与运动的几乎正常范围有令人满意的功能的结果。Ipsilateral 臀部和膝脱臼是稀罕损害，更多的小心为早诊断被需要。及时适当干预能处于这种状况提供好功能的结果给病人。

关键词：膝关节管理原则髋关节骨折不稳定性外固定架股骨头坏死损伤机制

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Simultaneous bilateral anterior shoulder dislocation： report of two cases and review of the literature

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Chinese Journal of Traumatology 2011年第5期14卷 312-315页

作者： sujit kumar tripathy Ramesh kumar Sen Sameer Aggarwal Sarvdeep Singh Dhatt Naveen Tahasildar Department of Orthopedics Postgraduate Institute of Medical Education and Research Sector 12 Chandigarh 160 012 India

双边的肩膀脱臼 arerare 并且几乎总是发生在以后的方向。同时的双边的前面的肩膀脱臼甚至更稀罕，仅仅一些案例在文学被说。当同步、同时的力量被需要导致它，双边的肩膀脱臼的最有趣的部分关于它的损害机制。在癫痫或电刑的情况下，... 详细信息

双边的肩膀脱臼 arerare 并且几乎总是发生在以后的方向。同时的双边的前面的肩膀脱臼甚至更稀罕，仅仅一些案例在文学被说。当同步、同时的力量被需要导致它，双边的肩膀脱臼的最有趣的部分关于它的损害机制。在癫痫或电刑的情况下，机制是不同的，肌肉的选择的组的有力的收缩导致脱臼。这篇文章报导在一个癫痫的病人发生在一个道路方面事故以后并且在骚动的一个事件以后的双边的同时的前面的肩膀关节脱臼的二个案例。脱臼早被诊断并且与合适的 postreduction 康复立即减少了。在他们的后续期间， bothpatients 有令人满意的功能的结果。这篇文章在道路方面事故牺牲品和癫痫的病人在肩膀检查的重要性上强调。所有矫形 surgeonsand 紧急情况医生应该知道如此的不平常的可能性有早诊断和治疗。早减小和适当康复能提供令人满意的功能的结果。这篇文章简短也讨论损害机制，诊断并且在文学报导了的双边的肩膀脱臼的治疗。

关键词：肩关节文献早期诊断复习损伤机制癫痫病后续过程双边

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Long term surgical treatment outcome of talar body fracture

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Chinese Journal of Traumatology 2011年第5期14卷 282-287页

作者： Ramesh kumar Sen sujit kumar tripathy Shakthivel RR Manoharan Vibhu Krishnan Tajir Tamuk Vanyambadi Jagadeesh Department of Orthopaedics Postgraduate Institute of Medical Education and Research Sector-12 Chandigarh 160012 India

lObjectiveTalar 身体破裂是稀罕的并且有差的处理结果。学习是报导关上的 talardome *** 的长期的外科的治疗结果的这的目的关上了 talar 身体破裂，在我们的水平与小碎片 cancellous 螺丝钉或 Herbert 螺丝钉由开的减小和内部固定对... 详细信息

lObjectiveTalar 身体破裂是稀罕的并且有差的处理结果。学习是报导关上的 talardome *** 的长期的外科的治疗结果的这的目的关上了 talar 身体破裂，在我们的水平与小碎片 cancellous 螺丝钉或 Herbert 螺丝钉由开的减小和内部固定对待我损伤中心回顾地被分析。脚(antero 以后、侧面、倾斜的看法) 和脚关节的外科手术前、手术后的拍(antero 以后，侧面并且榫眼看法) 被获得。病人被跟随在上面放射学地并且机能上地(脚功能索引， FFI ) 在 3 以后，星期， 6 个星期， 3 个月， 6 个月然后 *** 是五压碎破裂并且三砍破裂(二 sagittal 砍并且一个花冠砍) ，与 5 年的平均后续。没有早复杂并发症在这些病人被注意。迟了的复杂并发症在四个病人在 talar 身体的六个病人和 osteonecrosis 包括了 subtalar/ankle 关节的 osteoarthrosis。在功能的评价以后，在 5 年以后的吝啬的 FFI 是 104.63 个点，更坏的结果在压碎损害和花冠被注意砍破裂。Sagittal 砍破裂有对通过手术对待的 talar 身体破裂随后的复杂并发症是的好功能、放射学的 *** 不可避免尽管准确减小和僵硬固定被完成，因此，病人们应当关于不利结果被建议。尽管压碎和花冠砍，破裂有差的结果， sagittal 损害在长期的评估上有好预后。

关键词：手术治疗骨折剪切裂缝股骨头坏死并发症治疗效果固定治疗骨关节病

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Association of vitamin D and knee osteoarthritis in younger individuals

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World Journal of Orthopedics 2020年第10期11卷 418-425页

作者： sujit kumar tripathy Amrit Gantaguru Saurav Narayan Nanda Sandeep Velagada Anand Srinivasan Manaswini Mangaraj Department of Orthopaedics All India Institute of Medical SciencesBhubaneswarBhubaneswar 751019OdishaIndia Department of Pharmacology AIIMS BhubaneswarBhubaneswar 751019OdishaIndia Department of Biochemistry AIIMS BhubaneswarBhubaneswar 751019OdishaIndia

BACKGROUND The incidence of primary osteoarthritis knee is gradually increasing among young *** increasing prevalence of obesity,sedentary lifestyle,sporting activity,and vitamin D deficiency(VDD)has been hypothesized for this shifting disease *** study was designed to look for the association of serum vitamin D among these young arthritic *** To look for the association of serum vitamin D in younger knee osteoarthritis(KOA)*** In a 2-year observational study,146 non-obese KOA patients of 35-60 years were evaluated clinically(Knee injury and Osteoarthritis Outcome Score,KOOS)and radiologically(Kellegren-Lawrence stage,KL).The serum 25(OH)D level of these patients and 146 normal healthy individuals of same age group were *** Both the groups were comparable in terms of age and *** average serum 25(OH)D level in healthy individuals and KOA patients was 45.83 ng/mL and 34.58 ng/mL,respectively(P<0.001).Inadequate serum 25(OH)D level(<30 ng/mL)was found in 46.57%of KOA patients and 24%of normal healthy participants indicating a significant positive association(odds ratio 2.77,95%CI:1.67-4.54,P<0.001).The 25(OH)D level in KL grade I,II,III and IV was 43.40,30.59,31.56 and 33.93 ng/mL respectively(no difference,P=0.47).Similarly,the KOOS score in sufficient,insufficient and deficient groups were 65.31,60.36 and 65.31,respectively(no difference,P=0.051).CONCLUSION The serum 25(OH)D level is significantly low in younger KOA ***,the clinical and radiological severities have no association with serum vitamin D level.

关键词： Degenerative disease Early-onset arthritis Cholecalciferol Sunlight Knee joint Arthroplasty Knee replacement

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