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Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit kumar pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

Wind environment around the setback building models

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Building Simulation 2021年第5期14卷 1525-1541页

作者： Amlan kumar Bairagi sujit kumar Dalui Department of Civil Engineering Indian Institute of Engineering Science and TechnologyShibpurHowrahIndia

The irregular shape of buildings always tenders an enormous challenge to the *** wind velocity at the pedestrian level has a specific approach from a comfortable point of *** investigation highlighted the characteristic of the pedestrian level wind velocity for distinct types of asymmetrical setback *** passed study explored the pedestrian level effect for the axisymmetric models,while this study is based on the models that have symmetry about a single *** study investigates the pedestrian level flow fluctuation of setback models with single and double side setbacks at multiple *** double-side double setback buildings are efficient to reduce 28%-30%velocity in front of the building and 68%-70%velocity behind the *** it suggests that the double side double setback building is efficient to maintain the velocity at the pedestrian level,roof level,and backside of the *** setback building can easily control the frequency of fluctuating velocity at downstream flow for both along and across wind conditions.

关键词： amplification factor pedestrian level flow setback model velocity spectra wind environment computational fluid dynamics(CFD)

Effects of side ratio for ‘Y’ plan shaped tall building under wind load

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Building Simulation 2021年第4期14卷 1221-1236页

作者： Prasenjit Sanyal sujit kumar Dalui Department of Civil Engineering Meghnad Saha Institute of TechnologyKolkataIndia Department of Civil Engineering IIESTShibpurHowrahIndia

Wind load and response are the major factors that govern the most critical condition for designing tall buildings. This study discusses the variability of wind load and pressure on a Y plan shaped tall building due to the change in the building side ratio. The length to width ratio is changed keeping the total plan area same. The numerical study is done by ANSYS CFX. Two turbulence models, k-epsilon and shear stress transport (SST), are used for doing the numerical simulation and the results are compared with the previous wind tunnel results in a similar flow condition. Sample points were selected based on Audze–Eglais Uniform Latin Hypercube (AELH) method and the analytical expressions of force, moment and torsional coefficients of Y plan shaped tall building are proposed. These expressions are fitted very well and the AELH method has given a great set of sample points that have significantly decreased the total computational time. The graphical representations of these expressions for various coefficients are presented and discussed. Then pressure distributions on three different models are compared and the pros and cons of higher and lower values of side ratios are discussed.

关键词： computational fluid dynamics AELH sampling method least square polynomial side ratio force coefficient moment coefficient

Interaction behavior and load sharing pattern of piled raft using nonlinear regression and LM algorithm-based artificial neural network

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Frontiers of Structural and Civil Engineering 2021年第5期15卷 1181-1198页

作者： Plaban DEB sujit kumar PAL Department of Civil Engineering G H Raisoni College of Engineering&ManagementPune 412207India Department of Civil Engineering National Institute of TechnologyAgartala 799046India

In the recent era,piled raft foundation(PRF)has been considered an emergent technology for offshore and onshore *** previous studies,there is a lack of illustration regarding the load sharing and interaction behavior which are considered the main intents in the present *** element(FE)models are prepared with various design variables in a double-layer soil system,and the load sharing and interaction factors of piled rafts are *** obtained results are then checked statistically with nonlinear multiple regression(NMR)and artificial neural network(ANN)modeling,and some prediction models are *** models are prepared with Levenberg-Marquardt(LM)algorithm for load sharing and interaction factors through backpropagation *** factor of safety(FS)of PRF is also estimated using the proposed NMR and ANN models,which can be used for developing the design strategy of PRF.

关键词： interaction load sharing ratio piled raft nonlinear regression artificial neural network

Stabilization of expansive soils using chemical additives: A review

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第4期14卷 1319-1342页

作者： Dharmendra Barman sujit kumar Dash Department of Civil Engineering Indian Institute of Technology KharagpurKharagpur721302India

Volume instability of expansive soils due to moisture fluctuations is often disastrous,causing severe damages and distortions in the supported *** is,therefore,necessary to adequately improve the performance of such soils that they can favorably fulfil the post-construction stability *** can be achieved through chemical stabilization using additives such as lime,cement and fly *** this paper,suitability of such additives under various conditions and their mechanisms are reviewed in *** is observed that the stabilization process primarily involves hydration,cation exchange,flocculation and pozzolanic *** degree of stabilization is controlled by several factors such as additive type,additive content,soil type,soil mineralogy,curing period,curing temperature,delay in compaction,pH of soil matrix,and molding water content,including presence of nano-silica,organic matter and sulfate *** of nano-silica not only improves soil packing but also accelerates the pozzolanic ***,presence of deleterious compounds such as sulfate or organic matter can turn the treated soils unfavorable at times even worser than the unstabilized ones.

关键词： Expansive soil Cement Lime Fly ash Pozzolanic reactions Sulfate attack

H_(∞) Load Frequency Control Design Based on Delay Discretization Approach for Interconnected Power Systems with Time Delay

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Journal of Modern Power Systems and Clean Energy 2021年第6期9卷 1468-1477页

作者： Subrat kumar pradhan Dushmanta kumar Das Department of Electrical and Electronics Engineering National Institute of Technology Nagaland

This paper proposes a delay discretization based H∞load frequency control strategy for interconnected power *** effect of time delay is considered in the system for the design of stabilizing *** improve the tolerable delay margin of the system,a two-term state feedback controller structure is *** controller requires delayed state information as control *** the proposed approach,the amount of delay introduced in the state of the system,i.e.,artificial delay,for taking control action is assumed to be *** approach is based on the discretization of this delay *** order to define a simple Lyapunov-Krasovskii(LK)function for each of the discretized interval,a stabilization criterion is developed in such a way that a single one satisfies the requirement of all the *** developed criterion is computationally simple and efficient.

关键词： Interconnected power system load frequency control(LFC) state feedback controller time delay

A Compact Quad-Band Sickle-Shaped Monopole Antenna for GSM 900/WiMax/WLAN Applications

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Computers, Materials & Continua 2022年第10期73卷 397-410页

作者： sujit Goswami sujit kumar Mandal Soumen Banerjee Department of Electronics and Communication Engineering National Institute of TechnologyDurgapur713213West BengalIndia Department of Electronics and Communication Engineering University of Engineering and ManagementNew TownKolkata700156West BengalIndia

In this paper a novel,compact,microstrip-fed,quad-band monopole antenna is presented for the application of Global System for Mobile communication(GSM 900),Worldwide Interoperability for Microwave Access(WiMAX)and Wireless Local Area Network(WLAN).The proposed antenna comprises of a sickle-shaped structure with four circular arc strips,and a modified rectangular ground *** four strips of the antenna are independently responsible for the four different resonant frequencies of the operating bands and can be tuned separately to control the radiation *** proposed quad-band antenna is designed to resonate at 940 MHz for GSM 900,2.5 and 3.5 GHz for WiMAX and 5.85 GHz for WLAN *** the four intended operating bands,the antenna exhibits impedance bandwidth of 60 MHz(905–965MHz),80 MHz(2.45–2.53 GHz),110 MHz(3.48–3.59 GHz)and 2.39 GHz(4.82–7.21 GHz),*** the resonance frequency of the four bands,the gain of the proposed antenna is obtained as 4.2,2.5,1.7 and 1.9 dBi,respectively.A prototype of the designed antenna is fabricated and a good agreement between simulated and measured results is ***,the proposed antenna shows good radiation characteristics and gains at all the four operating bands.

关键词： Antenna gain GSM 900 IEEE 802.11a monopole strips quad-band sickle-shaped WiMAX WLAN

Position Control of a Flexible Manipulator Using a New Nonlinear Self-Tuning PID Controller

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 136-149页

作者： Santanu kumar pradhan Bidyadhar Subudhi School of Electrical Sciences National Institute of Science and Technology BerhampurOdisha 761008India School of Electrical Sciences Indian Institute of TechnologyFarmagudiGoa 403401India

In this paper, a new nonlinear self-tuning PID controller(NSPIDC) is proposed to control the joint position and link deflection of a flexible-link manipulator(FLM) while it is subjected to carry different payloads. Since, payload is a critical parameter of the FLM whose variation greatly influences the controller performance. The proposed controller guarantees stability under change in payload by attenuating the non-modeled higher order dynamics using a new nonlinear autoregressive moving average with exogenous-input(NARMAX) model of the FLM. The parameters of the FLM are identified on-line using recursive least square(RLS) algorithm and using minimum variance control(MVC) laws the control parameters are updated in real-time. This proposed NSPID controller has been implemented in real-time on an experimental set-up. The joint tracking and link deflection performances of the proposed adaptive controller are compared with that of a popular direct adaptive controller(DAC). From the obtained results, it is confirmed that the proposed controller exhibits improved performance over the DAC both in terms of accurate position tracking and quick damping of link deflections when subjected to variable payloads.

关键词： Flexible-link manipulator position control self-tuning control NARMAX trajectory tracking

Short-term mixed electricity demand and price forecasting using adaptive autoregressive moving average and functional link neural network

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Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1241-1255页

作者： sujit kumar DASH Pradipta Kishore DASH Siksha O Anusandhan Deemed to be University Bhubaneswar 751030India

A new hybrid adaptive autoregressive moving average(ARMA)and functional link neural network(FLNN)trained by adaptive cubature Kalman filter(ACKF)is presented in this paper for forecasting day-ahead mixed short-term demand and electricity prices in smart *** hybrid forecasting framework is intended to capture the dynamic interaction between the electricity consumers and the forecasted prices resulting in the shift of demand curve in electricity *** proposed model comprises a linear ARMA-FLNN obtained by using a nonlinear expansion of the weighted *** nonlinear functional block helps introduce nonlinearity by expanding the input space to higher dimensional space through basis *** train the ARMA-FLNN,an ACKF is used to obtain faster convergence and higher forecasting *** proposed method is tested on several electricity markets,and the performance metrics such as the mean average percentage error(MAPE)and error variance are compared with other forecasting methods,indicating the improved accuracy of the approach and its suitability for a real-time forecasting.

关键词： Mixed demand and price forecasting Cubature Kalman filter Price spikes Smart grids