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Increase in Organochlorine Contaminant Levels in Major Water Sources of the United States in Response to the Coronavirus Pandemic

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Journal of Biosciences and Medicines 2024年第5期12卷 111-143页

作者： Wendy Wilburn sujata Guha Ryan Beni Department of Biological Sciences Tennessee State University Nashville TN USA Department of Chemistry Tennessee State University Nashville TN USA

Organochlorine contaminants, such as triclosan (TCS), are present in major water sources across the United States. These antimicrobial compounds are widely used as multipurpose ingredients in everyday consumer products. They can be ingested or absorbed through the skin and are found in human blood, breast milk, and urine samples. Studies have shown that the increased use of antimicrobial agents leads to their presence and persistence in the ecosystem, particularly in soil and watersheds. Many studies have highlighted emerging concerns associated with the overuse of TCS, including dermal irritations, a higher incidence of antibacterial-related allergies, microbial resistance, disruptions in the endocrine system, altered thyroid hormone activity, metabolism, and tumor metastasis and growth. Organochlorine contaminant exposures play a role in inflammatory responsiveness, and any unwarranted innate response could lead to adverse outcomes. The capacity of TCS and other organochlorine contaminants to induce inflammation, resulting in persistent and chronic inflammation, is linked to various pathologies, such as cardiovascular disease and several types of cancers. Chronic inflammation presents a severe consequence of exposure to these antimicrobial agents, as any changes could result in the loss of immune competence. Organochlorine contaminant levels were established by the United States Environmental Protection Agency (EPA) in 2019-2020 and have consistently increased in response to the novel coronavirus (nCoV) (COVID-19) pandemic. Our previous research examined the overuse of products containing triclosan (TCS), which led to an increase in total trihalomethane (TTHM) levels affecting the quality of our water supply. We also investigated the impact of the FDA ban that now requires pre-market approval. To comprehend the consequences of excessive antimicrobial use on water quality, we conducted an analysis of the levels of total trichloromethane (chloroform), a byproduct of

关键词： Organochlorine Contaminants Triclosan Trihalomethane Chloroform Water Quality

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预测翻车华尔街错在哪儿了?

商业周刊（中文版） 2024年第1期 20-21页

作者： Alexandra Semenova Sagarika Jaisinghani Liz Capo McCormick Selcuk Gokoluk Ye Xie sujata Rao-Coverley Matt Turner 孟洁冰(译) 不详

回顾2022年底,不管是股票部门还是债券部门,无论是大公司还是小机构,整个华尔街的气氛都很低落。当时似乎大家都在未雨绸缪,认为经济衰退即将到来。在摩根士丹利(Morgan Stanley),看跌美股的策略师迈克·威尔逊(Mike Wilson)迅速成为市... 详细信息

回顾2022年底,不管是股票部门还是债券部门,无论是大公司还是小机构,整个华尔街的气氛都很低落。当时似乎大家都在未雨绸缪,认为经济衰退即将到来。在摩根士丹利(Morgan Stanley),看跌美股的策略师迈克·威尔逊(Mike Wilson)迅速成为市场宠儿,他预测标准普尔500指数即将大跌。

关键词：摩根士丹利经济衰退标准普尔500指数美股华尔街债券股票未雨绸缪

MSCs derived extracellular vesicles as a therapeutic paragon for neurodegenerative disorders:A viewpoint

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BIOCELL 2022年第6期46卷 1435-1438页

作者： YASHVI SHARMA SHARDA RAY sujata MOHANTY Stem Cell Facility(DBT-Centre of Excellence for Stem Cell Research) All India Institute of Medical SciencesNew DelhiIndia Jawaharlal Nehru Medical College KarnatakaIndia

Neurodegenerative disorders are a vicious woe to the public health and *** in their underlying causes,lack of effective biomarkers for their early detection,existence of only supportive therapy,and their ever rising incidence creates an unmatched need for targeted *** Stem Cells(MSCs)have found to be promising candidates for regenerative and remedial therapy in neurodegenerative disorders,however several biological risks and practical issues impede in their translational *** from MSCs are certain Extracellular Vesicles(EVs),which aid in the paracrine action of MSCs and have lately gained the scientific interest for their implacability in diverse set *** cargo is of utmost importance and is being explored in various different diseases like heart diseases,neuronal diseases,respiratory diseases and hepatic *** thereby hold the position of a likely prospective remedial candidate for therapy against neurodegenerative disorders.

关键词： Mesenchymal stem cells Extracellular vesicles Neurodegenerative disorders Cell-free therapy Regeneration

Swarm Optimization and Machine Learning for Android Malware Detection

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Computers, Materials & Continua 2022年第12期73卷 6327-6345页

作者： K.Santosh Jhansi P.Ravi Kiran Varma sujata Chakravarty Centurion University of Technology and Management ParalakhemundiOdishaIndia Maharaj Vijayaram Gajapathi Raj College of Engineering VizianagaramIndia Centurion University of Technology and Management BhubaneswarOdishaIndia

Malware Security Intelligence constitutes the analysis of applications and their associated metadata for possible security *** Programming Interfaces(API)calls contain valuable information that can help with malware *** malware analysis with reduced feature space helps for the efficient identification of *** goal of this research is to find the most informative features of API calls to improve the android malware detection *** swarm optimization methods,viz.,Ant Lion Optimization(ALO),Cuckoo Search Optimization(CSO),and Firefly Optimization(FO)are applied to API calls using auto-encoders for identification of most influential *** nature-inspired wrapperbased algorithms are evaluated using well-known Machine Learning(ML)classifiers such as Linear Regression(LR),Decision Tree(DT),Random Forest(RF),K-Nearest Neighbor(KNN)&SupportVector Machine(SVM).A hybrid Artificial Neuronal Classifier(ANC)is proposed for improving the classification of android *** experimental results yielded an accuracy of 98.87%with just seven features out of hundred API call features,i.e.,a massive 93%of data optimization.

关键词： Android malware API calls auto-encoders ant lion optimization cuckoo search optimization firefly optimization artificial neural networks artificial neuronal classifier

Double co-host emitter based top emitting white organic light emitting diodes with enhanced brightness and efficiency

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Optoelectronics Letters 2021年第10期17卷 581-585页

作者： Neha Jain sujata Pandey Rajiv Kr.singh O.P.Sinha Department of ECE Amity School of Engineering and TechnologyAmity UniversityUPNoidaIndia Department ofEEE Galgotia College of Engineering and TechnologyGreater NoidaIndia CSIR-National Physical Laboratory New DelhiIndia Amity Institute of Nanotechnology Amity University UPNoidaIndia

Novel and simplified bi-layer top-emitting white organic light emitting diodes(OLEDs)with dual co-host emitters have been simulated and *** consist of yellow-green emitting layer(EML)as electron transport layer(ETL)and blue EML as hole transport layer(HTL).Novelty of the device lies in simplification of tri-layer white OLED to a bi-layered device which is done by merging yellow-green EML with ETL and blue EML with *** simulated devices show Commission Internationale de L’Eclairage(CIE)colour coordinates well within the emission range of white *** results show that device A with 5,6,11,12-tetraphenylnaphthacene(rubrene)doped ETL has achieved the lowest luminance but longest excited state *** D with tris-(8-hydroxyquinoline)aluminum:4-(dicyanomethylene)-2-t-butyle-6-(1,1,7,7-tetra-methyljulolidyl-9-enyl)4 H-pyran(Alq3:DCJTB)as ETL which emits yellow light and 2,7-bis[N,N-bis(4-methoxy-phenyl)amino]-9,9-spirobifluorene(MS-TPD):bis(2-methyl-8-quninolinato)-4-phenylphenolate alu-minium(BAlq)as HTL which is responsible for blue light emission is found to have best characteristics when compared to other simulated *** has a maximum luminance of 10000 cd/m2 and current efficiency of 15.25 cd/A,respectively,and CIE coordinates are at(0.329,0.319).The device is found to be compatible to be used in solid state lighting applications because of the low driving voltage of the device.

关键词： emitter diodes white

Participant attrition and perinatal outcomes in prenatal vitamin Dsupplemented gestational diabetes mellitus patients in Asia: A metaanalysis

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World Journal of Methodology 2022年第3期12卷 164-178页

作者： Sumanta Saha sujata Saha Department of Community Medicine R.G.Kar Medical CollegeKolkata 700004West BengalIndia Department of Mathematics Mankar CollegeMankar 713144West BengalIndia

BACKGROUND The role of vitamin D supplementation in gestational diabetes mellitus(GDM)patients is *** To determine the burden and risk of post-randomization GDM patient attrition from vitamin D-supplemented arms of randomized controlled trials(RCTs).The auxiliary aim was to compare the effects of nutritional supplements on their fasting blood glucose(FPG)levels and perinatal *** RCTs were searched in the PubMed,Embase,and Scopus *** prevalence and pairwise meta-analysis were performed for the primary *** auxiliary aim was to compare the effects of nutritional supplements on their fasting blood glucose(FPG)levels and perinatal ***-effect network meta-analyses were undertaken for the secondary *** analyses were performed using Stata software,and statistical significance was determined at P<*** Thirteen RCTs from Iran and China were *** participant attrition burden in vitamin D recipients was 6%[95%confidence interval(CI):0.03,0.10],and its risk did not vary from *** D and calcium co-supplementation reduced the cesarean section incidence in GDM patients[risk ratio(RR):0.37;95%CI:0.18,0.74].The hyperbilirubinemia or hospitalization risk in their newborns decreased with vitamin D supplementation(RR:0.47;95%CI:0.27,0.83)and co-supplementation with calcium(RR:0.35;95%CI:0.16,0.77)or omega3 fatty acids(RR:0.25;95%CI:0.08,0.77).Vitamin D and probiotics co-supplementation decreased newborn hyperbilirubinemia risk(RR:0.28;95%CI:0.09,0.91).FPG levels and macrosomia risk did not vary across *** In RCTs,vitamin D supplementation or co-supplementation in GDM patients showed a low participant attrition burden and low risk of cesarean section,newborn hyperbilirubinemia,and newborn hospitalization.

关键词： Diabetes Gestational Vitamin D Prenatal care Nutrition therapy

Diversifying Clean Water: An Examination of Drinking Water Quality and Social Disparities in Michigan

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Journal of Geoscience and Environment Protection 2022年第5期10卷 125-138页

作者： Tyra Blair Ryan Beni sujata Guha Department of Chemistry Tennessee State University Nashville TN USA

Water is one of the most essential resources required to sustain life. However, it could be detrimental to the health of those without access to water that is properly treated. Although the Safe Drinking Water Act of 1974 set regulations to protect citizens from naturally occurring and man-made contaminants, some people are still without clean and safe water, which is speculated to be because of their race. This research examines the disproportionality of available clean water provided by government sources in Michigan and its correlation with race and household income. In the study, it has been found that one of the leading causes of water contamination is industrial activity, with the automobile industry being responsible for approximately 300 million tons of lead contamination in water, and that the manufacturing company’s locations mostly centered in minority and low-income areas. Lower income cities, such as Hamtramck and Benton Harbor, have an average of 14.8 drinking water standard violations with the highest being 99 total violations, while higher income cities, like Novi and Bloomfield hills, have an average of 4 violations. Cities, like Flint and Detroit, which have a higher minority population, are 10 times more likely to have a water standard violation, and the minority population is proportionally related to the possibility of industrial manufacturing being located in those areas. These communities also face a higher risk of birth defects, developmental issues in children, and organ failure in adults, due to continuous exposure to water contaminants. Race as a direct causation could not be proven, but there are links to direct correlation through historical redlining and housing trends.

关键词： Water Quality Social Disparity Michigan Contaminants Household Income Income per Capita Environmental Justice Automobile Industry

Comprehensive management of malocclusion in maxillary fibrous dysplasia:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10671-10680页

作者： Harneet Kaur sujata Mohanty Gulsheen Kaur Kochhar Shahid Iqbal Anjali Verma Ritasha Bhasin Anuraj singh Kochhar Department of Orthodontics and Dentofacial Orthopaedics Faculty of DentistryJamia Millia IslamiaDelhi 110025DelhiIndia Department of Oral and Maxillofacial Surgery Maulana Azad Institute of Dental SciencesDelhi 110002DelhiIndia Department of Pediatric and Preventive Dentistry National Dental College and HospitalDerabassi 140507PunjabIndia Faculty of Dentistry Jamia Millia IslamiaDelhi 110025DelhiIndia Faculty of Dentistry University of TorontoToronto M5G1G6OntarioCanada Department of Orthodontics and Dentofacial Orthopaedics Faculty of DentistryUniversity of TorontoToronto M5G0C1OntarioCanada

BACKGROUND Fibrous dysplasia(FD)is a developmental hamartomatous bone disease characterized by a blend of fibrous and osseous *** rarely malignant,the tumor can vary from being small and asymptomatic,to a fairly large sized lesion,progressing gradually,compromising occlusion and facial *** approach depends on the stage of skeletal *** primarily involves surgical management for stabilizing the disease ***-surgical comprehensive dental treatment is necessary for restoring form and function of the jaws and *** article describes comprehensive orthodontic management of severe malocclusion in a surgically operated case of FD *** SUMMARY A 19-year female presented with a chief complaint of excessive gingival display when *** history included swelling of gums around the upper right front teeth,diagnosed at the age of 15 as FD of the right anterior maxillary segment and treated with surgical recontouring of the dysplastic *** clinical and radiological examinations showed adequate post-surgical *** surgically treated dysplastic area presented with right canting of the maxillary anterior occlusal *** maxillary teeth were torqued palatally,with the root of the right maxillary canine exposed *** discuss sequential management of the associated malocclusion with comprehensive fixed orthodontics,along with special precautions taken to prevent reactivation of the quiescent and healed *** The adequate healing of fibro-dysplastic bone post-surgery must be allowed before initiating orthodontic tooth movement in the dysplastic *** follow-ups are needed to monitor stability of occlusion and any relapse of the lesion.

关键词： Craniofacial fibrous dysplasia Malocclusion Orthodontic tooth movement Jaw surgery Case report

Stem Cell Niche,the Microenvironment and Immunological Crosstalk

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Cellular & Molecular Immunology 2008年第2期5卷 107-112页

作者： Law sujata S.Chaudhuri Stem Cell Research and Application Unit Department of Biochemistry and Medical BiotechnologySchool of Tropical MedicineC R AvenueKolkata 700073India

The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, ＇how compatible these cells are immunologically？＇ Indeed, the medical aspects of stem cells are dependent on a large number of queries based on the basic properties of the cells. It has greatly been emphasized to probe into the basic research on stem cells before any successful therapeutic attempts are made. One of the intricate aspects of the adult stem cells is its immunological behavior in relation to the microenvironmental associates, the stromal cells in the presence of a suitable target. Cellular ＆ Molecular Immunology.

关键词： stem cell niche stromal immunology