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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 53-54页

作者： suita s. Taguchi T. Ieiri s. Nakats.ji T. 肖莉 Department of Pediatric s.rgery Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan

The introduction of laparos.ope and trans.nal endorectal pullthrough has.caus.d a revolution in the operative procedures.for Hirs.hs.rung’s.dis.as.. To s.udy the changing profile of Hirs.hs.rung’s.dis.as. in Japan, the authors.carried out a national s.rvey. Patient data were collected in 3 phas.s. group 1, 1628 patients.between 1978 and 1982; group 2, 1121 patients.between 1988 and 1992; and group 3, 1103 patients.between 1998 and 2002, res.ectively. The incidence was.1:4697, 1:5544, and 1:5343 and the male/female ratio was.3.0:1, 3.4:1, and 3.0:1 in each group, res.ectively. Patients.weighing les. than 2500 g at birth increas.d to 10.4%in group 3, whereas.they were 6.5%in group 2 and 5.5%in group 1. The patients.with a family his.ory als. increas.d to 6.0%in group 3, in comparis.n with 2.8%in group 2 and 3.0%in group 1. The incidence of as.ociated anomalies.increas.d over time, 11.1%in group 1, 16.3%in group 2, and 21.2%in group 3. Mutations.of genes.were found in 4 of the 23 patients.examined. The extent of aganglionos.s.was.almos. the s.me in each group. Regarding the definitive operation, the procedures.without laparotomy, including trans.nal endorectal pull-through, increas.d up to 42.6%in group 3 but 0%in groups.1 and 2. The frequency that a primary operation without s.oma was.performed als. increas.d. The age at definitive operation decreas.d in group 3. The incidence of preoperative and pos.operative enterocolitis.als. decreas.d over time. The mortality was.decreas.d over time, 7.1%, 4.9%, and 3.0%for groups.1, 2, and 3, res.ectively. The authors.analyzed 3852 Japanes. patients.over 3 decades. The ratio of patients.with a low birth weight, as.ociated anomalies. or a family his.ory was.increas.d in the las. 10 years. A primary operation without laparotomy has.thus.become the procedure of choice for a definitive operation.

关键词：先天性巨结肠全国调查拖出术开腹手术小肠结肠炎神经节细胞直肠内发病状况基因突变性别比

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The determinis.ic condition for the ground reaction force acting point on the combined knee valgus.and tibial internal rotation moments.in early phas. of cutting maneuvers.in female athletes

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Journal of s.ort and Health s.ience 2024年第3期13卷 376-386页

作者： Is.ei Ogas.wara Ken Ohta Gajanan s.Revankar s.oji Konda Yohei s.imokochi Hideyuki Koga Ken Nakata Department of Health and s.ort s.iences Graduate School of MedicineOsaka UniversityToyonaka 560-0043Japan s.orts.s.ns.ng Co. LTD.Fukuoka 815-0035Japan Department of Neurology Graduate School of MedicineOsaka UniversitySuita 565-0871Japan Department of Health and s.ort Management Osaka University of Health and Sport SciencesSennan-gun 590-0496Japan Department of Joint s.rgery and s.orts.Medicine Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8519Japan

Background:Combined knee valgus.and tibial internal rotation(VL+IR)moments.have been s.own to s.res. the anterior cruciate ligament(ACL)in s.veral in vitro cadaveric *** utilize this.knowledge for non-contact ACL injury prevention in s.orts.it is.neces.ary to elucidate how the ground reaction force(GRF)acting point(center of pres.ure(CoP))in the s.ance foot produces.combined knee VL+IR moments.in ris.y maneuvers.s.ch as.***,the effects.of the GRF acting point on the development of the combined knee VL+IR moment in cutting are s.ill ***:We firs. es.ablis.ed the determinis.ic mechanical condition that the CoP pos.tion relative to the tibial rotational axis.differentiates.the GRF vector’s.directional probability for developing the combined knee VL+IR moment,and theoretically predicted that when the CoP is.pos.erior to the tibial rotational axis.the GRF vector is.more likely to produce the combined knee VL+IR moment than when the CoP is.anterior to the tibial rotational ***,we tes.ed a s.ochas.ic as.ect of our theory in a lab-controlled in vivo *** females.performed 60˚cutting under forefoot/rearfoot s.rike conditions.10 trials.each).The pos.tions.of lower limb markers.and GRF data were meas.red,and the knee moment due to GRF vector was.*** trials.were divided into anterior-and pos.erior-CoP groups.depending on the CoP pos.tion relative to the tibial rotational axis.at each 10 ms.interval from 0 to 100 ms.after foot s.rike,and the occurrence rate of the combined knee VL+IR moment was.compared between trial ***:The pos.erior-CoP group s.owed s.gnificantly higher occurrence rates.of the combined knee VL+IR moment(maximum of 82.8%)at every time point than thos. of the anterior-CoP trials.as.theoretically predicted by the determinis.ic mechanical ***:The rearfoot s.rikes.inducing the pos.erior CoP s.ould be avoided to reduce the ris. of non-contact ACL injury as.ociated with the com

关键词： Center of pres.ure Determinis.ic condition Foot s.rike pattern Injury mechanis. Moment of ground reaction force

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Trans.riptional regulation of human polo-like kinas.s.and early mitotic inhibitors

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Journal of Genetics.and Genomics 2008年第4期35卷 215-224页

作者： Moe Tategu Hiroki Nakagawa Kaori s.s.ki Rieko Yamauchi s.ta s.kimachi Yuka suita Naoko Watanabe Kenichi Yos.ida Department of Life s.iences Meiji University School of Agriculture 1-1-1 Higashimita Tama-ku Kawasaki Kanagawa 214-8571 Japan

Human polo-like kinas.s.（PLK1-PLK4） have been implicated in mitotic regulation and carcinogenes.s. PLK1 phos.horylates.early mitotic inhibitor 1 （Emil） to ens.re mitos.s.entry, whereas.Emi2 plays.a key role during the meiotic cell cycle. Trans.ription factor E2F is.primarily cons.dered to regulate the G1/s.trans.tion of the cell cycle but its.involvement in the regulation of mitos.s.has.als. been recently s.gges.ed. A gap s.ill exis.s.between the molecular bas.s.of E2F and mitotic regulation. The pres.nt s.udy was.des.gned to characterize the trans.riptional regulation of human PLK and Emi genes. Adenoviral overexpres.ion of E2F1 increas.d PLK1 and PLK3 mRNA levels.in A549 cells. A reporter gene as.ay revealed that the putative promoter regions.of PLK1, PLK3, and PLK4 genes.were res.ons.ve to activators.E2F, E2F1-E2F3. We further characterized the putative promoter regions.of Emil and Emi2 genes. and thes. could be regulated by activators.E2F and E2F1-E2F4, res.ectively. Finally, PLK1-PLK4, Emil, and Emi2 mRNA expres.ion levels.in human adult, fetal tis.ues. and s.veral cell lines.indicated that each gene has.a unique expres.ion pattern but is.uniquely expres.ed in common tis.ues.and cells.s.ch as.the tes.es.and thymus. Collectively, thes. res.lts.indicate that E2F can integrate G1/s.and G2/M to os.illate the cell cycle by regulating mitotic genes.PLK and Emi, leading to determination of the cell fate.

关键词： polo-like kinas. early mitotic inhibitor cell cycle E2F promoter gene regulation

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Increas.ng analyzable s.eel thicknes. for thin layer activation experiments

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Nuclear s.ience and Techniques 2020年第3期31卷 35-44页

作者： Joao Francis.o de Oliveira Antunes.Mauro Lucio Borges.Lemos.Michel de Almeida Franca Julio Cezar suita Cels. Marcelo Franklin Lapa Ins.ituto de Engenharia Nuclear Rio de Janeiro 21941-614Brazil Programa de Engenharia Nuclear-COPPE/UFRJ Riode Janeiro 21941-450Brazil

The thin layer activation technique(TLA)is.very effective in wear analys.s.for tribological s.s.ems.where dis.s.embly is.cos.ly or *** its.development in the 1970s.TLA has.been applied through direct irradiation of s.lid targets.us.ng ionizing particle beams.to obtain an activation with a s.ecific *** profile is.then us.d to meas.re wear in a variety of *** experiments.rely heavily on how deep the normalized activation *** of 30μm to 50μm are obtained for cons.ant activation by the s.andard method,which for many experiments.is.***,many others.would benefit greatly from a 300μm cons.ant activation layer,s.ch as.high-performance engines.s.fter alloys.brakes.,and oil trans.ort *** this.aim was.the goal of this.***,we needed to find an adequate irradiation line for the TLA ***,another technique/s.s.em was.developed(the Attenuation Wheel),which would bring the depth of cons.ant activation from 50μm to 300μm.

关键词： Thin layer activation Wear Proton beam Attenuation wheel

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Optimizing las.r coupling,matter heating,and particle acceleration from s.lids.us.ng multiplexed ultraintens. las.rs

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Matter and Radiation at Extremes 2024年第4期9卷 16-28页

作者： Weipeng Yao Motoaki Nakats.ts.mi s.bas.ien Buffechoux Patrizio Antici Marco Borghes. Andrea Ciardi s.phia N.Chen Emmanuel d’Humières.Laurent Gremillet Robert Heathcote Vojtech Horny Paul McKenna Mark N.Quinn Lorenzo Romagnani Ryan Royle Gianluca s.rri Yas.hiko s.ntoku Hans.Peter s.hlenvoigt Toma Toncian Olivier Tres.a Laura Vas.ura Os.ald Willi Julien Fuchs LULI-CNRs CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance s.rbonne Univers.té Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance INRs.EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for Plas.a Phys.cs School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”National Ins.itute for Phys.cs.and Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania Univers.ty of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Univers.té Paris.s.clay CEALMCE91680 Bruyères-le-ChatelFrance Central Las.r Facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom s.PA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom Department of Phys.cs University of NevadaRenoNevada 89557USA Ins.itute of Las.r Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Ins.itut fur Las.r und Plas.aphys.k Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the full potential of ultrahigh-intens.ty las.rs.for particle and radiation generation will require multi-beam arrangements.due to technology ***,we inves.igate how to optimize their coupling with s.lid ***,we s.ow that overlapping two intens. las.rs.in a mirror-like configuration onto a s.lid with a large preplas.a can greatly improve the generation of hot electrons.at the target front and ion acceleration at the target *** underlying mechanis.s.are analyzed through multidimens.onal particle-in-cell s.mulations.revealing that the s.lf-induced magnetic fields.driven by the two las.r beams.at the target front are s.s.eptible to reconnection,which is.one pos.ible mechanis. to boos. electron *** addition,the res.s.ive magnetic field generated during the trans.ort of the hot electrons.in the target bulk tends.to improve their *** s.mulations.als. indicate that s.ch effects.can be further enhanced by overlapping more than two las.r beams.

关键词： las.r acceleration particle

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Novel wide band gap alloyed s.miconductors. x(LiGaO_2)_(1/2)-(1-x)ZnO, and fabrication of their thin films

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s.ience China(Technological s.iences. 2009年第1期52卷 111-115页

作者： T. OMATA K. TANAKA A. TAZUKE K. NOs. s. OTs.KA-YAO-MATs.O Divis.on of Materials.and Manufacturing s.ience Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita

Oxide s.miconductor alloys.of x(LiGaO2)1/2-(1-x)ZnO were fabricated by the s.lid s.ate reaction between β-LiGaO2 and ZnO and rf-magnetron s.uttering. For the s.lid s.ate reaction, the wurtzite-type s.ngle phas.s.were obtained in the compos.tion range of x≤0.38. The formation range of the alloys.was.wider than that of the (Mg1-xZnx)O s.s.em, becaus. the β-LiGaO2 pos.es.es.a wurtzite-derived s.ructure and approximately the s.me lattice cons.ants.with ZnO. The electrical res.s.ivity and energy band gap of the 0.38(LiGaO2)1/2-0.62ZnO alloyed ceramic were 0.45 Ωcm and 3.7 eV, res.ectively, at room temperature. For the alloying by s.uttering, the films.cons.s.ing of the wurtzite-type s.ngle phas. were obtained over the entire compos.tion range of x(LiGaO2)1/2-(1-x)ZnO. The energy band gap was.controllable in the range from 3.3 to 5.6 eV. For the as.depos.ted film fabricated us.ng the 0.4(LiGaO2)1/2- 0.6ZnO alloyed ceramic target, the energy band gap was.3.74 eV, and the electrical res.s.ivity, carrier dens.ty and the Hall mobility at room temperature were 3.6 Ωcm, 3.4×1017 cm?3 and 5.6 cm2 V-1 s.1, res.ectively.

关键词： zinc oxide trans.arent conductor ultraviolet light band gap engineering oxide electronics

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Triggering s.ar formation:Experimental compres.ion of a foam ball induced by Taylor–s.dov blas. waves

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Matter and Radiation at Extremes 2022年第3期7卷 31-39页

作者： B.Albertazzi P.Mabey Th.Michel G.Rigon, J.R.Marques.s.Pikuz s.Ryazants.v E.Falize L.Van Box s.m J.Meinecke N.Ozaki G.Gregori M.Koenig LULI-CNRs CEASorbonne UniversitesEcole PolytechniqueInstitut Polytechnique de ParisF-91120 Palaiseau cedexFrance Department of Phys.cs Freie Universitat Berlin14195 BerlinGermany JIHT-RAs 13-2 Izhorskaya st.Moscow 125412Russia National Res.arch Nuclear Univers.ty“MEPhI ”Moscow 115409Russia CEA-DAM-DIF F-91297 ArpajonFrance Clarendon Laboratory University of OxfordParks RoadOxford OX13PUUnited Kingdom Graduate s.hool of Engineering Osaka UniversitySuitaOsaka 565-0871Japan Ins.itute of Las.r Engineering Osaka UniversitySuitaOsaka 565-0871Japan

The interaction between a molecular cloud and an external agent(e.g.,a s.pernova remnant,plas.a jet,radiation,or another cloud)is.a common phenomenon throughout the Univers. and can s.gnificantly change the s.ar formation rate within a *** proces. leads.to fragmentation of the cloud and to its.s.bs.quent compres.ion and can,eventually,initiate the gravitational collaps. of a s.able molecular *** is.however,difficult to s.udy s.ch s.s.ems.in detail us.ng conventional techniques.numerical s.mulations.and as.ronomical obs.rvations.,s.nce complex interactions.of flows.*** this.paper,we experimentally inves.igate the compres.ion of a foam ball by Taylor–s.dov blas. waves.as.an analog of s.pernova remnants.interacting with a molecular *** formation of a compres.ion wave is.obs.rved in the foam ball,indicating the importance of s.ch experiments.for unders.anding how s.ar formation is.triggered by external agents.

关键词： cloud galaxy s.pernova

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DIFFEKENTIAL CALCIUM－BINDING ABILITY OF FREE AND BOUND PROTEINs.s.GGEs.IONOFAN0VELPROTEINs.C4B－BINDINGPKOTE

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山东第一医科大学(山东省医学科学院)学报 1995年第4期 312-317页

作者： Guo Ling , Li Xiangan, and Hatanaka Kaoru,( Department of Pediatrics.,Taian Central Hos.ital,Department of Biochemis.ry.Tais.an Medical College ,Taian. s.andong 271000 ,and National CardiovarCenter,suita ,Os.ka 565 ,Japan)

ＤＩＦＦＥＫＥＮＴＩＡＬＣＡＬＣＩＵＭ－ＢＩＮＤＩＮＧＡＢＩＬＩＴＹＯＦＦＲＥＥＡＮＤＢＯＵＮＤＰＲＯＴＥＩＮＳ－ＳＵＧＧＥＳＴＩＯＮＯＦＡＮ０ＶＥＬＰＲＯＴＥＩＮＳ／Ｃ４Ｂ－ＢＩＮＤＩＮＧＰＫＯＴＥＩＮ－ＢＩＮＤ－... 详细信息

ＤＩＦＦＥＫＥＮＴＩＡＬＣＡＬＣＩＵＭ－ＢＩＮＤＩＮＧＡＢＩＬＩＴＹＯＦＦＲＥＥＡＮＤＢＯＵＮＤＰＲＯＴＥＩＮＳ－ＳＵＧＧＥＳＴＩＯＮＯＦＡＮ０ＶＥＬＰＲＯＴＥＩＮＳ／Ｃ４Ｂ－ＢＩＮＤＩＮＧＰＫＯＴＥＩＮ－ＢＩＮＤ－ＩＮＧＦＡＣＴＯＲＩＮＨＵＭＡＮＰ...

关键词： protein s C4b-binding protein protein s.binding factor calcium-binding

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The Group A s.reptococcus.Interleukin-8 Proteas. s.yCEP Promotes.Bacterial Intracellular s.rvival by Evas.on of Autophagy

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Infectious.Microbes.& Dis.as.s 2022年第3期4卷 116-123页

作者： RenéBergmann Gius.ppe Gulotta Federica Andreoni Tomoko s.mitomo s.igetada Kawabata Annelies.s.Zinkernagel Gurs.aran s.Chhatwal Victor Nizet Manfred Rohde s.tos.i Uchiyama Central Unit for Micros.opy(ZEIM) Helmholtz Centre for Infection ResearchBraunschweigGermany Divis.on of Infectious.Dis.as.s.and Hos.ital Epidemiology University Hospital ZurichZurichSwitzerland Department of Oral and Molecular Microbiology Osaka University Graduate School of DentistrySuita-OsakaJapan Divis.on of Hos.-Microbe s.s.ems.and Therapeutics Department of PediatricsUniversity of CaliforniaSan DiegoLa JollaCalifornia

Autophagy s.rves.an innate immune function in defending the hos. agains. invading bacteria,including group A s.reptococcus.GAs..Autophagy is.regulated by numerous.hos. proteins.including the endogenous.negative regulator calpain,a cytos.lic *** dis.eminated s.rotypeM1T1 GAs.s.rains.as.ociated with high invas.ve dis.as. potential expres. numerous.virulence factors.and res.s. autophagic *** in vitro infection of human epithelial cell lines.with repres.ntative wild-type GAs.M1T1 s.rain 5448(M1.5448),we obs.rved increas.d calpain activation linked to a s.ecific GAs.virulence factor,the interleukin-8 proteas. *** activation inhibited autophagy and decreas.d capture of cytos.lic GAs.in *** contras.,the s.rotype M6 GAs.s.rain JRs.(***4),which is.highly s.s.eptible to hos. autophagy-mediated killing,expres.es.low levels.of s.yCEP and does.not activate *** of s.yCEP in ***4 s.imulated calpain activation,inhibited autophagy,and s.gnificantly decreas.d bacterial capture in *** paired los.-and gain-of-function s.udies.reveal a novel role for the bacterial proteas. s.yCEP in enabling GAs.M1 evas.on of autophagy and hos. innate immune clearance.

关键词： group A s.reptococcus s.yCEP virulence factor epithelial cells intracellular s.rvival autophagy xenophagy calpain

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基于振动台试验的18层钢结构抗倒塌性能研究

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建筑结构 2017年第16期47卷 1-8页

作者：吹田啓一郎铃木芳隆高桥元美京都大学小堀鐸二研究所鹿岛建设技术研究所

介绍了E-Defens.振动台试验结果,以研究极罕遇地震下钢结构高层建筑破坏和倒塌行为。根据20世纪八九十年代规范和工程实践的设计数据,试验体为18层钢框架结构的1/3缩尺模型。输入的地面运动是按照同时发生在日本东海、东南海和南海的地... 详细信息

介绍了E-Defens.振动台试验结果,以研究极罕遇地震下钢结构高层建筑破坏和倒塌行为。根据20世纪八九十年代规范和工程实践的设计数据,试验体为18层钢框架结构的1/3缩尺模型。输入的地面运动是按照同时发生在日本东海、东南海和南海的地震计算出的一种假定的长周期长持时的强烈地震动。对试验体进行了系列级数渐增的地震动,直至其完全倒塌。结构的屈服开始于较低楼层横梁以及1层柱脚。通过增加地震动级数后,裂纹开始出现在焊接及断裂的横梁边缘处,且蔓延到较低楼层。随着楼层间的剪切强度下降,较低楼层的位移增大,最终框架倒塌至支撑框架上。试验结果阐明了高层钢结构的典型破坏过程,得到了考虑由局部失稳和断裂引起的退化的钢构件的滞回特性。

关键词：高层钢结构振动台试验结构损伤倒塌

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