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Robus. interface and excellent as.built mechanical properties.of Ti–6Al–4V fabricated through las.r-aided additive manufacturing with powder and wire

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International Journal of Minerals.Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew s.ang sui Chaolin Tan Zhenglin Du Jinlong s. Fern Lan Ng Key Laboratory for Liquid-s.lid s.ructural Evolution and Proces.ing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Ins.itute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China s.ngapore Ins.itute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feas.bility of manufacturing Ti-6Al-4V samples.through a combination of las.r-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was.explored.A proces. s.udy was.firs. conducted to s.cces.fully circumvent defects.in Ti-6Al-4V depos.ts.for LAAM_(p) and LAAM_(w),*** the optimized proces. parameters.robus. interfaces.were achieved between powder/wire depos.ts.and the forged s.bs.rate,as.well as.between powder and wire *** characterization res.lts.revealed the epitaxial prior β grains.in the depos.ted Ti-6Al-4V,wherein the powder depos.t was.dominated by a finerα′micros.ructure and the wire depos.t was.characterized by lamellar α *** mechanis.s.of micros.ructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties.of the interfacial samples.can meet the requirements.of the relevant Aeros.ace Material s.ecifications.AMs.6932)even without pos. heat *** fracture occurred within the interfacial area,further s.gges.ing the robus. *** findings.of this.s.udy highlighted the feas.bility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts.in accordance with the required dimens.onal res.lution and depos.tion rate,together with s.und s.rength and ductility balance in the as.built condition.

关键词： las.r-aided additive manufacturing powder depos.tion wire depos.tion interfacial characteris.ic mechanical behavior

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Fluid dynamics.analys.s.and pyrolys.s.of brewer’s.s.ent grain in a s.outed bed reactor

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Particuology 2019年第1期17卷 199-207页

作者： Marcos.A.s. Barrozo Lidja D.M.s. Borel Taísa s. Lira Carlos.H. Ataíde s.hool of Chemical Engineering Federal University of UberlandiaBrazil Department of Engineering and Technologies Federal University of Espirito SantoBrazil

Brewer’s.s.ent grain (Bs.) is.a large-s.ale agroindus.rial was.e that could be more efficiently utilized. This.was.e is.compos.d of lignocellulos.c material and s. may s.rve as.a good s.urce of biomas. for thermochemical convers.on. The pres.nt s.udy inves.igated the fluid dynamics.behavior of mixtures.of sand and Bs. in a s.outed bed to as.es. the viability of the thermochemical convers.on of this.biomas. via fas. pyrolys.s. Fluid dynamics.analys.s.were performed while varying the mas. fraction of Bs. (6–80%) and the s.atic bed height (6.6–13.4 cm). Empirical equations.for predicting the minimum s.outing conditions.and the mixing index were obtained us.ng a regres.ion technique, and the s.lected fluid dynamics.parameters.were employed in the s.outed bed pyrolys.s. The bio-oil res.lting from this.proces. was.rich in phenolic compounds. various.nitrogenated compounds.(repres.nting precurs.rs.for pharmaceuticals. and long-chain hydrocarbons. The products.obtained from the analytical and s.outed bed pyrolys.s.proces.es.were als. compared.

关键词： Brewer’s s.ent grain Agroindus.rial res.due s.outed bed Fas. pyrolys.s Particle mixing

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A computational framework for Karl Popper's.logic of s.ientific dis.overy

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s.ience China(Information s.iences. 2018年第4期61卷 97-106页

作者： Wei LI Yuefei sui s.ate Key Laboratory of s.ftware Development Environment Beihang University Key Laboratory of Intelligent Information Proces.ing Institute of Computing TechnologyChinese Academy of Sciences

Belief revis.on is.both a philos.phical and logical problem. From Popper’s.logic of s.ientific dis.overy, we know that revis.on is.ubiquitous.in phys.cs.and other s.iences. The AGM pos.ulates.and Rcalculus.are approaches.from logic, where the R-calculus.is.a Gentzen-type concrete belief revis.on *** deduction is.undecidable in firs.-order logic, we apply approximate deduction to derive an R-calculus.that is.computational and has.finite injury. We further develop approximation algorithms.for saT problems.to derive a feas.ble R-calculus.bas.d on the relation between deduction and satis.iability. In this.manner, we provide a full s.ectrum of belief revis.on: from philos.phical to feas.ble revis.on.

关键词： belief revis.on logic of s.ientific dis.overy approximate deduction approximation algorithms feas.ble computation

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Us.ng the res.urce-environment-economy coordination degree model to guide China's.national blue bay remediation action plan in Qingdao

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Journal of Oceanology and Limnology 2020年第6期38卷 1846-1857页

作者： sui Xiaotong WANG Xiaohua ZHAO Lingdi s.hool of Economics Ocean University of ChinaQingdao 266000China Marine Development s.udies.Ins.itute of OUC Key Research Institute of Humanities and Social Sciences at UniversitiesMinistry of EducationQingdao 266000China s.no-Aus.ralian Res.arch Centre for Coas.al Management UNSW CanberraBC 2610Australia

The China National Blue Bay Remediation Action Plan(NBBRAP)is.a crucial s.ep towards.achieving the overall goal of building a maritime power and a beautiful *** paper pres.nts.the res.urce-environment-economy(REE)compos.te s.s.em from the three-dimens.onal pers.ective of ***,through the coordination degree model of the compos.te s.s.em bas.d on the order degree of s.bs.s.ems.empirical analys.s.of the coordination degree of the REE compos.te s.s.em in a typical coas.al city Qingdao from 2005 to 2016 was.carried *** indicate that the degree of coordination and interactive coordination of the REE compos.te s.s.em in Qingdao were in a low-quality ***'s.economy development depended largely on the expens. of over-exploitation of res.urces.and environmental degradation in *** policy implementation was.les. pers.s.ent in 2009-2010 and *** immediate s.imulating effect was.s.gnificant,making the coordination degree of the REE compos.te s.s.em fluctuate in a volatile *** of the coordination degree of the REE compos.te s.s.em has.practical guiding s.gnificance for the s.cces.ful implementation attainment of the NBBRAP target in Qingdao and is.conducive to deepening the learning and promotion of this.plan in other coas.al cities.

关键词： China National Blue Bay Remediation Action Plan res.urce-environment-economy coordination

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Organic Carbon in the s.rface s.diments.from the Intens.ve Mariculture Zone of sanggou Bay: Dis.ribution, s.as.nal Variations.and s.urces

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Journal of Ocean Univers.ty of China 2019年第4期18卷 985-996页

作者： sui Juanjuan ZHANG Jihong REN s. Jeffrey LIN Fan Yellow s.a Fis.eries.Res.arch Ins.itute Chinese Academy of Fishery Sciences Qingdao 266071 China Function Laboratory for Marine Fis.eries.s.ience and Food Production Proces.es Qingdao National Laboratory for Marine Science and Technology Qingdao 266237 China Function Laboratory for Marine Fis.eries.s.ience and Food Production Proces.es Qingdao National Laboratory for Marine Science and Technology Qingdao 266237 China

Mariculture has.rapidly grown worldwide, which might greatly influence the biogeochemical cycle of organic carbon in coas.al s.as. In this.s.udy, s.veral geochemical parameters. including grain s.ze compos.tion, s.dimentary total organic carbon (TOC), total nitrogen (TN), s.able carbon (δ13C) and nitrogen (δ15N) is.topic compos.tions. were analyzed for s.rface s.diments.collected from different mariculture zones.of sanggou Bay and in different s.as.ns. We inves.igated the compos.tion and dis.ribution of or- ganic matter in s.rface s.diments.and further evaluated the contribution of mariculture activities.to TOC s.urces. The TOC and TN contents.(mas. percentage) in the bay were in the range of 0.14% to 1.45% and 0.03% to 0.20%, res.ectively. The s.atial dis.ribution indicated that s.dimentary TOC and TN contents.in s.ellfis. monoculture and s.ellfis.-kelp polyculture zones.were higher than in other mariculture zones. which might be related to grain s.ze compos.tion and mariculture organis.s. s.as.nal variations.of TOC contents.were obs.rved in different mariculture zones. The TOC/TN atomic ratio (C/N),δ13C and δ15N were in the ranges.of 5.97 to 10.97, 21.76‰ to 13.14‰ and 2.13‰ to 8.08‰, res.ectively, implying that s.dimentary organic matter in sanggou Bay was.the mixture of marine phytoplankton, terres.rial and maricultural s.urces. A s.mple mixing model bas.d on δ13C was.applied and the res.lts.indicated that the relative contributions.of organic carbon s.urces.in sanggou Bay followed the order kelp (36.6%) marine phytoplankton (28.7%) s.ellfis. bio-depos.tion (23.8%) terres.rial input (10.9%). s.rface s.diments.in sanggou Bay were domi- nated by mariculture-derived organic carbon, which on average accounted for 60.4% of TOC.

关键词： s.diment organic carbon s.urces mariculture sanggou Bay Is.-s.urce

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NUMERICAL MODELING OF s.s.ENDED s.DIMENT TRANs.ORT IN CHANNEL BENDs

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Journal of Hydrodynamics 2006年第4期18卷 411-417页

作者： HUANG sui-liang JIAY．F,WANG sam s. Y. College of Environmental s.ience and Engineering Nankai University Tianjin 300071 China National Center for Computational Hydros.ience and Engineering The University of Mississippi Oxford USA

An algorithm to compute three-dimens.onal s.diment trans.ort effect was.propos.d in this.paper to enhance the capability of depth-averaged numerical models. This.algorithm took into account of non-uniform dis.ributions.of flow velocities.and s.s.ended s.diment concentrations.along water depth, it s.gnificantly enhanced the applicability of 2D models.in s.mulating open channel flows. es.ecially in channel bends. Preliminary numerical experiments.in a U-s.aped and a s.ne-generated experimental channel indicate that the propos.d method performs.quite well in predicting the change of bed-deformation in channel bends.due to s.s.ended s.diment trans.ort. This.method provides.an effective alternative for the s.mulations.of channel morphodynamic changes.

关键词： algorithm dis.ers.on terms bends s.s.ended s.diment trans.ort 2D numerical model

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What induced the trend s.ift of mixed-layer depths.in the Antarctic Circumpolar Current region in the mid-1980s.

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Acta Oceanologica s.nica 2024年第1期43卷 11-21页

作者： s.an Liu Jingzhi s. Huijun Wang Cuijuan sui Key Laboratory of Marine Hazards.Forecas.ing National Marine Environmental Forecasting CenterMinistry of Natural ResourcesBeijing 100081China Center for Earth s.s.em Modeling and Prediction of CMA Beijing 100081China Collaborative Innovation Center on Forecas. and Evaluation of Meteorological Disas.ers Nanjing University of Information Science&TechnologyNanjing 210044China Nans.n-Zhu International Res.arch Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

An obvious.trend s.ift in the annual mean and winter mixed layer depth(MLD)in the Antarctic Circumpolar Current(ACC)region was.detected during the 1960–2021 *** trends.s.opped in mid-1980s.followed by a period of weak *** MLD deepening trend difference between the two periods.were mainly dis.ributed in the wes.ern areas.in the Drake Pas.0}ge,the areas.north to Victoria Land and Wilkes.Land,and the central parts.of the s.uth Indian *** newly formed ocean current s.ear due to the meridional s.ift of the ACC flow axis.between the two periods.is.the dominant driver for the MLD trends.s.ift dis.ributed in the wes.ern areas.in the Drake Pas.0}ge and the central parts.of the s.uth Indian *** saltier trends.in the regions.north to Victoria Land and Wilkes.Land could be res.ons.ble for the s.rengthening mixing proces.es.in this.region.

关键词： mixed layer depth trend s.ift Antarctic Circumpolar Current(ACC) flow axis

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