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Induction of Anesthesia with Dexmedetomidine and Sevoflurane for a Pediatric Difficult Airway

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Chinese Medical Journal 2017年第16期130卷 1997-1998页

作者： ling-Xin Wei Xiao-Ming Deng Jing-Hu sui Lei Wang Department of Anesthesiology Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100144 China

Difficult airway is a challenge frequently faced by anesthesiologists. For children recovering from burns with severe scarring contracture in the neck and chest wall, the best strategy is to maintain spontaneous breathing during the induction of anesthesia and to insert a laryngeal mask airway to secure the airway as early as possible.

关键词： Children Dexmedetomidine Difficult Airway

Optical-fiber distributed temperature sensor:design and realization

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Optoelectronics Letters 2008年第6期4卷 415-418页

作者： MENG ling JIANG Ming-shun sui Qing-mei FENG De-jun School of Control Science and Engineering Shandong University Jinan 250061 China Information Industry Promotion Agency Shandong Province Information Office Jinan 250000 China School of Information Science and Engineering Shandong University Jinan 250100 China

Through analyzing theoretically the temperature effect of the optical-fiber Raman backscattering,a distributed temperature sensor is designed based on the single-mode fiber. Demodulation methods of temperature transduction are compared,and then the demodulation method using the ratio of the anti-Stokes and the Stokes Raman backscattering intensity is adopted. Both the hardware composition and the software realization of the system are introduced in detail. The experiment shows that the distinguishing ability of the temperature and that of the space are 1℃ and 2m,respectively,and that the system response time is about 180 s with a sensing range of 5km and with a temperature measurement range of 0-100℃.

关键词：光纤分布温度敏感度信号传输计算机技术

Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures

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Chinese Medical Sciences Journal 2023年第2期38卷 130-137页

作者： Xu Chen Hong-ling Liu Jin-sui Wang Feng-Hui Zhao Department of Pathology Gansu Provincial HospitalLanzhou 730000China Department of Occupational Medicine Third Gansu Provincial HospitalLanzhou 730000China

Objective Primary ovarian small cell carcinoma of pulmonary type(SCCOPT)is a rare ovarian tumor with a poor *** platinum-based chemotherapy is the standard ***,there is little research on the clinical characteristics of SCCOPT and the potential benefits of other treatments due to its low *** study aims to investigate clinicopathological characteristics and treatment of *** We summarized the clinical,imaging,laboratorical and pathological characteristics of 37 SCCOPT cases,in which 6 cases were admitted to the Gansu Provincial Hospital from the year of 2008 to 2022 and 31 cases reported in 17 English and 3 Chinese *** The median age of the studied SCCOPT cases(n=37)was 56.00(range,22-80)*** 80%of them had a stageⅢorⅣ*** patients underwent an operation and postoperative ***,all cases had a poor prognosis,with a median overall survival time of 12 *** y,the SCCOPT of all patients showed positive expressions of epithelial markers,such as CD56 and sex-determining region of Y chromosome-related high-mobility-group box 2(SOX-2),and negative expressions of estrogen receptor,progesterone receptor,vimentin,Leu-7,and somatostatin receptor *** tumor of above 80%cases expressed *** a few cases expressed neuron-specific enolase,chromogranin A,and thyroid transcription *** SCCOPT had a poor ***-2 could be a biomarker to be used to diagnose SCCOPT.

关键词： small cell carcinoma of the ovary primary ovarian small cell carcinoma of pulmonary type sex-determining region of Y chromosome-related high-mobility-group box 2 adjuvant chemotherapy

Synthesis and electrochemical properties of spherically shaped LiVPO_(4)F/C cathode material by a spray drying-roasting method

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Rare Metals 2021年第1期40卷 72-77页

作者： Yu-Lei sui ling Wu Wei Hong Jie-Qun Liu Xiao-Ping Zhang Wei Li Sheng-Kui Zhong School of Iron and Steel Soochow University.Suzhou 215000China Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials Guilin University of TechnologyGuilin 541004China

LiVPO_(4) F has attracted increasing research interest in the field of Li-ion batteries due to its high working voltage platform and high theoretical energy ***,the construction of stable LiVPO_(4) F cathode material with excellent electrochemical properties is still a major ***,we successfully synthesized spherically shaped LiVPO_(4) F/C via a spray dryingroasting method.X-ray diffraction(XRD)and scanning electron microscopy(SEM)results indicate that the well crystallized LiVPO_(4) F/C with triclinic structure shows spherical morphology with an average diameter of 1-3μ*** spherically shaped LiVPO_(4) F/C delivers a discharge capacity of 137.9 mAh·g^(-1) at 0.1 C rate in the range of3.0-4.5 V and remains 91.4%capacity retention of its initial discharge capacity after 50 *** results reveal that spray drying-roasting method is a promising approach to synthesize spherically shaped LiVPO_(4) F/C cathode material with stable crystal structure and excellent performance.

关键词： Lithium-ion batteries Cathode materials LiVPO_(4)F/C Spray drying-roasting Electrical properties

The“two-pronged”nanosystem to precisely improve lipid metabolism and inflammatory microenvironment for atherosclerotic plaque stabilization

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Nano Research 2023年第2期16卷 2706-2718页

作者： Huijuan Zhang Linyu Gao Mingli sui Jingjing Wang Yaping Wang Xiangyang Xuan Zhenzhong Zhang ling Zhu Lin Hou School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China

The rupture of atherosclerosis(AS)vulnerable plaque is the major cause of fatal arterial thrombosis related *** lipid dysbolism and pro-inflammatory microenvironment are considered two main driving factors for plaque ***,a“two-pronged”nanosystem LCS-Se/Res was designed to efficiently stabilize AS plaques,by precisely regulating lipid metabolism and inflammatory ***-Se/Res was constructed with the core of resveratrol(Res)loaded selenium(Se)nanoparticles(NPs),and the shell(LCS)of targeting peptide(LSIPPKA)modified chitosan(CS).This system was stable in blood *** it arrived at the plaque site,LCS-Se/Res could actively recognize the highly expressed lectin-like oxidized low-density lipoprotein receptor 1(LOX-1)receptor and accumulate ***,Res was released from LCS-Se nanocarriers in situ by responding to acidic plaque *** the one hand,Res increased autophagy flux in damaged endothelial cells by activating cAMP-PKA-AMPK-SIRT1 signaling pathway to promote lipid ***,LCS-Se also promoted cholesterol efflux to improve lipid *** the other hand,fixed-point separated Res and LCS-Se synergistically improved plaque inflammatory microenvironment by reversing macrophage phenotype(M1 to M2)and alleviating plaque oxidative *** result proved that the plaque vulnerability index(VI)decreased from 1.39±0.282 to 0.108±0.02 after LCS-Se/Res *** short,this study provided a new therapeutic strategy for the atherosclerosis through the two-pronged approach.

关键词： atherosclerotic plaque stabilization autophagy lipid metabolism inflammatory infiltration selenium nanoparticles resveratrol

Multi-modality measurement and comprehensive analysis of hepatocellular carcinoma using synchrotron-based microscopy and spectroscopy

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Nuclear Science and Techniques 2021年第9期32卷 136-149页

作者： Gong-Xiang Wei sui-Xia Zhang Zhao Li Fu-Li Wang Yan-ling Xue Te Ji Hui-Qiang Liu School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China State Key Laboratory of Pathogenesis PreventionTreatment of Central Asian High Incidence DiseasesFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China Oncology Department ZiBo Central HospitalZibo 255000China SSRF Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201800China

The visualization and data mining of tumor multidimensional information may play a major role in the analysis of the growth,metastasis,and microenvironmental changes of tumors while challenging traditional imaging and data processing *** this study,a general trans-scale and multi-modality measurement method was developed for the quantitative diagnosis of hepatocellular carcinoma(HCC)using a combination of propagation-based phase-contrast computed tomography(PPCT),scanning transmission soft X-ray microscopy(STXM),and Fourier transform infrared micro-spectroscopy(FTIR).Our experimental results reveal the trans-scale micro-morpho-logical HCC pathology and facilitate quantitative data analysis and comprehensive *** results include some visualization features of PPCT-based tissue microenvironments,STXM-based cellular fine structures,and FTIR-based bio-macromolecular spectral characteris-tics during HCC tumor differentiation and *** proposed method provides multidimensional feature data support for constructing a high-accuracy machine learning algorithm based on a gray-level histogram,gray-gradient co-occurrence matrix,gray-level co-occurrence matrix,and back-propagation neural network ***-dimensional information analysis and diagnosis revealed the morphological pathways of HCC pathological evolution and we explored the relationships between HCC-related feature changes in inflammatory microenviron-ments,cellular metabolism,and the stretching vibration peaks of biomolecules of lipids,proteins,and nucleic ***,the proposed methodology has strong potential for the visualization of complex tumors and assessing the risks of tumor differentiation and metastasis.

关键词： Propagation based phase contrast tomography Soft X-ray microscopy Infrared micro spectroscopy Machine learning Tumor microenvironment and metastasis

Aggregate stability and associated C and N in a silty loam soil as affected by organic material inputs

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Journal of Integrative Agriculture 2015年第4期14卷 774-787页

作者： LONG Pan sui Peng GAO Wang-sheng WANG Bin-bin HUANG Jian-xiong YAN Peng ZOU Juan-xiu YAN ling-ling CHEN Yuan-quan Circular Agriculture Research Center/College of Agronomy and Biotechnology China Agricultural University

To make recycling utilization of organic materials produced in various agricultural systems, five kinds of organic materials were applied in a field test, including crop straw （CS）, biogas residue （BR）, mushroom residue （MR）, wine residue （WR）, pig manure （PM）, with a mineral fertilizer （CF） and a no-fertilizer （CK） treatment as a control. Our objectives were： i） to quantify the effects of organic materials on soil C and N accumulation; ii） to evaluate the effects of organic materials on soil aggregate stability, along with the total organic carbon （TOC）, and N in different aggregate fractions; and iii） to assess the relationships among the organic material components, soil C and N, and C, N in aggregate fractions. The trial was conducted in Wuqiao County, Hebei Province, China. The organic materials were incorporated at an equal rate of C, and combined with a mineral fertilizer in amounts of 150 kg N ha^-1, 26 kg P ha^-1 and 124 kg K ha-1 respectively during each crop season of a wheat-maize rotation system. The inputted C quantity of each organic material treatment was equivalent to the total amount of C contained in the crop straw harvested in CS treatement in the previous season. TOC, N, water-stable aggregates, and aggregate-associated TOC and N were investigated. The results showed that organic material incorporation increased soil aggregation and stabilization. On average, the soil macroaggregate proportion increased by 14%, the microaggregate proportion increased by 3%, and mean-weight diameter （MWD） increased by 20%. TOC content followed the order of PM〉WR〉MR〉BR〉CS〉CK〉CF; N content followed the order WR〉PM〉MR〉BR〉CS〉CF〉CK. No significant correlation was found between TOC, N, and the quality of organic material. Soil silt and clay particles contained the largest part of TOC, whereas the small macroaggregate fraction was the most sensitive to organic materials. Our results indicate that PM and WR exerted better effects on soil C and N accumulation, followed by

关键词： organic materials aggregates soil organic carbon soil nitrogen stabilization

五味消毒饮加减联合面部滚针治疗痤疮后色素沉着疗效观察

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中国美容医学 2024年第2期33卷 114-117页

作者：王馨苒隋智林李晓雨李领娥石家庄市中医院皮肤科河北石家庄050000

目的:研究五味消毒饮加减联合面部滚针治疗痤疮后色素沉着的临床疗效。方法:选取2022年5月-2023年5月石家庄市中医院收治的100例痤疮后色素沉着患者为研究对象,依照就诊次序、按照随机数字表法分为对照组(n=50)及观察组(n=50)。对照组... 详细信息

目的:研究五味消毒饮加减联合面部滚针治疗痤疮后色素沉着的临床疗效。方法:选取2022年5月-2023年5月石家庄市中医院收治的100例痤疮后色素沉着患者为研究对象,依照就诊次序、按照随机数字表法分为对照组(n=50)及观察组(n=50)。对照组运用面部滚针疗法进行治疗,观察组在此基础上实施五味消毒饮加减联合治疗。比较两组临床疗效、皮损情况、色素沉着情况及不良反应发生情况。结果:观察组临床总有效率(92.00%)高于对照组(76.00%)(P0.05),治疗后皮损颜色、数目及大小评分均较治疗前低,且观察组各项评分均低于对照组(P<0.05);两组均未出现不良反应;随访患者满意度情况,观察组总满意度(90.00%)高于对照组(72.00%)(P<0.05)。结论:五味消毒饮加减联合面部滚针治疗痤疮后色素沉着,效果显著,可提高患者满意度,且安全性良好。

关键词：五味消毒饮面部滚针痤疮瘀热互结证色素沉着

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药物临床试验机构文件受控管理现状及调查分析

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中国新药杂志 2024年第13期33卷 1362-1369页

作者：陈娜蔡雪玲叶穗雯潘芸芸曾参吕丽虹孙萍萍戴婕沈杰邹燕琴中山大学孙逸仙纪念医院药物临床试验机构广州510000 中山大学孙逸仙纪念医院Ⅰ期临床研究中心广州510000 南方医科大学南方医院临床药学中心广州510000 广州市第一人民医院药物临床试验机构广州510000 中山大学附属第一医院药物临床试验机构广州510000 重庆大学附属肿瘤医院Ⅰ期病房重庆400030

目的:了解临床试验中文件受控管理的现状及存在的问题,为药物临床试验机构的临床试验文件受控管理提供参考。方法:以全国71家药物临床试验机构为调查对象,采用问卷调查方式,围绕药物临床试验机构及临床试验项目开展文件受控管理基本情... 详细信息

目的:了解临床试验中文件受控管理的现状及存在的问题,为药物临床试验机构的临床试验文件受控管理提供参考。方法:以全国71家药物临床试验机构为调查对象,采用问卷调查方式,围绕药物临床试验机构及临床试验项目开展文件受控管理基本情况、受控管理文件范畴、文件受控管理方式、文件受控管理的问题及难点等方面进行调查。结果:本次调研涉及全国13个省、市、自治区的71家药物临床试验机构,共收回71份问卷,调查发现94.37%的机构已实现文件受控管理,其中25.37%采用电子系统进行文件受控,超过95%的受访者认为应进行受控管理且做到唯一、不可替换的纸质记录文件有:肿瘤评估表、受试者日记卡、药物管理表格。目前文件受控管理方式存在工作量大、难以实现闭环受控、电子受控系统保密性较差等问题。结论:对调研结果进行分析并结合各类文件在临床试验过程中的重要性提出将受控文件分为:一般受控文件、重要受控文件、核心受控文件3个受控管理级别,根据受控分级给出相应受控管理建议,以明确临床试验文件受控管理重点,提高临床试验文件管理效率及质量。

关键词：药物临床试验文件受控受控管理问卷调查