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Jianpi-Huatan-Huoxue-Anshen formula ameliorates gastrointestinal inflammation and microecological imbalance in chemotherapytreated mice transplanted with H22 hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4209-4231页

作者： Ya-Nan Wang Xiang-Yang Zhai Zheng Wang Chun-ling Gao sui-Cai Mi Wen-Li Tang Xue-Min Fu Huai-Bang Li Li-Feng Yue Peng-Fei Li Sheng-Yan Xi Department of TCM Xiang’an HospitalSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Radiotherapy Chenggong Hospital of Xiamen UniversityPLA 73rd Army HospitalXiamen 361003Fujian ProvinceChina Department of Oncology Xiamen Hospital of Traditional Chinese MedicineXiamen 361015Fujian ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China

BACKGROUND Jianpi-Huatan-Huoxue-Anshen formula[Tzu-Chi cancer-antagonizing&lifeprotecting II decoction(TCCL)]is a Chinese medical formula that has been clinically shown to reduce the gastrointestinal side effects of chemotherapy in cancer patients and improve their quality of ***,its effect and mechanism on the intestinal microecology after chemotherapy are not yet *** To discover the potential mechanisms of TCCL on gastrointestinal inflammation and microecological imbalance in chemotherapy-treated mice transplanted with hepatocellular carcinoma(HCC).METHODS Ninety-six mice were inoculated subcutaneously with HCC *** week later,the mice received a large dose of 5-fluorouracil by intraperitoneal injection to establish a HCC chemotherapy ***-six mice were randomly selected before administration,and feces,ileal tissue,and ileal contents were collected from each *** remaining mice were randomized into normal saline,continuous chemotherapy,Yangzheng Xiaoji capsulestreated,and three TCCL-treated *** treatment,feces,tumors,liver,spleen,thymus,stomach,jejunum,ileum,and colon tissues,and ileal contents were *** changes,serum levels of IL-1β,IL-6,IL-8,IL-10,IL-22,TNF-α,and TGF-β,intestinal SIgA,and protein and mRNA expression of ZO-1,NF-κB,Occludin,MUC-2,Claudin-1,and IκB-αin colon tissues were *** effect of TCCL on the abundance and diversity of intestinal flora was analyzed using 16S rDNA *** TCCL treatment improved thymus and spleen weight,thymus and spleen indexes,and body weight,decreased tumor volumes and tumor tissue cell density,and alleviated injury to gastric,ileal,and colonic mucosal *** proteins and genes associated with inflammation,IL-10,TGF-β,SIgA,ZO-1,MUC-2,and Occludin were upregulated,whereas NF-κB,IL-1β,IL-6,TNF-α,IL-22,IL-8,and IκB-αwere ***,TCCL increased the proportions of fecal Actinobacteria,AF12,Adlercreutzia,Clostridium,Coriobac

关键词： Chinese medicine Chemotherapy H22 hepatocellular carcinoma Intestinal barrier function Intestinal microecological balance

Anti-inflammatory effects of Tao Hong Si Wu Tang in mice with lung cancer and chronic obstructive pulmonary disease

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World Journal of Clinical Oncology 2024年第9期15卷 1198-1206页

作者： Guo-Li Wang Yan-ling Xu Ke-Ming Zhao Ai-Feng sui Li-Na Wang Hu Deng Ge Wang First Department of Respiratory and Critical Care Medicine/Pulmonary Disease The First Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina Second Department of Respiratory and Critical Care Medicine/Pulmonary Disease The First Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina Department of Spleen and Stomach Oncology The Fourth Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110101Liaoning ProvinceChina

BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of ***-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with *** studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy *** To observe the effects of THSW on COPD and LC in *** A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell *** The blank control group exhibited a clear alveolar *** model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating *** changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control *** serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlev

关键词： Tao Hong Si Wu Tang Anti-inflammatory Chronic obstructive pulmonary disease Lung cancer Traditional Chinese medicine

Milestone progress of the HEPS booster commissioning

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Nuclear Science and Techniques 2024年第1期35卷 170-177页

作者： Yue-Mei Peng Jian-She Cao Jin-Hui Chen Hai-Yi Dong Ping He Yi Jiao ling Kang Wen Kang Jian Li Jing-Yi Li Guo-Ping Lin Fang Liu Feng-Li Long Cai Meng Xin Qi Hua-Min Qu Yan-Feng sui Sheng Wang Gang Xu Qiang Ye Jing Zhang Pei Zhang Wei-Min Pan Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadShijingshan DistrictBeijing 100049China University of the Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China

The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in *** HEPS injector consists of a linear accelerator(Linac)and a full energy *** booster captures the electron beam from the Linac and increases its energy to the value required for the storage *** full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target *** milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam *** measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,*** paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.

关键词： High energy photon source Booster Beam commissioning

撕裂蜡孔菌活化土壤氮磷及其对豆科作物生长的影响

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微生物学报 2024年第8期64卷 3047-3058页

作者：宁诗琪隋宗明袁玲杨红军西南大学资源环境学院重庆400715

【目的】利用微生物活化土壤中的原本无效养分种植豆科作物,有益于土地资源的长期可持续利用。【方法】利用自主分离的白腐真菌撕裂蜡孔菌新株(Ceriporia lacerata)HG2011,通过培养和田间微区试验,研究***的分泌作用、土壤氮磷活化以及... 详细信息

【目的】利用微生物活化土壤中的原本无效养分种植豆科作物,有益于土地资源的长期可持续利用。【方法】利用自主分离的白腐真菌撕裂蜡孔菌新株(Ceriporia lacerata)HG2011,通过培养和田间微区试验,研究***的分泌作用、土壤氮磷活化以及对绿豆和光叶紫花苕养分吸收、生长和产量的影响。【结果】***能分泌纤维素酶、几丁质酶、β-l,3-葡聚糖酶、蛋白酶、磷酸酶和铁载体,溶解Ca_(3)(PO_(4))_(2);在土壤表面,***形成菌落,其菌丝伸入土壤,降低土壤pH,提高有效氮磷含量,进而增强蛋白酶和磷酸酶活性;接种***改善了土壤氮磷供应能力,增强根系活力,促进根系生长、根瘤形成和发育,提高作物养分积累量,增加绿豆籽粒产量和苕子生物量。【结论】***能在土壤中定殖,活化土壤氮磷,提高肥料利用率,促进绿豆和苕子生长。***以木屑、秸秆和谷壳等农林有机废弃物为基质,容易培养,菌剂生产成本低廉。本研究为活化土壤养分,促进绿豆和苕子等豆科作物生长,保育耕地提供了新策略。

关键词：撕裂蜡孔菌土壤氮磷豆科作物

和厚朴酚对脂多糖诱导心肌细胞自噬和凋亡的影响

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中药药理与临床 2024年第7期40卷 57-62页

作者：孟楚浛鲁美丽隋海娟张玲锦州医科大学心脑血管药物研究重点实验室辽宁121001 锦州医科大学基础医学院辽宁121001

目的:探讨和厚朴酚对脂多糖诱导心肌细胞损伤、自噬和凋亡的影响及潜在作用机制。方法:以10μg/mL脂多糖作用H9C2细胞建立心肌细胞损伤模型,分为空白对照组、模型对照组、和厚朴酚12.5、25.0、50.0μmol/L组和和厚朴酚50.0μmol/L+3-MA... 详细信息

目的:探讨和厚朴酚对脂多糖诱导心肌细胞损伤、自噬和凋亡的影响及潜在作用机制。方法:以10μg/mL脂多糖作用H9C2细胞建立心肌细胞损伤模型,分为空白对照组、模型对照组、和厚朴酚12.5、25.0、50.0μmol/L组和和厚朴酚50.0μmol/L+3-MA(自噬抑制剂3-MA 10 mmol/L)组。CCK-8法检测细胞活力;ELISA法检测炎性因子水平;DCFH法测活性氧(ROS)水平;LC3免疫荧光染色观察自噬;流式细胞术检测细胞凋亡率;Western blot法检测与自噬、凋亡及PI3K/AKT/mTOR通路相关的蛋白表达。结果:与空白对照组比较,模型对照组细胞活力降低,LAMP2蛋白表达显著下调(P<0.01),而炎症因子含量、ROS水平、自噬细胞数量、细胞凋亡率显著增加,LC3II/I、Beclin 1、P62、Cleaved caspase 3/Caspase 3、p-PI3K/PI3K和p-AKT/AKT的蛋白表达均显著上调(P<0.01);与模型对照组相比,和厚朴酚可明显降低炎症因子含量、ROS水平、细胞凋亡率、P62表达,下调Cleaved caspase 3/Caspase 3蛋白表达及PI3K/AKT/mTOR通路相关蛋白表达(P<0.01),提高细胞活力、自噬细胞数量及上调LC3II/I、Beclin 1和LAMP2蛋白表达(P<0.01),且和厚朴酚对细胞活力、炎症因子水平、ROS水平、自噬细胞数量和细胞凋亡率的调节均呈浓度依赖性;与和厚朴酚50.0μmol/L组相比,和厚朴酚50.0μmol/L+3-MA组的炎症因子含量、ROS水平、细胞凋亡率显著升高,P62和Cleaved caspase 3/Caspase 3蛋白表达显著上调(P<0.01),细胞活力、自噬细胞数量显著降低,LC3II/I、Beclin 1、LAMP2、p-PI3K/PI3K和p-AKT/AKT的蛋白表达明显下调(P<0.05或P<0.01)。结论:和厚朴酚可激发自噬,减少脂多糖诱导的心肌细胞损伤、ROS水平和细胞凋亡率,且效应与药物浓度成正相关,这些作用可能与和厚朴酚抑制PI3K/AKT/mTOR信号通路,上调自噬、促进自噬流有关。

关键词：和厚朴酚脂多糖自噬凋亡磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白通路

Spin gap in quasi-one-dimensional S=3/2 antiferromagnet CoTi2O5

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Chinese Physics B 2024年第3期33卷 609-617页

作者：徐浩航刘庆元辛潮申沁鑫罗军周睿程金光刘健陶玲玲刘志国霍明学王先杰隋郁 School of Physics Harbin Institute of TechnologyHarbin 150001China School of Science Changchun University of Science and TechnologyChangchun 130022China Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China Laboratory for Space Environment and Physical Sciences Harbin Institute of TechnologyHarbin 150001China Southwest Institute of Applied Magnetics Mianyang 621000China

Quasi-one-dimensional(1D)antiferromagnets are known to display intriguing phenomena especially when there is a spin gap in their spin-excitation *** we demonstrate that a spin gap exists in the quasi-1D Heisenberg antiferromagnet CoTi2O5 with highly ordered Co2+/Ti4+occupation,in which the Co2+ions with S=3/2 form a 1D spin chain along the ***2O5 undergoes an antiferromagnetic transition at TN~24 K and exhibits obvious anisotropic magnetic susceptibility even in the paramagnetic *** a gapless magnetic ground state is usually expected in a quasi-1D Heisenberg antiferromagnet with half-integer spins,by analyzing the specific heat,the thermal conductivity,and the spin-lattice relaxation rate(1/T1)as a function of temperature,we found that a spin gap is opened in the spin-excitation spectrum of CoTi2O5 around TN,manifested by the rapid decrease of magnetic specific heat to zero,the double-peak characteristic in thermal conductivity,and the exponential decay of 1/T1 below *** the magnetic measurements and the first-principles calculations results indicate that there is spin-orbit coupling in CoTi2O5,which induces the magnetic anisotropy in CoTi2O5,and then opens the spin gap at low temperature.

关键词： quasi-one-dimensional antiferromagnet magnetic anisotropy spin gap

中华优秀传统文化融入大学生廉洁教育的价值意蕴与实践路径

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齐齐哈尔大学学报（哲学社会科学版） 2024年第1期 168-172页

作者：隋灵灵李小雪山东建筑大学马克思主义学院山东济南250100 山东建筑大学思想政治教育虚拟仿真研究中心山东济南250100

中华优秀传统文化是中华民族经过长期实践凝结起来的智慧结晶,蕴含着十分丰富的育人资源,其中的廉洁思想也尤为丰富。中华优秀传统文化融入大学生廉洁教育有助于社会主义和谐社会的构建、传承和弘扬中华优秀传统文化、增强大学生文化认... 详细信息

中华优秀传统文化是中华民族经过长期实践凝结起来的智慧结晶,蕴含着十分丰富的育人资源,其中的廉洁思想也尤为丰富。中华优秀传统文化融入大学生廉洁教育有助于社会主义和谐社会的构建、传承和弘扬中华优秀传统文化、增强大学生文化认同与自信以及提高高校大学生廉洁教育实效。中华优秀传统文化融入大学生廉洁教育可以借力于课堂教学、实践教育、自主学习、文化场域、网络传播而展开。

关键词：中华优秀传统文化大学生廉洁教育实践路径

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长期轮作施肥处理对植烟土壤有机碳组分和酶活性的影响

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土壤 2024年第3期56卷 510-516页

作者：蒋如宁诗琪隋宗明袁玲刘京西南大学资源环境学院重庆400715 贵州省烟草公司遵义市公司贵州遵义563000

以贵州省遵义市烤烟长期(18年)定位试验为平台,研究两种种植制度(烤烟-玉米轮作和烤烟连作)下的3种不同施肥模式(不施肥、单施化肥、化肥有机肥配施)对植烟土壤有机碳组分、酶活性和碳库管理指数的影响,探究植烟土壤的碳素转化,为土壤... 详细信息

以贵州省遵义市烤烟长期(18年)定位试验为平台,研究两种种植制度(烤烟-玉米轮作和烤烟连作)下的3种不同施肥模式(不施肥、单施化肥、化肥有机肥配施)对植烟土壤有机碳组分、酶活性和碳库管理指数的影响,探究植烟土壤的碳素转化,为土壤碳素科学管理提供依据。结果显示:在相同种植模式下,化肥有机肥配施处理比单施化肥处理的土壤总有机碳(TOC)增加5.65%~12.13%,其中,轻组有机碳(LFOC)、溶解性有机碳(DOC)和易氧化有机碳(ROC)分别提高23.33%~28.71%、24.46%~25.54%、10.26%~18.99%,碳库管理指数增加12.89%~23.34%;土壤纤维素酶、β-葡萄糖苷酶、淀粉酶、过氧化氢酶和蔗糖酶活性显著增强,且与土壤有机碳各组分含量和碳库管理指数呈显著正相关(0.59^(*)~0.97^(**),n=18)。在相同施肥条件下,轮作处理的土壤有机碳含量、酶活性和碳库管理指数分别比连作处理提高6.14%~23.51%、9.00%~37.92%和4.74%~14.44%,以烤烟-玉米轮作+化肥有机肥配施处理最优。综上,通过“轮作+化肥有机肥配施”不仅能显著提高植烟土壤有机碳含量和碳库管理指数,还能增加土壤微生物生物量和活性有机碳(LOC)组分,对于提高植烟土壤肥力和维持土地生产力具有重要意义。

关键词：长期施肥活性有机碳土壤酶活性碳库管理指数

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美国卓越数学与科学教师特质研究

数学教育学报 2024年第4期33卷 73-77,102页

作者：姚一玲贾随军蔡金法杭州师范大学中国教育现代化研究院浙江杭州311121 浙江外国语学院浙江杭州310023 特拉华大学数学系纽瓦克19716

教师质量是有效教学的关键,揭示卓越教师的专业特质,能够为普通教师的专业发展提供重要依据.研究基于美国卓越数学与科学教学总统奖评选标准,对获奖教师的专业特质进行分析,主要聚焦于卓越数学与科学教师在职前训练、职后发展、课堂教学... 详细信息

教师质量是有效教学的关键,揭示卓越教师的专业特质,能够为普通教师的专业发展提供重要依据.研究基于美国卓越数学与科学教学总统奖评选标准,对获奖教师的专业特质进行分析,主要聚焦于卓越数学与科学教师在职前训练、职后发展、课堂教学3方面的具体表现.分析表明:卓越数学与科学教师比普通教师会修读更多学科专业课程,有更好的教学准备,参与更多专业发展活动,更倾向于主动运用新的和灵活的教学方法,对学生的评价手段也更加多元和开放,能够不断反思和学习.

关键词：卓越教师数学教师科学教师专业特质