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Non-coding RNAs expression in SARS-CoV-2 infection:pathogenesis,clinical significance,and therapeutic targets

Signal Transduction and Targeted Therapy 2024年第1期9卷 55-78页

作者： Xiaoxing Liu Wandi Xiong Maosen Ye Tangsheng Lu Kai Yuan suhua chang Ying Han Yongxiang Wang Lin Lu Yanping Bao Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)100191 BeijingChina Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking University100871 BeijingChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan University570228 HaikouChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences650204 KunmingYunnanChina National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Institute of Brain Science and Brain-inspired Research Shandong First Medical University&Shandong Academy of Medical Sciences250117 JinanShandongChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina School of Public Health Peking University100191 BeijingChina

The coronavirus disease 2019(COVID-19)pandemic has been looming globally for three years,yet the diagnostic and treatment methods for COVID-19 are still undergoing extensive exploration,which holds paramount importance in mitigating future *** non-coding RNAs(ncRNAs)display aberrations in the context of ***,microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)exhibit a close association with viral infection and disease *** this comprehensive review,an overview was presented of the expression profiles of host ncRNAs following SARS-CoV-2 invasion and of the potential functions in COVID-19 development,encompassing viral invasion,replication,immune response,and multiorgan deficits which include respiratory system,cardiac system,central nervous system,peripheral nervous system as well as long ***,we provide an overview of several promising host ncRNA biomarkers for diverse clinical scenarios related to COVID-19,such as stratification biomarkers,prognostic biomarkers,and predictive biomarkers for treatment *** addition,we also discuss the therapeutic potential of ncRNAs for COVID-19,presenting ncRNA-based strategies to facilitate the development of novel *** an in-depth analysis of the interplay between ncRNA and COVID-19 combined with our bioinformatic analysis,we hope to offer valuable insights into the stratification,prognosis,and treatment of COVID-19.

关键词： invasion therapeutic infection

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Whole-genome sequencing identifies novel genes for autism in Chinese trios

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Science China Life Sciences 2024年

作者： suhua chang Jia Jia Liu Yilu Zhao Tao Pang Xiangyu Zheng Zhirui Song Anyi Zhang Xuping Gao Lingxue Luo Yanqing Guo Jing Liu Li Yang Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health (Peking University)National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) Chinese Academy of Medical Sciences Research Unit (No.2018RU006) Peking University School of Nursing Peking University Wuhan Biobank National Institute on Drug Dependence Peking University

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with high genetic heritability but *** understanding its genetics requires whole-genome sequencing (WGS),but the ASD studies utilizing WGS data in Chinese population are *** this study,we present a WGS study for 334 individuals,including 112 ASD patients and their non-ASD *** identified 146 de novo variants in coding regions in 85 cases and 60 inherited variants in coding *** integrating these variants with an association model,we identified 33 potential risk genes (P<0.001) enriched in neuron and regulation related biological *** the well-known ASD genes (SCN2A,NF1,SHANK3,CHD8 etc.),several high confidence genes were highlighted by a series of functional analyses,including CTNND1,DGKZ,LRP1,DDN,ZNF483,NR4A2,SMAD6,INTS1,and MRPL12,with more supported evidence from GO enrichment,expression and network *** also integrated RNA-seq data to analyze the effect of the variants on the gene expression and found 12 genes in the individuals with the related variants had relatively biased *** further presented the clinical phenotypes of the proband carrying the risk genes in both our samples and Caucasian samples to show the effect of the risk genes on *** variants in noncoding regions,a total of 74 de novo variants and 30 inherited variants were predicted as pathogenic with high confidence,which were mapped to specific genes or regulatory *** number of de novo variants found in patient was significantly associated with the parents’ages at the birth of the child,and gender with *** also identified small de novo structural variants in ASD *** results in this study provided important evidence for understanding the genetic mechanism of ASD.

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Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources

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Protein & Cell 2012年第7期3卷 526-534页

作者： suhua chang Weina Zhang Lei Gao Jing Wang Key Laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing 100101China Graduate University of the Chinese Academy of Sciences Beijing 100039China􀀍

Attention deficit hyperactivity disorder(ADHD)is a common,highly heritable psychiatric disorder charac-terized by hyperactivity,inattention and increased *** recent years,a large number of genetic studies for ADHD have been published and related ge-netic data has been accumulated *** pro-vide researchers a comprehensive ADHD genetic re-source,we previously developed the first genetic data-base for ADHD(ADHDgene).The abundant genetic data provides novel candidates for further ***,it also brings new challenge for selecting promising candidate genes for replication and verification *** this study,we surveyed the computational tools for candidate gene prioritization and selected five tools,which integrate multiple data sources for gene prioritiza-tion,to prioritize ADHD candidate genes in *** prioritization analysis resulted in 16 prioritized can-didate genes,which are mainly involved in several major neurotransmitter systems or in nervous system development *** these genes,nervous system development related genes,especially SNAP25,STX1A and the gene-gene interactions related with each of them deserve further *** results may provide new insight for further verification study and facilitate the exploration of pathogenesis mechanism of ADHD.

关键词： gene prioritization attention deficit hyper-activity disorder candidate genes multiple data sources

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Synthetic biology: From the first synthetic cell to see its current situation and future development

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Chinese Science Bulletin 2011年第3期56卷 229-237页

作者： ZHANG LiuYan chang suhua WANG Jing Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China

Synthetic biology is an emerging field,which,since its birth,has shown great value and potential in many fields including medicine,energy,environment and *** is also important for the study of the origin and evolution of *** the publication of the first synthetic cell in May,2010,synthetic biology again attracts high attention and leads to extensive discussions all over the *** have been a number of researches and achievements on synthetic biology in the United States and European *** in China,so far there is no systematic research on synthetic *** order to promote the development of this new discipline in China,we organized this review to systematically introduce the concept and research content of synthetic biology,summarize the achievements,and investigate the current situation in both China and *** also analyzed the opportunities and challenges in synthetic biology,and looked forward to the future development of synthetic biology,especially its future development in China.

关键词：合成生物学细胞生命起源欧洲国家中国系统价值

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Causal relationships between chronotype and risk of multiple cancers by using longitudinal data and Mendelian randomization analysis

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Science China(Life Sciences) 2023年第10期66卷 2433-2436页

作者： Shanshan Tian Longtao Huangfu Sizhi Ai Junwei Zheng Le Shi Wei Yan Ximei Zhu Qianwen Wang Jiahui Deng Yanping Bao suhua chang Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China Department of Cardiology Heart CenterThe First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100China National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Chinese Academy of Medical Sciences Research Unit(No.2018RU006) Peking UniversityBeijing 100191China Peking-Tsinghua Center for Life Sciences PKU-IDG/McGovern Institute for Brain ResearchBeijing 100871China

Dear Editor,Cancer is the second leading cause of death worldwide,and the cancer situation is becoming more complicated(Zhou et al.,2022).The International Agency for Research on Cancer(IARC)Monographs Working Group c... 详细信息

关键词： Cancer death

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Pathway-based analysis for genome-wide association study data of bipolar disorder provides new insights for genetic study

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Protein & Cell 2015年第12期6卷 912-915页

作者： suhua chang (1) Jinglu Wang (1) (2) Kunlin Zhang (1) Jing Wang (1) 1.Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China 2.University of Chinese Academy of Sciences Beijing 100049 China

Bipolar disorder （BD） is an episodic recurrent pathological mood disturbance with estimated heritability ranging from 80%-85% （Barnett and Smoller, 2009）. Although many studies have indicated that BD is a polygenic disease influenced by many genes with small effect, the pathogenesis of BD is still not well understood. According to the catalog of published genome-wide association studies （GWAS）（Welter et al., 2014）, there have been 31 BD GWASs （including bipolar disorder related symptoms and combined GWAS with other related disorders）till 01/15/2015, including the largest BD GWAS from the Psychiatric Genomics Consortium （PGC）（Sklar et al., 2011）.

关键词： Bipolar Disorder Retinol GWAS Data Wellcome Trust Case Control Consortium Candidate Pathway

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Shared functional connectivity associated with sleep quality and crystallized cognition

Shared functional connectivity associated with sleep quality...

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中国睡眠研究会第十四届全国学术年会

作者： Ximei Zhu Yongbo Zheng Xiao Lin Jiahui Deng suhua chang Lin Lu Peking University Sixth Hospital Peking University Institute of Mental Health NHC Key Laboratory of Mental Health(Peking University) National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital) Chinese Academy of Medical Sciences Research Unit(No.2018RU006) Peking University Peking-Tsinghua Centre for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking University National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking University

Mounting evidence points to a potential connection between sleep and cognitive function. Findings from observational studies support a role for sleep disturbances in the development of cognitive impairment. Less consistent evidence exists for associations of sleep quality with crystallized cognition which is the ability to solve problems based on prior knowledge and experience. To identify the functional connectivity(FC) associated with sleep quality and crystallized *** study collected data from participants in the Human Connectome Project using the Pittsburgh sleep quality index(PSQI), crystallized cognition scores of NIH Toolbox cognitive battery(including language decoding and language comprehension) and resting-state functional magnetic resonance imaging. Correlations between FC, sleep quality and crystallized cognition.A total of 968 participants from the Human Connectome Project(of whom 511 [52.8%] were female;age range, 22 to 37 years) drawn from a general population in the United States were included. The crystallized cognition was negatively correlated with sleep quality(r =-0.067;P < 0.05), sleep latency(r =-0.091;P < 0.05), sleep duration(r =-0.073;P < 0.05), and sleep disturbances(r =-0.073;P < 0.05). A total of 7 fFC links involving areas associated with crystallized cognition, such as right precentral gyrus, right middle cingulate gyrus, right fusiform gyrus, right middle frontal gyrus, left precuneus, and left frontal gyrus, were identified. A total of 182 FC links involving areas associated with sleep duration. A total of 7 FC links involving areas associated with sleep disturbances. The brain areas with decreased FC associated with both sleep duration/disturbances and crystallized cognition included the right precentral gyrus, right middle cingulate gyrus, right fusiform gyrus, and right middle frontal *** implication of these findings is that the decreased FC between these brain regions provides a neural basis for the association

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Entorhinal cortex: a novel target to treat the chronic pain patients with sleep disturbance

Entorhinal cortex: a novel target to treat the chronic pain ...

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中国睡眠研究会第十一届全国学术年会

作者： Jie Sun Lin Lu suhua chang Peking University Third Hospital Peking University Sixth Hospital

Background Sleep problems and pain are major public health concerns. Sleep problems and pain represent major public health concerns, but the nature of the association between 2 conditions is inadequately studied. Evidence from both clinical and epidemiological studies shows that individuals with chronic pain are also likely to have a range of sleep problems. Although the direction of causality is not entirely clear, and is most likely ***, an increased understanding of mechanisms that may underlies the sleep aspects of chronic pain and the potential overlap with comorbid insomnia states are key factors in the development of new *** pain is a rising public health epidemic. The socioeconomic burden is staggering. The effective treatment is *** comorbidity rate of chronic pain and insomnia is 88% according to the research. Sleep loss increases the experience of pain. However, the brain mechanisms underlying altered pain processing following insomnia are unknown. Objective The sleep quality could indicate the pain severity next day. Understanding the brain structure abnormality that underlies both conditions and mediates the association between them is likely to lead to better-directed treatments for chronic pain and associated sleep disturbance. To identify the brain areas that mediate the association of pain with sleep disturbance and advanced understanding of the differences in brain structure in co-morbidity of sleep disturbance in pain. To find the new brain target to treat chronic pain patients with poor sleep quality. Methods This study collected data from 1207 participants in the Human Connectome Project using the pain intensity survey, a survey of self-reported sleep quality and FreeSurfer Summary Statistics. This research uses the linear regression analysis to investigate the association between brain structure and sleep quality/pain condition. To assess whether the abnormal brain structure significantly mediated this

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内嗅皮质在疼痛感知与睡眠障碍间的中介效应分析

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中国疼痛医学杂志 2023年第2期29卷 101-106页

作者：孙杰郑永博李赓常素华李水清北京大学第三医院疼痛医学中心北京100191 北京大学第六医院北京大学精神卫生研究所北京100191 北京大学前沿交叉科学研究院北京100191 国家卫生健康委员会精神卫生学重点实验室北京100191

目的:本研究旨在探索疼痛感知与睡眠障碍共病的关系及潜在的脑影像学机制。方法:通过人类连接组计划,共纳入1043名受试者,收集一般人口学数据、7天内疼痛程度平均分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)及磁共振... 详细信息

目的:本研究旨在探索疼痛感知与睡眠障碍共病的关系及潜在的脑影像学机制。方法:通过人类连接组计划,共纳入1043名受试者,收集一般人口学数据、7天内疼痛程度平均分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)及磁共振等数据。运用偏相关探索睡眠情况与疼痛情况的相关性,使用多元线性回归探索与睡眠、疼痛相关的脑区结构,并应用中介分析探索脑区与疼痛、睡眠三者关联性。结果:发现疼痛程度评分与PSQI评分呈正相关,并且右侧内嗅皮质厚度与疼痛程度评分和PSQI评分均呈负相关,疼痛对睡眠的影响可通过右侧内嗅皮质介导。结论:疼痛症状与睡眠障碍的发生相关,疼痛评分越高,睡眠质量越差,并且右侧内嗅皮质厚度降低是疼痛情况和睡眠障碍共病的潜在神经机制。

关键词：慢性疼痛睡眠障碍脑影像内嗅皮质

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Risk factors and an early prediction model for methamphetaminerelated psychiatric symptoms

Risk factors and an early prediction model for methamphetami...

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中国毒理学会第七次全国会员代表大会暨中国毒理学会第六次...

作者： Yan Sun Yang Zhang Lin Lu suhua chang Jie Shi National Institute on Drug Dependence Peking University Peking University Sixth Hospital (Institute of Mental Health)

＜正＞Background:Methamphetamine-related psychiatric symptoms （MAP） are serious adverse reactions of methamphetamine use which would result in many social problems such as violence

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