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Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer

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World Journal of Gastroenterology 2007年第33期13卷 4437-4444页

作者： Sibel Erdamar Esra Ucaryilmaz Gokhan Demir Tayfun Karahasanoglu Gulen Dogusoy Ahmet Dirican suha goksel Department of Pathology Cerrahpasa Medical CollegeIstanbul University Cerrahpasa 34303 Istanbul Turkey Department of Oncology Cerrahpasa Medical College Istanbul University Cerrahpasa 34303 Istanbul Turkey Department of General Surgery Cerrahpasa Medical College Istanbul University Cerrahpas34303 Istanbul Turkey Department of Statistics Cerrahpasa Medical College Istanbul University Cerrahpasa 34303 Istanbul Turkey

AIM： To assess the incidence of MLH1 （the human MutL homologue） and MSH2 （the human MutS homologue） protein expression in Turkish patients with sporadic colorectal cancers and to compare their survival and clinicopathological features. METHODS： We validated the tissue microarray technology in 77 colorectal carcinomas by analyzing the immunohistochemical expression of proteins involved in two main pathways of colorectal carcinogenesis： p53 protein for loss of heterozygosity tumors; MLH1 and MSH2 proteins for microsatellite instability （MSI）. RESULTS： Our analysis showed that 29 （39.2%） had loss of MLH1 expression, 5 （6.8%） had loss of MSH2 expression and 2 cases had loss of expression of both proteins. We found that 60% of MSH2-negative tumors were located in the right side of the colon; all MSH2-negative cases were women. In addition, the loss of MSH2 expression was correlated with low p53 expression. Neither MLH1 nor MSH2 expressions were associated with prognosis, although there seemed a tendency of longer survival （71.7 ± 8.65 mo vs 47.08± 5.26 too） for the patients with MLHl-negative versus MLHl-positive carcinomas. There were not significant differences in overall and recurrence-free survival among MLH1/MSH2-positive and -negative cases.CONCLUSION： Our data supports that Turkish patients with MLH1- and MSH2-defective tumors have some distinct features from each other. Although prognostic importance remains controversial, immunohistochemical analysis of mismatch repair genes may be used as a routine histopathological examination of sporadic colorectal carcinomas.

关键词： Colorectal carcinoma MLH1 MSH2 Immunohistochemistry Prognosis

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Schwannoma in Ascending Colon: A Rare Cause of Abdominal Pain

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Case Reports in Clinical Medicine 2014年第5期3卷 314-318页

作者： Ozdal Ersoy Umit Sekmen suha goksel Hulya Hamzaoglu Melih Paksoy Department of Gastroenterology Acibadem Fulya Hospital Istanbul Turkey Department of Gastroenterology Acibadem University Acibadem Fulya Hospital Istanbul Turkey Department of Pathology Acibadem Maslak Hospital Istanbul Turkey Department of Surgery Acibadem Fulya Hospital Istanbul Turkey

Schwannoma, (also called neurilemoma, neurinoma) is a benign tumor originating from nerve sheath of the Schwann cells. They rarely occur in gastrointestinal tract. We report a rare case of colonic schwannoma in a 38-year-old woman presenting with worsening right-sided pelvic pain, discovered after laparoscopic right-colon resection performed after the detection of a atypical polypoid mass in the ascending colon. Diagnosis is confirmed by immunohistochemical staining panel.

关键词： Schwannoma Colon S-100

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