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miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastric cancer

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World Journal of Gastrointestinal Oncology 2018年第10期10卷 344-350页

作者： suguru maruyama Shinji Furuya Kensuke Shiraishi Hiroki Shimizu Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Daisuke Ichikawa First Department of Surgery Faculty of Medicine University of Yamanashi

AIM To investigate the clinical utility of alpha-fetoprotein(AFP)-producing gastric cancer(AFPGC)-specific microRNA(mi RNA)for monitoring and prognostic prediction of *** We performed a comprehensive miRNA array-based approach to compare miRNA expression levels between AFP-positive and AFP-negative cells in three patients with primary *** next examined the expression levels of the selected miRNAs in five AFPGC and ten non-AFPGC tissue samples by quantitative reverse transcription-polymerase chain reaction to validate their *** also investigated the expression levels of the selected miRNA not only in tissue but also in plasma ***,we investigated the relationship between plasma AFP levels and plasma selected miRNA expression levels,and also investigated the correlation of the selected miRNA expression levels and malignant *** Among the five miRNAs selected from the miRNA array results,the expression levels of miR-122-5p were significantly higher in the AFPGC patients than in the non-AFPGC patients(P<0.05).In tissue samples,mi R-122-5p expression level tended to be lower in the non-AFPGC tissue than the normal gastric ***,in the AFPGC tissue,miR-122-5p expression level was significantly higher in the AFPGC tissue than both the normal gastric mucosa and the nonAFPGC tissue samples(P<0.05).Plasma mi R-122-5p expression levels were also significantly higher in the AFPGC patients than the health volunteers and the nonAFPGC patients(P<0.05)and were strongly correlated with plasma AFP levels(r=0.7975,P<0.0001).Moreover,the correlation of miR-122-5p expression in tissue samples with malignant potential was stronger than that of plasma AFP level in the AFPGC *** contrast,no correlation was found between mi R-122-5p expression levels and liver metastasis in the non-AFPGC *** miR-122-5p might be a useful biomarker for early detection and disease monitoring in AFPGC.

关键词： Gastric cancer Alpha-fetoprotein Alphafetoprotein producing gastric cancer MicroRNA miR-122-5p

Laparoscopic Choledochoduodenostomy for Biliary Alleviation

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Surgical Science 2017年第2期8卷 65-72页

作者： Hirotaka Okamoto suguru maruyama Kazunori Takahashi Kenji Kawashima Toshio Fukasawa Hideki Fujii Department of Surgery Tsuru Municipal Hospital Tsuru Japan Gastrointestinal & Breast Endocrine Surgery Faculty of Medicine University of Yamanashi Yamanashi Japan

Choledochoduodenostomy (CDD) was very useful alternatives for treatment for patients with common bile duct (CBD) stones, especially recurrent stones, giant stones with choledochal dilatation, and difficult or failed cases by endoscopic treatment. Furthermore, CDD was also applied to biliary bypass by malignant obstruction. In these days, minimal invasive laparoscopic approach is adapted in these disorders. We have conducted to perform a laparoscopic CDD for biliary alleviation for patients with endoscopic management of difficult CBD stone with choledochal dilatation. A side-to-side CDD was created intra-corporeally using water-tight running absorbable suture by handmade 4-0 monofilament with double side needles, starting from the right side of choledochus, and continued along posterior wall until the left side of the choledochus followed by anterior-wall anastomosis as the same manner. Five patients were treated successfully by this laparoscopic procedure and remained well without bile leakage and reflux cholangitis for the short-term follow-up. The median operative time and intracorporeally anastomosis time were 182 (167 - 209) min and 33 (30 - 38) min, respectively. Median blood loss was 32 (little-90) ml, median hospital stay was 7 (5 - 14) days, and median follow-up time was 18 months. Although this series was relatively small, this laparoscopic technique is feasible and safe for biliary alleviation, especially for endoscopic management of difficult or failed CBD stones, and would also potentially adapt to biliary bypass by malignant obstruction.

关键词： Laparoscopic Choledochoduodenostomy Biliary Alleviation Endoscopic Management Difficult Choledocholithiasis

A combination of tides and nontidal variations in ocean bottom pressure may generate interannual slip fluctuations in the transition zone along a subduction plate interface

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Geodesy and Geodynamics 2023年第1期14卷 43-51页

作者： Yoshiyuki Tanaka Hiromu Sakaue Masayuki Kano suguru Yabe Department of Earth and Planetary Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Graduate School of Science Tohoku University6-3Aramaki-aza-aobaAoba-kuSendai980-8578Japan Geological Survey of Japan National Institute of Advanced Industrial Science and Technology(AIST)Tsukuba Central 71-1-1 HigashiTsukubaIbaraki 305-8567Japan

The tidal triggering of earthquakes has been studied for many *** discovery of slow earthquakes in the early 2000s,including slow slip,has urged scientists to investigate the tidal responses of these earthquakes due to their sensitivity to weak stress *** studies have shown that slow earthquakes correlate with diurnal and semidiurnal tides and seasonal variations in surface loads more clearly than ordinary ***,little is known about long-term responses to external *** this paper,based on a widely accepted frictional law for faults,a mechanism is proposed by which nontidal variations in ocean bottom pressure,when combined with tides,pro mote the occurrence of slow *** slow earthquakes accompany a slip on the plate interface,this mechanism allows one to estimate slip modulations.A one-degree-of-freedom slip model is constructed and applied to Ise Bay in the Tonankai region of southwestern Japan,where large-scale ocean mass redistributions have *** model calculated with parameters determined from the observation of tectonic tremors is quantitatively consistent with the slip during 1997-2013 inferred from GNSS data,suggesting that the decrease in the sea-level change in approximately 2006 could cause the accele ration of a slip observed after *** result implies that the decreases in sea level in approximately 1996 and 2014 could also cause subsequent slip *** three slip acceleration periods temporally coincide with the increases in background seismicity in a shallower portion of the plate *** changes in seismicity are common to shallow earthquakes in the Tokai area,and a similar model can reproduce *** studies are expected to reveal causality between shallow earthquakes and long-term slip fluctuations based on modeling that considers changes in the frictional property along the plate interface.

关键词： Tides Ocean bottom pressure Slow earthquake Seismicity Kuroshio current

Analysis of value of flexibility in Japan’s power system with increased VRE

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Clean Energy 2018年第1期2卷 37-44页

作者： Sumie Nakayama Hitoshi Azuma suguru Fukutome Kazuhiko Ogimoto J-POWER/Electric Power Development Co. Ltd.6-15-1GinzaChuo-kuTokyo 104-8165Japan JP Business Service Corporation 2-2-18FukagawaKoto-kuTokyo 135-8451Japan Institute of Industrial Science Collaborative Research Center for Energy EngineeringThe University of Tokyo4-6-1KomabaMeguro-kuTokyo153-8585Japan

The growth of renewable energy has accelerated globally toward a low-carbon economy since the Paris Agreement entered into force in *** a result of the increase of variable renewable energy(VRE),namely solar PV and wind,power systems require more flexibility from conventional power plants with less power generation to regulate increased *** are sources of flexibility other than conventional power plants,including enhanced power networks,storage capacity and demand *** maximize economic utilization of VRE power generation,it is necessary to use the flexibility potential from all these *** Japan,the share of VRE has increased since the introduction of a feed-in tariff(FIT)and,in parallel,power market reform is *** has a unique power system of nine grids connected like a fish bone,making the uptake of an increasing share of VRE *** paper assesses the value of flexibility by source in Japan’s power system in *** analysis of different VRE scenarios is undertaken based on a newly developed production cost *** result of the simulation shows the quantitative impact of each source of flexibility to the generation cost and VRE curtailment and demonstrates the mechanism by which flexibility works to impact VRE curtailment.

关键词： component power demand and supply renewable energy flexibility Japan’s power system produc-tion cost model analysis

DiffMat:Latent diffusion models for image-guided material generation

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Visual Informatics 2024年第1期8卷 6-14页

作者： Liang Yuan Dingkun Yan suguru Saito Issei Fujishiro Graduate School of Science and Technology Keio UniversityKanagawaJapan School of Computing Tokyo Institute of TechnologyTokyoJapan Department of Information and Computer Science Keio UniversityKanagawaJapan

Creating realistic materials is essential in the construction of immersive virtual *** existing techniques for material capture and conditional generation rely on flash-lit photos,they often produce artifacts when the illumination mismatches the training *** this study,we introduce DiffMat,a novel diffusion model that integrates the CLIP image encoder and a multi-layer,crossattention denoising backbone to generate latent materials from images under various *** a pre-trained StyleGAN-based material generator,our method converts these latent materials into high-resolution SVBRDF textures,a process that enables a seamless fit into the standard physically based rendering pipeline,reducing the requirements for vast computational resources and expansive *** surpasses existing generative methods in terms of material quality and variety,and shows adaptability to a broader spectrum of lighting conditions in reference images.

关键词： SVBRDF Diffusion model Generative model Appearance modeling

Hydrogen Adsorption by Woodceramics Produced from Biomass

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Journal of Shanghai Jiaotong university(Science) 2012年第3期17卷 330-333页

作者： TAKASAKI Akito IIJIMA suguru YAMANE Tomoka OKABE Toshio Department of Engineering Science and Mechanics Shibaura Institute of TechnologyTokyo 135-8548Japan Aomori Prefectural Industrial Technology Research Center Aomori 030-0142Japan

Hydrogen adsorption characteristics of woodceramics,made from radiata pine wood fiber boards carbonized at 1 473 K after impregnation with phenolic resin,with and without chemical treatment in an alkaline(KOH) or an acid(H 2 SO 4) solution were investigated The hydrogen adsorption capacity is improved by chemical *** chemical treatment by KOH improves the adsorption capacity more than by H 2 SO *** improvement of the capacity level,in any solution,is dependent on the type of chemical in the solution and its *** maximum hydrogen capacity measured at 93 K is mass fraction about w(H) = 2% for the woodceramics after chemical treatment in a volume fraction = 50% KOH solution,although that is about w(H) = 0.7% for one without chemical *** microscopic condition of pores in the woodceramics is thought to vary after chemical treatment.

关键词： woodceramics biomass hydrogen adsorption chemical treatment isotherm

Tissue pad degradation of ultrasonic device may enhance thermal injury and impair its sealing performance in liver surgery

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World Journal of Hepatology 2022年第7期14卷 1357-1364页

作者： Masatoshi Kajiwara Takahisa Fujikawa suguru Hasegawa Department of Gastroenterological Surgery Fukuoka UniversityFukuoka 814-0180FukuokaJapan Department of Surgery Kokura Memorial HospitalKitakyushu 802-8555FukuokaJapan

BACKGROUND Ultrasonic devices are widely used in many surgical fields,including hepatectomy;however,the negative effects of tissue pad degradation of ultrasonic devices,including those in liver surgery,remain *** Harmonic®1100(H-1100)scalpel has advanced heat control technology than previous models,such as the Harmonic®HD1000i(H-HD1000i).We hypothesized that,because of its advanced temperature-control technology,the H-1100 scalpel would show less tissue pad degradation,resulting in superior sealing performance,compared to that with the H-HD1000i *** To elucidate ultrasonic device tissue pad degradation effects on instrument temperature and sealing performance using ex vivo porcine liver/vessel *** Two different harmonic scalpels were used and compared:A newer model,the H-1100 scalpel,and an older model,the H-HD1000i *** ex vivo porcine livers,each instrument was activated until the liver parenchyma was *** device temperature(passive jaw temperature)was measured after every 10 consecutive activations,until 300 transections of the porcine liver were *** pad degradation was evaluated after 300 *** performance was evaluated using excised porcine carotid vessels;vessel sealing speed and frequency of vessel burst pressure below 700 mmHg were determined after 300 transections of porcine liver *** The temperature of the H-HD1000i scalpel was approximately 10℃higher than that of the H-1100 scalpel,and gradually increased as the number of activations *** median passive jaw temperature of the H-HD1000i scalpel was significantly higher than that of the H-1100 scalpel(73.4℃vs 65.1℃;P<0.001).After 300 transections of porcine liver parenchyma,less tissue pad degradation was observed with the H-1100 scalpel than with the H-HD1000i scalpel(0.08 mm vs 0.51 mm).The H-1100 scalpel demonstrated faster vessel-sealing speed(4.9 *** 5.1 sec.)and less frequent vessel burst pressure<700 mm

关键词： Ultrasonic device Harmonic scalpel Tissue pad degradation Hepatectomy Device temperature Vessel sealing

Preliminary evidence of renal function improvement in chronic progressive kidney disease using autologous CD34+cell therapy:A clinical trial

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World Journal of Stem Cells 2024年第12期16卷 1012-1021页

作者： Takayasu Ohtake Tsutomu Sato Toshitaka Tsukiyama suguru Muraoka Ayaka Mitomo Haruka maruyama Mizuki Yamano Yasuhiro Mochida Kunihiro Ishioka Machiko Oka Hidekazu Moriya Sumi Hidaka Haruchika Masuda Takayuki Asahara Shuzo Kobayashi Regenerative Medicine The Center for Cell Therapy&Regenerative MedicineShonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Kidney Disease and Transplant Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Regenerative Medicine Shonan Research Institute of Innovative MedicineKamakura 247-8533KanagawaJapan Clinical Laboratory Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Radiology and Interventional Radiology Shonan Kamakura General HospitalKamakura 247-8533Japan

BACKGROUND To date,no specific treatment has been established to reverse progressive chronic kidney disease(CKD).AIM To evaluate the safety and efficacy of autologous CD34^(+)cell transplantation in CKD patients who exhibited a progressive decline in renal *** The estimated glomerular filtration rate(eGFR)at the beginning of the study was 15.0-28.0 mL/minute/1.73 m^(2).After five days of treatment with the granulocyte colony-stimulating factor,mononuclear cells were harvested and CD34^(+)cells were magnetically ***34^(+)cells were directly injected into the bilateral renal arteries twice(at 0 and 3 months),and their safety and efficacy were evaluated for 6 *** Four patients were enrolled and completed the *** of four patients showed improvement in eGFR slope(eGFR slope>0 mL/minute/1.73 m^(2)),with the monthly slope of eGFR(delta eGFR)changing from-1.36±1.1(pretreatment)to^(+)0.22±0.71(at 6 months)mL/minute/1.73 m^(2)/month(P=0.135)after cell ***,intrarenal resistive index(P=0.004)and shear wave velocity(P=0.04)were significantly improved after cell *** patient experienced transient fever after cell therapy,and experienced bone pain during granulocyte colony-stimulating factor ***,no severe adverse events were *** In conclusion,our findings suggest that repetitive peripheral blood-derived autologous CD34^(+)cell transplantation into the renal arteries is safe,feasible,and may be effective for patients with progressive ***,a large-scale clinical trial is warranted to validate the efficacy of repetitive regenerative cell therapy using autologous CD34^(+)cells in patients with progressive CKD.

关键词： CD34+cell Chronic kidney disease Clinical trial Granulocyte colony-stimulating factor Regenerative therapy

E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance

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World Journal of Gastroenterology 2007年第29期13卷 3925-3931页

作者： Chihaya Koriyama Suminori Akiba Tetsuhiko Itoh Kazunobu Sueyoshi Yoshie Minakami Alejandro Corvalan suguru Yonezawa Yoshito Eizuru Department of Epidemiology and Preventive Medicine Kagoshima University Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima Japan Geriatric Health Services Facility 551 Akasegawa Akune Kagoshima Japan Kazunobu Sueyoshi Department of Pathology Kagoshima City Hospital 20-17 Kajiya-cho Kagoshima Japan Division of Oncogenic and Persistent Viruses Center for Chronic Viral Diseases Kagoshima University Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima Japan Department of Anatomic Pathology P. Catholic University Santiago Chile Department of Human Pathology Kagoshima University Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima Japan

AIM： To examine the role of E-cadherin and betacatenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas （EBV-GCs）. METHODS： We compared the frequency of E-cadherin and beta-catenin expression in 59 EBV-GCs and 120 non-EBV-GCs, and examined the association between patients＇ prognosis and the expressions of these proteins. RESULTS： Neither the cellular-membranous nor the cytoplasmic E-cadherin expression showed any difference between EBV-GCs and non-EBV-GCs. On the other hand, loss of membranous expression of beta- catenin occurred more frequently in non-EBV-GCs than EBV-GCs [odds ratio = 0.41; 950 confidence interval （CI）, 0.19-0.90]. Furthermore, the nuclear and/or cytoplosmic expression of beta-catenin was seen more frequently in EBV-GCs than non-EBV-GCs （odds ratio = 2.23; 95% CI, 0.97-5.09）, and was observed in a larger proportion of carcinoma cells of EBV-GCs than non-EBV-GCs （P = 0.024）. Survival analysis for non-EBV-GC revealed that lymph node metastasis was significantly associated with poor prognosis （P 〈 0.001）. Among EBV- GCs, the depth of invasion （P = 0.005）, lymph node metastasis （P = 0.004） and an intestinal type by Lauren classification （hazard ratio = 9.47; 95% CI, 2.67-33.6） were significantly associated with poor prognosis. On the other hand, nuclear and/or cytoplasmic expression of beta-catenin was associated with a better prognosis in patients with EBV-GC （hazard ratio = 0.32; 95% CI, 0.11-0.93）. CONCLUSION： We observed more frequent preservation of beta-catenin in cell membrane and accumulation in nuclei and/or cytoplasm in EBV-GCs than in non-EBV- GCs. Factors involved in the prognosis of EBV-GCs and non-EBV-GCs are different in the two conditions.

关键词： Epstein-Barr virus Gastric carcinoma E-cadherin Beta-catenin Prognosis