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Petroleum Science 2014年第3期11卷 439-445页

作者： sugumar ramasamy Prabhakaran Mathiyalagan Preethy Chandran Centre for Nanotechnology and Advanced Biomaterials School of Chemical and Biotechnology SASTRA University

Petroleum refinery wastewater （PRW） containing hydrocarbon is highly toxic to the environment and the surrounding ecosystem. Proper treatment of the PRW effluent is necessary to remove the pollutants before discharge. Bioremediation is considered to be a promising approach as it is eco- friendly and efficient. The exopolysaccharide （EPS） produced by the O. anthropi acts as a bioemulsifier and showed the highest emulsification activity of 60% on diesel. An EPS yield of about 0.42 g/L was obtained under optimized conditions. The carbohydrate and protein content of the EPS was found to be 71.1% and 19.7% respectively, showing the glycoprotein nature. The structural properties of EPS were analyzed by FT-IR and 1H NMR. The batch degradation of oil in PRW by O. anthropi was studied gravimetrically, and showed about 53% degradation in 7 days, indicating the strong ability of the isolated strain to degrade the hydrocarbons in PRW.

关键词： Hydrocarbons Ochrobactrum anthropi MP3 EPS bioemulsifier degradation

Heavy metal stress induced hyperglycemia in blue swimmer crab, Portunus pelagicus

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Acta Oceanologica Sinica 2018年第5期37卷 47-53页

作者： SARAVANAN R. sugumar V. BEEMA MAHIN M.I. Department of Oceanography and Coastal Area Studies Alagappa UniversityThondi Campus

The study was to find out the effect of cadmium and mercury on levels of hemolymph glucose, crustacean hyperglycemic hormone（CHH） and hepatopancreas glycogen in the blue swimmer crab Portunus pelagicus. The experiments were performed in both intact and eyestalk ablated crabs. Quantification of CHH was done by the indirect ELISA with the aid of primary anti-Carcinus maenas-CHH antibody. Higher glucose concentration was observed on exposure to 8×10^–6 of cadmium（（825.6±5.42） μg/m L） and 6×10^–6 of mercury（（90.5±6.25） μg/m L）after 48 h and 24 h respectively. Higher level of hemolymph glucose was observed in eyestalk intact crabs on exposure to cadmium and mercury than eyestalk ablated crabs. Decrease in the levels of CHH was observed in both eyestalk intact and ablated crabs on heavy metal exposure. Decline of the hepatopancreas glycogen level was also witnessed with the exposure to heavy metal, which validated its utilization in the production of glucose. Thus this study brings to light, the variations in hemolymph glucose, CHH and hepatopancreas glycogen on heavy metal stress. These carbohydrate metabolites can be used as biomarkers in assessing heavy metal contamination in water bodies.

关键词： crustacean hyperglycemic hormone cadmium mercury decapod crustaceans blue swimmer crab

Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea

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Chinese Herbal Medicines 2021年第2期13卷 243-249页

作者： K.P.Swathi Saravanan Jayaram Deepa sugumar Emdormi Rymbai Department of Pharmacology KMCH College of PharmacyTamil Nadu Dr.M.G.R.Medical UniversityCoimbatore 641048India Department of Pharmacology JSS College of PharmacyJSS Academy of Higher Education and ResearchOoty 643001India

Objective:Clitoria ternatea is a well-known bioactive plant used to treat several inflammatory ailments in Ayurvedic system of medicine in *** present investigation aimed to determine the antiinflammatory and anti-arthritic activity of ethanolic extract of Clitoria ternatea roots(EECT) in animal ***:The anti-inflammatory activity of the EECT was evaluated by carrageenan and histamineinduced paw ***:EECT showed a significant reduction in mean paw edema volume in both carrageenan and histamine-induced *** efficacy of EECT in rheumatoid arthritis was tested against Freund's complete adjuvant(CFA) induced arthritic model in Wistar *** anti-arthritic effect of EECT was determined by systematic scoring of arthritis symptoms and measuring paw edema.A considerable decrease in paw diameter was observed in the EECT(200 and 400 mg/kg) and diclofenac(10 mg/kg) treated groups after day ***(10 mg/kg) and EECT(400 mg/kg) showed a significant reduction in paw diameter from day 14 compared with CFA control(P <0.001).The anti-arthritic activity was also confirmed from the altered biochemical,haematological(Hb,RBC and WBC) and anti-oxidant parameters(SOD,MDA,CAT,and GSH).EECT(400 and 200 mg/kg) also showed a marked inhibition of joint ***:This study provides a pharmacological rationale for the traditional use of *** against inflammation and rheumatoid arthritis in India.

关键词： antioxidants Clitoria ternatea Linn. inflammation rheumatoid arthritis

Nano-engineered catalysts for high-performance oxygen reduction reaction

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Chinese Chemical Letters 2024年第10期35卷 510-516页

作者： Kunsong Hu Yulong Zhang Jiayi Zhu Jinhua Mai Gang Liu Manoj Krishna sugumar Xinhua Liu Feng Zhan Rui Tan School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Energy Innovation Centre Warwick Manufacture GroupUniversity of WarwickCoventry CV47ALUnited Kingdom School of Transportation Science and Engineering Beihang UniversityBeijing 100191China IDTECH(Suzhou)Co. Ltd.Suzhou 215217China College of Mechatronical and Electrical Engineering Hebei Agricultural UniversityBaoding 071001China

The efficient energy conversion of fuel cells is greatly constrained by the slow oxygen reduction reac tion(ORR)kinetics,which necessitates the use of highly active metal catalysts such as platinum(Pt).The critical challenge limiting large-scale usage of Pt is the capital cost that can be addressed through a pro totypical approach by embedding metal nanoparticles(NPs),e.g.,Pt NPs,in the conductive framework However,previously reported embedding approaches are sophisticated and suffer from limited yields leading to higher chemical process costs and remaining distant from commercial ***,we re port a facile,cost-effective and time-efficient structural tuning approach to synthesizing ultrafine Pt NP impregnated within a conductive and highly porous carbon framework via a microwave-assisted polyo reduction *** NPs with a uniform size of~2.27 nm can be successfully integrated within the pore of the carbon framework,enabling homogeneous *** from these highly dispersed and ultrafine Pt NPs,the electrochemical surface area(ECSA)is improved to 142.98 m^(2)/gPt,2.25 times highe than that of the commercial counterpart(63.52 m^(2)/gPt).Furthermore,our structurally optimized catalys composite features a remarkably catalytic activity with a high half-wave potential(E_(1/2))of 0.895 V and an improved mass activity(MA)of 0.2289 A/mgPt,2.39-fold improvement compared to the commercia *** addition,orthogonal experiments were designed to identify the key process parameter for fabricating Pt/C catalysts,offering insights for scaled-up and industrial production.

关键词： Fuel cells Oxygenreductionreaction Structural engineering Microwave method Ultrafine nanoparticles

Drug interaction presenting as acute abdomen

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第1期1卷 40-42页

作者： Rajesh Pendlimari Rajeswari Anaparthy Aravind sugumar Division of Colon & Rectal Surgery Mayo Clinic Division of Internal Medicine Mayo Clinic Division of Gastroenterology & Hepatology Division of Gastroenterology & Hepatology Mayo Clinic

Warfarin is the most common oral anticoagulant prescribed around the world. Adverse drug interactions with warfarin are a huge problem especially in the elderly and in patients who take multiple medications. Most adverse drug interactions involve concomitantly prescribed oral or intravenous medications. Occasionally, topical or mucosally absorbed drugs can interact, leading to fluctuations in warfarin levels with adverse consequences. In this case report, we describe a case of intestinal intramural hematoma, a rare but known consequence of a supra therapeutic international normalized ratio (INR). The supra therapeutic INR was a consequence of mucosally absorbed miconazole, prescribed for vaginal candidiasis. We wish to highlight this rare and potentially fatal drug interaction, along with the need for frequent INR monitoring when new drugs are added or removed in patients taking warfarin.

关键词： Warfarin Intramural hematoma Miconazole Drug interactions International normalized ratio Supra therapeutic

Implant Electrical Characteristics Predict Response to Cardiac Resynchronization Therapy

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World Journal of Cardiovascular Diseases 2014年第10期4卷 513-521页

作者： Tina Lin Paula Crosby Hariharan sugumar Ryan Spencer Michael Darragh Flannery David O’Donnell Department of Electrophysiology Austin Health Heidelberg Australia Heart Care Victoria Heidelberg Australia

Background: The optimal site for left ventricular (LV) lead placement in cardiac resynchronization therapy (CRT) remains uncertain. Intra-procedural measures for predicting response to CRT have shown mixed results. Hypothesis: This study analyzed intracardiac electrogram (IEGM) characteristics at implant and assessed patients’ response rates (RR) to CRT. Methods: Forty-one consecutive patients undergoing CRT were enrolled. Medically optimized patients in sinus rhythm, with ejection fraction (EF) 34 were included. Right ventricular (RV) leads were positioned mid-septum. LV leads were targeted to the latest mechanical activation on echocardiography. IEGMs were measured, assessing intrinsic RV-to-LV delay (int RV-LV), RV-paced delay (RVp-LV), and LV-paced delay (LVp-RV). The difference between LVp-RV and RVp-LV was recorded as delta-LV. Response was defined as improvement of EF > 10%, reduction in LVEDD > 15% and improvement of ≥1 NYHA class. Results: Overall RR was 79%. LV leads were placed in the target location in 91%. Int RV-LV was 101 ± 14 ms in responders;78 ± 11 ms in non-responders (p 100 had a RR of 87%;int RV-LV 40 ms had a RR of 56%;delta-LV < 40 ms had a RR of 85%. There was no significant correlation between lead position, DI, QRS duration or EF and IEGM measurements. Conclusions: IEGM measures at implant are easily obtained. Significant intrinsic electrical delay and shorter delta-LV both predict response, even when LV leads are implanted in the targeted mechanically-delayed segment. These assessments of electrical dyssynchrony may be used to determine optimal lead positions and response to CRT.

关键词： Cardiac Resynchronization Therapy Biventricular Pacing Intracardiac Electrograms Pacemaker Lead Position Echocardiography Heart Failure

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提高家禽饲料的脂肪消化率

国外畜牧学（猪与禽） 2014年第2期34卷 21-23页

作者：纪少丽陈琳 C.sugumar 建明农副食品亚洲有限公司

植物油和动物脂肪通常会被添加到家禽饲料中，以提高日粮的能量浓度。脂肪除了作为能量来源使用外，其他营养应用还包括：提供必需脂肪酸和作为脂溶性维生素的溶剂；

关键词：脂肪消化率家禽饲料脂溶性维生素必需脂肪酸动物脂肪能量浓度能量来源植物油

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自身免疫性胰腺炎

中华消化外科杂志 2011年第5期10卷 325-328页

作者： sugumar Aravind Chari Suresh T 王槐志（译）美国梅奥医学院胃肠病学和肝病学科明尼苏达PA55905 第三军医大学西南医院全军肝胆外科研究所、中国人民解放军西南肝胆外科医院

自身免疫性胰腺炎（autoimmune pancreatitis，AIP）是一种少见而特殊的慢性胰腺炎。尽管Sarles领导的法国科学团队于1961年发表了第1篇关于自身免疫对胰腺影响的报道，但直到1995年AIP这个概念才为人所知。2001年，Hamano等里程碑式地... 详细信息

自身免疫性胰腺炎（autoimmune pancreatitis，AIP）是一种少见而特殊的慢性胰腺炎。尽管Sarles领导的法国科学团队于1961年发表了第1篇关于自身免疫对胰腺影响的报道，但直到1995年AIP这个概念才为人所知。2001年，Hamano等里程碑式地阐述了AIP与免疫球蛋白（immunoglobulin，Ig）G4抗体的关系，

关键词：自身免疫性胰腺炎慢性胰腺炎免疫球蛋白 AIP