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Moco biosyn.hesis an. the ATAC acetyltran.ferase en.age tran.lation.in.tiation.by in.ibitin. laten. PKR activity

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分子细胞生物学报:英文版 2016年第1期8卷 44-50页

作者： Tamaki suganuma Selen. KSwan.on.Lauren.e Floren. Michael PWashburn.Jerry LWorkman Stowers In.titute for Medical Research 1000 East 50th StreetKansas CityMO 64110USA Departmen. of Pathology an. Laboratory Medicin. The University of Kansas Medical Center3901 Rainbow BoulevardKansas CityKS 66160USA

Molybden.m cofactor(Moco)biosyn.hesis is lin.ed to c-Jun.n.termin.l kin.se(Jn.)sign.lin. in.Drosophila through MoaE,a molybdopterin.MPT)syn.hase subun.t that is also acompon.n. of theAdaTwoAcon.ain.n.(ATAC)***,weshow thathuman.PTsyn.hase an. ATAC in.ibited PKR,a double-stran.ed Rn.-depen.en. protein.kin.se,to facilitate tran.lation.in.tiation.of iron.respon.ive *** syn.hase an. ATAC directly in.eracted with PKR an. suppressed laten. autophosphorylation.of PKR an. its down.tream phosphorylation.of Jn. an. eukaryotic in.tiation.factor 2a(eIF2a).The suppression.of eIF2a phosphorylation.via MPT syn.hase an. ATAC preven.ed sequestration.of the guan.n. n.cleotide exchan.e factor eIF2B,which recycles eIF2-GDP to eIF2-GTP,resultin. in.the promotion.of tran.lation.***,tran.lation.of the iron.storage protein.ferritin.was reduced in.the absen.e of MPT syn.hase or ATAC ***,MPT syn.hase an. ATAC regulate laten. PKR sign.lin. an. lin. tran.cription.an. tran.lation.in.tiation.

关键词： ATAC Moco biosyn.hesis MPT syn.hase PKR

The Surface Coatin. of Commercial LiFePO_4 by Utilizin. ZIF-8 for High Electrochemical Performan.e Lithium Ion.Battery

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n.n.-Micro Letters 2018年第1期10卷 3-11页

作者： XiaoLon. Xu Con.Yu Qi Zhen.on. Hao Hao Wan. Jin.in. Jiu Jin.Bin. Liu Hui Yan.Katsuaki suganuma The College of Materials Scien.e an. En.in.erin. Beijing University of Technology The In.titute of Scien.ific an. In.ustrial Research Osaka University

The requiremen. of en.rgy-storage equipmen. n.eds to develop the lithium ion.battery(LIB) with high electrochemical performan.e. The surface modification.of commercial LiFePO_4(LFP) by utilizin. zeolitic imidazolate frameworks-8(ZIF-8) offers n.w possibilities for commercial LFP with high electrochemical *** this work, the carbon.zed ZIF-8(C_(ZIF-8)) was coated on.the surface of LFP particles by the in.situ growth an. carbon.zation.of ZIF-8. Tran.mission.electron.microscopy in.icates that there is an.approximate 10 n. coatin. layer with metal zin. an. graphite-like carbon.on.the surface of LFP/C_(ZIF-8) sample. The n.2 adsorption.an. desorption.sotherm suggests that the coatin. layer has un.form an. simple con.ectin. mesopores. As cathode material, LFP/C_(ZIF-8) cathode-active material delivers a discharge specific capacity of 159.3 m Ah g^(-1) at 0.1 C an. a discharge specific en.rgy of 141.7 m Wh g^(-1) after 200 cycles at 5.0 C(the reten.ion.rate is approximate 99%). These results are attributed to the syn.rgy improvemen. of the con.uctivity,the lithium ion.diffusion.coefficien., an. the degree of freedom for volume chan.e of LFP/C_(ZIF-8) cathode. This work will con.ribute to the improvemen. of the cathode materials of commercial LIB.

关键词： LiFePO4 Zeolitic imidazolate frameworks-8 Surface coatin. Cathode Lithium ion.battery

A FRAMEWORK OF FUZZY LAn.SCAOE THEORY WITH An.APPLICATIOn.TO ALLIAn.E An.LYSIS

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Journ.l of Systems Scien.e & Complexity 2003年第1期16卷 1-12页

作者： S. suganuma V. n. Huyn. Y. n.kamori S. Y.Wan. Academy of Mathematics an. Systems Scien.es Chin.se Academy of Scien.es Beijin. 100080 Chin.) K. K. Lai Japan.Advan.ed In.titute of Scien.e an. Techn.logy Department of Computer Science University of Quinhon 170 - An Duong VuongJapan Advanced Institute of Science and Technology 1-1 Asahidai TatsunokuchiDepartment of Management Sciences City University of Hong Kong 1 - 1 Asahidai Tatsunokuchi Ishikawa 923-1292 Japan Academy of Mathematics an. Systems Scien.es Chinese Academy of SciencesBeijing 100080 ChinaQuinhon VietnamIshikawa 923-1292JapanKowloon Hong Kong

In.this paper, we provide a framework of fuzzy lan.scape theory an. discuss an.application.to allian.e an.lysis. The fuzzy lan.scape theory may allow us to an.lyses a variety of aggregation.processes in.political, econ.mic, an. social problems in.a more flexible man.er. The simulation.results for the problems of the in.ern.tion.l align.en. of the Secon. World War in.Europe an. the coalition.formation.in.stan.ard-settin. allian.es in.the case of the Un.X operatin. system are compared with those given.by the origin.l theory.

关键词： Fuzzy lan.scape theory allian.e partition gen.tic algorithm.

Facile fabrication.of stretchable Ag n.n.wire/polyurethan. electrodes usin. high in.en.ity pulsed light

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n.n. Research 2016年第2期9卷 401-414页

作者： Yan. Yan.1 Su Din. Teppei Araki Jin.in. Jiu Tohru Sugahara Jun.Wan. Jan.Van.leteren.Tsuyoshi Sekitan. Katsuaki suganuma Cen.er for Microsystems Techn.logy IMEC and Ghent University 9052 Gent-Zwijnaarde Belgium The In.titute of Scien.ific an. In.ustrial Research Osaka University Ibaraki Osaka 567-0047 Japan State Key Laboratory of Advan.ed Weldin. an. Join.n. Harbin Institute of Technology Harbin 150001 China

Silver n.n.wires （Agn.s） have emerged as a promisin. n.n.material for n.xt gen.ration.stretchable electron.cs. However, un.il n.w, the fabrication.of Agn.- based compon.n.s has been.hampered by complex an. time-con.umin. steps. Here, we in.roduce a facile, fast, an. on.-step methodology for the fabrication.of highly con.uctive an. stretchable Agn./polyurethan. （PU） composite electrodes based on.a high-in.en.ity pulsed light （HIPL） techn.que. HIPL simultan.ously improved wire-wire jun.tion.con.uctivity an. wire-substrate adhesion.at room temperature an. in.air within.50 μs, omittin. the complex tran.fer-curin.-implan.in. process. Owin. to the localized deformation.of PU at in.erfaces with Agn.s, embeddin. of the n.n.wires was rapidly carried out without substan.ial substrate damage. The resultin. electrode retain.d a low sheet resistan.e （high electrical con.uctivity） of 〈10 Ω/sq even.un.er 100% strain. or after 1,000 con.in.ous stretchin.-relaxation.cycles, with a peak strain.of 60%. The fabricated electrode has foun. immediate application.as a sen.or for motion.detection. Furthermore, based on.our electrode, a light emittin. diode （LED） driven.by in.egrated stretchable Agn. con.uctors has been.fabricated. In.con.lusion. our presen. fabrication.approach is fast, simple, scalable, an. cost- efficien., makin. it a good can.idate for a future roll-to-roll process.

关键词： silver n.n.wires stretchable electrode photon.c sin.erin. n.n.fabrication

Sulforaphan.-rich broccoli sprout extract improves hepatic abn.rmalities in.male subjects

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World Journ.l of Gastroen.erology 2015年第43期21卷 12457-12467页

作者： Masahiro Kikuchi Yusuke Ushida Hirokazu Shiozawa Rumiko Umeda Kota Tsuruya Yudai Aoki Hiroyuki suganuma Yasuhiro n.shizaki Digestive an. Liver Disease Cen.er Tokai University Tokyo Hospital Research an. Developmen. Division Kagome Co.Ltd. Departmen. of Clin.cal Health Scien.e Tokai University Tokyo Hospital

AIM: To evaluate effects of dietary supplemen.ation.of sulforaphan.(SF)-rich broccoli sprout(BS) extract on.hepatic abn.rmalities in.Japan.se male ***: In.a ran.omized,placebo-con.rolled,double blin. trial,male participan.s with fatty liver received either BS capsules con.ain.n. glucoraphan.n.[GR; a precursor of SF(n.= 24)] or placebo(n.= 28) for 2 mo. Liver fun.tion.markers,serum levels of aspartate an. alan.n. amin.tran.ferases(AST an. ALT,respectively) an. γ-glutamyl tran.peptidase(γ-GTP) an. an.oxidative stress marker,urin.ry levels of 8-hydroxydeoxyguan.sin.(8-OHd G),were measured an. compared in.participan.s before an. after the trial period. In.an.an.mal model,chron.c liver failure was in.uced in.Sprague-Dawley rats by successive in.raperiton.al in.ection.with n.n.trosodimethylamin.(n.MA) for 4 wk. Con.omitan.ly,rats received AIn.76 diets supplemen.ed with or without BS extract. Thereafter,rats were sacrificed,an. their sera an. livers were collected to measure serum liver fun.tion.markers an. hepatic levels of thiobarbituric acid reactive substan.es(TBARS) levels an. hepatic glutathion. S-tran.ferase(GST) activity,a prototypical phase 2 an.ioxidan. ***: Dietary supplemen.ation.with BS extract con.ain.n. SF precursor GR for 2 mo sign.fican.ly decreased serum levels of liver fun.tion.markers,ALT [median.in.erquartile ran.e),before: 54.0(34.5-79.0) vs after supplemen.ation. 48.5(33.3-65.3) IU/L,P n. γ-GTP [before: 51.5(40.8-91.3) vs after: 50.0(37.8-85.3) IU/L,P n. sign.fican. effects on.the markers. The urin.ry level of 8-OHd G,an.established oxidative stress marker,was sign.fican.ly reduced in.participan.s who had received BS capsules but n.t the placebo [before: 6.66(5.51-9.03) vs after: 5.49(4.89-6.66) n./mg-creatin.n.,P n.of urin.ry 8-OHd G was sign.fican.ly correlated with decreased levels of both ALT an. γ-GTP [?8-OHd G an. ?ALT: S

关键词： Sulforaphan. Glucoraphan.n Broccoli sprout n.f2 He

Broccoli sprout extract in.uces detoxification.related gen. expression.an. atten.ates acute liver in.ury

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World Journ.l of Gastroen.erology 2015年第35期21卷 10091-10103页

作者： Kazutaka Yoshida Yusuke Ushida Tomoko Ishijima Hiroyuki suganuma Takahiro In.kuma n.buhiro Yajima Keiko Abe Yuji n.kai Research an. Developmen. Division Kagome Co.Ltd. Departmen. of Applied Biological Chemistry Graduate School of Agricultural and Life ScienceThe University of Tokyo Faculty of Con.emporary Human.Life Scien.e Department of Food and NutritionTezukayama University In.titute for Food Scien.e Hirosaki University

AIM: To in.estigate the effects of broccoli sprout extract(BSEx) on.liver gen. expression.an. acute liver in.ury in.the ***: First, the effects of BSEx on.liver gen. expression.were examin.d. Male rats were divided in.o two groups. The Con.rol group was fed the AIn.76 diet, an. the BSEx group was fed the AIn.76 diet con.ain.n. BSEx. After a 10-d feedin. period, rats were sacrificed an. their livers were used for Dn. microarray an. realtime reverse tran.cription.polymerase chain.reaction.RT-PCR) an.lyses. n.xt, the effects of BSEx on.acute liver in.ury were examin.d. In.experimen.s usin. acute liver in.ury models, 1000 mg/kg acetamin.phen.APAP) or 350 mg/kg D-galactosamin.(D-Gal n. was used to in.uce in.ury. These male rats were divided in.o four groups: Con.rol, BSEx, In.ucer(APAP or D-Gal n., an. In.ucer+BSEx. The feedin. regimen. were iden.ical for the two an.lyses. Twen.y-four hours followin. APAP admin.stration.via p.o. or D-Gal n.admin.stration.via i.p., rats were sacrificed to determin. serum aspartate tran.amin.se(AST) an. alan.n. tran.amin.se(ALT) levels, hepatic glutathion.(GSH) an. thiobarbituric acid-reactive substan.es accumulation.an. glutathion.S-tran.ferase(GST) activity. RESULTS: Microarray an. real-time RT-PCR an.lyses revealed that BSEx upregulated the expression.of gen.s related to detoxification.an. glutathion. syn.hesis in.n.rmal rat liver. The levels of AST(70.91 ± 15.74 IU/m L vs 5614.41 ± 1997.83 IU/m L, P n. ALT(11.78 ± 2.08 IU/m L vs 1297.71 ± 447.33 IU/m L, P n.fican.ly suppressed in.the APAP + BSEx group compared with the APAP group. The level of GSH(2.61 ± 0.75 n.ol/g tissue vs 1.66 ± 0.59 n.ol/g tissue, P n. liver GST activity(93.19 ± 16.55 U/g tissue vs 51.90 ± 16.85 U/g tissue, P n.fican.ly in.reased in.the APAP + BSEx group compared with the APAP group. AST(4820.05 ± 3094.93 IU/m L vs 12465.63 ± 3223.97 IU/m L, P n. ALT(1808.95 ± 1014.04 IU/m L vs 3936.46 ± 777.52 IU/

关键词： Broccoli sprout Galactosamin. Acute liver in.ury G