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Tolerance protocol of living kidney transplant for developing countries through basic strategy of lymphocyte depletion

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World Journal of Transplantation 2022年第6期12卷 112-119页

作者： sufi m suhail Department of Renal medicine Singapore General HospitalSingapore 169856Singapore Department of Clinical Research Duke-NUS Graduate Medical SchoolSingapore 169856Singapore

End-stage kidney failure(ESKD)is a global issue where kidney replacement therapy imposes enormous economic burden to people of developing countries,in addition to the severe limitations to the availability of hemodialysis and peritoneal dialysis *** best option of kidney transplantation also requires lifelong combination immunosuppressive medicines,the cost of which is equally comparable to lifelong dialysis.A strategy of achieving transplant tolerance that requires minimum immunosuppressive medicines,although in experimental stage,also requires state-of-art technology with costly medicines and *** is evidently beyond the reach of ESKD patients of developing ***,globally in developing countries,a need for an innovative but cost-effective tolerance protocol is a burning need for a successful transplant *** brief,transplant tolerance is defined as a state of donorspecific unresponsiveness to the allograft antigens without the need for ongoing pharmacologic immunosuppression or with a minimal *** state-of-art techniques involves:(1)A state of hematological chimera,for complete tolerance;(2)Prope or partial tolerance where immune-reactive T-lymphocytes are inhibited using monoclonal antibodies;and(3)Chimeric antigen receptor for T-regulatory(T-reg)cell therapy using genetically engineered T-reg cells targeting specific Tlymphocyte receptors for inducing *** our real-world experience in transplant management in post-transplant lympho-proliferative disorders(PTLD),we noticed frequently a drastic reduction in the need of immunosuppressive medicines following lympho-ablative therapy for *** recently published a case study on a real-world experience transplant case where we explained a partial or prope tolerance that developed after lymphocyte ablation therapy,following which the allograft was maintained with low dose dual standard immunosuppressive *** on this publication,we propose here an innovat

关键词： Renal allograft B and T lymphocytes depletion Tolerance protocol Immunosuppressive medicines Living renal transplant

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Revealing high-dimensional dynamical symmetry in alignment magnetic resonance

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Science China(Physics,mechanics & Astronomy) 2024年

作者： m.suhail Zubairy Institute for Quantum Science and Engineering (IQSE) and Department of Physics and Astronomy Texas A&M University

Symmetry permeates throughout science, underlying people's understanding on intriguing physical properties. These include conserved quantities, critical phenomena and selection rules. Dynamical symmetry, the counterpart of geometrical symmetry or static symmetry referring to the geometrical shape or structure of a physical system, is present in the motion behavior.

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Nitrosamines crisis in pharmaceuticals Insights on toxicological implications, root causes and risk assessment: A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth P.R.Vikram Tegginamath Pramod Kumar Gunjan Kumar Narasimha m.Beeraka Rajashree Deka Sheik mohammed suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod Kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity mutagenicity molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

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Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

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Journal of Pharmaceutical Analysis 2024年第6期14卷 934-936页

Original statement in the Section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning

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A novel hybrid cybersecurity scheme against false data injection attacks in automated power systems

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Protection and Control of modern Power Systems 2023年第3期8卷 1-15页

作者： Shahbaz Hussain S.m.suhail Hussain marziyeh Hemmati Atif Iqbal Rashid Alammari Stefano Zanero Enrico Ragaini Giambattista Gruosso Department of Electrical Engineering Qatar UniversityDohaQatar Dipartimento di Elettronica Informazione e BioingegneriaPolitecnico di MilanoMilanItaly Department of Electrical Engineering King Fahd University of Petroleum and Minerals(KFUPM)DhahranSaudi Arabia Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum and Minerals(KFUPM)DhahranSaudi Arabia

The conventional power systems are evolving as smart *** recent times cyberattacks on smart grids have been *** different attacks,False Data Injection(FDI)is considered as an emerging threat that has significant *** exploiting the vulnerabilities of IEC 61850 Generic Object-Oriented Substation Events(GOOSE)and Sam-pled Values(SV)attackers can launch different FDI *** this paper,a real-time set up capable of simulating FDI on GOOSE and SV protocols is developed to evaluate the impact of such attacks on power *** 62351 stipulates cybersecurity guidelines for GOOSE and SV,but only at communication or Information Technology(IT)*** there is a need to develop a holistic security both at IT and Operation Technology(OT)*** this regard,a novel sequence content resolver-based hybrid security scheme suitable to tackle FDI attacks on GOOSE and SV is ***,the computational performance of the proposed hybrid security scheme is presented to demonstrate its applicability to the time critical GOOSE and SV protocols.

关键词： Cyberattacks False data injection Real time digital simulation IEC 61850 Communication protocols Control authority Countermeasures

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Deep Reinforcement Learning Based Unmanned Aerial Vehicle (UAV) Control Using 3D Hand Gestures

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Computers, materials & Continua 2022年第9期72卷 5741-5759页

作者： Fawad Salam Khan mohd Norzali Haji mohd Saiful Azrin B.m.Zulkifli Ghulam E mustafa Abro suhail Kazi Dur muhammad Soomro Faculty of Electrical and Electronics(FKEE) Universiti Tun Hussein Onn MalaysiaParit Raja81756Malaysia Department of Electrical&Electronic Engineering Universiti Teknologi PETRONASSeri Iskandar32610Malaysia Faculty of Engineering Science and Technology Isra UniversityHyderabad71000Pakistan Department of Innovation CONVSYS(Pvt)Ltd.44000IslamabadPakistan

The evident change in the design of the autopilot system produced massive help for the aviation industry and it required frequent *** learning delivers appropriate outcomes when considering a continuous environment where the controlling Unmanned Aerial Vehicle(UAV)required maximum *** this paper,we designed a hybrid framework,which is based on Reinforcement Learning and Deep Learning where the traditional electronic flight controller is replaced by using 3D hand *** algorithm is designed to take the input from 3D hand gestures and integrate with the Deep Deterministic Policy Gradient(DDPG)to receive the best reward and take actions according to 3D hand gestures *** UAV consist of a Jetson Nano embedded testbed,Global Positioning System(GPS)sensor module,and Intel depth *** collision avoidance system based on the polar mask segmentation technique detects the obstacles and decides the best path according to the designed reward *** analysis of the results has been observed providing best accuracy and computational time using novel design framework when compared with traditional Proportional Integral Derivatives(PID)flight *** are six reward functions estimated for 2500,5000,7500,and 10000 episodes of training,which have been normalized between 0 to−*** best observation has been captured on 2500 episodes where the rewards are calculated for maximum *** achieved training accuracy of polar mask segmentation for collision avoidance is 86.36%.

关键词： Deep reinforcement learning UAV 3D hand gestures obstacle detection polar mask

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An Improved Security Scheme for IEC 61850mmS messages in Intelligent Substation Communication Networks

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Journal of modern Power Systems and Clean Energy 2020年第3期8卷 591-595页

作者： Taha Selim Ustun S.m.suhail Hussain Fukushima Renewable Energy Institute AIST(FREA)FukushimaJapan Research Institute of the Energy Frontier TsukubaJapan

Advanced connectivity in substations brings along cybersecurity considerations. Especially, the use of standardized data objects and message structures stipulated by IEC 61850 makes them much more vulnerable to unauthorized access and manipulation. In order to tackle these vulnerabilities, different methods are investigated by researchers all over the world. An important aspect of such efforts is the real-time performance consideration since power systems are bound by the rules of physics and all control/communication tasks need to be completed in a certain time frame. Security schemes for substation communication have been proposed in the recent literature. However, they must be improved to ensure a full security solution. Recently published IEC 62351 standard aims to fill this gap. Node authentication is vital for substation communication networks based on IEC 61850 to mitigate a variety of attacks such as man-in-the-middle(mITm) attack. This short communication presents a node authentication mechanism based on transport layer security(TLS) with certificates to address this knowledge gap. It also investigates the real-time performance by implementing the proposed scheme with Python.

关键词： IEC 62351 standard certificate authority cer-tificate-based authentication cybersecurity smart grid

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Biochemical association between the prevalence of genetic polymorphism and myocardial infarction

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BIOCELL 2023年第3期47卷 473-484页

作者： mOmINA SHAHID KANWAL REHmAN mUHAmmAD SAJID HAmID AKASH SHALEEm suhail SUmBAL RASHEED mUHAmmAD ImRAN mOHAmmED AASSIRI Department of Pharmaceutical Chemistry Government College UniversityFaisalabad38000Pakistan Department of Pharmacy The Women UniversityMultan60000Pakistan Research Center for Advanced materials Science(RCAmS) King Khalid UniversityAbha62413Saudi Arabia Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha62413Saudi Arabia

Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction(mI).Single nucleotide polymorphism at any one of the amino acid sequences can result in a diseased state.A single gene can exhibit genetic polymorphism at more than one position giving rise to different *** polymorphism of angiotensinogen(AGT)m235T,AGT T174m,and angiotensin-1-converting enzyme(ACE)I/D,endothelial nitric oxide synthase(eNOS),and methylenetetrahydrofolate reductase(mTHFR)can be a risk factor for ***,it is important to study the prevalence of genetic polymorphisms of these genes among different *** is influenced by genetic polymorphism of various genes,including AGT,ACE,eNOS,mTHFR,***,the association of genetic polymorphism of these genes varies among different populations,but different ethnic groups could show contradictory *** genes have shown a positive association with risks of mI in some populations,whereas the results have not been consistent with every ethnic *** this article,we have summarized the genetic variations in the aforementioned genes and their association with mI.

关键词： Endothelial nitric oxide synthase methylenetetrahydrofolate reductase AGT m235T AGT T174m

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In-situ copolymerization of aniline with alkyl amine by APS:Kinetics and application

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Chinese Chemical Letters 2008年第11期19卷 1358-1362页

作者： m.Rashid Shams Qamar Usmani suhail Sabir Polymer Research Laboratory Department of ChemistryAligarh Muslim UniversityAligarh 202002India

The kinetic study of in-situ eopolymerization of aniline with o- and p-methylaniline by ammonium persulfate （APS） has been carried out. UV-vis spectroscopic method was used to investigate the course of copolymerization. Structural characterization was studied by PT-IR spectral analysis. The electronic spectra of the copolymers poly（aniline-co-p-toluidine） and poly（aniline-co-o- toluidine） show blue shift. The shift has been observed in the bands corresponding to π→π^＊ transition as well as in the exciton transition. The increase in absorbance recorded during the reaction for different concentration of aniline, o- and p-toluidine at various intervals of time of polymerization reaction indicates a growth in the polymer formation. The resulting first-order rate constant was used to calculate the rate of copolymer formation using the rate equation -d[A]/dt = kc^n.

关键词： Copolymerization Corrosion inhibition Electronic and vibrational spectra

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Stock market Trading Based on market Sentiments and Reinforcement Learning

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Computers, materials & Continua 2022年第1期70卷 935-950页

作者： K.m.Ameen suhail Syam Sankar Ashok S.Kumar Tsafack Nestor Naglaa F.Soliman Abeer D.Algarni Walid El-Shafai Fathi E.Abd El-Samie Department of Computer Science&Engineering NSS College of EngineeringPalakkad678008KeralaIndia Department of Electronics and Communication Engineering NSS College of EngineeringPalakkad678008KeralaIndia Unitéde Recherche de matière Condensée D’Electronique et de Traitement du Signal(URAMACETS)Department of PhysicsUniversity of DschangP.O.Box 67DschangCameroon Department of Information Technology College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh84428Saudi Arabia Department Electronics and Electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

Stock market is a place,where shares of different companies are *** is a collection of buyers’and sellers’*** this digital era,analysis and prediction in the stock market have gained an essential role in shaping today’s *** market analysis can be either fundamental or *** analysis can be performed either with technical indicators or through machine learning *** this paper,we report a system that uses a Reinforcement Learning(RL)network and market sentiments to make decisions about stock market *** system uses sentiment analysis on daily market news to spot trends in stock *** sentiment analysis module generates a unified score as a measure of the daily news about *** score is then fed into the RL module as one of its *** RL section gives decisions in the form of three actions:buy,sell,or *** objective is to maximize long-term future *** have used stock data of Apple from 2006 to 2016 to interpret how sentiments affect *** stock price of any company rises,when significant positive news become available in the public *** results reveal the influence of market sentiments on forecasting of stock prices.

关键词： Deep learning machine learning daily market news reinforcement learning stock market

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