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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way yin Ng Grace Lui Lowell Ling Agnes S.Y.leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan yi Chan Albert Martin Li David Shu Cheong Hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui yi Ho Feijun Hu Yujeong Kim Hill Lam Lau ying Lo Law Chi Seng leung Chun yin Tong Kai Kap Wong Wing Lam yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Recent Trends in Sedentary Behaviors among Chinese Children According to Demographic and Social Characteristics

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Biomedical and Environmental Sciences 2021年第8期34卷 593-605页

作者： YANG Xi leung Wai yi CHEN Yuan Sheng OUYANG yi Fei ZHAO Wen Hua Chinese Center for Disease Control and Prevention Beijing 102206China National Institution for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Chinese University of Hong Kong Hong Kong 999077China

Objective This study aims to explore trends in sedentary behavior among Chinese children aged 6–17 years per demographic and social *** A total of 4,341 children aged 6–17 years who participated in the China Health and Nutrition Survey from 2004 to 2015 were *** measures from mixed-effects models were applied to test trends in sedentary behaviors,which were further analyzed after applying stratification according to gender,age,urbanization level,residential area,and ***-effects ordinal regression models were used to examine the trends at sedentary *** From 2004 to 2015,sedentary time among children aged 6–17 years increased from 23.9±0.6 h/week to 25.7±0.6 h/week(P<0.001).Increases of 3.1 h/week(P<0.001),2.3 h/week(P=0.012),and 1.3 h/week(P=0.042)were found among the low-,medium-,and high-urbanization groups respectively and increased by 2.0 h/week(P<0.001)and 1.3 h/week(P=0.002)among rural and urban children,*** proportion of Chinese children with average daily screen time below 2 hours declined by 10.2%(OR=0.51,95%CI:0.42–0.63,P<0.001);a decreasing trend was observed in both boys and *** Sedentary time among Chinese children aged 6–17 years showed an upward trend from 2004 to 2015,especially among children residing in rural areas and regions with low urbanization levels.

关键词： Sedentary behaviors Child China Trends

Recent Trends in Physical Activity among Chinese Children Based on Their Demographic and Social Characteristics

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Biomedical and Environmental Sciences 2021年第5期34卷 404-409页

作者： YANG Xiu leung Alice Waiyi ZHAI yi ZHAO Wen Hua Chinese Center for Disease Control and Prevention Beijing 102206China National Institution for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Chinese University of Hong Kong Hong Kong 999077China Beijing Tian Tan Hospital Capital Medical UniversityBeijing 100070China

Aimed to explore the trends in physical activity among Chinese children,data of 4,341 children aged6-17 years who participated in at least one round of"China Health and Nutrition Survey"from 2004 to2015 were *** measures mixed models were applied to test the trends in physical activity,which were further analyzed after applying stratification on gender,age,urbanization level,residential area and region.

关键词： ed. applying children

Investigation on the Consumption Values of Hong Kong People on Tie Products

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Journal of Donghua University(English Edition) 2004年第2期21卷 52-59页

作者： Sarah Mei-yi leung Alice Wai-ching Chu Kit-lun yick Institute of Textiles & Clothing The Hong Kong Polytechnic University Hung Hom Kowloon Hong KongDrInstitute of Textiles & Clothing The Hong Kong Polytechnic University Hung Hom Kowloon Hong KongInstitute of Textiles & Clothing The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong

This study aims at investigating the consumption values of Hong Kong people on necktie. Based on the Sheth-Newman-Gross Model of consumption values on consumers’ choice decision as conceptual framework, results from the focus group interview, a questionnaire was designed and adopted for conducting the survey. Data collected from 245 respondents were analysed using the Factor Analysis to review the important elements of consumers’ decision of purchasing tie products. Implications on the results on the Functional value were reviewed and discussed in details. Interesting elements such as fabric hand-feel were also identified as influential associated in Hong Kong consumers’ selection of necktie. Since, both fibre content and fabric handle were also found as major selection criteria for fabric materials, the study was focused on the analysis of functional value of the product and further extended to study the handle preference for Hong Kong customers, in which a subjective handle assessment of a wide range of tie fabrics being newly developed and introduced in the market was conducted and objective fabric physical and mechanical properties were measured. Important fabric handle attributes that influence the consumers’ preference on tie fabrics were identified and their objective translation by fabric physical and mechanical properties were also obtained. The investigation provides decision support to necktie manufacturers and retailers through scientific and quantitative recommendations for product development of tie products and material selection.

关键词： Necktie Hand-feel Consumption Values and Consumer Behaviour

Expert insights on Malaysia’s residential solar-energy policies:shortcomings and recommendations

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Clean Energy 2022年第4期6卷 619-631页

作者： Lin-Sea Lau Yuen-Onn Choong suet-Ling Ching Chooi-yi Wei Abdelhak Senadjki Chee-Keong Choong Ai-Na Seow Faculty of Business and Finance Universiti Tunku Abdul RahmanMalaysia

Malaysia has a long way before achieving the 20%renewable-energy penetration by ***,merely 2%of the country’s electricity is generated by renewable energy sources including solar *** the abundant literature about solar energy,qualitative studies that focus on experts’opinions on the weaknesses of residential solar-energy policies have received less attention,particularly in the context of *** the flaws in the existing policies would lead to creating a better policy framework for solar-energy ***,this study aims to identify the shortcomings of the current government initiatives and policies that deter solar photovoltaic adoption among households from experts’*** also provide recommendations for better future policy design and *** study employs a qualitative research approach(via semi-structured interviews)in collecting experts’*** concerns emerging from the interviews include insufficient financial support,lack of awareness programmes and subsidized electricity ***,interviewed experts suggest sufficient financial incentives,increased public awareness programmes and comprehensive legislation aimed at safeguarding consumer interests as a means to raising solar-energy adoption in the *** underlines the need for policymakers to create public awareness,provide financial support and develop regulatory measures aimed at managing solar companies for the sake of solar development in Malaysia.

关键词： qualitative study interview expert insights solar energy households policy shortcomings policy recommendations

UV light-induced oxygen doping in graphitic carbon nitride with suppressed deep trapping for enhancement in CO_(2) photoreduction activity

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Journal of Materials Science & Technology 2023年第2期133卷 135-144页

作者： Xiaolong Zhao Xiaoping yi Wending Pan yifei Wang Shijing Luo yingguang Zhang Ruijie Xie Dennis Y.C.leung Department of Mechanical Engineering the University of Hong KongPokfulam RoadHong KongChina School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen 518055China

While photoreduction of CO_(2) to CH 4 is an effective means of producing value-added fuels,common pho-tocatalysts have poor activity and low selectivity in photocatalytic CO_(2)-reduction *** though creating defects is an effective photocatalyst fabrication route to improve photocatalytic activity,there are some challenges with the facile photocatalyst synthesis *** this work,an O element is in-troduced into a graphitic carbon nitride(CN)skeleton through a precursory ultraviolet light irradiation pretreatment to increase the visible light absorption and enhance the carrier density of this modified non-metal CN photocatalyst;the charge transfer dynamics thereof are also studied through electrochem-ical tests,photoluminescence spectroscopy,and nanosecond transient *** verify that the op-timized sample exhibits lower charge recombination and a suppressed 84 ns electron-trapping lifetime,compared to the 103 ns electron-trapping lifetime of the CN counterpart,and thereby contributes to ro-bust detrapping and a fast transfer of active *** density functional theory calculations,we find that the improved light absorption and increased electron density are ascribed to O-element doping,which enhances the CO_(2) adsorption energy and improves the CO_(2)-to-CH 4 photoreduction activity;it be-comes 17 times higher than that of the bare CN,and the selectivity is 3.8 times higher than that of ***,the optimized sample demonstrates excellent cyclic stability in a 24-hour cycle test.

关键词： UV light Oxygen doping Charge transfer Graphitic carbon nitride CO_(2)reduction

A new species of the genus Kurixalus(Anura:Rhacophoridae)from Sichuan Province,southwestern China

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Zoological Research 2022年第1期43卷 90-94页

作者： Chun-Peng Guo Mao-Jun Zhong Ka Wah leung Xiao-yi Wang Jun-Hua Hu Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuan 610041China University of Chinese Academy of Sciences Beijing 100049China

Combining morphological and molecular data,we describe a new amphibian species of the genus Kurixalus Ye,Fei,&Dubois,1999 from the Qionglai Mountain within the western margin of the Sichuan Basin in *** qionglaiensis *** be diagnosed based on a combination of the following morphological characters:medium-sized within genus(snout-vent length(SVL)in males 28.9−33.3 mm);tympanum distinct,subequal to half of eye diameter;snout pointed,prominence on tip;iris golden with brown spots;slight nuptial pad on first finger in males;background coloration of dorsal surface brown,lateral body and femoral yellow;white,dark brown edged triangular markings on cheek;chin shaded dark brown;pair of large symmetrical dark patches on chest;belly clouded brown and scattered black spots;toes moderately webbed,formulaⅠ2-2Ⅱ1.5-2.5Ⅲ1.5-2.5Ⅳ2.5-1.5Ⅴ;tibia length slightly shorter than half of SVL,tibiotarsal articulation reaching posterior border of eye;single external vocal sac *** on the 16S rRNA gene,the genetic distance between the new species and its sister taxon ***(Kuramoto&Wang,1987)was 4%.At present,the new species is known only from a single location at an elevation of~600 m in Pingle Town,Qionglai City,Sichuan,southwestern *** location can represent a new northernmost geographical limit of the genus Kurixalus.

关键词： southwestern sized scattered

Synthesis of benzo[b]phosphole-based alkynylgold(I)complexes with resistive memory properties modulated by donor–acceptor chromophores

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SmartMat 2021年第3期2卷 406-418页

作者： Yat-Hin Cheng Eugene Yau-Hin Hong Ming-yi leung Shiu-Lun Lai Vivian Wing-Wah Yam Institute of Molecular Functional Materials and Department of Chemistry The University of Hong KongHong KongChina

A class of benzo[b]phosphole-based alkynylgold(I)complexes has been synthesized and *** complexes share a similar benzo-[b]phosphole ligand,in which the phosphole moiety is substituted with variousπ-conjugated units with different donor strengths,namely phenoxazinylphenyl,tris(di-tert-butylcarbazolyl)phenyl and 2,4-dimethylphenyl *** phosphole-containing gold(I)complexes are found to be strongly luminescent in toluene with tunable emission maxima and possess solvatochromic behaviors,suggesting an emission of metal-perturbed intraligand charge transfer *** voltammetry studies reveal that the presence of gold(I)metal center strongly perturbs the electronic properties of the phosphole moiety of the resultant complexes,which can be further finetuned by the auxiliary ligand on the gold(I)*** the resistive memory studies,devices based on these alkynylgold(I)complexes exhibit satisfactory binary memory behaviors,demonstrating low threshold voltages in narrow distributions,high durability and low misreading *** performances are believed to be originated from a field-induced charge transfer of the alkynylgold(I)complexes,in which the electron-accepting phosphole-gold(I)unit plays a crucial role in stabilizing the charge transfer state and that led to the observed resistive switching and memory behavior.

关键词： alkynylgold(I)complexes benzo[b]phosphole charge transfer donor-acceptor resistive memories