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Journal of Integrative Agriculture 2018年第9期17卷 2024-2030页

作者： Tamaki Masahiko Kobayashi Fumiyuki suehiro keisuke Ohsato Shuichi Sato Michio School of Agriculture Meiji University Faculty of Applied Life Science Nippon Veterinary and Life Science University

We investigated the possibility to reduce the usage of Blasin^Flowable （BF）, a disinfectant inhibiting the germination and appressorium formation of Pyricularia oryzae Cavara conidia, by using carbon dioxide microbubbles （CO2MB）. Germination was significantly inhibited by 10 000-fold diluted BF solution containing CO2MB generated by the decompression-type generator compared to CO2 millibubbles （CO2MMB） and CO2MB generated by the gas-water circulating-type generator. Appressodum formation in the 10 000-fold diluted BF solution containing both CO2MBs was less than that in CO2MMB. Scanning electron microscopy showed wrinkles and dents on the surface of conidia treated with 5 000-fold diluted BF solution containing both CO2MBs. Via transmission electron microscopy, we observed the expansion of the vacuole and the intracellular space and bloated or absent lipid granules in the conidia treated with BF solution containing both CO2MBs. Our results show that inhibition of the conidium germination and appressorium formation of P. oryzae Cavara by 10 000-fold diluted BF solution could be achieved by using the decompression-type CO2MB.

关键词： appressorium formation Blasin^Flowable germination Pyricularia oryzae carbon dioxide microbubble

Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver function

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World Journal of Gastroenterology 2016年第32期22卷 7252-7263页

作者： Taro Takami Takahiro Yamasaki Issei Saeki Toshihiko Matsumoto Yutaka suehiro Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine

Hepatocellular carcinoma(HCC) is one of the deadliest cancers in the world and is associated with a high risk of recurrence. The development of a wide range of new therapies is therefore essential. In this study, from the perspective of supportive therapy for the prevention of HCC recurrence and preservation of liver function in HCC patients, we surveyed a variety of different therapeutic agents. We show that branched chain amino acids(BCAA) supplementation and late evening snack with BCAA, strategies that address issues of protein-energy malnutrition, are important for liver cirrhotic patients with HCC. For chemoprevention of HCC recurrence, we show that viral control after radical treatment is important. We also reviewed the therapeutic potential of antiviral drugs, sorafenib, peretinoin, iron chelators. Sorafenib is a kinase inhibitor and a standard therapy in the treatment of advanced HCC. Peretinoin is a vitamin A-like molecule that targets the retinoid nuclear receptor to induce apoptosis and inhibit tumor growth in HCC cells. Iron chelators, such as deferoxamine and deferasirox, act to prevent cancer cell growth. These chelators may have potential as combination therapies in conjunction with peretinoin. Finally, we review the potential inhibitory effect of bone marrow cells on hepatocarcinogenesis.

关键词： Hepatocellular carcinoma Liver cirrhosis Branched-chain amino acids Late evening snack Iron chelators Bone marrow cells

Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy

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World Journal of Gastroenterology 2019年第4期25卷 457-467页

作者： Hideaki Harada Satoshi suehiro Daisuke Murakami Ryotaro Nakahara Takuya Nagasaka Tetsuro Ujihara Ryota Sagami Yasushi Katsuyama Kenji Hayasaka Yuji Amano Department of Gastroenterology New Tokyo Hospital Department of Endoscopy New Tokyo Hospital

BACKGROUND Endoscopic submucosal dissection(ESD) for gastric neoplasms during continuous low-dose aspirin(LDA) administration is generally acceptable according to recent guidelines. This retrospective study aimed to investigate the effect of continuous LDA on the postoperative bleeding after gastric ESD in patients receiving dual antiplatelet therapy(DAPT).AIM To investigate the feasibility of gastric ESD with continuous LDA in patients with *** A total of 597 patients with gastric neoplasms treated with ESD between January2010 and June 2017 were enrolled. The patients were categorized according to type of antiplatelet therapy(APT).RESULTS The postoperative bleeding rate was 6.9%(41/597) in all patients. Patients were divided into the following two groups: no APT(n = 443) and APT(n = 154). APT included single-LDA(n = 95) and DAPT(LDA plus clopidogrel, n = 59)subgroups. In the single-LDA and DAPT subgroups, 56 and 39 patients were received continuous LDA, respectively. The bleeding rate with continuous singleLDA(10.7%) was similar to that with discontinuous single-LDA(10.3%)(P >0.99). Although the bleeding rate with continuous LDA in patients receiving DAPT(23.1%) was higher than that with discontinuous LDA in patients receiving DAPT(5.0%), no significant difference was observed(P = 0.141).CONCLUSION The bleeding rate with continuous LDA in patients receiving DAPT was not statistically different from that with discontinuous LDA in patients receiving DAPT. Therefore, continuous LDA administration may be acceptable for ESD in patients receiving DAPT, although patients should be carefully monitored for possible bleeding.

关键词： Dual antiplatelet therapy Endoscopic submucosal dissection Low-dose aspirin Postoperative bleeding Thienopyridine

Hyperbaric oxygenation promotes regeneration of biliary cells and improves cholestasis in rats

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World Journal of Gastroenterology 2011年第17期17卷 2229-2235页

作者： Akihito Idetsu Taketoshi suehiro Kohji Okada Tatsuo shimura Hiroyuki Kuwano Department of General Surgical Science Gunma University Graduate School of Medicine 3-39-22 Showamachi Maebashi Gunma 371-8511 Japan

AIM:To investigate the effects of hyperbaric oxygenation(HBO) on regeneration of the biliary ductal system and postoperative cholestasis in hepatectomized ***:HBO was performed in Wistar rats daily starting 12 h after a 70% partial *** liver weight,serum parameters and the proliferating cell nuclear antigen labeling index of hepatocytes and biliary ductal cells were *** growth factor(HGF),c-Met and transforming growth factor(TGF) β-1 mRNA expression levels were analyzed by quantitative reverse transcription polymerase chain ***:HBO improved the postoperative serum levels of total bile acid but not transaminase *** promoted hepatocyte and biliary ductal cell *** hematoxylin and eosin-stained specimens revealed fewer ballooned hepatocytes and higher cell densities in the HBO group compared to the control *** suppressed c-Met mRNA levels at 15 h but did not modulate HGF or TGF β-1 mRNA expression levels.

关键词： Hyperbaric oxygenation Liver regeneration Partial hepatectomy Cholestasis Ballooning

Can early precut reduce post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with difficult bile duct cannulation?

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 519-525页

作者： Tomohiro Tanikawa keisuke Miyake Mayuko Kawada Katsunori Ishii Takashi Fushimi Noriyo Urata Nozomu Wada Ken Nishino Mitsuhiko suehiro Miwa Kawanaka Hidenori Shiraha Ken Haruma Hirofumi Kawamoto Department of General Internal Medicine 2 Kawasaki Medical SchoolOkayama 7008505Japan

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is associated with a variety of adverse events(AEs).One of the most important AEs is post-ERCP pancreatitis(PEP),which is most common in cases of difficult biliary *** the precut technique has been reported as a PEP risk factor,recent studies indicate that early precut could reduce PEP,and that precut itself is not a risk *** To evaluate the safety of the precut technique,especially in terms of *** We conducted a retrospective study,spanning the period from November 2011 through December *** included 1556 patients,aged≥20 years,who underwent their initial ERCP attempt for biliary disease with a naïve papilla at the Kawasaki University General Medical *** compared the PEP risk between the early precut and the delayed precut *** The PEP incidence rate did not significantly differ between the precut and nonprecut ***,the PEP incidence was significantly lower in the early precut group than the delayed precut group(3.5%vs 10.5%;P=0.02).The PEP incidence in the delayed precut group without pancreatic stent insertion(17.3%)was significantly higher compared to other cases(P<0.01).CONCLUSION Our findings indicate that early precut may reduce PEP *** the precut decision is delayed,a pancreatic stent should be inserted to prevent PEP.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Precut Needle-knife precut papillotomy

Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells

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Cellular & Molecular Immunology 2021年第7期18卷 1729-1738页

作者： Ken-Ichi suehiro Akira Suto Kensuke Suga Hiroki Furuya Arifumi Iwata Taro Iwamoto Shigeru Tanaka Takahiro Kageyama Kotaro Suzuki Koichi Hirose Véronique Lefebvre Hiroshi Nakajima Department of Allergy and Clinical Immunology Graduate School of MedicineChibaJapan Institute for Global Prominent Research Chiba UniversityChibaJapan Department of Surgery/Division of Orthopedic Surgery Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA

Allergic asthma that is caused by inhalation of house dust mites(HDMs)is mainly mediated by Th2 ***,the roles of Sox(SRY-related high-mobility-group(HMG)-box)family members in various immune responses have been ***,the roles of Sox12,a member of the SoxC group,in Th2 cell differentiation and allergic airway inflammation,remain *** showed that Sox12 mRNA was significantly increased during Th2 cell *** vivo,HDM-induced eosinophil infiltration into the lung and Th2 cell differentiation were exacerbated in Sox12−/−mice compared with those in control Sox12+/−*** vitro,Sox12−/−CD4^(+)T cells that were cultured under Th2 conditions had increased production of Th2 cytokines and GATA3 protein compared with those of control Sox12+/−CD4^(+)T ***,forced expression of Sox12 decreased the protein levels of GATA3 in CD4^(+)T cells under Th2 conditions without affecting mRNA ***,Sox12 induced degradation of GATA3 through the proteasome pathway in CD4^(+)T ***,Sox12 enhanced ubiquitination of GATA3,which was mediated by the E3 ligase ***,we found that Fbw7 knockdown partly abrogated Sox12-mediated GATA3 suppression in CD4^(+)T *** together,these results suggest that Sox12 suppresses Th2 cell differentiation by accelerating Fbw7-mediated GATA3 degradation,and attenuates HDM-induced allergic inflammation.

关键词： Sox12 Asthma GATA3 Th2 ubiquitination

CNVs Associated with Susceptibility to Cancers: A Mini-Review

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Journal of Cancer Therapy 2015年第5期6卷 413-422页

作者： Tomoko Furuya Yutaka suehiro Yukihisa Namiki Kohsuke Sasaki Department of Pathology Yamaguchi University Graduate School of Medicine Ube Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Ube Japan BraCare Genetics Inc. Shimonoseki Japan Research Institute for Animal Science in Biochemistry and Toxicology (RIAS) Sagamihara Japan JCHO Shimonoseki Medical Center Shimonoseki Japan

Copy number variations (CNVs) that are frequent in genome influence on susceptibility of various diseases including cancers. The present mini-review focuses on CNVs associated with susceptibility to the cancers. Since CNVs are different between cancer types, the analysis of the specific CNV makes it possible to estimate the susceptibility to the cancers of interest in individuals. Although it is true that available data on CNVs associated with cancer susceptibility are limited at present, accumulation of the data is accelerated with the research progression of CNVs in near future. Information on CNVs associated with cancer susceptibility is useful for not only cancer research but also personalized healthcare including cancer prevention.

关键词： CNV Cancer Susceptibility Carcinogenesis Cancer Genome Genomic Polymorphism

Combination of type Ⅳ collagen 7S, albumin concentrations, and platelet count predicts prognosis of non-alcoholic fatty liver disease

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World Journal of Hepatology 2021年第5期13卷 571-583页

作者： Miwa Kawanaka Ken Nishino Katsunori Ishii Tomohiro Tanikawa Noriyo Urata Mitsuhiko suehiro Takako Sasai Ken Haruma Hirofumi Kawamoto Department of General Internal Medicine Kawasaki Medical SchoolOkayama 700-8505Japan

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common cause of chronic liver disease and affects approximately 25%of the general global adult *** prognosis of NAFLD patients with advanced liver fibrosis is known to be *** is difficult to assess disease progression in all patients with NAFLD;thus,it is necessary to identify patients who will show poor *** To investigate the efficacy of non-invasive biomarkers for predicting disease progression in patients with *** We investigated biomarkers associated with mortality in patients with NAFLD who visited the Kawasaki Medical School General Medical Center from 1996 to 2018 and underwent liver biopsy and had been followed-up for>1 *** overall mortality and liver-related events during follow-up were calculated using the Kaplan-Meier analysis and compared using log-rank *** calculated the odds ratio and performed receiver operating characteristic curve analysis with logistic regression analysis to determine the optimal cut-off value with the highest prognostic *** We enrolled 489 patients who were followed-up for a period of 1-22.2 *** total,13 patients died(2.7%of total patients enrolled);7 patients died due to liverrelated *** prognosis was associated with liver fibrosis on histological examination but not with inflammation or *** biomarkers associated with mortality were platelet counts,albumin levels,and type IV collagen 7S *** optimal cutoff index for predicting total mortality was a platelet count of 15×10^(4)/μL,albumin level of 3.5 g/dL,and type IV collagen 7S level of 5 mg/*** particular,only one-factor patients with NAFLD presenting with platelet counts≤15×10^(4)/μL,albumin levels≤3.5 g/dL,or type IV collagen 7S≥5 mg/dL showed 5-year,10-year,and 15-year survival rates of 99.7%,98.3%,and 94%,***,patients with two factors had lower 5-year and 10-year survival rates of 98%and 43%,respect

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Platelet count Albumin Type IV collagen 7S All-cause mortality

Combined Effects of Temperature and Nutrient Enrichment on Palatability of the Brown Alga Sargassum yezoense (Yamada) Yoshida &T. Konno

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American Journal of Plant Sciences 2015年第2期6卷 275-282页

作者： Hikaru Endo Kentaro suehiro Junji Kinoshita Yukio Agatsuma Graduate School of Agricultural Science Tohoku University Sendai Japan

Global warming is predicted to strengthen marine plant-herbivore interactions. However, little is known about the effect of temperature on palatability and the associated chemical composition of marine macroalgae. To study the effects of physiological stress caused by the warm water temperatures and nutrient-poor conditions that occur during summer, we cultured the brown alga Sargassum yezoense at three different temperatures (16°C, 22°C, and 28°C) in both nutrient-enriched and non-enriched media. We then compared phlorotannin (i.e., defensive compounds) and nitrogen concentrations of S. yezoense as well as consumption rate by the sea urchin Hemicetrotus pulcherrimus among the treatment groups. No effect of culture temperature on phlorotannin and ni-trogen concentrations or consumption rate was detected. Nutrient enrichment resulted in decreased phlorotannin concentration and increased nitrogen concentration. Although nutrient enrichment did not affect consumption rate, a positive correlation between nitrogen concentration and consumption rate was detected. In contrast, there was no correlation between phlorotannin concentration and consumption rate. These results suggested that palatability of S. yezoense to H. pulcherrimus might not be affected by elevated temperature but that it could increase with nutrient enrichment.

关键词： Climate Change Plant-Herbivore Interaction Defensive Compound Marine Macroalgae Sea Urchin Grazing

Combined Effects of Temperature and Nutrient Availability on Growth and Phlorotannin Concentration of the Brown Alga <i>Sargassum patens</i>(Fucales;Phaeophyceae)

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American Journal of Plant Sciences 2013年第12期4卷 14-20页

作者： Hikaru Endo Kentaro suehiro Junji Kinoshita Xu Gao Yukio Agatsuma Graduate School of Agricultural Science Tohoku University Sendai Ja-pan

Global warming is predicted to affect plant-herbivore interactions. However, little is known about the effects of temperature on marine plant secondary chemistry and how these effects may impact plant-herbivore interactions. As marine macroalgae can become physiologically stressed due to warm water temperatures and nutrient-poor conditions during summer, we conducted a culture experiment to test the combined effects of temperature (10°C, 20°C, 30°C) and nutrient availability (seawater enriched with 25% PESI medium and non-enriched seawater) on relative growth rate (RGR) and concentration of phlorotannins (i.e., defensive compounds) in the upper and lower parts of shoots of the brown alga Sargassum patens. RGR was affected by temperature but not by nutrient availability. Phlorotannnin concentration was affected by nutrient availability but not by temperature, although there was a significant interaction between temperature and part of the shoots. Correlations between RGR and phlorotannin concentration were significant for the upper part of the shoots but not for the lower part. These correlations were slightly positive in the nutrient-enriched medium but negative in the non-enriched medium. These results suggest that temperature affects phlorotannin concentration of S. patens indirectly via changes in the growth rate and that its effect depends on the part of the shoot and nutrient availability.

关键词： Climate Change Plant-Animal Interaction Anti-Herbivore Defense Secondary Metabolite Habitat-Forming Macroalga