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Acupuncture at the San Jiao meridian affects brain stem tissue G protein content in a rat migraine model

Neural Regeneration Research 2008年第9期3卷 958-961页

作者： sue wang wei li guangwei zhong zhenyan li lingbo wen Institute of Integrated Traditional Chinese and Westem Medicine Xiangya Hospital Central South University Changsha 410008 HunanProvince China

BACKGROUND： G protein is closely associated with vasomotion. Vasomotor dysfunction accompanies migraine attack. OBJECTIVE： To investigate the effects of the San Jiao meridian acupuncture on G protein content in a rat migraine model. DESIGN, TIME AND SETTING： The present randomized grouping, cellular and molecular biological level trial was performed at the Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University ＆ Key Laboratory for Tumor Proteomics of Ministry of Health between October 2003 and June 2004. MATERIALS： Forty healthy, male, Sprague Dawtey rats were included in this study. The G6805-2A electro-acupuncture apparatus was a product of Shanghai Huayi Medical Instrument Factory, China. Nitroglycerin was produced by Guangzhou Mingxing Pharmaceutical Factory, China. Antibodies against inhibitory and stimulatory G proteins were purchased from Sigma Chemical Company, USA. METHODS： All 40 rats were randomly and evenly divided into 4 groups. In the blank control group, the rats remained untouched. Rats from the normal control group were subcutaneously administered 2 mL/kg physiological saline. In the model group, migraine was induced with a subcutaneous injection of 10 mg/kg nitroglycerin （5 g/L）, and the rats received no further treatment. In the acupuncture-treated group, 30 minutes after migraine induction, acupuncture was performed at the bilateral Waiguan （SJ 5） and Yifeng （SJ 17） points, with an acupuncture depth of 1 mm. Electric-stimulation parameters of 20 Hz for low frequency, 40 Hz for high frequency, and 0.5-1.0 mA for current intensity were set. Ten acupuncture sessions were applied, with 20-minute low-frequency and 20-minute high-frequency stimulation and 3 seconds of interval time. MAIN OUTCOME MEASURES： Inhibitory and stimulatory G protein contents were detected by Western blot analysis. RESULTS： At 4 hours after migraine induction, compared with the blank control and normal control groups stimula

关键词： acupuncture G protein: migraine San Jiao meridian Western blot

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Acupuncture for cerebral ischemia/reperfusion injury Does it reduce the inflammatory reaction?

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Neural Regeneration Research 2010年第14期5卷 1055-1060页

作者： zhenyan li guangwei zhong Sujuan Huang Yunsheng liu sue wang wei li Department of Neurosurgery Xiangya Hospital Central South University Changsha 410008 Hunan Province China Institute of Integrated Traditional and Westem Medicine Xiangya Hospital Central South University Changsha 410008 Hunan Province China Operating Room Xiangya Hospital Central South University Changsha 410008 Hunan Province China

BACKGROUND： Nuclear factor-κB （NF-κB）, intercellular adhesion molecule-1 （ICAM-1）, and vascular cell adhesion molecule-1 （VCAM-1） in brain tissue can participate in inflammatory reactions after cerebral ischemia. Acupuncture treatment for acute cerebral ischemia produces abnormal protein expression. OBJECTIVE： To investigate the effects of acupuncture on NF-KB, ICAM-1, and VCAM-1 mRNA and protein expression in the brain tissue of rats with cerebral ischemiaJreperfUsion injury. DESIGN, TIME AND SETTING： Randomized, controlled, animal experiments were performed at the Laboratory of Department of Neurosurgery, Xiangya Hospital, Central South University, China between December 2008 and October 2009. MATERIALS： Rabbit anti-NF-KB polyclonal antibody, rabbit anti-ICAM-1 polyclonal antibody, and rabbit anti-VCAM-1 polyclonal antibody were purchased from Santa Cruz Biotechnology, USA. METHODS： A total of 46 healthy, Sprague Dawley rats were randomly assigned to sham surgery （n= 10）, model （n = 12）, acupuncture pretreatment （n = 12）, and acupuncture intervention （n = 12） groups. Models of middle cerebral artery occlusion were established by right common carotid artery ligation. In the acupuncture pretreatment group, rats received acupuncture for 3 consecutive days, and then models were established. In the acupuncture intervention group, rats received acupuncture for 3 consecutive days at Waiguan （SJ 5）, Sanyinjiao （SP 6）, and Dazhui （DU 14） acupoints following model establishment. MAIN OUTCOME MEASURES： Somatosensory asymmetry and forelimb use asymmetry were tested, as well as NF-KB, ICAM-1, and VCAM-1 mRNA and protein expression in the frontal and parietal cortex at 4, 12, 24, 48 and 72 hours following cerebral ischemia/reperfusion injury. RESULTS： Acupuncture improved neurological function and significantly decreased NF-KB, ICAM-1, and VCAM-1 mRNA and protein expression in the frontal and parietal cortex of rats with cerebral ischemia/reperfusion injury （P 〈 0.05）. CONCLUSI

关键词： cerebral ischemia/reperfusion nuclear factor-κB, intercellular adhesion molecule-1 vascular cell adhesion molecule-1 acupuncture traditional Chinese medicine neural regeneration

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ACUPUNCTURE TREATMENT OF MIGRAINE AND PLASMA CGRP AND SP CONTENT CHANGES

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World Journal of Acupuncture-Moxibustion 2001年第3期11卷 11-14页

作者：李炜钟广伟祁敏刘卫平王素娥文玲波徐琳兰陈欣龙春香李学文

Objective: To observe the therapeutic effect of acupuncture in treatment of migraine and the accompanied changes of plasma OGRP and SP. Methods: 186 migraine patients were randomly divided into acupuncture group (n=126) and medication group (n=60). Acupoints used were Taichong (LR 3), Xingjian (LR 2), Fengchi (GB 20) and Yanglingquan (GB 34). Patients of the medication (control) group were asked to take Nimodipine 30 mg (3 times per day), Sibelium 5 mg (once every night), and Ergotamine caffeine (taken curing attack). Plasma OGRP and SP contents were detected by using radioimmunoassay. Results: The therapeutic effect of acupuncture was significantly su- perior to that of medication group (P < 0. 01). In migraine patients, plasma CGRP and SP levels were significantly higher than those of normal people (P <0. 01). After acupuncture treatment, CGRP and SP levels lowered obviously (P<0.05).

关键词： Acupuncture treatment Migraine Plasma CGRP and SP

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