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Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

World Journal of Gastroenterology 2016年第11期22卷 3117-3126页

作者： Jonathan Landy Emma Ronde Nick English sue k clark Ailsa L Hart Stella C knight Paul J Ciclitira Hafid Omar Al-Hassi IBD Unit St Mark's Hospital Harrow London HA1 3UJ United Kingdom Antigen Presentation Research Group Department of Immunology Imperial College London HA1 3UJ United Kingdom Department of Biosurgery and Surgical Technology Imperial College London HA1 3UJ United Kingdom Department of Gastroenterology The Rayne Institute St Thomas' Hospital London HA1 3UJ United Kingdom

Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.

关键词： Claudin Tight junction Ulcerative colitis Pouchitis Crohn’ s disease

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Robotic Assisted, Total Laparoscopic, and Total Abdominal Hysterectomy for Management of Uterine Cancer

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Journal of Cancer Therapy 2012年第2期3卷 162-166页

作者： Nevadunsky Nicole clark Rachel Muto Michael Berkowitz Ross Ghosh sue Vitonis Allison Feltmate Colleen Department of Obstetrics and Gynecology Division of Gynecologic Oncology Brigham and Women’s Hospital Harvard Medical School Boston USA

Objectives: The purpose was to compare robotic assisted total laparoscopic hysterectomy (TRH), laparoscopic assisted hysterectomy (TLH) and total abdominal hysterectomy (TAH) with surgical staging +/- lymphadenectomy for the management of uterine cancer. Methods: Institutional review board approval was obtained and patient characteristics, pathologic data, and data related to the surgical procedure were collected from chart review. Data were analyzed with SAS statistical software. Results: A total of 102 TRHs were compared to 115 TLHs and 79 TAHs. There were more grade I and endometrial intraepithelial (EIN) lesions in the preoperative pathology of TLHs (P P P P P P P < 0.05). Conclusion: Despite longer surgical times, benefits of minimally invasive technology included shortened length of stay, decreased wound infections, transfusions, and blood loss. In our population, procedure selection for TLH versus TRH may have been influenced by lower preoperative grade, with reservation of robotic technology for cases anticipated to be more complex, and therefore justifying increased technology costs and operating times.

关键词： Robotics Laparoscopy Endometrial Cancer

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顾客感知审核——对博物馆和美术馆提供的服务进行监测的方法

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杭州文博 2012年第2期 170-174页

作者： Nick Johns sue L.clark 盛洁桦杭州西湖博物馆

引言质量审核(quality auditing)目前已经在许多行业被确立为评估和提升服务质量的一种于段,本文暗示博物馆和美术馆采用质量审核的方法来积极应对服务质量挑战的时机已经成熟。质量审核是对服务质量的系统性评价。质量审核是一种从顾... 详细信息

引言质量审核(quality auditing)目前已经在许多行业被确立为评估和提升服务质量的一种于段,本文暗示博物馆和美术馆采用质量审核的方法来积极应对服务质量挑战的时机已经成熟。质量审核是对服务质量的系统性评价。质量审核是一种从顾客角度出发,快速、有效地进行服务质量评估的方法。事实上,质量审核往往是进行服务质量评估唯一实用的方法。

关键词：时机博物馆质量方法评估服务质量

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