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The Determination of Heritability in palatal Rugae Pattern among Parents and their Off-Springs in Western India-A Cross-sectional Study

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Journal of Forensic Science and Medicine 2024年第1期10卷 42-46页

作者： Aishwarya Bhatnagar Sugandha Arya Jyothi S Kumar Aishwarya Arya Kailash Chandra Morya sudhir Baroopal Department of Oral Medicine and Radiology Vyas Dental College and HospitalJodhpurRajasthanIndia Department of Conservative and Endodontics Vyas Dental College and HospitalJodhpurRajasthanIndia

Background:Palatal rugae are asymmetrical elevations present on hard palate and are significant due to their uniqueness,stability and thus,aid in forensic ***:The objective is to determine palatal rugae morphology between parents and their offsprings and to determine their genetic *** and Methods:This randomized controlled cross-sectional single-blinded study was conducted on 50 families(randomly selected)who visited Vyas Dental College and Hospital.A total of 150 maxillary study models were examined and rugae were delineated and shape,size,and pattern of rugae were ***:Weak but significant correlation was seen in the nonspecific and angular type of palatal rugae between child and mother and child and father as P<*** with either or both of their parent was seen for curved,wavy,divergent,straight,horseshoe,angular,and nonspecific type of rugae with the higher%of wavy pattern matching(52%with mother and 54%with father).A considerable number of samples showed high heritability of primary and secondary rugae from both parents,but more predominantly to their mothers(branched,nonspecific,and straight).Conclusion:Both environmental and genetic factors can influence the rugae ***,studies should be conducted on a larger sample size to get more significant results.

关键词： Forensic identification heredity palatal rugae uniqueness

Renal resistive index measurements by ultrasound in patients with liver cirrhosis:Magnitude and associations with renal dysfunction

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World Journal of Radiology 2024年第6期16卷 221-231页

作者： Himanshu Surya Ramesh Kumar Rajeev Nayan Priyadarshi Sabbu Surya Prakash sudhir Kumar Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Department of Radiodiagnosis All India Institute of Medical SciencesPatna 801507India

BACKGROUND The hemodynamic alterations seen in liver cirrhosis lead to renal vasoconstriction,ultimately causing acute kidney injury(AKI).The renal resistive index(RRI)is the most common Doppler ultrasound variable for measuring intrarenal vascular *** To evaluate the association of the RRI with AKI in patients with liver cirrhosis and to identify risk factors for high *** This was a prospective observational study,where RRI was measured using Doppler ultrasound in 200 consecutive hospitalized patients with *** association of RRI with AKI was *** receiver operating characteristic(ROC)curve analysis was utilized to determine discriminatory cut-offs of RRI for various AKI *** analysis was conducted to determine the predictors of high *** The mean patient age was 49.08±11.68 years,with the majority(79.5%)being male;the predominant etiology of cirrhosis was alcohol(39%).The mean RRI for the study cohort was 0.68±0.09,showing a progressive increase with higher Child-Pugh class of ***,AKI was present in 129(64.5%)*** mean RRI was significantly higher in patients with AKI compared to those without it(0.72±0.06 vs 0.60±0.08;P<0.001).A total of 82 patients(41%)had hepatorenal syndrome(HRS)-AKI,29(22.4%)had prerenal AKI(PRA),and 18(13.9%)had acute tubular necrosis(ATN)-*** mean RRI was significantly higher in the ATN-AKI(0.80±0.02)and HRS-AKI(0.73±0.03)groups than in the PRA(0.63±0.07)and non-AKI(0.60±0.07)*** demonstrated excellent discriminatory ability in distinguishing ATN-AKI from non-ATN-AKI(area under ROC curve:93.9%).AKI emerged as an independent predictor of high RRI(adjusted odds ratio[OR]:11.52),and high RRI independently predicted mortality among AKI patients(adjusted OR:3.18).CONCLUSION In cirrhosis patients,RRI exhibited a significant association with AKI,effectively differentiated between AKI phenotypes,and predicted AKI mortality.

关键词： Renal resistive index Cirrhosis Acute kidney injury Hepatorenal syndrome Renal Doppler

Cluster sampling methodology to evaluate immunization coverage

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World Journal of Methodology 2024年第3期14卷 78-89页

作者： Aishwarya Sharma RB Jain Jitesh Satija Aditi Sharma Avani Sharma sudhir Shekhawat Department of Community Medicine School of Medical Sciences&ResearchSharda UniversityGreater Noida 201306UPIndia Department of Community Medicine World College of Medical Sciences&ResearchJhajjar 124103HaryanaIndia Department of Community Medicine ESIC Medical College&HospitalFaridabad 121012HaryanaIndia Department of Community Medicine Hamdard Institute of Medical Sciences&ResearchNew Delhi 110062India Department of Community Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Independent Biostatistician Ghaziabad 201014UPIndia

BACKGROUND Immunization is a key component of primary health care and an indisputable human *** are critical to the prevention and control of infectious disease *** coronavirus disease 2019(COVID-19)pandemic and associated disruptions over the past two years have strained the health systems,with many children missing out on essential childhood *** To evaluate the immunization coverage among 12-23-month-old children in the rural areas of Community Health Centre(CHC)Dighal and to determine the factors influencing the existing immunization *** A coverage evaluation survey was conducted according to the 30-cluster sampling technique,which is the standard methodology for such surveys devised by World Health Organization.A total of 300 children aged 12-23 months were included,whose immunization details were noted from their immunization *** Full immunization rate was noted in 86.7%of the children,with partial and non-immunized children accounting for 9%and 4.3%*** full immunization dropout rate was 4.2%.The common reasons for partial or non-immunization were family problem including illness of mother,vaccine not being available and child being *** of birth(P=0.014)and availability of immunization card(P<0.001)were significant predictors of the immunization *** the study was conducted in 2020/2021,health services were disrupted due to the COVID-19 *** Due to the coverage being higher than the national average,it was concluded that the immunization coverage was optimal and not affected by the COVID-19 pandemic.

关键词： Immunization coverage Children COVID 19 pandemic Vaccines Family health Routine immunization

Identification of a Native Novel Oncolytic Immunoglobulin on Exfoliated Colon Epithelial Cells: A Bispecific Heterodimeric Chimera of IgA/IgG*

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Open Journal of Preventive Medicine 2020年第6期10卷 126-150页

作者： George P. Albaugh sudhir K. dutta Vasantha Iyengar Samina Shami Althaf Lohani Eduardo Sainz George Kessie Prasanna Nair Sara Lagerholm Alka Kamra J.-H. Joshua Chen Shilpa Kalavapudi Rakesh Vinayek Robert Shores Laila E. Phillips Ram Nair Padmanabhan P. Nair Beltsville Human Nutrition Research Centre Agricultural Research Service Beltsville MD USA Division of Gastroenterology Sinai Hospital of Baltimore Baltimore MD USA Department of International Health Johns Hopkins University Bloomberg School of Public Health Baltimore MD USA NonInvasive Technologies LLC Elkridge MD USA Department of Pediatrics University of Maryland School of Medicine Baltimore MD USA

Understanding the nature of cell surface markers on exfoliated colonic cells is a crucial step in establishing criteria for a normally functioning mucosa. We have found that colonic cells isolated from stool samples (SCSR-010 Fecal Cell Isolation Kit, NonInvasive Technologies, Elkridge, MD), preserved at room temperature for up to one week, with viability of >85% and low levels of apoptosis (8% - 10%) exhibit two distinct cell size subpopulations, in the 2.5 μM - 5.0 μM and 5.0 μM - 8.0 μM range. In addition to IgA, about 60% of the cells expressed a novel heterodimeric IgA/IgG immunoglobulin that conferred a broad-spectrum cell mediated cytotoxicity against tumor cells. In a cohort of 58 subjects the exclusive absence of this immunoglobulin in two African-Americans was suggestive of a germline deletion. Serial cultures in stem cell medium retained the expression of this heterodimer. Since a majority of the cystic cells expressed the stem cell markers Lgr5 and Musashi-1 we termed these cells as gastrointestinal progenitor stem cells (GIP-C**). CXCR-4, the cytokine co-receptor for HIV was markedly expressed. These cells also expressed CD20, IgA, IgG, CD45, and COX-2. We assume that they originated from mature columnar epithelium by dedifferentiation. Our observations indicate that we have a robust noninvasive method to study mucosal pathophysiology and a direct method to create a database for applications in regenerative medicine.

关键词： Colon Epithelial Cells CXCR-4 IgA/IgG Chimeric Immunoglobulin Heterodimer COX-2 LGR-5 Musashi-1 Dedifferentiation Cellular Engraftment Oncoly-sis Gastrointestinal Progenitor Stem Cells (GIP-C)

Selective Mapping Scheme for Universal Filtered Multicarrier

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Intelligent Automation & Soft Computing 2023年第5期36卷 1273-1282页

作者： Akku Madhusudhan sudhir Kumar Sharma Jaipur National University JagatpuraJaipur302017RajasthanIndia

The next step in mobile communication technology,known as 5G,is set to go live in a number of countries in the near *** wireless applica-tions have high data rates and mobility requirements,which have posed a chal-lenge to mobile communication technology researchers and designers.5G systems could beneﬁt from the Universal Filtered Multicarrier(UFMC).UFMC is an alternate waveform to orthogonal frequency-division multiplexing(OFDM),inﬁltering process is performed for a sub-band of subcarriers rather than the entire band of subcarriers Inter Carrier Interference(ICI)between neighbouring users is reduced via the sub-bandﬁltering process,which reduces out-of-band ***,the UFMC system has a high Peak-to-Average Power Ratio(PAPR),which limits its *** optimization based Selective mapping(SLM)is used in this paper to optimise the *** on the cognitive behaviour of crows,the research study suggests an innovative metaheuristic opti-mization known as Crow Search Algorithm(CSA)for SLM ***-pared to the standard UFMC,SLM-UFMC system,and SLM-UFMC with conventional metaheuristic optimization techniques,the suggested technique sig-niﬁcantly reduces *** the UFMC system,the suggested approach has a very low Bit Error Rate(BER).

关键词： -Universalﬁltered multicarrier(UFMC) selective mapping(SLM) metaheuristic optimization crow search algorithm(CSA) bit error rate(BER)

Comprehensive isotopic characterization of the hydrological processes of the Indus river basin(IRB):A comparison between Upper Indus Basin(UIB)and Lower Indus Basin(LIB)

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Journal of Mountain Science 2023年第3期20卷 705-723页

作者： Akhtar JAHAN Tanveer DAR sudhir KUMAR Nachiketa RAI Department of Earth Sciences Indian Institute of TechnologyRoorkee 247667India National Institute of Hydrology Roorkee 247667India

The Indus river basin(IRB)is one of the most depleted water basins globally,having significant challenges for its water *** of stable isotope composition(δ^(18)O and δ^(2)H)across IRB is a critical aspect that can provide deeper insights for investigating complex hydrological *** work analyses the spatial pattern of the isotopic signature using a comprehensive compilation of available datasets of the Global Network of Isotopes in River(GNIR)and Global Network of Isotopes in Precipitation(GNIP),along with the previously published isotopic studies in the Indus ***,this work provides a detailed comparison of the isotopic signature of the Upper Indus Basin(UIB),and Lower Indus Basin(LIB).The IRBs waterline was found to beδ^(2)H=7.89×δ^(18)O+13.51,which shows a close similarity with the Global Meteoric Water Line(GMWL),indicating the meteoric origin of the water with insignificant secondary evaporation prevailing across the *** Main Indus Channel(MIC)river water line(δ^(2)H=8.88×δ^(18)O+26.05)indicates a major contribution from the meteoric origin(precipitation/rain)of water with minimal effect of evaporation *** water line for UIB samples,(δ^(2)H=7.88×δ^(18)O+11.94)was found to be moderately higher in slope than LIB samples(δ^(2)H=7.17×δ^(18)O+7.16).However,the slopes of both UIB and LIB river water lines closely approached the slope of GMWL and were consistent with the slope of IRB water line,which indicates similarity in contribution of water *** higher slope and intercept in UIB suggest that meteoric water sources contributed to streamflow *** snow/glacier with insignificant evapotranspiration,which is also validated by the scarce vegetation cover in the ***,the lower slope and intercept in LIB suggest stream water contribution from significantly evaporated groundwater and precipitation with a complete homogenization of discharge coming from the *** substantiate that distinct isotopi

关键词： Isotopes Spatial variability Indian summer monsoon Western Disturbance Indus river Water

聚丙烯纳米复合材料对蜻蜓翅膀形态的仿生及评价

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Acta Mechanica Sinica 2022年第11期38卷 1-15页

作者： Vivek Khare sudhir Kamle Advanced Materials and Structures Laboratory Department of Aerospace EngineeringIndian Institute of Technology KanpurKanpur208016India

本文针对柔性扑翼微型飞行器(FWMAV)的应用,研究了由后翼启发的两种不同扑翼形态.采用1%功能化碳纳米管增强聚丙烯纳米复合材料,以碳纤维环氧复合材料股为脉络,研制了翼皮.共振频率是仿生的基本信息,由刚度数据进行理论计算.由弯曲刚度... 详细信息

本文针对柔性扑翼微型飞行器(FWMAV)的应用,研究了由后翼启发的两种不同扑翼形态.采用1%功能化碳纳米管增强聚丙烯纳米复合材料,以碳纤维环氧复合材料股为脉络,研制了翼皮.共振频率是仿生的基本信息,由刚度数据进行理论计算.由弯曲刚度数据得到弯曲主导的一阶固有频率,与蜻蜓固有后翅的扑动频率接近;通过扭转刚度计算得到了扭转主导的第二固有频率,这表明可以将人工机翼制作得更薄.人工翅膀的扑动频率不受扭转变形的影响.利用DIC系统研究了弯曲和扭转主导振型.为了验证静态和动态结果,进行了与实验结果一致的有限元模拟.研究发现,所提出的柔性纳米复合材料机翼蒙皮可以在不影响模态振型的情况下,通过改变机翼形态来控制机翼弯曲和扭转的主导频率.

关键词：聚丙烯纳米复合材料共振频率仿生碳纤维环氧复合材料蜻蜓翅膀弯曲刚度扭转变形扭转刚度

Psychiatric disorders and caregiver burden in children with transfusion dependentβ-thalassaemia and their caregivers

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World Journal of Clinical Pediatrics 2023年第3期12卷 125-132页

作者： Samiksha Sahu Amit Agrawal Jyotsna Shrivastava sudhir Tonk Department of Psychiatry Gandhi Medical CollegeBhopal 462030Madhya PradeshIndia Department of Pediatrics Gandhi Medical CollegeBhopal 462030Madhya PradeshIndia

BACKGROUND Children with thalassemia need care from the first years of life owing to the physical and psychological effects of their *** is a concern not only for the children’s physical health but also the mental health of themselves and their *** To screen the psychosocial problems and assessment of psychiatric morbidities among thalassaemic children and their caretakers,along with an assessment of caregiver burden in *** In this observational cross-sectional study,children with transfusion-dependent thalassemia,were included and were assessed for psychiatric morbidity and global *** parents were assessed for psychiatric morbidity and the caregiver burden they *** the parents completed two different questionnaires to assess their knowledge about the psycho-social functioning[using Pediatric Symptom Checklist-35(PSC-35)]of their children and the level of the burden faced by them by Caregiver Burden Scale(CBS).RESULTS A total of 46 children(28 boys and 18 girls)with transfusion-dependent thalassemia with a mean age of 8.83±2.70 years and 46 parents(12 fathers and 34 mothers)were included in this *** than 32 children had some psychosocial problems on screening by *** assessment by CBS moderate caregiver burden was perceived in domains of general strain,isolation,disappointment,emotional involvement,and environment.A total of 65.3%of children and 62.7%of parents were diagnosed with psychiatric *** Thalassemia affects not only the persons with the disorder but also their caregivers in several aspects,including their psychosocial *** study emphasizes the role of a supportive group in the psychological well-being of caregivers,which could be used to prevent the pathological effects of caregiver burden and enhance their psychological well-being through counselling.

关键词： Thalassemia Children Caregiver burden scale Psychiatric morbidity

Potential of Essential Oils as Alternative Permeation Enhancers for Transdermal Delivery

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 258-269页

作者： Jayshree Mahanty Sofi Haamid Rasheed sudhir Kumar Harjeet Singh Alok Sharma Department of Pharmacognosy ISF College of PharmacyMogaPunjab CCRAS Ministry of AYUSHJhansiUttar PradeshIndia

Transdermal drug delivery plays a significant part in the drug delivery system when compared to other routes of drug *** function of the stratum corneum(SC)is a ***,numerous methods have been thrived to improve the perforation of drugs across the *** most effective method is to use enhancers since these agents enhance skin *** penetration enhancers like essential oils demonstrate higher enhancement activity and are more widely accepted than synthetic penetration *** potential in the expansion and interaction with the SC intercellular lipids has led to an increasing interest in these oils as penetration *** article gives an overview of a few essential oils,including their mode of action and important parameters for permeation *** present work can provide essential oils as alternative enhancers,and this could be useful in transdermal administration.

关键词： Essential oil natural permeation enhancers skin stratum corneum transdermal drug delivery