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Primary graft dysfunction following lung transplantation:From pathogenesis to future frontiers

World Journal of Transplantation 2023年第3期13卷 58-85页

作者： Sanjeet Singh Avtaar Singh sudeep das de Ahmed Al-Adhami Ramesh Singh Peter MA Hopkins PhilipAlan Curry department of Cardiothoracic Surgery Royal Infirmary of EdinburghEdinburgh EH164SAUnited Kingdom Institute of Cardiovascular and Medical Sciences University of GlasgowGlasgow G128QQUnited Kingdom Heart and Lung Transplant Unit Wythenshawe HospitalManchester M239NJUnited Kingdom department of Heart and Lung Transplant Royal Papworth HospitalCambridge CB20AYUnited Kingdom Mechanical Circulatory Support Inova Health SystemFalls ChurchVA 22042United States Queensland Lung Transplant Service Prince Charles HospitalBrisbaneQLD 4032Australia department of Cardiothoracic Surgery Golden Jubilee National HospitalGlasgow G814DYUnited Kingdom

Lung transplantation is the treatment of choice for patients with end-stage lung ***,just under 5000 lung transplants are performed worldwide ***,a major scourge leading to 90-d and 1-year mortality remains primary graft *** is a spectrum of lung injury ranging from mild to severe depending on the level of hypoxaemia and lung injury *** review aims to provide an in-depth analysis of the epidemiology,pathophysiology,risk factors,outcomes,and future frontiers involved in mitigating primary graft *** current diagnostic criteria are examined alongside changes from the previous *** also highlight the issues surrounding chronic lung allograft dysfunction and identify the novel therapies available for ex-vivo lung *** primary graft dysfunction remains a significant contributor to 90-d and 1-year mortality,ongoing research and development abreast with current technological advancements have shed some light on the issue in pursuit of future diagnostic and therapeutic tools.

关键词： Primary graft dysfunction Lung transplantation Pathophysiology Risk factors Extracorporeal membranous oxygenation

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decision fusion-based approach for content-based image classification

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International Journal of Intelligent Computing and Cybernetics 2017年第3期10卷 310-331页

作者： sudeep Thepade Rik das Saurav Ghosh department of Information Technology Pimpri Chinchwad College of EngineeringPuneIndia department of Information Technology Xavier Institute of Social ServiceRanchiIndia A.K.Choudhury School of Information Technology University of CalcuttaKolkataIndia

Purpose–Current practices in data classification and retrieval have experienced a surge in the use of multimedia *** of desired information from the huge image databases has been facing increased complexities for designing an efficient feature extraction *** approaches of image classification with text-based image annotation have faced assorted limitations due to erroneous interpretation of vocabulary and huge time consumption involved due to manual ***-based image recognition has emerged as an alternative to combat the aforesaid ***,exploring rich feature content in an image with a single technique has lesser probability of extract meaningful signatures compared to multi-technique feature ***,the purpose of this paper is to explore the possibilities of enhanced content-based image recognition by fusion of classification decision obtained using diverse feature extraction ***/methodology/approach–Three novel techniques of feature extraction have been introduced in this paper and have been tested with four different classifiers *** four classifiers used for performance testing were K nearest neighbor(KNN)classifier,RIDOR classifier,artificial neural network classifier and support vector machine ***,classification decisions obtained using KNN classifier for different feature extraction techniques have been integrated by Z-score normalization and feature scaling to create fusion-based framework of image *** has been followed by the introduction of a fusion-based retrieval model to validate the retrieval performance with classified *** works on content-based image identification have adopted fusion-based ***,to the best of the authors’knowledge,fusion-based query classification has been addressed for the first time as a precursor of retrieval in this ***–The proposed fusion techniques have successfull

关键词： Classification Information fusion Content-based feature extraction Retrieval

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deoxyribonucleic acid methylation driven aberrations in pancreatic cancer-related pathways

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World Journal of Gastrointestinal Oncology 2023年第9期15卷 1505-1519页

作者： Akash Bararia Amlan das Sangeeta Mitra sudeep Banerjee Aniruddha Chatterjee Nilabja Sikdar Human Genetics Unit Indian Statistical InstituteKolkata 700108India department of Biochemistry Royal Global UniversityAssam 781035India department of Biochemistry and Biophysics University of KalyaniWest Bengal 741235India department of Gastrointestinal Surgery Tata Medical CenterKolkata 700160India department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand School of Health Sciences and Technology University of Petroleum and Energy StudiesDehradun 248007India

Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment *** genetic mutations,epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic *** beneath the deoxyribonucleic acid methylation and its utility in developing of epi-drugs in PanCa are under *** of epigenetic medicines with conventional cytotoxic treatments or targeted therapy are promising options to improving the dismal response and survival rate of PanCa *** studies have identified potentially valid pathways that support the prediction that future PanCa clinical trials will include vigorous testing of epigenomic *** thus promises to generate a significant amount of new knowledge of biological and medical *** review could identify various components of epigenetic mechanisms known to be involved in the initiation and development of pancreatic ductal adenocarcinoma and related precancerous lesions,and novel pharmacological strategies that target these components could potentially lead to *** aim to highlight the possibilities that exist and the potential therapeutic interventions.

关键词： Methylation driven pathways Pancreatic cancer methylation markers Signaling pathway targeted therapy PanCa enriched methylated pathway Pre-cancer methylated pathways

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Efficacy of selective laser trabeculoplasty following incisional glaucoma surgery

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 71-76页

作者： Robert Allan Sharpe Leah L Kammerdiener David B.Williams sudeep K.das Matthew J.Nutaitis department of Ophthalmology Storm Eye InstituteMedical University of South CarolinaCharlestonSouth Carolina 29425USA Jacksonville Naval Hospital JacksonvilleFlorida 32214USA

AIM： To evaluate the efficacy of selective laser trabeculoplasty（SLT） in glaucomatous eyes with previous incisional glaucoma surgery. METHODS： A retrospective cohort of eyes that underwent SLT at a single institution from 2013-2015 were followed for 1 y. Reduction in intraocular pressure（IOP） following SLT was evaluated in eyes with prior trabeculectomy with Ex Press mini shunt（Alcon, Ft Worth, TX, USA）, Ahmed valve（New World Medical, Cucamonga, CA, USA）, or combined phacoemulsification-trabeculectomy. A control group was included with eyes without prior surgery that underwent SLT. Success was defined as 〉20% drop in IOP from pre-SLT baseline. RESULTS： One-hundred and six eyes were included with 53 in both the prior glaucoma surgery（PGS） and no prior glaucoma surgery（NPGS） groups. Mean pre-SLT IOP was 19.2±4.3 and 20.6±6.0 mm Hg for PGS and NPGS groups, respectively（P=0.17）. Both groups produced statistically significant IOP reductions at 1 and 6 mo（P〈0.04）. At 6 mo, mean IOP reduction reached 7.3% and 10.8% for the PGS and NPGS groups, respectively（P=0.42）. Overall, 27.9% and 31.7% of eyes in PGS and NPGS groups met success criteria at 1 y（P=0.70）. In the PGS group, eyes with baseline IOP ≥21 mm Hg had IOP reductions of 18.1%（P〈0.001）, 16.7%（P〈0.01）, and 8.4%（P=0.31） compared to eyes with baseline IOP 〈21 mm Hg who had IOP reductions of 2.3%（P=0.39）, 3.4%（P=0.19）, and 1.1%（P=0.72） at 1, 6 mo, and 1 y, respectively. CONCLUSION： SLT is efficacious in eyes with prior incisional glaucoma surgery and results in similar IOP reductions compared to eyes without PGS. A larger IOP reduction is observed following SLT in eyes with higher pre-SLT IOP.

关键词： glaucoma selective laser trabeculoplasty trabeculectomy Ahmed glaucoma valve intraocular pressure

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Histological difference in ligament flavum between degenerative lumbar canal stenosis and non-stenotic group:A prospective,comparative study

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World Journal of Orthopedics 2022年第9期13卷 791-801页

作者： Mantu Jain Mukund Sable Amit Purushottam Tirpude Rabi Narayan Sahu sudeep Kumar Samanta Gurudip das department of Orthopaedics All India Institute of Medical Sciences BhubaneswarBhuabneswar 751019OdishaIndia department of Pathology All India Institute of Medical Sciences BhubaneswarBhubaneswar 751019OdishaIndia department of Anatomy All India Institute of Medical Sciences RaipurRaipur 492009ChattisgarhIndia department of Neurosurgery All India Institute of Medical Sciences BhubaneswarBhubaneswar 751019OdishaIndia

BACKGROUND Ligament flavum(LF)hypertropy is the main etiopathogenesis of lumbar canal stenosis(LCS).The purely elastic LF undergoes a morphological adaptation including a reduction in the elastic fibers and a consequent increase in the collagen content,fibrosis,cicatrization,and ***,the morphometric analysis can delineate the LF in patients with LCS from those without LCS,which would help in better understanding LCS *** To compare the histopathological changes in LF between the degenerative LCS and non-stenotic(non-LCS)*** The present prospective study was conducted in 82 patients who were divided into two groups,namely LCS and *** details of the patients such as duration of symptoms,level of involvement,and number of segments were *** LF obtained from both groups was histopathologically examined for the fibrosis score,elastic fiber degeneration,calcification,and chondroid *** details included a change in elastin and collagen percentages,elastin/collagen ratio,elastic fiber fragmentation,and ligamentocyte *** parameters were compared between the two groups by using the independent t test,Chi-square test,and Pearson’s correlation *** Out of 82 cases,74 were analysed,34 in LCS and 40 in non-LCS *** mean±SD age of presentation in LCS and non-LCS group was 49.2±8.9 and 43.1±14.3 *** LCS group(n=34)exhibited significant differences in fibrosis(P=0.002),elastic fiber degeneration(P=0.01),%elastic fragmentation(66.5±16.3 vs 29.5±16.9),%elastic,content(26.9±6.7 vs 34.7±8.4),%collagen content(63.6±10.4 vs 54.9±6.4),reduction of elastic/collagen(0.4±0.1 vs 0.6±0.1),and ligamentocyte number(39.1±19.1 vs 53.5±26.9)as compared to non-LCS group(n=40).The calcification(P=0.08)and Pearson’s correlation between duration and loss of elastin was not *** difference in LF morphology is consistent in patient’s≥40 years of age among the groups as found in

关键词： Spinal stenosis Lumbar spine Ligamentum flavum histopathology Morphometry

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