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Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation

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Bone Research 2018年第1期6卷 83-94页

作者： Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles michael C.Ostrowski sudarshana m.sharma Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State University Wexner Medical Center College of Veterinary medicine The Ohio State University Department of Biochemistry and molecular Biology and Hollings Cancer Center Medical University of South Carolina Division of Rheumatology Immunology and Allergy Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Division of Rheumatology and Immunology Department of Internal Medicine The Ohio State University Wexner Medical Center Department of Biomedical Informatics The Ohio State University Wexner Medical Center

Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and mITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states.

关键词： Genome-wide GWASs mITF

Study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics

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Plasma Science and Technology 2024年第4期26卷 94-100页

作者： Sunil KANCHI Rohit SHUKLA Archana sharma Pulsed Power and Electromagnetics Division Bhabha Atomic Research CentreVisakhapatnam 531011India Homi Bhabha National Institute Mumbai 400085India Beam Technology Development Group Bhabha Atomic Research CentreMumbai 400085India

Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon *** triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.

关键词： coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature

microRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

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Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender sharma melissa mTorres Sheryl Rodriguez Laxman Gangwani Subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate School of Biomedical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

Role of Social Capital in Determining Happiness and Life Satisfaction:mediation of Self-reported Health Using Path Analysis

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Fudan Journal of the Humanities and Social Sciences 2024年第2期17卷 211-242页

作者： Suraj sharma Department of Economics S.M.(P.G.)CollegeChandausiM.J.P.Rohilkhand UniversityBareilly243006India

This study links social capital with people’s health and well-being using data from the seventh wave of the World Value Survey,logistic regression,and path *** study’s findings show that happiness and life satisfaction are two different measures of the same construct,or *** determinants of each are also characterised differently:while life satisfaction is more of a stable and relative measure and is more strongly influenced by civic cooperation,social participation,and educational attainment,happiness is more of an unstable measure and is more strongly influenced by community belonging,trust and confidence aggregates,including employment and location of residence of an ***,freedom of choice,financial satisfaction or social comparison,and state of health were the most important factors influencing happiness and life *** findings also show that self-reported health(SRH)has a greater impact on happiness than a measure of life *** analysis shows out of the three other components of social capital—community belonging,civic engagement,and social participation—trust and confidence aggregates are the ones that have the biggest impact on increased social *** both well-being measures,SRH mediated the *** life satisfaction measure had a higher level of mediation of SRH than happiness,but social capital had a smaller direct impact on life satisfaction than on *** was found to be partially mediating this relationship for both happiness and life satisfaction measures,which means that people with higher social capital reported feeling better off.

关键词： Happiness Health Life satisfaction Path analysis Social capital

Experimental investigation on effective aerosol scavenging using different spray configurations with pre-injection of water mist for Fukushima Daiichi decommissioning

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Nuclear Science and Techniques 2024年第5期35卷 154-172页

作者： Rui-Cong Xu Avadhesh Kumar sharma Erdal Ozdemir Shuichiro miwa Shunichi Suzuki Department of Nuclear Engineering and management The University of Tokyo7‑3‑1 HongoBunkyo‑KuTokyo 113‑8656Japan Nuclear Professional School The University of Tokyo2‑2

During the decommissioning of the Fukushima Daiichi nuclear power plant,it is important to consider the retrieval of resolidified debris both in air and underwater *** the subsequent retrieval of debris from the reactor building,the resolidified debris must be cut into smaller pieces using various cutting *** the cutting process,aerosol particles are expected to be generated at the submicron *** has been noted that such aerosols sizing within the Greenfield gap(0.1-1μm)are difficult to remove effectively using traditional spraying ***,to improve the aerosol removal efficiency of the spray system,a new aerosol agglomeration method was recently proposed,which involves injecting water mist to enlarge the sizes of the aerosol particles before removing them using water *** this study,a series of experiments were performed to clarify the proper spray configurations for effective aerosol scavenging and to improve the performance of the water *** experimental results showed that the spray flow rate and droplet characteristics are important factors for the aerosol-scavenging efficiency and performance of the water *** results obtained from this study will be helpful for the optimization of the spray system design for effective aerosol scavenging during the decommissioning of the Fukushima Daiichi plant.

关键词： Fukushima Daiichi decommissioning Aerosol scavenging multiphase flow Spray system Aerosol-mist agglomeration

Optoelectronic and thermoelectric properties of spinel chalcogenides HgLa_(2)X_(4)(X=S and Se):A first-principles study

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Journal of Rare Earths 2024年第10期42卷 1927-1936页

作者： Aparna Dixit Inas AAhmed Jisha Annie Abraham Zeinhom mEl-Bahy mumtaz manzoor Sajad Ahmad Dar Ramesh sharma Department of Basic Science and Humanities Pranveer Singh Institute of TechnologyKanpur209305UPIndia Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha62224Saudi Arabia Department of Physics National Defence AcademyPune209305MaharashtraIndia Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City.11884CairoEgyp Institute of Physics Slovak Academy of SciencesDubravska cesta 984507BratislavaSlovakia Department of Physics Motilal Vigyan Mahavidyalya CollegeBhopal462008India Department of Applied Science Feroze Gandhi Institute of Engineering and TechnologyRaebareli229001India

We investigated spinel chalcogenides HgLa_(2)(S/Se)_(4)by using density function theory,and scrutinized the structural,optical,electrical,mechanical and thermoelectric transport characteristics of HgLa_(2)(S/Se)_(4)spinel *** enthalpy of formation,energy of cohesion,and energy volume optimum plots were used to obtain the stability as well as the perfect ground state of these *** ductility of these materials was the best illustrated with the help of Poisson's and Pugh's *** band gap results were obtained using Trans and Blaha modified Becke-Johanson potential(TB-mBJ).Both the materials present semi-conducting nature with direct band gap equal to 1.449 and 0.892 eV respectively for HgLa_(2)S_(4)and HgLa_(2)Se_(4).Calculations were also made for optical characteristics with the values of dielectric function,absorption coefficient,optical conductivity,reflectivity,and refractive *** to the findings,both of these materials are suitable for infrared optoelectronic *** materials were found to have promising optoelectronic and thermoelectric applications after their optical properties and transport aspects were *** tiny levels of temperature conductivities,substantial am ounts of power conductivities,the figure of merit(more than unity),as well as Seebecs coefficients all point to the potential use of both the materials in thermoelectric power generators.

关键词： Density functional theory Direct band gap Optoelectronic Thermoelectric Semiconductors Power factor

Effect of process parameter on the flowability of nanocrystalline CoNiCrAlY powder synthesized by mechanical milling

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Particuology 2024年第9期92卷 210-223页

作者： Annadaa Shankara Dash Indranil manna Deepa Devapal Sharad Chandra sharma Jyotsna Dutta majumdar School of Nanoscience and Technology IIT KharagpurWest BengalIndia BIT mesra RanchiJharkhandIndia Department of metallurgical and materials Engineering IIT KharagpurWest BengalIndia Vikram Sarabhai Space Centre ThiruvanthapuramKeralaIndia

The present study concerns understanding the effect of process parameters on the characteristics and flowability of nanocrystalline CoNiCrAlY powder synthesized by mechanical *** milling has been conducted in a planetary ball mill with tungsten carbide(WC)ball,with ball to powder ratio of 10:1 at 300 rpm speed,using 1%stearic acid and toluene as process control agent(PCA)with time varying from 10 h to 36 *** synthesized nanocrystalline powder were characterized by Scanning Electron microscopy,X-ray Diffraction technique,X-ray Photoelectron Spectroscopy,and Differential Scanning ***,flowability in terms of Hausner ratio was assessed by Tap Density *** particle size of the powder was found to decrease from 33μm to 22μm after 10 h of milling and further increases to 43μm and 38μm after 25 and 36 h of milling,respectively,in stearic acid ***,in toluene medium particle size continuously decreases from 33μm to 9.7μm with increasing milling *** particle morphology changes from spherical to platelet shape at low milling hours in both of the *** 25 h of milling,the shape of the particles is nearly spherical for stearic acid and irregular for toluene used as a *** size was found to decrease with increasing milling time from 147 nm to 7.7 nm and to 6.4 nm in stearic acid and toluene media,*** was presence ofγ,γʹ,β,hcp-Co,Al_(2)O_(3)and AlOOH phases on the powder particles milled in both the *** measured Hausner ratio of the powders was found to vary from 1.18 to 1.32 in stearic acid medium,and was found to increase with increasing milling *** the other hand,in toluene media flowability decreases(Hausner ratio increases from 1.33 to 1.44)with increasing milling time.

关键词： mechanical milling microstructure Process control agent(PCA) CoNiCrAIY Toluene Stearic acid Flowability

Exploring the Potential of Syzygium cumini(L.)Skeels(Jamun)Seed Powder as an Eco-Friendly Agent for Developing Friction Ridges on Porous and Nonporous Surfaces

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Journal of Forensic Science and medicine 2024年第2期10卷 75-83页

作者： Vaibhav sharma Abhishek R.Rai Divyansh Jain Poonam Kumari Varad Nagar Anubhav Singh Kumud Kant Awasthi Archana Gautam Tina sharma mahipal Singh Sankhla Anuj sharma Department of Forensic Science Vivekananda Global UniversityJaipurRajasthanIndia School of Forensics Risk Management and National SecurityRashtriya Raksha UniversityLavadGujaratIndia Department of Life Sciences Vivekananda Global UniversityJaipurRajasthanIndia Department of Forensic Science UIAHSChandigarh UniversityMohaliPunjabIndia University Centre for Research and Development Chandigarh UniversityMohaliPunjabIndia Department of Forensic Science ITM UniversityGwaliorM.P.India

Background:Development of obscured fingerprints on a diverse range of surfaces is a crucial aspect of forensic *** and Objectives:In this particular study,the utilization of Syzygium cumini(L.)Skeels(Jamun)seed powder was examined for the purpose of revealing hidden fingerprints on a variety of surfaces,including both permeable and impermeable *** and methods:The seed powder was extracted using a simple process and was analysed using multiple analytical *** efficacy of the jamun seed powder in developing latent fingerprints was ***:The findings of this investigation demonstrate that the jamun seed powder was capable of producing fingerprint patterns of exceptional quality and clarity on numerous ***:This research highlights the potential use of jamun seed powder as a practical and effective alternative for the development of hidden fingerprints in forensic investigations,while also providing cost-effectiveness.

关键词： Forensic investigation jamun seed latent fingerprints medicinal value

QT AG-modules whose h-Pure-S-High Submodules Have Closure

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Journal of mathematical Research with Applications 2024年第1期44卷 18-24页

作者： mohd Noman ALI Vinit Kumar sharma Ayazul HASAN Department of mathematics Shri Venkateshwara University College of Applied Industrial Technology Jazan University

A right module m over an associative ring R with unity is a QTAG-module if every finitely generated submodule of any homomorphic image of m is a direct sum of uniserial *** article considers the closure of h-pure-S-high submodules of ***,we determine all submodules S of a QTAG-module m such that each closure of h-pure-S-high submodule of m is h-pure-■-high in■.A few results of this theme give a comparison of some elementary properties of h-pure-S-high and S-high submodules.

关键词： QTAG-modules closures h-pure-S-high submodules