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Utilization of kinase inhibitors as novel therapeutic drug targets:A review

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Oncology Research 2022年第5期30卷 221-230页

作者： suchitra NISHAL VIKAS JHAWAT SUMEET GUPTA PARMITA PHAUGAT Department of Pharmacy School of Medical and Allied SciencesGD Goenka UniversityGurugramIndia Department of Pharmaceutical Sciences Maharishi Markandeshwar(Deemed to be)UniversityMullanaAmbalaHaryanaIndia

Kinase inhibitors are a signiﬁcant and continuously developing division of target *** drug discovery and improvement efforts have examined numerous attempts to target the signaling pathway of *** Kinase inhibitors have been heralded as a game-changer in cancer *** developing kinase inhibitors as a treatment for various non-malignant disorders like auto-immune diseases,is currently undergoing extensive *** may be beneﬁcial to investigate whether cell-speciﬁc kinase inhibitor administration enhances therapeutic efﬁcacy and decreases adverse *** goal of the current review is to gain insight into the role of kinase inhibitors in facilitating effective target drug delivery for the treatment of various anti-inﬂammatory,auto-immune,and anticancer *** aim of this review is also to shed light on drug discovery approaches for kinase inhibitors,their mode of action,and delivery *** variation in the binding of kinases bestows different target approaches in drug design,which can be employed for designing the targeted *** target sites have been studied,exceeding the design of drugs for various diseases like cancer,Alzheimer’s,rheumatoid arthritis,*** delivery approaches have also been studied for the targeted application of kinase inhibitors.

关键词： Kinase inhibitors Targeted Drug designing Anti-cancer Auto-immune diseases

Microstructural Features of Spray-Deposited Immiscible Bearing Alloys Al-43Sn and Al-7Sn-1.3Cu-1.3Ni

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Journal of Materials Science & Technology 2003年第5期19卷 437-443页

作者： O.P.pandey Thapar Institute of Engineering & Technology Deemed University Patiala-147004 India

Two commercial grade aluminum based immiscible bearing alloys were spray-deposited using convergent-divergent type of nozzle. The processing parameters for spray-deposition were adjusted in such a way that most of the droplets arrived on the deposition substrate in either liquid or semi-liquid state. The microstructural features of spray-formed and as-cast alloys are compared. In spray-formed alloys equiaxed grains were observed. The cell boundaries and intercellular regions were observed to be decorated with sub-micron sized particles whereas in normal casting the second phase was observed to be segregated along grain boundaries. The morphology and distribution of second phase were observed to have similarity with those in over-spread and atomized powders produced under similar processing conditions. The microstructural features observed with variation in spray conditions are discussed in detail.

关键词： Spray deposition Immiscible bearing alloys Microstructure Atomization

Effect of ultrasonic assisted sintering on mechanical properties and degradation behaviour of Mg15Nb3Zn1Ca biomaterial

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Journal of Magnesium and Alloys 2021年第6期9卷 1989-2008页

作者： Ajit Kumar Pulak M pandey Department of Mechanical Engineering Indian Institute of TechnologyDelhiNew Delhi 110016India

The present work investigates the effect of ultrasonic power(%)and the time of ultrasonic vibration on the sintered density and ultimate compressive strength(UCS)of Mg15Nb3Zn1Ca fabricated using ultrasonic assisted conventional sintering(UACS).The customized UACS setup was designed and manufactured to conduct the experimentations.A customized ultrasonic stepped horn assembly was used for providing vibrations to the sample during ***,to evaluate the efficacy of ultrasonic vibration parameters,the developed setup was used to sinter Mg15Nb3Zn1Ca composite *** study unveiled an increased sintered density and UCS of the fabricated sample by the increase in ultrasonic power(%).Moreover,a decrease in sintered density and UCS was observed with an increase in the time of ultrasonic vibration beyond a certain *** sintered with the assistance of ultrasonic vibration at 100%ultrasonic power,and 20 min of ultrasonic vibration resulted in a sintered density of 1.928±0.062 g·cm^(-3)and UCS of 234.9±12.3 *** obtained mechanical properties of the fabricated sample were comparable to the properties of cortical *** surface morphology and elemental compositions of samples fabricated using UACS declared a fair dispersion of reinforcement in the matrix containing merely the source *** results of corrosion test have showed that the assistance of ultrasonic vibration suppressed the degradation behaviour of the sintered sample after performing electrochemical study of samples using 3-electorde cell ***15Nb3Zn1Ca fabricated using UACS showed a 50.18%and 9.08%of reduction in corrosion rate over conventionally sintered pure Mg and Mg15Nb3Zn1Ca *** addition,electrochemical impedance spectroscopy(EIS)results indicated an enhanced corrosion resistance of the Mg15Nb3Zn1Ca composite material when fabricated at 100%of ultrasonic power with 20 min of vibration *** from that,electrochemical equivalent circuits also result

关键词： Ultrasonic assisted sintering Magnesium Corrosion EIS Mechanical properties

Alkaline phosphatase as a bio-indicator of phosphorus-eutrophy in freshwater ecosystems: A review

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International Journal of Sediment Research 2023年第3期38卷 349-360页

作者： Madhulika Singh Jitendra pandey Ganga River Ecology Research Laboratory Environmental Science Division Centre of Advanced Study in Botany Institute of Science Banaras Hindu University

Limnologists have greatly advanced the understanding of indicators of phosphorus(P)-eutrophy in surface waters. Biotic variables such as macro-invertebrates, fish, zooplankton, benthic algae, and diatoms are extensively used for bio-assessment of eutrophy. New concepts highlight the importance of bed-sediment based “response” variables predicting functional shifts during eutrophication. A cross analysis of studies reveals that alkaline phosphatase(ALP), which serves as a proxy of P-deficiency, and also as an indicator of benthic anoxia/hypoxia-driven feedbacks, can be an easy to measure, cost-effective and reliable tool to assess changes in nutrient stoichiometry, trophic status, and ecological functioning at the sediment-water interface. Here, the issues discussed in this paper are highly relevant to explore new domains of research and “response” based ecosystem models for potential eutrophication management decisions. Because ALP is used in molecular cloning and fingerprinting studies, it is suggested that approaches based on the “omics” technologies need to be used to explore more intricate connections to empirically address ALP-P-eutrophy linkages to track eutrophication in freshwater ecosystems.

关键词： Alkaline phosphatase Sediment based-indicators Ecosystem feedback Nutrient stoichiometry Phosphorus-eutrophy

Can we constrain the evolution of HI bias using configuration entropy?

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Research in Astronomy and Astrophysics 2021年第2期21卷 82-88页

作者： Biswajit Das Biswajit pandey Department of Physics Visva-Bharati UniversitySantiniketanBirbhum731235India

We study the evolution of the configuration entropy of HI distribution in the post-reionization era assuming different time evolution of HI *** describe time evolution of linear bias of HI distribution using a simple form b(a)=b_(0)a^(n) with different index *** derivative of the configuration entropy rate is known to exhibit a peak at the scale factor corresponding to theΛ-matter equality in the unbiasedΛCDM *** show that in theΛCDM model with time-dependent linear bias,the peak shifts to smaller scale factors for negative values of *** is related to the fact that the growth of structures in the HI density field can significantly slow down even before the onset ofΛdomination in the presence of a strong time evolution of the HI *** find that the shift is linearly related to the index *** obtain the best fit relation between these two parameters and propose that identifying the location of this peak from observations would allow us to constrain the time evolution of HI bias within the framework of theΛCDM model.

关键词： methods analytical-cosmology theory-large scale structure of the universe

Exploration of deep seabed polymetallic sulphides: Scientific rationale and regulations of the International Seabed Authority

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矿业科学技术学报：英文版 2013年第3期23卷 457-462页

作者： Anju pandey Ministry of Earth Sciences Prithvi Bhavan New Delhi 110003 India

Polymetallic sulphides have been consistent source of metals like iron, copper, zinc and lead. Apart from these they are also seen as economically viable resources of silver and gold. As the demand of these metals is showing an astoundingly increasing trend, the search for their resources has also increased in similar folds. This has resulted in many nations' focus on deep seabed resources of the polymetallic sulphides. Consequently, International Seabed Authority (ISBA) has provided 'Regulations' to obtain plan of work for exploration of polymetallic sulphide deposits in deep seabed 'Area'. Following the release of these Regulations, several countries are in the process of obtaining the licence for exploration of these metals from the deep seabed regions. Detailed information about the science and ISBA Regulations for exploration of polymetallic sulphide deposits is prerequisite to submit an application to ISBA for their exploration. The current contribution provides a comprehensive review of the science behind locating polymetallic sulphide deposits in geological setting of deep seabed as well as about the ISBA Regulations for their exploration.

关键词： Polymetallic sulphide International Seabed Authority Exploration Mid ocean ridges

A multiwavelength view of a classical T Tauri star CV Cha

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Research in Astronomy and Astrophysics 2019年第1期19卷 75-86页

作者： Jeewan Chandra pandey Subhajeet Karmakar Arti Joshi Saurabh Sharma Shashi Bhushan pandey Anil Kumar pandey Aryabhatta Research Institute of Observational Sciences (ARIES)

Using long-term optical, ultraviolet(UV) and X-ray data, we present a study of a classical T Tauri star CV Cha. The V-band light curve obtained from the All Sky Automated Survey(ASAS) shows short as well as long-term variability. The short-term variability could be due to rotational modulation of CV Cha. We derive the rotational period of 3.714 ± 0.001 d for CV Cha. UV light curves obtained from Swift also show the variations. X-ray light curves from XMM-Newton and Swift do not show any significant short as well as long-term variability. However, the light curve from Chandra appears to be variable, which could be due to the emergence of flaring activities. X-ray spectra from all observations are explained well by the single temperature plasma of 0.95 keV with X-ray luminosity of 1030.4erg s-1in the 0.5–7.5 keV energy band. It appears that variability in optical and UV bands could be due to the presence of both hot and cool spots on the surface, while X-ray emission is dominated by magnetic processes.

关键词： stars:activity stars:individual(CV Cha) stars:pre-main sequence stars:variable:T Tauri X-ray:stars

Impedance Studies of La_2Mo_(2-x)Sn_xO(9-δ) Oxide Ion Conductors

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Acta Metallurgica Sinica(English Letters) 2013年第4期26卷 425-434页

作者： Lakhi Nath Borah A.pandey Department of Physics North Eastern Regional Institute of Science and Technology

A series of compounds La2Mo2-xSnxO9-6 （x=0-0.3） have been synthesized by solid-state reaction technique. Materials have been characterized by XRD, SEM, DSC and impedance study. In the temperature regime 520℃-590 ℃, the specimens with x〈0.05 have the conductivity higher than La2Mo2O9. Conductivity of Sn-doped compound decreases consistently with increasing Sn-doping, compared to the undoped compound both below and above phase transition, barring the specimens with x〈 0.05, where conductivity values remains almost same as that of undoped specimen in high temperature region. In the intermediate temperature regime （520℃-590℃）, the conductivity of doped compounds increases for x〈0.05 as compared to parent compound. Also, there is no indication of phase stabilization with Sn-doping in this compound even with the highest doping level, x=0.3. Electric modulus analysis suggests that thermally activated oxygen ion hopping mechanism is responsible for the conduction in Sn-doped compound.

关键词： Ionic conduction La2M0209 Oxide ion conductor Impedance spectroscopy Electric modulus

Graph Convolutional Network Based Fault Detection and Identification for Low-voltage DC Microgrid

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 917-926页

作者： Ambuj pandey Soumya R.Mohanty Department of Electrical Engineering Indian Institute of Technology(BHU)VaranasiUttar PradeshIndia IEEE

This paper presents a novel fault detection and identification method for low-voltage direct current(DC)microgrid with meshed *** proposed method is based on graph convolutional network(GCN),which utilizes the explicit spatial information and measurement data of the network topology to identify a *** has a more substantial feature extraction ability even in the presence of noise and bad *** adjacency matrix for GCN is developed by considering the network topology as an inherent *** bus voltage and line current samples after faults are regarded as the node ***,the DC microgrid model is developed using PSCAD/EMTDC simulation,and fault simulation is carried out by considering different possible events that include environmental and physical *** performance of the proposed method under different conditions is compared with those of different machine learning techniques such as convolutional neural network(CNN),support vector machine(SVM),and fully connected network(FCN).The results reveal that the proposed method is more effective than others at detecting and classifying *** method also possesses better robustness under the presence of noise and bad data.

关键词： DC microgrid graph convolution network fault detection topological information