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Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka Ramesh kumar Ashwani kumar Mishra Shivanand Gamanagatti Shashi Bala Paul subrat kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

H_(∞) Load Frequency Control Design Based on Delay Discretization Approach for Interconnected Power Systems with Time Delay

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Journal of Modern Power Systems and Clean Energy 2021年第6期9卷 1468-1477页

作者： subrat kumar Pradhan Dushmanta kumar Das Department of Electrical and Electronics Engineering National Institute of Technology Nagaland

This paper proposes a delay discretization based H∞load frequency control strategy for interconnected power *** effect of time delay is considered in the system for the design of stabilizing *** improve the tolerable delay margin of the system,a two-term state feedback controller structure is *** controller requires delayed state information as control *** the proposed approach,the amount of delay introduced in the state of the system,i.e.,artificial delay,for taking control action is assumed to be *** approach is based on the discretization of this delay *** order to define a simple Lyapunov-Krasovskii(LK)function for each of the discretized interval,a stabilization criterion is developed in such a way that a single one satisfies the requirement of all the *** developed criterion is computationally simple and efficient.

关键词： Interconnected power system load frequency control(LFC) state feedback controller time delay

Sliding mode controller design via delay-dependent H_(∞) stabilization criterion for load frequency regulation

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Protection and Control of Modern Power Systems 2023年第3期8卷 225-251页

作者： subrat kumar Pradhan Dushmanta kumar Das Department of Electrical Engineering Indira Gandhi Institute of TechnologySarangDhenkanal 759146India Department of Electrical and Electronics Engineering National Institute of Technology NagalandDimapur 797103India

This work presents a control approach based on sliding-mode-control(SMC)to design robust H∞state feedback controllers for load frequency regulation of delayed interconnected power system(IPS)with parametric *** both state feedback control strategy and delayed feedback control strategy,two SMC laws are *** proposed control laws are designed to improve the stability and disturbance rejection performance of delayed IPS,while stabilization criteria in the form of linear matrix inequality are derived by choosing a Lyapunov–Krasovskii *** artificial time-delay is incorporated in the control law design of the delayed feedback control struc-ture to enhance the controller performance.A numerical example is considered to study the control performance of the proposed controllers and simulation results are provided to observe the dynamic response of the IPS.

关键词： Sliding mode control Delay-dependent stabilization H∞performance Time-delay Load frequency control

Impact of Cumulative Exposure to Circulating Ovarian Sex Hormones on Increasing the Risk of Hormone Receptor-Positive Breast Cancer

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Journal of Bio-X Research 2024年第1期7卷 36-43页

作者： Swati Sucharita Mohanty Sumit Subhadarshi Mohanty Soumya Surath Panda Chita Ranjan Sahoo Prafulla kumar Mohanty Rabindra Nath padhy Siksha O Anusandhan University Institute of Medical Sciences and SUM Hospital BhubaneswarOdishaIndia Regional Medical Research Centre Bhubaneswar BhubaneswarOdishaIndia Khallikote Unitary University BrahmapurOdishaIndia

There were 2.3 million new cases of breast cancer registered in 2020,establishing it as the world’s leading *** regular exposure of breast cells to circulating ovarian sex hormones may contribute to cancer growth at all stages.A literature review was performed by downloading research articles from PubMed Central,with keywords such as breast cancer,hormone exposure in breast cancer,estrogen/progesterone exposure in breast cancer,and breast cancer risk *** breast cancer is a hormone-related disease,several factors that influence hormonal conditions or are indicators of alterations in hormonal conditions have been linked with the risk for breast ***,an elevated risk for breast cancer has been related to reproductive history and exogenous estrogen exposure because they may amplify lifetime estrogen *** these factors address the total cumulative exposure to circulating ovarian sex hormones that a female is vulnerable to in her lifetime.A healthy lifestyle,a more extended breastfeeding period,and regular physical activity may help lower one’s *** review summarizes the factors that increase the risk of estrogen/progesterone(hormone receptor)receptor-positive breast cancer due to overall cumulative estrogen exposure,with an understanding of estrogen biosynthesis mechanisms and estrogen receptor signaling.

关键词： alterations elevated exposure

Impacts of soil fertility management on productivity and economics of rice and fodder intercropping systems under rainfed conditions in Odisha,India

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Journal of Integrative Agriculture 2021年第12期20卷 3114-3126页

作者： Dilip kumar BASTIA subrat kumar BEHERA Manas Ranjan PANDA All India Coordinated Research Project for Dryland Agriculture Odisha University of Agriculture and Technology(OUAT)Phulbani 762001India

Under small and marginal farm conditions,allocation of land exclusively for forages is not ***,integration of forages in existing crop geometry can ensure production of grain and fodder,simultaneously under rainfed *** experiment was conducted to study the effect of different nutrient management practices on rice and fodder intercropping systems under rainfed conditions during *** intercropping system comprised(i)sole rice(R),(ii)rice and cowpea(5:2)(CP)and(iii)rice and ricebean(5:2)(RB)whereas the different nutrient management practices comprised(i)application of farm yard manure(FYM)at 5t ha^(-1)(farmers'practice)(N_(1)),(ii)application of inorganic fertilizer(recommended dose of fertilizer(RDF)of rice,60:30:30 kg ha^(-1) of N:P_(2)O_(5):K_(2)O)(N_(2))and(iii)application of both FYM at 5t ha^(-1) and 50%of RDF inorganic fertilizer(N3).The results of the experiment revealed that the growth attribute such as leaf area was influenced significantly when fodder crops were taken as intercrops because rice plant was getting more nitrogen from soil due to nitrogen fixation of leguminous fodder *** the nutrient management practices,significant differences in leaf area were found beween N2 and and between N_(3)and N_(1)***,regarding total number of effective tillers,significant differences were found neither between nutrient management practices nor between cropping *** rice equivalent yield(REY)based on price(REY_(P))was found to be significantly lower in CP(2615 kg ha^(-1);-6.4%)and RB intercropping systems(2571 kg ha^(-1);-8.0%)than in R monocropping system(2794 kg ha^(-1)).However,the REY based on energy(REY_(E))of CP(2999 kg ha^(-1);+7.3%)and RB(2960 kg ha^(-1);+5.9%)were found to be significantly higher than that of R(2794 kg ha^(-1))irrespective of nutrient management *** different nutrient management practices,the N3 treatment recorded the highest REY_(P)and REY_(E)which was at par with

关键词： rice-based intercropping system fodder cultivation nutrient management rice and cowpea fodder intercropping system rice and ricebean fodder intercropping system

Chlorination roasting-coupled water leaching process for potash recovery from waste mica scrap using dry marble sludge powder and sodium chloride

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International Journal of Minerals,Metallurgy and Materials 2020年第9期27卷 1203-1215页

作者： Sandeep kumar Jena Jogeshwar Sahu Geetikamayee padhy Swagatika Mohanty Ajit Dash Mineral Processing and Central Characterization Department Council of Scientific and Industrial Research(CSIR)-Institute of Minerals and Materials Technology(IMMT)BhubaneswarOdisha 751013India

The present paper reports the effective utilization of marble sludge powder(MSP)for the recovery of potash values from waste mica scrap using chlorination roasting-water leaching *** studies indicated the presence of dolomite as the major mineral phase in MSP,whereas muscovite and quartz were observed in the mica *** acid leaching studies suggest a maximum of 22%potash recovery under conditions:4 M H2SO4 acid,particle size of^100μm,stirring speed of 600 r/min,leaching temperature of 75℃,and leaching time of 90 *** chlorination roasting-water leaching process was adopted to achieve the lowest level of 80%-90%potash *** optimum conditions for the recovery of^93%potash from mica(~8.6wt%K2O)requires 900℃ roasting temperature,30 min roasting time,and 1:1:0.75 mass ratio of mica:MSP:*** roasting temperature and amount of NaCl are found to be the most important factors for the recovery *** reaction mechanism suggests the formation of different mineral phases,including sylvite(KCl),wollastonite,kyanite,and enstatite,during roasting,which were confirmed by X-ray diffraction(XRD)analyses and scanning electron microscopy(SEM)*** MSP-blended NaCl additive is more effective for potash recovery compared with the other reported commercial roasting additives.

关键词： potash recovery mica scrap marble sludge powder chlorination roasting water leaching

Local binary pattern-based reversible data hiding

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CAAI Transactions on Intelligence Technology 2022年第4期7卷 695-709页

作者： Monalisa Sahu Neelamadhab padhy Sasanko Sekhar Gantayat Aditya kumar Sahu Department of Computer Science and Engineering School of Engineering and TechnologyGIET UniversityGunupurOdishaIndia Department of Computer Science and Engineering GMRITRajamAndhra PradeshIndia Department of CSE Vignan's Foundation for Science Technology and ResearchVadlamudiAndhra PradeshIndia

A novel local binary pattern-based reversible data hiding(LBP-RDH)technique has been suggested to maintain a fair symmetry between the perceptual transparency and hiding *** embedding,the image is divided into various 3×3 ***,using the LBP-based image descriptor,the LBP codes for each block are ***,the obtained LBP codes are XORed with the embedding bits and are concealed in the respective blocks using the proposed pixel readjustment ***,each cover image(CI)pixel produces two different stego-image ***,during extraction,the CI pixels are restored without the loss of a single bit of *** outcome of the proposed technique with respect to perceptual transparency measures,such as peak signal-to-noise ratio and structural similarity index,is found to be superior to that of some of the recent and state-of-the-art *** addition,the proposed technique has shown excellent resilience to various stego-attacks,such as pixel difference histogram as well as regular and singular ***,the out-off boundary pixel problem,which endures in most of the contemporary data hiding techniques,has been successfully addressed.

关键词： hiding capacity(HC) local binary pattern(LBP) peak signal-to-noise ratio(PSNR) reversible data hiding

A review on developing high-performance ZE41 magnesium alloy by using bulk deformation and surface modification methods

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Journal of Magnesium and Alloys 2023年第3期11卷 776-800页

作者： subrat kumar Baral Manjusha M.Thawre B.Ratna Sunil Ravikumar Dumpala Department of Mechanical Engineering Visvesvaraya National Institute of TechnologyNagpur 440010India Department of Metallurgical and Materials Engineering Visvesvaraya National Institute of TechnologyNagpur 440010India Department of Mechanical Engineering Bapatla Engineering CollegeBapatla 522102India

Magnesium(Mg)alloys are generally used in light-weight structural applications due to their higher specific ***,the usage of these Mg alloys is limited due to their poor formability at room temperature,which is attributed to lower count of slip systems associated with the hcp crystal *** address these limitations,several new magnesium alloys and also many processing strategies have been developed and reported in the ***41 Mg is an alloy with significant quantities of zinc(Zn)and rare earth(RE)elements and has emerged as a promising material for aerospace,automotive,electronics,biomedical and many other *** make this alloy more competitive and viable,it should possess better mechanical and corrosion ***,the current paper reviews the effect of bulk mechanical processing on grain refinement,microstructural modification,and corresponding changes in the mechanical behaviour of ZE41Mg ***,the effect of various surface modification techniques on altering the surface microstructure and surface properties such as wear and corrosion are also briefly summarized and *** review also discusses the challenges and the future perspectives in developing high-performing ZE41 Mg alloys.

关键词： ZE41 magnesium alloy Bulk deformation Surface modification Mechanical properties Wear Corrosion

The incidence of sporadic viral hepatitis in North India:a preliminary study

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Hepatobiliary & Pancreatic Diseases International 2007年第6期6卷 596-599页

作者： subrat kumar Radha Kanta Ratho Yogesh kumar Chawla Anuradha Chakraborti Department of Virology Department of Hepatology Department of Experimental Medicine and Biotechnology

BACKGROUND: Viral hepatitis is one of the major causes of mortality and morbidity in developing countries. Hepatitis E virus (HEV) among the major etiological agents is responsible for both sporadic and epidemic outbreaks. The epidemic outbreak is water-borne whereas the sporadic outbreak is possibly through contact. Various diagnostic tools at times fail to pinpoint the cause of viral hepatitis. This study was carried out to evaluate the utility of ELISA and nRT-PCR (nested reverse transcriptase polymerase chain reaction) for the diagnosis of sporadic and acute viral hepatitis (AVH) caused by HEV in an endemic situation in North India. METHODS: Serum samples were collected from all the affected and suspected persons and subjected to serological detection of HAV IgM, HBsAg, HCV antibody and HEV IgM. The samples that were positive for HEV IgM were further processed for the detection of HEV RNA by nRT-PCR. RESULTS: A total of 843 samples were collected from 685 patients with AVH, 70 patients with fulminant hepatic failure (FHF), 53 patients with chronic liver disease (CLD), 11 patients with antituberculosis therapy (ATT)-induced jaundice, and 24 pregnant women. The percentage of positivity for anti-HEV IgM was 58.3% in the pregnant women, 41.4% in the paients with FHF, 38.6% in the patients with AVH, 9.4% in the patients with CLD and 18.2% in the patients with ATT induced jaundice. 9.4% of HBsAg carriers were positive for anti-HEV IgM. Males outnumbered females (62.8% vs. 37.1%). Furthermore, the rates of fulminant and acute outbreaks of hepatitis with HEV RNA positivity were 41.4% and 9.4%, respectively. CONCLUSION: Serological and molecular analysis should be combined for the diagnosis of viral infections, especially in endemic areas.

关键词： viral hepatitis fulminant liver failure pregnancy