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Acetic acid chromoendoscopy: Improving neoplasia detection in Barrett's esophagus

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World Journal of Gastroenterology 2016年第25期22卷 5753-5760页

作者： Fergus JQ Chedgy Sharmila subramaniam Kesavan Kandiah Sreedhari Thayalasekaran Pradeep Bhandari Department of Gastroenterology Queen Alexandra Hospital

Barrett’s esophagus (BE) is an important condition given its significant premalignant potential and dismal five-year survival outcomes of advanced esophageal adenocarcinoma. It is therefore suggested that patients with a diagnosis of BE undergo regular surveillance in order to pick up dysplasia at an earlier stage to improve survival. Current “gold-standard” surveillance protocols suggest targeted biopsy of visible lesions followed by four quadrant random biopsies every 2 cm. However, this method of Barrett’s surveillance is fraught with poor endoscopist compliance as the procedures are time consuming and poorly tolerated by patients. There are also significant miss-rates with this technique for the detection of neoplasia as only 13% of early neoplastic lesions appear as visible nodules. Despite improvements in endoscope resolution these problems persist. Chromoendoscopy is an extremely useful adjunct to enhance mucosal visualization and characterization of Barrett’s mucosa. Acetic acid chromoendoscopy (AAC) is a simple, non-proprietary technique that can significantly improve neoplasia detection rates. This topic highlight summarizes the current evidence base behind AAC for the detection of neoplasia in BE and provides an insight into the direction of travel for further research in this area.

关键词： Barrett’ s esophagus Acetic acid Esophageal adenocarcinoma Chromoendoscopy Dysplasia

Ale beer containing free and immobilized Lactobacillus brevis, a potential deliverysystem for probiotics

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Food Production, Processing and Nutrition 2021年第1期3卷 92-105页

作者： Kriza Faye Calumba Vondel Reyes Franklin Bonilla Elio Villasmil subramaniam Sathivel School of Nutrition and Food Sciences 220 H.D.Wilson LaboratoriesLouisiana State University Agricultural CenterBaton RougeLA 70803USA Department of Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA

Probiotics in ale beer may be attractive to health-conscious ***,beer conditions may decrease probiotic *** produced from durian(Durio zibethinus)rind,a by-product that is currently unutilized,can be used for the immobilization of *** medium was incubated with Lactobacillus brevis and periodically sampled to obtain the growth *** beer with free *** and cells immobilized in durian rind powder was produced and separately assessed during storage at 21°C for 24 *** physico-chemical parameters of both beers did not differ *** rind powder conferred protection up to 12 days of storage with the immobilized cells in the beer having a significantly higher count than the free cells,which can be due to the acid detergent fiber content(19.67%).Free and immobilized cells remained viable with counts of 4.89 and 5.00 log CFU/mL of beer,respectively,at the end of the storage *** treatments had approximate counts of 5 log CFU/mL after 120 min in simulated gastric and intestinal *** predominant bacterial species present at the end of storage were *** and *** study suggests that ale beer could be a potential delivery system for free and immobilized probiotic *** is one of the few studies demonstrating the use of probiotic lactic acid bacteria in beer brewing.

关键词： Probiotics Beer Durian Viability

Reinforcement Learning to Improve QoS and Minimizing Delay in IoT

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Intelligent Automation & Soft Computing 2023年第5期36卷 1603-1612页

作者： Mahendrakumar subramaniam V.Vedanarayanan Azath Mubarakali S.Sathiya Priya Department of Electronics and Communications Engineering Velalar College of Engineering and TechnologyErodeTamil NaduIndia Department of Electronics and Communication Engineering Sathyabama Institute of Science and TechnologyChennaiTamil NaduIndia College of Computer Science King Khalid UniversityAbhaSaudi Arabia Department of Electronics and Communications

Machine Learning concepts have raised executions in all knowledge domains,including the Internet of Thing(IoT)and several business *** of Service(QoS)has become an important problem in IoT surrounding since there is a vast explosion of connecting sensors,information and ***-sor data gathering is an efﬁcient solution to collect information from spatially dis-seminated IoT *** Learning Mechanism to improve the QoS(RLMQ)and use a Mobile Sink(MS)to minimize the delay in the wireless IoT s proposed in this ***,we use machine learning concepts like Rein-forcement Learning(RL)to improve the QoS and energy efﬁciency in the Wire-less Sensor Network(WSN).The MS collects the data from the Cluster Head(CH),and the RL incentive values select *** incentives value is computed by the QoS parameters such as minimum energy utilization,minimum bandwidth utilization,minimum hop count,and minimum time *** MS is used to col-lect the data from CH,thus minimizing the network *** sleep and awake scheduling is used for minimizing the CH dead in the *** work is simu-lated,and the results show that the RLMQ scheme performs better than the base-line *** prove that RLMQ increased the residual energy,throughput and minimized the network delay in the WSN.

关键词： Wireless sensor network quality of service parameters Internet of things reinforcement learning mobile sink

Immobilization of Lactobacillus plantarum NCIMB 8826 ameliorates Citrobacter rodentium induced lesions and enhances the gut inflammatory response in C57BL/6 weanling mice

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Food Production, Processing and Nutrition 2022年第1期4卷 447-458页

作者： Emmanuel Kyereh Diana Coulon Ingeborg Langohr Anne Raggio Michael Keenan subramaniam Sathivel School of Nutrition and Food Sciences Louisiana State University Agriculture Center220 H.D.Wilson LaboratoriesLSU Agricultural CenterBaton RougeLA 70803USA Bioassay Core Laboratory Agricultural CenterLouisiana State UniversityBaton RougeLAUSA Department of Pathobiological Sciences Louisiana State UniversityBaton RougeLAUSA Department of Biological and Agriculture Engineering Louisiana State UniversityBaton RougeLAUSA

Infectious diarrhea is a major cause of infant mortality in most developing countries. In this research, we evaluated the potential of immobilized Lactobacillus plantarum NCIMB 8826 on weanimix infant cereal and its effectiveness in reducing the severity of Citrobacter rodentium-induced diarrhea in weanling mice. Thirty-six C57BL/6 weanling mice were placed into four groups (n = 9 each;negative, positive, prevention and cure). Mice received either L. plantarum (109 CFU/g) immobilized on weanimix infant cereal 3 days before C. rodentium (109 CFU/ ml) infection (Prevention) or 3 days after C. rodentium infection (Cure). A positive control group was infected with C. rodentium only, while a nega-tive control group received neither L. plantarum nor C. rodentium. Positive control mice showed colonic mucosal and submucosal inflammation, erosion, and mucosal epithelia hyperplasia with the C. rodentium infection. Mice in the prevention and cure groups had less severe histologic alterations in the colon. Some beneficial effect of L. plantarum was observed in cecal short-chain fatty acid concentrations, which stimulates water and electrolytes absorption to reduce diarrhea. Our findings demonstrated that L. plantarum NCIMB 8826 could be immobilized on weanimix infant cereal to help reduce diarrhea during weaning.

关键词： Probiotics Citrobacter rodentium Lactobacillus plantarum Inflammation Weanimix

Modelling and Coordinated Control of Grid Connected Photovoltaic,Wind Turbine Driven PMSG,and Energy Storage Device for a Hybrid DC/AC Microgrid

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Protection and Control of Modern Power Systems 2023年第1期8卷 180-193页

作者： Prabhakaran Koothu Kesavan Umashankar subramaniam Dhafer Jaber Almakhles Sivakumar Selvam Renewable Energy Laboratory the Department of Electrical EngineeringPrince Sultan UniversityRiyadh11586Saudi Arabia 不详

In a DC/AC microgrid system,the issues of DC bus voltage regulation and power sharing have been the subject of a significant amount of ***-tion of renewable energy into the grid involves multiple converters and these are vulnerable to perturbations caused by transient *** enhance the flexibility and controllability of the grid connected converter(GCC),this paper proposes a common DC bus voltage maintenance and power sharing control strategy of a GCC for a DC/AC microgrid.A maximum power point tracking algorithm is employed to enhance the power delivered by the wind turbine and photovoltaic *** proposed control strategy consists of primary and secondary *** the primary layer control,the DC bus voltage is regulated by the *** the secondary layer,the DC bus voltage is maintained by the energy storage *** ensures reliable power for local loads during grid failures,while power injection to the grid is controlled by an en-ergy management algorithm followed by reference gen-eration of inductor current in the *** proposed control strategy operates in different modes of DC voltage regulation,power injection to the grid and a hybrid op-erating *** provides wide flexible control and en-sures the reliable operation of the *** pro-posed and conventional techniques are compared for a 15.8 kW DC/AC microgrid system using the MATLAB/Simulink *** simulation results demonstrate the transient behaviour of the system in different operating *** proposed control technique is twice as fast in its transient response and produces less oscillation than the conventional *** Terms—Wind energy,photovoltaic energy,DC/AC microgrid,battery energy storage system,co-ordinated control.

关键词： Wind energy photovoltaic energy DC/AC microgrid battery energy storage system co-ordinated control

Metaheuristic Based Clustering with Deep Learning Model for Big Data Classification

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Computer Systems Science & Engineering 2023年第1期44卷 391-406页

作者： R.Krishnaswamy Kamalraj subramaniam V.Nandini K.Vijayalakshmi Seifedine Kadry Yunyoung Nam Department of Electronics and Communication Engineering University College of Engineering AriyalurAriyalur621704India Department of Biomedical Engineering Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore641021India Department of Computer Science and Engineering Sona College of TechnologySalem636005India Department of Electronics and Communication Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai600077India Deparmtent of Applied Data Science Noroff University CollegeKristiansandNorway Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea

Recently,a massive quantity of data is being produced from a distinct number of sources and the size of the daily created on the Internet has crossed two *** the same time,clustering is one of the efficient techniques for mining big data to extract the useful and hidden patterns that exist in ***-based clustering techniques have gained significant attention owing to the fact that it helps to effectively recognize complex patterns in spatial *** data clustering is a trivial process owing to the increasing quantity of data which can be solved by the use of Map Reduce *** this motivation,this paper presents an efficient Map Reduce based hybrid density based clustering and classification algorithm for big data analytics(MR-HDBCC).The proposed MR-HDBCC technique is executed on Map Reduce tool for handling the big *** addition,the MR-HDBCC technique involves three distinct processes namely pre-processing,clustering,and *** proposed model utilizes the Density-Based Spatial Clustering of Applications with Noise(DBSCAN)techni-que which is capable of detecting random shapes and diverse clusters with noisy *** improving the performance of the DBSCAN technique,a hybrid model using cockroach swarm optimization(CSO)algorithm is developed for the exploration of the search space and determine the optimal parameters for density based ***,bidirectional gated recurrent neural network(BGRNN)is employed for the classification of big *** experimental validation of the proposed MR-HDBCC technique takes place using the benchmark dataset and the simulation outcomes demonstrate the promising performance of the proposed model interms of different measures.

关键词： Big data data classification clustering mapreduce dbscan algorithm

Echovirus serotypes circulating in Malaysia from 2002 to 2013

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 246-249页

作者： Jeyanthi Suppiah TS Saraswathy subramaniam Amry Khursany Ismail Apandi Yusof Zainah Sa'at Virology Unit Infectious Disease Research CentreInstitute for Medical Research

Objective:To identify the circulating serotypes of human echovinis in Malaysia from 2002 in ***:A toial of 31 retrospective samples from non-polio acute flacid paralysis,hand-food-and-mouth disease,viral meningitis and enterovirus cases were subjected to amplification of partial VPI gene by ***:Sequencing and phylogeneiic analysis of the partial sequences identified presence of human echovinis and human coxsackie *** was found that echovinis 11 was the commonly circulating serotype followed by *** *** *** *** 30 and echovinis I in decreasing *** two types of human coxsackie virus isolates were detected which were coxsackie A24 and ***:From the findings,there is a possibility that echovinis 11 is the predominant serotype among Malaysian patients with echovinis ***,a larger sample size will yield a more confident result to support this evidence.____________________

关键词： Echovirus VPI Malaysia Phylogenetic Serotype

Assessment of Dental Caries and Oral Hygiene Status Among Twins

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Journal of Forensic Science and Medicine 2018年第1期4卷 18-22页

作者： Priya subramaniam K L Girish Babu Bharath Vardhana Department of Pedodontics and Preventive Dentistry The Oxford Dental College and HospitalBengaluru1Departmentof DentistryHassan Institute of Medical SciencesHassanKarnatakaIndia

The study of twins provides a unique opportunity to evaluate the genetic and nongenetic contributions to a variance of multitude of *** research has revealed the impact of a strong genetic component to the variance of many dental *** present study was conducted to assess the dental caries and oral hygiene status in monozygotic(MZ)and dizygotic(DZ)twins.A random sample of 129 MZ and DZ twin pairs aged 6-15 years were included in this *** zygosity of twin pairs was initially recorded by facial appearance and later determined by *** caries and oral hygiene status were recorded in these twin pairs and the data were subjected to statistical *** significant difference was observed in the mean decayed,extracted due to caries and filled teeth(deft)in primary dentition and decayed,missing and filled(DMFT)in permanent dentition scores and oral hygiene status in MZ and DZ twin pair&The similarity observed in oral health status reflects the effects of a shared environment in MZ and DZ twin pairs.

关键词： Dental caries dermatoglyphics facial appearance oral hygiene index-simplified zygosity

Safety and efficacy of intravitreal anti vascular endothelial growth factor for severe posterior retinopathy of prematurity with flat fibrovascular proliferation

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世界临床儿科杂志 2023年第4期12卷 220-229页

作者： Puja Maitra subramaniam Prema Venkatapathy Narendran Parag K Shah Pediatric Retina and Ocular Oncology Aravind Eye Hospital and Postgraduate Institute of OphthalmologyCoimbatore 641014Tamil NaduIndia

BACKGROUND Intravitreal anti-vascular endothelial growth factor(IVA)injection is known to cause contraction of fibrovascular proliferation(FVP),when present in severe retinopathy of prematurity(ROP).AIM To assess the structural outcomes of IVA injection in the treatment of severe posterior ROP with significant *** It was a retrospective study in which 36 eyes of 18 preterm babies who developed>4 clock hours of FVP in zone I or posterior zone II,were treated with either intravitreal 0.625 mg bevacizumab or intravitreal 0.2 mg of *** structural outcome included resolution of plus disease and FVP without the development of tractional retinal *** outcome measure included either full retinal maturation at follow-up or development of recurrent disease requiring additional *** outcomes included progression to retinal *** The mean gestational age of the 18 preterm babies was 30 wk(range 27-36),and mean birth weight was 1319 g(range 650-1980 g).Mean post-menstrual age(PMA)at the time of primary treatment was 35.5 wk(range 31-41 wk).All eyes showed regression of plus disease and FVP.5 eyes of 3 babies showed reactivation of disease and were treated with repeat IVA(n=2 eyes)or peripheral laser photocoagulation(n=3 eyes)respectively.16 out of 36(44%)reached retinal vascular maturation at final follow up at 5 *** There was good resolution of severe posterior ROP with FVP with IVA,with retinal maturity of 44%at 5 year follow-up and a reactivation rate of 13.8%.When the IVA injection is given prior to 37 wk PMA,while disease is in phase 2,it is less likely to cause contracture of pre-existing FVP.

关键词： Retinopathy of prematurity Anti-vascular endothelial growth factor injection Contraction Crunch phenomenon