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Anti-Osteoporosis and Anti-Osteoarthritis Activity of Fresh Water Snail <i>(Viviparous bengalensis)</i>Flesh Extract in Experimental Animal Model

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第1期3卷 10-17页

作者： Amrita Sarkar Poulami Datta Aparna Gomes subir chandra das gupta Antony Gomes Department of Zoology Maulana Azad College Kolkata India Indian Institute of Chemical Biology Kolkata India Laboratory of Toxinology & Experimental Pharmacodynamics Department of Physiology University of Calcutta Kolkata India

Aims: Aim was to evaluate the anti-osteoporotic and anti-osteoarthritic activity of fresh water snail (Viviparous bengalensis) (VB) flesh extract (VBE) in experimental model. Settings and Design: Experimental osteoporosis (OSP) was developed in female Wistar rats by bilateral overectomy and Osteoarthritis (OA) was developed in male Wistar rats by bacterial collagenase injection. Methods and Material: VB was collected locally and authenticated, then homogenized in 3500 rpm × 15 mins and supernatant was collected. Rats were divided into-Group-1: Sham control, Group-2: OSP/OA control, Group-3: Standard (vitD3 200 mg·kg -1;p.o., calcium i.p. 1500 mg·kg -1?× 15 days in OSP and indomethacin 0.25 mg·kg-1, p.o. × 5 alternative days in OA), Group-4: VBE treated (1 gm·kg-1;p.o. × 15 days), Group-5: VBE treated (2 mg·kg-1;p.o. × 15 days). Anti-osteoporotic and anti-osteoarthritic activity of VBE was examined through physical, urinary and serum parameters. Statistical use: Data were expressed in terms of mean ± SEM (n = 6). ANOVA was performed, p Key findings: It was observed that the body weight, ankle/ knee diameters, urinary markers hydroxyproline/glucosamine/calcium/phosphate/creatinine, serum ACP/ALP/TRAP, calcium/creatinine, cytokines (TNF-α/IL-1β/CINC-1) levels were changed significantly and restored after VBE treatment. Significance: Fresh water snail flesh extract possess anti-osteoporosis and anti-osteoarthritic activity in experimental animal models.

关键词： Water Snail Viviparous bengalensis Traditional Medicine Osteoporosis Osteoarthritis

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SCN1A rs6732655A/T polymorphism:Diagnostic and therapeutic insights for drug-resistant epilepsy

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World Journal of Experimental Medicine 2024年第3期14卷 72-79页

作者： Aroop Viswas Pradeep K Dabla Dharmsheel Shrivastav Swapan gupta Manisha Yadav Subhash Yadav Bidhan chandra Koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biotechnology Amity University GwaliorGwalior 474005Madhya PradeshIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACKGROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs,resulting in heightened mortality rates,psychosocial challenges,and a diminished quality of *** factors,particularly within the SCN1A gene,and the pro-inflammatory cytokine response is important in intricating the drug resistance in idiopathic epilepsy *** this extended study,we determined the correlation of rs6732655A/T single nucleotide polymorphism to understand the causative association of SCN1A gene with epilepsy drug resistance and inflammatory *** To find the correlation of SCN1A gene rs6732655A/T polymorphism with the drug-resistant epilepsy and inflammatory *** The study enrolled 100 age and sex-matched patients of both drug-resistant and drug-responsive epilepsy *** analysed the rs6732655A/T polymorphism to study its association and causative role in drug-resistant epilepsy cases using restriction fragment length polymorphism *** diagnostic performance of interleukin(IL)-1β,IL-6,and high mobility group box 1(HMGB1)protein levels was evaluated in conjunction with genotypic outcome receiver operating characteristic *** AT and AA genotypes of rs6732655 SCN1A gene polymorphism were associated with higher risk of drug resistance *** biomarkers IL-6,IL1βand HMGB1 demonstrated diagnostic potential,with cutoff values of 4.63 pg/mL,59.52 pg/mL and 7.99 ng/mL,respectively,offering valuable tools for epilepsy ***,specific genotypes(AA and AT)were found to be linked to the elevated levels of IL-1βand IL-6 and potentially reflecting increased oxidative stress and neuro-inflammation in drug-resistant cases supporting the previous reported outcome of high inflammatory markers response in drug resistance *** SCN1A genotypes AA and AT are linked to higher drug-resistant epilepsy *** findings underscore the potential influence of inflammation

关键词： Epilepsy Drug resistance SCN1A gene Pro-inflammatory cytokines Genetic factors

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An Autopsy and Histopathology-based Study to Ascertain the Cause of Death of Brought Dead Cases

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Journal of Forensic Science and Medicine 2024年第1期10卷 28-33页

作者： Chandan Bandyopadhyay Prabir chandra Paul Prabhas chandra Chakraborty Department of Forensic and State Medicine Medical CollegeKolkataWest BengalIndia Department of Pathology Jagannath Gupta Institute of Medical Science and HospitalKolkataWest BengalIndia Department of Forensic Medicine and Toxicology NRS Medical College and HospitalKolkataand M.G.M Medical College and L S.K HospitalKishanganjBiharIndia

Background and Objectives:The cases of apparent natural deaths are encountered in the hospital casualties who are noted dead at the time of the first medical attention and as such are labeled as“Brought Dead.”These include the cases of sudden death,unexplained death,and unattended *** cause of such deaths is reported in the literature to emanate principally from the cardiovascular system,though there are some documented geographical,racial,and other *** the present study,we endeavored to detect the cause of such natural deaths in terms of the disease and the organ system involved,in the deceased individuals of the contemporary Bengali population,with cases due to obvious unnatural causes being *** and Methods:An observational,cross-sectional study with 105(n=105,male:89,female:16)study subjects of age group of 20-80 years,selected by systemic random sampling,from the brought dead subjects coming to the mortuary of the NRS Medical College and Hospital for medicolegal autopsy from April 2011 to March 2012,excluding cases having a history of the obvious unnatural *** system-wise gross examination was done,followed by tissue sampling for histopathological *** case-wise findings were tabulated and analyzed for descriptive statistics using SPSS ***:In the present study,89 cases were male(84.8%)and 16 cases were female(15.2%),which reflects a male:female ratio of 5.56:*** dead bodies are mostly recovered from the footpaths(47 cases,44%).Sixty-four(61%)cases are of known *** 54 cases out of 105(51.4%),morbid pathology is detected in the respiratory system(RS),lobar pneumonia,and cavitary pulmonary tuberculosis being the most frequent disease entity,in both ***-one years-sixty-five years is found to be the most commonly affected age group,in both *** and Conclusions:The present study shows that the most common organ system involved in brought dead cases is the RS,which is s

关键词： Autopsy brought dead cause of death histopathology

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Visibility improvement and mass segmentation of mammogram images using quantile separated histogram equalisation with local contrast enhancement

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CAAI Transactions on Intelligence Technology 2019年第2期4卷 73-79页

作者： Bhupendra gupta Mayank Tiwari subir Singh Lamba PDPM Indian Institute of Information Technology Design & Manufacturing Jabalpur MP 482005 India

In this work, the authors develop a working software-based approach named ‘linearly quantile separated histogram equalisation-grey relational analysis’ for mammogram image (MI). This approach improves overall contrast (local and global) of given MI and segments breast-region with a specific end goal to acquire better visual elucidation, examination, and grouping of mammogram masses to help radiologists in settling on more precise choices. The fundamental commitment of this work is to demonstrate that results of good quality of breast-region segmentation can be accomplished from basic breast-region segmentation if the input image has good contrast and a better interpretation of hidden details. They have evaluated the proposed strategy for MIAS-MIs. Experimental results have shown that the proposed approach works better than state-of-the-art.

关键词： develop contrast approach

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Gallbladder perforation:A single-center experience in north India and a step-up approach for management

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 168-174页

作者： Vivek gupta Abhijit chandra Vishal gupta Ravi Patel Amit Dangi Ajay Pai Department of Surgical Gastroenterology King George’s Medical UniversityLucknowUttar Pradesh 226003India

Background: Spontaneous gallbladder perforation(GBP) is an uncommon diagnosis. This study presented the experience of managing spontaneous GBP over nine years at a large, tertiary care university hospital in north India and investigated the outcomes and treatment strategies. Methods: A retrospective review of prospectively maintained digital database of consecutive patients was performed. All patients received medical and/or surgical treatment for spontaneous GBP in our department between January 2010 and June 2018. Results: We identifed 151 patients(81 females and 70 males) with mean age of 53 years. Most common presenting features were pain(96.7%), fever(54.3%) and jaundice(31.1%). Most common cause was gallbladder stones(84.8%) followed by common bile duct stones(30.5%), xanthogranulomatous cholecystitis(17.9%) and malignancy(11.9%). As per Niemeier classifcation, 8.6% had type 1 GBP(free perforation in peritoneal cavity), 76.2% had type 2 GBP(localized perforation) and 13.2% had type 3 GBP(cholecystoenteric fstula). About 60% of the perforations were diagnosed preoperatively. Type 1 was more common in patients with diabetes and also had the worst prognosis. Surgery was performed in 109 patients(72.2%). Seven patients(4.6%) had a postoperative morbidity of Clavien-Dindo Ⅲ or higher. There were three mortalities in patients who underwent surgery. Conclusions: High index of suspicion is required for preoperative diagnosis of GBP, especially in types 2 and 3. Laparoscopic cholecystectomy can be difficult in these patients and patients may require open or partial cholecystectomy. Early diagnosis and step-up approach for the treatment of GBP is critical.

关键词： Acute calculus cholecystitis Cholecystectomy Cholecysto-enteric fstula Niemeier classifcation

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An evaluation of the emission profile for two-wheelers at a traffic junction

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Particuology 2015年第1期13卷 112-119页

作者： Avinash Kumar Agarwal Prakhar Bothra Tarun gupta Pravesh chandra Shukla Engine Research Laboratory Department of Mechanical EngineeringIndian Institute of Technology Kanpur Department of Civil Engineering Indian Institute of Technology Kanpur

Two-wheeler vehicles are an important mode of transportation in developing countries. However, the emissions from two-wheeler vehicles are significant. Urban two-wheeler vehicles with gasoline-fueled engines produce NOx and particulate matter emissions that affect urban air quality. During traffic light stops and programmed stops, for instance, pollutants are emitted and are dangerous to human health. In this experimental study, two-wheeler vehicles with different makes, technologies and engine capacities were tested for exhaust emissions including gravimetric and online measurements at different engine speeds and a no load condition at a simulated traffic junction. Gravimetric measurements were performed by collecting the particulate mass （at two engine speeds： 1500 and 2500 rpm） from a diluted engine-out exhaust on quartz filter paper. Next, these collected particulates were used to determine the presence of metals, as well as the benzene soluble organic fraction （BSOF）. The total particulate mass, BSOF and trace elements were slightly higher at a higher engine speed （2500 rpm）. Online measurements were performed by sampling the engine exhaust （at four engine speeds： 1500, 2000, 2500, and 3000rpm） and using online instruments to determine the particle number and size distribution, the particle-bound polyaromatic hydrocarbons （PAHs）, the gaseous emissions and the smoke opacity. Engines with higher cubic capacity emitted a higher concentration of nano-particles. The particle-bound PAH concentration increased as the engine speed increased, but this concentration was notably low for the highest engine speed tested （3000 rpm）. The regulated gaseous emissions increased as the engine speed increased for all vehicles.

关键词： Benzene soluble organic fraction (BSOF) Particle number and size distribution Trace elements Polyaromatic hydrocarbons (PAHs) Regulated gaseous emissions

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Emission profiling of diesel and gasoline cars at a city traffic junction

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Particuology 2015年第1期13卷 186-193页

作者： Avinash Kumar Agarwal Tarun gupta Prakhar Bothra Pravesh chandra Shukla Engine Research Laboratory Department of Mechanical EngineeringIndian Institute of Technology Kanpur Department of Civil Engineering Indian Institute of Technology Kanpur

In congested urban roads, cars must stop at intersections because of city traffic lights. As a result, pedestri- ans and traffic police personnel are exposed to pollutants emanating from the tailpipe of various vehicles at such city trafficjunctions. In this study, various gasoline- and diesel-fueled cars complying with differ- ent emission standards were tested for their emissions in simulated city traffic junction conditions. The engine exhaust from these cars was subjected to physicochemical characterization at different engine speeds under no-load conditions. These engine conditions were chosen because the cars idle at differ- ent engine speeds at a city traffic junction. Gravimetric and real-time measurements were performed for the tailpipe exhaust sampled from these vehicles. Exhaust particles were collected on 47 mm diameter quartz filter papers and subjected to gravimetric analysis for determining the total particulate mass （TPM） and trace metals while the engines were operated at two different engine idling speeds, 1500 rpm （representing low idling） and 2500 rpm （representing high idling）. At similar engine operating condi- tions, TPM and trace metals were lower for the exhaust from gasoline engines compared to the exhaust from diesel engines. Real-time measurements were performed for particle-bound poly-aromatic hydro- carbons （PAHs）, particle number and size distribution, regulated gaseous emissions and smoke opacity of the exhaust at four different engine speeds, 1500, 2000, 2500, and 3000 rpm. Particle-bound PAHs showed a decreasing trend for the vehicles that complied with stricter vehicular emission standards. Higher particle peak number concentrations were observed for diesel exhausts compared to the results for gasoline exhaust. Regulated gaseous emissions were also comoared.

关键词： Traffic junctions Traffic stop emissions Particle number emission Particle mass emissions Diesel and gasoline fueled cars

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Optimization of substrate ratio for beer production from finger millet and barley

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International Journal of Agricultural and Biological Engineering 2015年第2期8卷 110-120页

作者： Sanjay Kumar Anupama Singh Navin chandra Shahi Khan Chand Kopal gupta Department of Post-harvest Process&Food Engineering College of TechnologyG.B.Pant University of Agriculture and TechnologyPantnagar 263145Udham Singh NagarUttarakhandIndia

Seventeen designed experiments were conducted in three steps(malting,brewing and fermentation)to produce beer from barley,finger millet and the combination of *** of independent variables with three levels for each *** ratios of grains(100:0,50:50,0:100),kilning temperature(50℃,70℃,90℃)and malted grain to water ratios(1:3,1:5,1:7)were investigated on product *** results of the study indicated that all the independent parameters *** ratio,kilning temperature and slurry ratio affected the responses(pH,colour,bitterness and alcohol content)*** values of parameters,from the simultaneous optimization done using Design Expert 8.***.6.1 software,for beer production,were found to be 68:32 blend ratio,50℃ kilning temperature and 1:7 slurry *** model F-value was found to be highly significant at 1% level of significance for all the *** the responses could be predicted by fitting the second order mathematical model and adequacy checked by R^(2).

关键词： beer production fermentation technology blend ratio alcohol content bitterness finger millet barley

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Blumgart's technique of pancreaticojejunostomy: Analysis of safety and outcomes

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 181-187页

作者： Vishal gupta Saket Kumar Vivek gupta Pradeep Joshi Rahul Rahul Rakesh Kumar Yadav Amit Dangi Abhijit chandra Department of Surgical Gastroenterology King George's Medical University Department of Human Organ Transplant King George's Medical University

Background: Blumgart's pancreaticojejunostomy(PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes. Methods: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. The primary endpoint was the occurrence of a clinically relevant postoperative pancreatic fistula(CR-POPF) and analysis of its risk factors. Results: The CR-POPF rate was 12.3%. Fistula risk score(FRS) was the only significant risk factor for the occurrence of overall POPF in multivariate analysis. However, none of the other factors including FRS was found to be significantly associated with CR-POPF risk. A strong positive correlation was found between the CR-POPF and the incidence of delayed gastric emptying, post-pancreatectomy hemorrhage and increased length of hospital stay. Conclusion: Blumgart's technique is a safe technique of pancreatico-enteric anastomosis with low rates of CR-POPF. CR-POPF with this technique is independent of most of the preoperative and intraoperative factors. Therefore, this technique can be used for all types of the pancreas with consistently good results.

关键词： Pancreaticoduodenectomy Pancreatico-jejunal anastomosis Postoperative pancreatic fistula Pancreatic leak

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Morpho-anatomical and physicochemical studies of Fumaria indica(Hausskn.)Pugsley

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Asian Pacific Journal of Tropical Biomedicine 2012年第10期2卷 830-834页

作者： Prakash chandra gupta Ch V Rao University Institute of Pharmacy Chhatrapati Shahu Ji Maharaj University National Botanical Research Institute

Objective:To study morpho-anatomical characters and physicochemical analysis of Fumaria indica(***)(Hausskn.)Pugsley,(Fumariaceae),an important medicinal plant used extensively for treating a variety of ailments in various system of indigenous ***:Evaluation of the different parts of the plant was carried out to determine the morphoanatomical,physicochemical,phytochemical and HPTLC fingerprinting profile of *** and other WHO recommended methods were performed for ***:Morphoanatomical studies showed compound and pinnatifid leaf,4 to 6 cm in length,linear and oblong in shape and anomocytic arrangement of stomata,thin walled parenchymatous cells,scattered,sclerenchymatous,capped vascular bundles and radiating medullary *** studies showed foreign matter 0.2%,loss on drying 6.8%,total ash 16.77%,alcohol and water soluble extractives 8.92%and 20.26%,respectively,sugar 17.75%,starch 22.97%and tannins 2.37%.Phytochemical evaluation revealed the presence of carbohydrate,alkaloids,flavonoids,saponins,tannins and *** layer chromatography was carried out with different solvents and the best solvent system was chloroform and methanol in 80:20 ratio and revealed 12 spots with different R_f value under UV light 366λ.Conclusions:The results of the study can serve as a valuable source of information and provide suitable standards for identification of this plant material for future investigations and applications.

关键词： Morpho-anatomy Transverse sections HPTLC Stomata Xylem Physicochemical

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