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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-377页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim yoo Min Kim Minah Cho Keun Won Ryu Hong Man yoon Young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Republic of Korea Gastric Cancer Center Yonsei Cancer CenterYonsei University Health SystemSeoul 03722Republic of Korea Center for Gastric Cancer National Cancer CenterGoyang 10408Republic of Korea Department of Surgery Chonnam National University Hwasun HospitalChonnam National University College of MedicineGwangju 58128Republic of Korea Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273Republic of Korea Department of Hematology-Oncology Yeungnam University Medical CenterDaegu 42415Republic of Korea Department of Surgery Soonchunhyang University College of MedicineBucheon 14584Republic of Korea Department of Surgery Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151Republic of Korea Department of Surgery Chung-Ang University HospitalChung-Ang University College of MedicineSeoul 06973Republic of Korea

Objective:Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy *** this study,we evaluated the clinical feasibility of the single patient classifier(SPC)test,a new clinical-grade prognostic assay,in stageⅡ-Ⅲgastric cancer ***:A prospective multicenter study was conducted,involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine *** SPC test was employed to stratify patients into risk groups,and its feasibility and performance were *** primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative ***,3-year disease-free survivals of risk groups were ***:The SPC test met the primary endpoint *** 99.5%of SPC tests were timely delivered to hospitals before the postoperative treatment *** a clinical setting,the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 ***,3-year disease-free survivals were significantly different between risk groups classified with SPC ***:This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment *** also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test advanced gastric cancer adjuvant chemotherapy feasibility gastrectomy

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黄海大海洋生态系滨海湿地保护:进展与建议

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国家公园（中英文） 2024年第4期2卷 272-280页

作者：曲方圆 Jae-Won yoo 王守强自然资源部第一海洋研究所渤海海峡生态通道野外科学观测研究站青岛266061 Korea Institute of Coastal Ecology Inc. Bucheon 14449

黄海大海洋生态系(YSLME)滨海湿地是东亚—澳大利西亚候鸟的中转站和越冬栖息地,对东亚-澳大利西亚迁徙路线的候鸟至关重要。由于过去几十年的经济发展,中国和韩国都开垦了大量的滨海湿地,因此生境丧失被确定为是对YSLME的一个重大跨界... 详细信息

黄海大海洋生态系(YSLME)滨海湿地是东亚—澳大利西亚候鸟的中转站和越冬栖息地,对东亚-澳大利西亚迁徙路线的候鸟至关重要。由于过去几十年的经济发展,中国和韩国都开垦了大量的滨海湿地,因此生境丧失被确定为是对YSLME的一个重大跨界威胁。为缓解这一跨界威胁,YSLME二期项目在其战略行动计划中提出数项管理行动计划,同时,旨在2030年前保护30%海洋的全球生物多样性保护目标(3030目标)也得到了通过。因此,重点介绍了中国和韩国在湿地保护法律法规、滨海湿地保护地建设、公众意识以及国际合作等方面的进展,并简要介绍了朝鲜的滨海湿地保护情况,为更好地解决滨海湿地丧失这一跨界威胁和实现3030目标提供了建议。YSLME滨海湿地保护主要进展为:中韩两国逐渐完善其湿地保护法律法规体系、早期滨海湿地面积急剧丧失的趋势在近年来得到缓解、两国都建立了越来越多的滨海湿地保护地、提升公众意识已经体现在各级法律法规中、中韩之间有持续的滨海湿地国际合作交流活动。对于未来的保护工作,提出了四点建议:扩大滨海湿地保护地面积、保护迁徙动物的生态廊道、加强YSLME滨海湿地保护地网络建设以及增强保护地信息的可获得性。

关键词：黄海大海洋生态系滨海湿地保护进展建议

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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan Win yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

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Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm Edwin J.yoo Ariel Isser Vivek P.Jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan P.Schneck Jordan J.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

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Ground settlement during tunneling in groundwater drawdown environment-Influencing factors

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Underground Space 2016年第1期1卷 20-29页

作者： Chungsik yoo School of Civil Architectural Engineering and Landscape ArchitectureSungkyunkwan University2066 Seoboo RoJan-An GuSuwonKyong-Gi Do 16419Republic of Korea

In this paper,the results of a parametric study on groundwater drawdown-induced surface settlement during tunneling in waterbearing ground are presented.A calibrated stress–pore pressure coupled finite element model was adopted for the parametric *** results were analyzed to establish the relationships between key design issues,such as the ground surface settlement and groundwater drawdown,and influencing *** artificial neural network(ANN)-based sensitivity analysis was performed to obtain insight into the relative importance of the influencing *** results indicated that the primary influencing factors on the settlement development are the thickness and stiffness of the soil layer within the drawdown zone and the lining permeability,while the initial void ratio and the permeability of the soil layer were considered secondary influencing *** implications and findings of the study are discussed.

关键词： Conventional tunneling Ground settlement Groundwater Finite element method Stress-pore pressure coupled analysis

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Representation of Urban Buildings Using Modified Relief Mapping

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Journal of Computer Science & Technology 2006年第2期21卷 204-208页

作者： Byounghynn yoo Soonhung Han Department of Mechanical Enginccring Koren Aduanced Institute of Science and TechnologyDeajeon305-701Korea

This paper describes the real-time mapping displacement of buildings onto the polygon model of base terrain of geo-spatial information,The buildings are represented as height maps,lcading to low memory requirements and not involving changes of the original geometry（*** vertices are created or displaced）.The displacement of buildings is mapped toward the protruding direction,The base of textrue which represents the ground in topography is correctly mapped onto base polygon without any *** approach can exhibit the correct,occlusions between buildings and ground due to parallax and correct self-occlusion.

关键词： acrial photograph digital map displacement mapping gco-visualization image-based rendering

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Numerical Modeling of a Spar Platform Tethered by a Mooring Cable

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 785-792页

作者： ZHU Xiangqian yoo Wan-Suk Computer Aided Engineering Laboratory School of Mechanical Engineering Pusan National University

Virtual simulation is an economical and efficient method in mechanical system design. Numerical modeling of a spar platform, tethered by a mooring cable with a spherical joint is developed for the dynamic simulation of the floating structure in ocean. The geometry modeling of the spar is created using finite element methods. The submerged part of the spar bears the buoyancy, hydrodynamic drag force, and effect of the added mass and Froude-Krylov force. Strip theory is used to sum up the forces acting on the elements. The geometry modeling of the cable is established based on the lumped-mass-and-spring modeling through which the cable is divided into 10 elements. A new element-fixed local frame is used, which is created by the element orientation vector and relative velocity of the fluid, to express the loads acting on the cable. The bottom of the cable is fixed on the seabed by spring forces, while the top of the cable is connected to the bottom of the spar platform by a modified spherical joint. This system suffers the propagating wave and current in the X-direction and the linear wave theory is applied for setting of the propagating wave. Based on the numerical modeling, the displacement-load relationships are analyzed, and the simulation results of the numerical modeling are compared with those by the commercial simulation code, Proteus DS. The comparison indicates that the numerical modeling of the spar platform tethered by a mooring cable is well developed, which provides an instruction for the optimization of a floating structure tethered by a mooring cable system.

关键词： numerical modeling dynamic simulation spar platform mooring cable spherical joint

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Numerical Modeling of a Spherical Buoy Moored by a Cable in Three Dimensions

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 588-597页

作者： ZHU Xiangqian yoo Wan-Suk Computer Aided Engineering Laboratory School of Mechanical Engineering Pusan National University

Floating facilities have been studied based on the static analysis of mooring cables over the past decades. To analyze the floating system of a spherical buoy moored by a cable with a higher accuracy than before, the dynamics of the cables are considered in the construction of the numerical modeling. The cable modeling is established based on a new element frame through which the hydrodynamic loads are expressed efficiently. The accuracy of the cable modeling is verified with an experiment that is conducted by a catenary chain moving in a water tank. In addition, the modeling of a spherical buoy is established with respect to a spherical coordinate in three dimensions, which can suffers the gravity, the variable buoyancy and Froude-Krylov loads. Finally, the numerical modeling for the system of a spherical buoy moored by a cable is established, and a virtual simulation is proceeded with the X- and Y-directional linear waves and the X-directional current. The comparison with the commercial simulation code Proteus DS indicates that the system is accurately analyzed by the numerical modeling. The tensions within the cable, the motions of the system, and the relationship between the motions and waves are illustrated according to the defined sea state. The dynamics of the cables should be considered in analyzing the floating system of a spherical buoy moored by a cable.

关键词： numerical modeling dynamic simulation spherical buoy mooring cable dynamics of cable

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Dynamic Inertia Response Support by Energy Storage System with Renewable Energy Integration Substation

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 260-266页

作者： Yeuntae yoo Seungmin Jung Gilsoo Jang Korea University SeoulKorea Hanbat National University DaejeonKorea

In recent years,the expansion of renewable energy in electric power systems has been increasing at such a rapid pace that it has started affecting frequency *** generators connected to the grid produce variable amounts of power,and in most cases have no inherent inertia response(IR)to the system ***,the high penetration of renewable generators in the system results in low inertia and frequency *** renewable generators account for a high proportion of the supply in a power system,the use of energy storage systems(ESSs)with frequency-support algorithms(in the place of synchronous generators)can stabilize the *** participation of ESSs in frequency support must be organized precisely,so that they are fully devoted to their own *** this paper,the frequency-support parameters of ESSs are calculated for achieving stable frequency response from a *** estimation and calibration process is conducted during the active power-order change of the ESSs in the substation,and is verified through electromagnetic-transients-including-DC(EMTDC)-based simulations.

关键词： Energy storage system(ESS) frequency response inertia renewable energy substation

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EP-Bot: Empathetic Chatbot Using Auto-Growing Knowledge Graph

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Computers, Materials & Continua 2021年第6期67卷 2807-2817页

作者： SoYeop yoo OkRan Jeong Gachon University Seongnam-si13120Korea

People occasionally interact with each other through *** particular,we communicate through dialogue and exchange emotions and information from *** are essential characteristics of natural *** artificial intelligence is an integral part of all the technologies that allow computers to communicate like *** a computer to interact like a human being,it must understand the emotions inherent in the conversation and generate the appropriate ***,existing dialogue systems focus only on improving the quality of understanding natural language or generating natural language,excluding *** propose a chatbot based on emotion,which is an essential element in ***-Bot(an Empathetic PolarisX-based chatbot)is an empathetic chatbot that can better understand a person’s utterance by utilizing PolarisX,an autogrowing knowledge *** extracts new relationship information and expands the knowledge graph *** is helpful for computers to understand a person’s common *** proposed EP-Bot extracts knowledge graph embedding using PolarisX and detects emotion and dialog act from the *** it generates the next utterance using the ***-Bot could understand and create a conversation,including the person’s common sense,emotion,and *** verify the novelty and accuracy of EP-Bot through the experiments.

关键词： Emotional chatbot conversational AI knowledge graph emotion 1 Introduction

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