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SCN1A rs6732655A/T polymorphism:Diagnostic and therapeutic insights for drug-resistant epilepsy

World Journal of Experimental Medicine 2024年第3期14卷 72-79页

作者： Aroop Viswas Pradeep K Dabla Dharmsheel Shrivastav Swapan Gupta Manisha yadav subhash yadav Bidhan Chandra Koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biotechnology Amity University GwaliorGwalior 474005Madhya PradeshIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACKGROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs,resulting in heightened mortality rates,psychosocial challenges,and a diminished quality of *** factors,particularly within the SCN1A gene,and the pro-inflammatory cytokine response is important in intricating the drug resistance in idiopathic epilepsy *** this extended study,we determined the correlation of rs6732655A/T single nucleotide polymorphism to understand the causative association of SCN1A gene with epilepsy drug resistance and inflammatory *** To find the correlation of SCN1A gene rs6732655A/T polymorphism with the drug-resistant epilepsy and inflammatory *** The study enrolled 100 age and sex-matched patients of both drug-resistant and drug-responsive epilepsy *** analysed the rs6732655A/T polymorphism to study its association and causative role in drug-resistant epilepsy cases using restriction fragment length polymorphism *** diagnostic performance of interleukin(IL)-1β,IL-6,and high mobility group box 1(HMGB1)protein levels was evaluated in conjunction with genotypic outcome receiver operating characteristic *** AT and AA genotypes of rs6732655 SCN1A gene polymorphism were associated with higher risk of drug resistance *** biomarkers IL-6,IL1βand HMGB1 demonstrated diagnostic potential,with cutoff values of 4.63 pg/mL,59.52 pg/mL and 7.99 ng/mL,respectively,offering valuable tools for epilepsy ***,specific genotypes(AA and AT)were found to be linked to the elevated levels of IL-1βand IL-6 and potentially reflecting increased oxidative stress and neuro-inflammation in drug-resistant cases supporting the previous reported outcome of high inflammatory markers response in drug resistance *** SCN1A genotypes AA and AT are linked to higher drug-resistant epilepsy *** findings underscore the potential influence of inflammation

关键词： Epilepsy Drug resistance SCN1A gene Pro-inflammatory cytokines Genetic factors

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New Efficient Estimators of Population Mean Using Non-Traditional Measures of Dispersion

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Open Journal of Statistics 2017年第3期7卷 394-404页

作者： Rajesh Kumar Gupta subhash Kumar yadav Department of Statistics Lucknow University Lucknow India Department of Mathematics and Statistics (A Centre of Excellence) Dr. RML Avadh University Faizabad India

One of the aims in survey sampling is to search for the estimators with highest efficiency. In the present paper, three improved estimators of population mean have been proposed using some non-traditional measures of dispersion of auxiliary variable such as Gini’s mean difference, Downton’s method and probability weighted moments early given by Abid [1] with a special population parameter of auxiliary variable. The large sample properties that are biased and mean squared errors of the proposed estimators have been derived up to the first order of approximation. A theoretical comparison of the proposed estimators has been made with the other existing estimators of population mean using auxiliary information. The conditions under which the proposed estimators perform better than the other existing estimators of population mean have been given. A numerical study is also carried out to see the performances of the proposed and existing estimators of population mean and verify the conditions under which proposed estimators are better than other estimators. It has been shown that the proposed estimators perform better than the existing estimators as they are having lesser mean squared error.

关键词： Study Variable Auxiliary Variable Bias Mean Squared Error Efficiency

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Surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini subhash Kanase Getasew Mulualem Zewdie Maheswari Arunachalam Jyoti Badiger Suzan Abdelfattah Sayed Kwang-Soon Ahn Jun-Seok Ha Uk Sim Hyeyoung Shin Soon Hyung Kang Department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 M KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochemical CO_(2)reduction

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Alignment Techniques in Total Knee Arthroplasty:Where do We Stand Today?

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Chinese Medical Sciences Journal 2024年第3期39卷 224-233页

作者： Hemanta Dhungana subhash Jangid Meghal Goyal Department of Orthopedics Fortis HospitalGurgaonHaryanaIndia

Achieving optimal alignment in total knee arthroplasty(TKA)is a critical factor in ensuring optimal outcomes and long-term implant ***,mechanical alignment has been favored to achieve neutral post-operative joint ***,contemporary approaches,such as kinematic alignments and hybrid techniques including adjusted mechanical,restricted kinematic,inverse kinematic,and functional alignments,are gaining attention for their ability to restore native joint kinematics and anatomical alignment,potentially leading to enhanced functional outcomes and greater patient *** ongoing debate on optimal alignment strategies considers the following factors:long-term implant durability,functional improvement,and resolution of individual anatomical ***,advancements of computer-navigated and robotic-assisted surgery has augmented the precision in implant positioning and objective measurements of soft tissue *** ongoing debates on balancing implant longevity and functional outcomes,there is an increasing advocacy for personalized alignment strategies that are tailored to individual anatomical *** review evaluates the spectrum of various alignment techniques in TKA,including mechanical alignment,patient-specific kinematic approaches,and emerging hybrid *** technique is scrutinized based on its fundamental principles,procedural techniques,inherent advantages,and potential limitations,while identifying significant clinical gaps that underscore the need for further investigation.

关键词： total knee arthroplasty hybrid alignment functional alignment kinematic alignment alignment axes anatomical alignment mechanical alignment

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冷弯带肋薄壁不锈钢管再生混凝土短柱轴压力学性能研究

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工程力学 2024年

作者：潘爽廖飞宇张伟杰 Pantha subhash 福建农林大学交通与土木工程学院福建农林大学数字福建智能交通技术物联网实验室

为研究冷弯带肋薄壁不锈钢管再生混凝土短柱的轴压力学性能，完成了14个冷弯薄壁不锈钢管再生混凝土短柱试件(包括12根带肋试件和2个无肋对比试件)的轴压试验，考察了加劲肋宽度和钢管宽厚比对试件破坏模态、荷载-应变关系曲线、极限承... 详细信息

为研究冷弯带肋薄壁不锈钢管再生混凝土短柱的轴压力学性能，完成了14个冷弯薄壁不锈钢管再生混凝土短柱试件(包括12根带肋试件和2个无肋对比试件)的轴压试验，考察了加劲肋宽度和钢管宽厚比对试件破坏模态、荷载-应变关系曲线、极限承载力和延性的影响规律。采用ABAQUS建立了冷弯带肋薄壁不锈钢管再生混凝土短柱轴压性能的有限元分析模型，计算结果与试验结果吻合良好，利用有限元模型，进行了典型构件的荷载-应变曲线、荷载分配比例、不锈钢管和核心再生混凝土的纵向应力分布及其相互作用的分析。通过参数分析，研究了不锈钢屈服强度、核心再生混凝土强度、加劲肋宽度、再生骨料替代率和钢管宽厚比等参数对构件轴压受力性能的影响。最后，提出了冷弯带肋薄壁不锈钢管再生混凝土短柱轴压承载力的简化计算公式，可为实际工程设计提供参考。

关键词：冷弯薄壁不锈钢再生骨料混凝土轴压试验有限元分析简化计算公式

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Potential of conservation tillage and altered land configuration to improve soil properties,carbon sequestration and productivity of maize based cropping system in eastern Himalayas,India

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International Soil and Water Conservation Research 2021年第2期9卷 279-290页

作者： Gulab Singh yadav Anup Das subhash Babu Kamal Prasad Mohapatra Rattan Lal Dipjyoti Rajkhowa Indian Council of Agricultural Research(ICAR) Research Complex for North Eastern HillRegionTripura CentreTripuraIndia ICAR eIndian Agricultural Research Institute New DelhiIndia ICAR-National Bureau of Plant Genetic Resources New DelhiIndia Carbon Management and Sequestration Center Ohio State UniversityColumbusUSA ICAR Research Complex for NEH Region Nagaland CentreNagalandIndia

Poor soil properties especially low soil organic carbon(SOC)and nutrient and water retention capacities are major concern for sustainable agriculture in *** experiments were conducted to assess the effects of six combinations of tillage[conventional tillage(CT)and no-till(NT)]and land configurations[flat bed planting(FB),ridge and furrow planting(RF),and raised bed planting(RB)]on productivity and carbon(C)-sequestration potential of maize[(Zea mays L.)for green-cob in summer]-maize(for grains in rainy season)-field pea[(Pisum sativum *** winter]cropping system under humid mildtropical climate of Tripura,*** maize under NT-FB in 2012 and NT-RF in 2013 produced significantly higher green cob yield than that under ***,in rainy season,CT produced higher maize grain yield than NT *** pea seed yield was significantly the highest under *** two cropping cycles,NT systems had higher available N,P,K and 18.6e31.4%higher soil moisture content after rainy season maize than CT *** highest SOC-stock(0e30 cm)was observed under NT-FB,whereas,SOC-sequestration rate was maximum under NT-RB(0.85 Mg ha1 year1).Therefore,NT based systems can enhance the productivity and improve SOC-sequestration in cultivated soils of eastern ***,study recommended adoption of NT-RB/NT-FB to raise maize-maize-field pea system for improving productivity,improving C-sequestration and soil properties in the eastern Himalayas and similar eco-regions elsewhere.

关键词： Soil fertility Carbon sequestration Soil moisture Low productivity Hill ecosystem

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以掺氢天然气为燃料直接内重整固体氧化物电池堆的稳定性

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电化学（中英文） 2024年第1期30卷 46-54页

作者：汤亚飞武安祺韩贝贝刘华包善军林王林陈铭官万兵 subhash C.Singhal 中国科学院宁波材料技术与工程研究所浙江宁波315201 浙江启明电力集团有限公司浙江舟山316099 浙江大学舟山海洋研究中心浙江舟山316021 丹麦技术大学能源转换与储存系川麦哥本哈根

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验,结果显示,电堆的总体衰减率为2.3%·kh^(-1),电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm^(2)、0.254Ω·cm^(2... 详细信息

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验,结果显示,电堆的总体衰减率为2.3%·kh^(-1),电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm^(2)、0.254Ω·cm^(2)和0.249Ω·cm^(2),但电堆中两个电池的电压反而分别增加了3.38 m V·kh^(-1)和3.78 m V·kh^(-1)。电堆衰减主要由金属连接件表层氧化及其与阴极集流层材料反应生成Sr CrO_(4)物质,两者共同作用增大了电池与金属连接体间的界面电阻所致。结果表明,以掺氢天然气为燃料直接内重整平管型固体氧化物燃料电池电堆具有良好的稳定性。本文工作为掺氢天然气在固体氧化物燃料电池堆中的直接内重整应用提供了理论参考与实验依据。

关键词：掺氢天然气内重整稳定性固体氧化物电堆

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以掺氢天然气为燃料直接内重整固体氧化物电池堆的稳定性（英文）

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电化学(中英文) 2024年第1期 49-57页

作者：汤亚飞武安祺韩贝贝刘华包善军林王林陈铭官万兵 subhash C.Singhal 中国科学院宁波材料技术与工程研究所浙江启明电力集团有限公司浙江大学舟山海洋研究中心丹麦技术大学能源转换与储存系

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验，结果显示，电堆的总体衰减率为2.3%kh–1，电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm2、0.254Ω·cm2和0.24... 详细信息

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验，结果显示，电堆的总体衰减率为2.3%kh–1，电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm2、0.254Ω·cm2和0.249Ω·cm2，但电堆中两个电池的电压反而分别增加了3.38 m V·kh–1和3.78 m V·kh–1。电堆衰减主要由金属连接件表层氧化及其与阴极集流层材料反应生成Sr Cr O4物质，两者共同作用增大了电池与金属连接体间的界面电阻所致。结果表明，以掺氢天然气为燃料直接内重整平管型固体氧化物燃料电池电堆具有良好的稳定性。本文工作为掺氢天然气在固体氧化物燃料电池堆中的直接内重整应用提供了理论参考与实验依据。

关键词：掺氢天然气内重整稳定性固体氧化物电堆

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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

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Double mulching improves soil properties and productivity of maize-based cropping system in eastern Indian Himalayas

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International Soil and Water Conservation Research 2020年第3期8卷 308-320页

作者： Bidyapati Ngangom Anup Das Rattan Lal Ramkrushna Gandhiji Idapuganti Jayanta Layek Savita Basavaraj subhash Babu Gulab Singh yadav Probir Kumar Ghosh ICAR Research Complex for NEH Region UmiamMeghalayaIndia Krishi Vigyan Kendra-ICAR Research Complex for NEH Region Arunachal Pradesh CentreBasarArunachal PradeshIndia College of Post Graduate Studies Central Agricultural UniversityUmiamMeghalayaIndia ICAR Research Complex for NEH Region Tripura CentreLembucherraTripuraIndia Carbon Management and Sequestration Centre Ohio State UniversityUSA ICAR-Central Institute for Cotton Research NagpurMaharashtraIndia ICAR-KrishiVigyan Kendra IndiUniversity of Agricultural SciencesDharwadIndia ICAR-Indian Agricultural Research Institute New DelhiIndia ICAR-National Institute of Biotic Stress Management RaipurChhattisgarhIndia

A field experiment was conducted for two consecutive years at North Eastern Indian Himalayan region to assess the effect of soil moisture conservation measures on soil and water productivity of different rainfed maize(Zea mays L.)-based cropping *** revealed that double mulching with in-situ maize stover mulch(MSM)+fresh biomass of white hoary pea(WHP-Tephrosia candida)and MSM+fresh biomass of ragweed(RW-Ambrosia artemisiifolia)improved soil moisture content(SMC)and leaf relative water content of crops during dry *** soil organic carbon(SOC)content and stocks under MSM+WHP and MSM+RW mulches were significantly higher than that under no mulch at 0-15 cm *** soil microbial biomass carbon and dehydrogenase activity were maximum under MSM+WHP/*** highest system productivity was obtained from maize-French bean(Pole type-PT)sequence under MSM+RW followed by MSM+*** water productivity was the highest under MSM+*** SOC content was the highest under maize-French bean(PT),the maximum plant available nitrogen and phosphorus were obtained under maize-black gram ***,double mulching technology involving MSM and RW(available in plenty)is a viable option for improving soil,crop and water productivity under rainfed hill ecosystems of eastern Indian Himalayas.

关键词： Cropping systems Rainfed agriculture Residual soil moisture Soil properties Water productivity

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