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Bitter melon： a panacea for inflammation and cancer

chinese Journal of Natural Medicines 2016年第2期14卷 81-100页

作者： Prasad R. Dandawate Dharmalingam Subramaniam subhash B. Padhye Shrikant Anant Department of Molecular and Integrative Physiology The University of Kansas Medical Center Kansas City KS 66160 USA Department of Surgery The University of Kansas Medical Center Kansas City KS 66160 USA The University of Kansas cancer center Kansas City KS 66160 USA Interdisciplinary Science & Technology Research Academy Abeda lnamdar Senior College Azam Campus Pune 411001 lndia

Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. Momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds （Kuguacin J, Karaviloside XI, Kuguaglycoside c, Momordicoside Q-U, charantin, a-eleostearic acid） and proteins （a-Momorcharin, RNase Mc2, MAP30） possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents.

关键词： Momordica charantia Bitter melon Anti-oxidant activity Anti-inflammatory activity Anti-cancer activity Na^n'al products

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Photonics bridges between turbulence and spin glass phenomena in the 2021 Nobel Prize in Physics

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Light(Science & Applications) 2022年第5期11卷 743-745页

作者： A.S.L.Gomes c.B.de Araújo A.M.S.Macêdo I.R.R.González L.de S.Menezes P.I.R.Pincheira R.kashyap G.L.Vasconcelos E.P.Raposo Departamento de Física Universidade Federal de PernambucoRecifePE 50670-901Brazil Unidade Acadêmica de Belo Jardim Universidade Federal Rural de PernambucoBelo JardimPEBrazil chair in Hybrid Nanosystems Nanoinstitut MünchenFakultät für PhysikLudwig-Maximilians-Universität München80539 MünchenGermany Departamento de ciencias Físicas Universidad de La FronteraTemucoChile Fabulas Laboratory Department of Engineering PhysicsDepartment of Electrical EngineeringPolytechnique MontrealMontreal H3C 3A7 QCCanada Departamento de Física Universidade Federal do ParanáCuritibaPR 81531-990Brazil

A photonic connection between turbulence and spin glasses has been recently established both theoretically and experimentally using a random fiber laser as a photonic *** unveiling this interplay,it links the works of... 详细信息

关键词： fiber turbulence Nobel

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User Perspective of Misplaced PPIUcD and Factors Resulting in PPIUcD Removal: Qualitative Pilot Study

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Open Journal of Epidemiology 2024年第3期14卷 517-532页

作者： A. G. Radhika Rashmi Gupta Pooja kashyap Ravleen Bakshi Department of Obstetrics and Gynecology University College of Medical Sciences & Guru Teg Bahadur Hospital Dilshad Garden Delhi India GTB Hospital Delhi India Indian council of Medical Research Delhi India

Objective: The aim of the current study was to assess the impact of operative interventions for misplaced device among women who opted for PPIIUcD and the evaluation of reasons for PPIUcD removal within the follow up period of two years. Design: A descriptive exploratory study was conducted over three months among fourteen PPIUcD acceptors at a tertiary care health facility in Delhi, India. Face-to-face & telephonic in-depth interviews were conducted with a selected sample of PPIUcD acceptors who had later opted for its removal. Results: Participants (n = 14) aged 24 – 40 exhibited generally positive attitudes towards PPIUcDs indicating an indicate an understanding of the importance of PPIUcD in preventing unintended pregnancies. Menstrual disturbance and misplaced IUcD were major reasons for removal. despite their own experience necessitating the removal of IUcD, positive experience by other family members (mothers in law) in this study helped to keep the confidence on the contraceptive. Themes included (a) general experience of PPIUcD use (b) Health Facility accessed for removal of IUcD (c) Would she recommend it to others? (d) preferred contraceptive after removal of IUcD. conclusion: Misplaced IUcD, missing thread, menstrual irregularities, and pain are all associated with PPIUcD and are important reasons for dissatisfaction. Appropriate, timely and supportive individualized care that address knowledge gaps, societal perceptions, and healthcare system challenges would certainly help in reducing dissatisfaction due to PPIUcD and thereby the removal rates.

关键词： Postpartum Intrauterine Device PPIUcD LARc Long Acting Reversible contraception Postpartum Family Planning contraception

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Study of Hydrophobic Nature of Fullerene-Based Poly (Methyl Hydro Siloxane) and Polyacrylonitrile Interpenetrating Polymer Network

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Journal of Materials Science and chemical Engineering 2023年第11期11卷 15-27页

作者： Mohd. Meraj Jafri Meet Kamal subhash Mandal Sanjay Kanojia Department of chemistry C.S.J.M. University Kanpur India Department of chemistry Christ Church Degree College. Kanpur India Nano Science and coating Division DMSRDE (DRDO) Kanpur India

In this study, the effect of combining different molecular domains on single platform has been reported that revealed a proper packing and interpenetration of fullerene spheres with the monomeric species. The fabricated IPN system exhibits hydrophobic behavior in nature. An interpenetrating polymer network (IPN) of fullerene-based poly (methyl hydro siloxane) (PMHS) and polyacrylonitrile (PAN) was prepared. The synthesized polymer network was characterized using infrared (IR) spectroscopy, differential scanning calorimetric analysis (DSc), and scanning electron microscopic (SEM) technique. The IPN was analyzed by IR spectroscopy, which depicts presence of fullerene at 500 cm−1 and 1632 cm−1, presence of PHMS at 1050 cm−1, 1250 cm−1, 2225 cm−1, and 3000 cm−1 and presence of PAN at 3077 cm−1, 1299 cm−1, 1408 cm−1 and 2083 cm−1. Shifting in band positions indicated the interpenetration of the reacting species. DSc endotherm showed crystalline peak (Tc) at 117˚c, which indicated the crystalline nature of the synthesized IPN. The absence of Tg peak and clear observable Tc peak revealed crystalline behavior of polymeric network. The microstructure of the polymer network was observed by SEM technique, which revealed transparent and dual-phase morphology of the IPN surface. The fluorescent emission spectra of polymeric network were recorded on a spectrofluorometer which revealed fluorescent excitation and emission spectra of the IPN. The Emission spectra generated by radiative decay of excitations exhibit a maximal peak at 450 nm, suggesting that the synthesized IPN nanosheets were typically high-intensity blue light emitting materials. The FTIR investigations revealed multiple non-covalent interactions achieved by polymerization with physical anchoring on the polymeric network surfaces. Such interactions can be recognized as the dri

关键词： Polyacrylonitrile PMHS IPN Polymeric Network

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Virological course of hepatitis A virus as determined by real time RT-PcR: correlation with biochemical, immunological and genotypic profiles

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World Journal of Gastroenterology 2006年第29期12卷 4683-4688页

作者： Zahid Hussain Bhudev c Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar PcR Hepatitis Laboratory Department of Medicine Maulana Azad Medical CollegeNew Delhi 110002India Human Genetics LaboratoryDepartment of BiosciencesJamia Millia IslamiaNew Delhi 110025India Division of Molecular Oncology Institute of cytology and Preventive Oncology (ICMR)NoidaSector 39Uttar PradeshIndia Human Genetics Laboratory Department of Biosciences Jamia Millia IslamiaNew Delhi 110025India PcR Hepatitis Laboratory Department of Medicine Maulana Azad Medical CollegeNew Delhi 110002India Advance center for AIDS National Institute of communicable Diseases New Delhi 110041India Viral Hepatitis Research Unit Department of Pediatric Faculty of MedicineChulalolongkorn University and HospitalRama Ⅳ RoadBangkok 10330Thailand PcR Hepatitis Laboratory Department of Medicine Maulana Azad Medical College New Delhi 110002India

AIM： To undertake analysis of hepatitis A viral load, alanine aminotransferase （ALT）, and viral genotypes with duration of viremia, and to correlate these parameters with cD4^＋/ cD8^＋ lymphocyte populations that control cell-mediated immunity. METHODS： cell counts were carried out using fresh whole blood collected in EDTA vials using a fluorescence activated cell sorter. Hepatitis A virus （HAV） RNA was extracted from blood serum, reverse transcribed into cDNA and quantified by Real-Time polymerase chain reaction and was genotyped. RESULTS： Among 11 patients, 10 could be analyzed completely. Of these, 3 had severe acute hepatitis （s-AH） and the remainder had a self-limited acute hepatitis A （AHA）, with one patient with fulminant disease （encephalopathy Grade IV） dying on the 4^th d. The ALT level was significantly higher both in AHA （1070.9±894.3; P = 0.0014） and s-AH （1713.9±886.3; P = 0.001） compared to normal controls （23.6±7.2）. The prothrombin time in s-AH patients （21.0 ±2.0; P=0.02） was significantly higher than in AHA （14.3±1.1;P = 0.44）. The cD4^＋/cD8^＋ ratio in AHA patients （1.17 ＋ 0.11; P = 0.22） and s-AH （0.83 ＋ 0.12; P = 0.0002） were lower than seen in normal healthy controls （1.52）. Self-limited cases had peak viral load at the beginning of analysis while in s-AH patients this occurred at the 15TM or 30^th d. In acute and severe groups, one patient each belonged to genotype IA, with the remaining 8 cases belonging to genotype IIIA. The only fulminant hepatic failure case belonged to genotype IA. HAV viral load and AIT values collected during the entire course of the selflimited infection were directly correlated but this was not the case for s-AH patients.cONcLUSION： Based on a small-scale study, the persistently higher viral load of s-AH might be due to diminished cellular immunity and hemolysis. The duration of viremia was dependent on the host, as the viral genotype had no apparent role in clinical outcome of AVH and s-AH cases.

关键词： Viral load Real-time PcR Immunologicalresponse Severe acute hepatitis Self-limited acute henatitis

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以掺氢天然气为燃料直接内重整固体氧化物电池堆的稳定性

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电化学（中英文） 2024年第1期30卷 46-54页

作者：汤亚飞武安祺韩贝贝刘华包善军林王林陈铭官万兵 subhash c.Singhal 中国科学院宁波材料技术与工程研究所浙江宁波315201 浙江启明电力集团有限公司浙江舟山316099 浙江大学舟山海洋研究中心浙江舟山316021 丹麦技术大学能源转换与储存系川麦哥本哈根

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验,结果显示,电堆的总体衰减率为2.3%·kh^(-1),电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm^(2)、0.254Ω·cm^(2... 详细信息

本文研究了掺氢天然气直接内重整平管型固体氧化物电池短堆的长期稳定性和衰减机理。通过约3000小时的实测实验,结果显示,电堆的总体衰减率为2.3%·kh^(-1),电堆中三个金属连接板的面积比电阻分别增加了0.276Ω·cm^(2)、0.254Ω·cm^(2)和0.249Ω·cm^(2),但电堆中两个电池的电压反而分别增加了3.38 m V·kh^(-1)和3.78 m V·kh^(-1)。电堆衰减主要由金属连接件表层氧化及其与阴极集流层材料反应生成Sr crO_(4)物质,两者共同作用增大了电池与金属连接体间的界面电阻所致。结果表明,以掺氢天然气为燃料直接内重整平管型固体氧化物燃料电池电堆具有良好的稳定性。本文工作为掺氢天然气在固体氧化物燃料电池堆中的直接内重整应用提供了理论参考与实验依据。

关键词：掺氢天然气内重整稳定性固体氧化物电堆

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SERS study on the synergistic effects of electric field enhancement and charge transfer in an Ag2S quantum dots/plasmonic bowtie nanoantenna composite system

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Photonics Research 2020年第4期8卷 548-563页

作者： BIN WANG cHEN ZHAO HUANYU LU TINGTING ZOU subhash c.SINGH ZHI YU cHAONAN YAO XIN ZHENG JUN XING YUTING ZOU cUNZHU TONG WEILI YU BO ZHAO cHUNLEI GUO The Guo china-US Photonics Laboratory State Key Laboratory of Applied OpticsChangchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China University of chinese Academy of Sciences Beijing 100049China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China The Institute of Optics University of RochesterNew York 14627USA

Localized surface plasmon resonance(LSPR)of nanostructures and the interfacial charge transfer(cT)of semiconductor materials play essential roles in the study of optical and photoelectronic *** this paper,a composite substrate of Ag2S quantum dots(QDs)coated plasmonic Au bowtie nanoantenna(BNA)arrays with a metalinsulator-metal(MIM)configuration was built to study the synergistic effect of LSPR and interfacial cT using surface-enhanced Raman scattering(SERS)in the near-infrared(NIR)*** Au BNA array structure with a large enhancement of the localized electric field(E-field)strongly enhanced the Raman signal of adsorbed p-aminothiophenol(PATP)probe ***,the broad enhanced spectral region was achieved owing to the coupling of LSPR The as-prepared Au BNA array structure facilitated enhancements of the excitation as well as the emission of Raman signal simultaneously,which was established by finite-difference time-domain ***,Ag2S semiconductor QDs were introduced into the BNA/PATP system to further enhance Raman signals,which benefited from the interfacial cT resonance in the BNA/Ag2S-QDs/PATP *** a result,the Raman signals of PATP in the BNA/Ag2S-QDs/PATP system were strongly enhanced under 785 nm laser excitation due to the synergistic effect of E-field enhancement and interfacial ***,the SERS polarization dependence effeas of the BNA/Ag2S-QDs/PATP system were also *** SERS spectra indicated that the polarization dependence of the substrate increased with decreasing polarization angles(θpola)of excitation from p-polarized(θpola=90°)excitation to s-polarized(θpola=0°)*** study provides a strategy using the synergistic effect of interfacial cT and E-field enhancement for SERS applications and provides a guidance for the development of SERS study on semiconductor QD-based plasmonic substrates,and can be farther extended to other material-nanostructure systems for various optoelectron

关键词： SERS the synergistic effects electric field enhancement charge transfer an Ag2S quantum dots/plasmonic bowti

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Viral Genotypes and Associated Risk Factors of Hepatocellular carcinoma in India

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clinical oncology and cancer researeh 2012年第3期9卷 172-181页

作者： Manash Pratim Sarma Mohammad Asim subhash Medhi Thayumanavan Bharathi Richa Diwan Premashis Kar PcR Hepatitis Laboratory Department of MedicineMaulana Azad Medical CollegeUniversity of Delhi Department of Gastroenterology Rajaji Government Hospital

Objective This study aims to investigate the etiological relationship among hepatitis B virus （HBV）, hepatitis c virus （HcV）, and alcohol as risk factors in a cohort of hepatocellular carcinoma （Hcc） patients from India. The clinical and biochemical profiles and tumor characteristics in the Hcc cases were also evaluated. Methods A total of 357 consecutive cases of Hcc fulfilling the diagnostic criteria from the Barcelona-2000 EASL conference were included in the study. The blood samples were evaluated for serological evidence of HBV and HcV infection, viral load, and genotypes using serological tests, reverse transcription-polymerase chain reaction, and restriction fragment length polymorphism. Results The male/female ratio for the Hcc cases was 5.87：1. Majority of the Hcc patients （33.9%） were 50 to 59 years of age, with a mean age of 4±13.23 years. More than half the cases （60.8%） had underlying cirrhosis at presentation. Among the Hcc patients, 68.9% were HBV related, 21.3% were HcV related, 18.8%, were alcoholic, and 18.2% were of cryptogenic origin. The presence of any marker positive for HBV increased the risk for developing Hcc by almost 27 times [OR： 27.33; （12.87-60.0）]. An increased risk of 10.6 times was observed for Hcc development for cases positive for ally HcV marker [OR： 10.55; （3.13-42.73）]. Heavy alcohol consumption along with HcV RNA positivity in cirrhotic patients was found to be a risk for developing Hcc by 3 folds ]OR： 3.17; （0.37-70.71）]. conclusions Patients of chronic HBV infection followed by chronic HcV infection were at higher risk of developing Hcc in India. chronic alcohol consumption was found to be a risk factor in cirrhotic cases only when it was associated with HcV RNA positivity. Most of the patients had a large tumor size （〉5 cm） with multiple liver nodules, indicating an advanced stage of the disease thus making curative therapies difficult.

关键词： hepatocellular carcinoma hepatitis B virus hepatitis c virus risk factors

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Photonic properties of novel Yb3＋ doped germanium-lead oxyfluoride glass-ceramics for laser cooling applications

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Frontiers of Optoelectronics 2018年第2期11卷 189-198页

作者： Lauro J. Q. MAIA Jyothis THOMAS Yannick LEDEMI Kummara V. KRISHNAIAH Denis SELETSKIY Younes MESSADDEQ Raman kashyap Instituto de Fisica Universidade Federal de Goias Av. Esperanga 1533 Campus Samambaia Goiania GO 74690-900 Brazil Department of Electrical Engineering Ecole Polytechnique de Montrral P.O. Box 6079 Station Centre-ville Montreal QC H3C 3A7 Canada Department of Engineering Physics Ecole Polytechnique de Montrral P.O. Box 6079 Station Centre-ville Montreal QC H3C 3A7 Canada centre d'Optique Photonique et Laser 2375 Rue de la Terrasse Universite Laval Qurbec QC G1V 0A6 Canada

Abstract In recent years, our research group has developed and studied new rare-earth doped materials for the promising technology of solid-state laser cooling, which is based on anti-stokes fluorescence. To the best of our knowledge, our group is the only one in canada leading the research into the properties of nanoparticles, glasses and glass-ceramics for optical refrigeration appli- cations. In the present work, optical properties of 50GeO2- 30PbF2-18PbO-2YbF3 glass-ceramics for laser cooling are presented and discussed as a function of crystallization temperature. Spectroscopic results show that samples have near infrared photoluminescence emission due to the 2F5/2 - 2F7/2 Yb3＋ transition, centered at -1016 nm with an excitation wavelength of 920 nm or 1011 nm, and the highest photoluminescence emission efficiency occurs for heat-treatment for 5 h at 350℃. The internal photolumi- nescence quantum yield varies between 99% and 80%, depending on the temperature of heat-treatment, being the most efficient under 1011 nm excitation. The 2F5/2 lifetime increases from 1.472 to 1.970 ms for heat treatments at 330℃ to 350℃, respectively, due to energy trapping and the low phonon energy of the nanocrystals. The sample temperature dependence was measured with a fiber Bragg grating sensor, as a function of input pump laser wavelength and processing temperature. These measure- ments show that the heating process approaches near zero for an excitation wavelength between 1020 and 1030 nm, which is an indication that phonons are removed effectivelly from the glass-ceramic materials, and they can be used for optical laser cooling applications. On theother hand, the temperature increase as a function of input laser power into samples remains constant between 920 and 980 nm wavelength excitation, a temperature variation of 36 K/W （temperature of 58℃/W） was attained under excitation at 950 nm, showing a possible use for biomedical applications to be explored.

关键词： optical refrigeration oxyfluoride glass-cera-mics Yb3+ doping quantum yield infrared emission lifetime

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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan subhash c.chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas center of Excellence in cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a cAF-like phenotype,which may be due to regulation of ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAc tumors,thus imply feasibility of developing a novel personalized medicine for PDAc patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

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