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Journal of Pharmacy and Pharmacology 2014年第3期2卷 185-193页

作者： Prasad Pandit Pratiksha Chandrakant Mainkar Sanket subhash Sawant Department of Pharmacology Topiwala National Medical College & B. Y.L. Nair Charitable Hospital Mumbai 400008 India Miracalus Pharma Pvt. ltd Andheri Mumbai 400072 India

There is a renewed interest in ARBs （angiotensin receptor blockers） for their effects on inflammation, as they are commonly used in the elderly suffering from disorders like arthritis, atherosclerosis which may have a potential inflammatory etiology. But there have been conflicting reports on the effect of ARBs on inflammation. The present study was aimed to evaluate the anti-inflammatory effect of ARBs in rat model of acute inflammation. Albino Wistar rats were randomly assigned to seven groups, i.e., Control （1% CMC （carboxy methyl cellulose））, Aspirin, losartan, Telmisartan, Valsartan, Candesartan and Irbesartan groups. Rats were orally pretreated with drugs for three consecutive days. On the 3rd day, rats were challenged by a subcutaneous injection of 0.05 ml of 1% carrageenan into the plantar side of right hind paw, 30 min after drug administration. Paw edema was measured using a mercury plethysmograph and paw diameter by micrometer screw-gauge at 0, 3, 6 and 24 h after carrageenan challenge. Percentage inhibition of edema was also calculated. All the ARBs showed a significant anti-inflammatory effect at 3, 6 and 24 h as compared to control, although not comparable to that of aspirin. This anti-inflammatory effect, although not comparable to a known anti-inflammatory agent like aspirin, would perhaps prove beneficial in elderly patients routinely treated with these drugs.

关键词： Angiotensin receptor blockers inflammation carrageenan paw edema.

Integrated self-referencing single shot digital holographic microscope and optical tweezer

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light(Advanced Manufacturing) 2022年第3期3卷 205-218页

作者： subhash Utadiya Sachin Joshi Nimit Patel Chetna Patel Mugdha Joglekar Vani Cahhniwal Timothy O’Connor Bahram Javidi Arun Anand Optics laboratory Applied Physics DepartmentFaculty of Technology and EngineeringThe Maharaja Sayajirao University of BarodaVadodara 390001India Department of Electrical and Computer Engineering University of ConnecticutStorrsCT06269-4157USA Institute of Interdisciplinary Studies The Maharaja Sayajirao University of BarodaVadodaraIndia

Digital holographic microscopy is a single-shot technique for quantitative phase imaging of samples,yielding thickness profiles of phase *** provides sample features based on their morphology,leading to their classification and ***,observing samples,especially cells,in fluids using holographic microscopes is difficult without immobilizing the *** tweezers can be used for sample immobilization in *** present manuscript provides an overview of our ongoing work on the development of a compact,low-cost microscopy system for digital holographic imaging of optically trapped *** of digital holographic microscopy system with tweezers is realized by using the optical pickup unit extracted from DVD burners to trap microsamples,which are then holographically imaged using a highly compact self-referencing interferometer along with a low-cost,in-house developed quadrant photodiode,providing morphological and spectral information of trapped *** developed integrated module was tested using polystyrene microspheres as well as human *** investigated system offers a multitude of sample features,including physical and mechanical parameters and corner frequency information of the *** features were used for sample *** proposed technique has vast potential in opening up new avenues for low-cost,digital holographic imaging and analysis of immobilized samples in fluids and their classification.

关键词： Digital holographic microscopy Optical tweezers Red blood cells Quantitative phase imaging

Identification of Potential Flavonoid Inhibitors of the SARS-CoV-2 Main Protease 6YNQ:A Molecular Docking Study

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Digital Chinese Medicine 2020年第4期3卷 239-248页

作者： SUMIT Arora GOVIND lohiya KESHAV Moharir SAPAN Shah subhash Yende Pharmacognosy and Phytochemistry Department Gurunanak College of PharmacyNagpurMaharashtra 440026India Pharmaceutics Department Gurunanak College of PharmacyNagpurMaharashtra 440026India Pharmaceutical Chemistry Department Priyadarshini J.L.College of PharmacyNagpurMaharashtra 440016India Pharmacology Department Gurunanak College of PharmacyNagpurMaharashtra 440026India

Objective Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent for coronavirus disease 2019(COVID-19),is responsible for the recent global *** there are no effective drugs or vaccines available for SARS-CoV-2,we investigated the potential of flavonoids against SARS-CoV-2 main protease *** In silico molecular simulation study against SARS-CoV-2 main protease *** Among the 21 selected flavonoids,rutin demonstrated the highest binding energy(−8.7 kcal/mol)and displayed perfect binding with the catalytic *** Our study demonstrates the inhibitory potential of flavonoids against SARS-CoV-2 main protease *** computational simulation studies support the hypothesis that flavonoids might be helpful for the treatment of COVID-19.

关键词： COVID-19 SARS-CoV-2 Protease 6YNQ In silico Molecular simulation Virtual drug screening Flavonoids

Exploring the phytoconstituents targeting TNF-αas potential lead compounds to treat inflammatory diseases:an in-silico approach

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Digital Chinese Medicine 2022年第3期5卷 264-275页

作者： Sumit Arora Pallavi Rushiya Kalpana Tirpude Nidhi Sapkal subhash Yende Abhay Ittadwar Sapan Shah Department of Pharmacognosy and Phytochemistry Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmaceutical Chemistry Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmacology Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmaceutical Chemistry Priyadarshini J.L.College of PharmacyNagpurMaharashtra 440016India

Objective To explore the anti-inflammatory phytoconstituents from various plant sources as tumour necrosis factor-α(TNF-α)-inhibitor,a mediator involved in the inflammatory disorder,by in silico molecular *** Based on previous findings,we performed the in silico assessment of anti-inflammatory phytoconstituents from different medicinal plants to understand their binding patterns against TNF-α(PDB ID:6OP0)using AutoDock *** docking was performed by setting a grid box(25×25×25)Åcentered at[-12.817×(-1.618)×19.009]A with 0.375A of grid ***,Discovery Studio Client 2020 program was utilized to assess two-and three-dimensional(2D and 3D)hydrogen-bond interactions concerning an amino acid of target and *** properties were reported using the lipinski’s rule and SwissADME database to support the in silico *** From the selected medicinal plants,more than 200 phytocompounds were screened against TNF-α protein with binding scores in the range of -12.3 to -2.5 kcal/*** them,emodin,aloe-emodin,pongamol,purpuritenin,semiglabrin,ellagic acid,imperatorin,α-tocopherol,and octanorcucurbitacin A showed good binding affinity as -10.6,-10.0,-10.5,-10.1,-11.2,-10.3,-10.1,-10.1,and -10.0 kcal/mol,***,the absorption,distribution,metabolism,excretion,and toxicology(ADMET)profiles were well within acceptable *** Based on our preliminary findings,we conclude that the selected phytoconstituents have the potential to be good anti-inflammatory candidates by inhibiting the TNF-α *** compounds can be further optimized and validated as new therapeutic components to develop more effective and safe anti-inflammatory drugs.

关键词： Inflammation Tumour necrosis factor-α(TNF-α) Medicinal plants Phytoconstituents Molecular docking Absorption,distribution,metabolism,excretion,and toxicology(ADMET) studies

高油和普通玉米自交系类胡萝卜素和生育酚含量的比较分析

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作物学报 2009年第11期35卷 2073-2084页

作者：周毅付志远李青徐淑兔 CHANDER subhash 杨小红李建生严建兵中国农业大学/国家玉米改良中心/农业部作物基因组学与遗传改良重点实验室 International Maize and Wheat Improvement Center (CIMMYT) Apdo.Postal 6-64106600 MexicoD.F.Mexico

建立了利用高效液相色谱法同时测定玉米籽粒类胡萝卜素和生育酚各组分含量的技术体系,分析了112份黄色胚乳玉米自交系的类胡萝卜素和生育酚含量,其中包括32份高油自交系和80份在生产上广泛应用的普通玉米自交系。结果表明,不同自交系间... 详细信息

建立了利用高效液相色谱法同时测定玉米籽粒类胡萝卜素和生育酚各组分含量的技术体系,分析了112份黄色胚乳玉米自交系的类胡萝卜素和生育酚含量,其中包括32份高油自交系和80份在生产上广泛应用的普通玉米自交系。结果表明,不同自交系间存在广泛的变异,各组分含量变幅最大的是α-生育酚,含量相差达162倍;变幅最小的是δ-生育酚,含量相差也接近4倍。类胡萝卜素各组分含量在高油和普通玉米自交系之间并没有显著差异,但普通玉米的变异范围更为广泛;高油玉米生育酚各组分含量显著高于普通玉米,其中γ-生育酚、α-生育酚和总生育酚含量的均值分别是普通玉米均值的2.4、2.5和2.4倍。尽管供试的高油玉米材料仅32份,但其生育酚的某些组分比普通玉米具有更广泛的遗传变异。这为进一步的玉米高油、高维生素A原、高维生素E,即"三高"品质成分育种提供了有益参考。

关键词：高油玉米维生素A原维生素E 高效液相色谱 “三高”玉米

In silico prediction of phytoconstituents from Ehretia laevis targeting TNF-αin arthritis

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Digital Chinese Medicine 2021年第3期4卷 180-190页

作者： subhash R.Yende Sapan K.Shah Sumit K.Arora Keshav S.Moharir Govind K.lohiya Department of Pharmacology Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmaceutical Chemistry Priyadarshini J.L.College of PharmacyNagpurMaharashtra 440016India Department of Pharmacognosy and Phytochemistry Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmaceutics Gurunanak College of PharmacyNagpurMaharashtra 440026India

Objective Rheumatoid arthritis(RA)is an autoimmune disease involving the synovial lining of the major *** therapies have noteworthy side *** study involved in silico evaluation of Ehretia laevis(***)phytoconstituents targeting tumor necrosis factor-α(TNF-α).Methods Molecular docking studies performed to investigate the binding pattern of the plant *** phytoconstituents along with the crystal structure of TNF-α(PDB ID:2 AZ5)using AutoDock Vina followed by a study of interacting amino acid residues and their influence on the inhibitory potentials of the active *** the pharmacokinetic profile and toxicity screening carried out using Swiss ADME and pk *** The docked results suggest that lupeol(-9.4 kcal/mol)andα-amyrin(-9.4 kcal/mol)has best affinity towards TNF-αcompared to standard drug thalidomide(-7.4 kcal/mol).The active chemical constituents represents better interaction with the conserved catalytic residues,leading to the inhibition/blockade of the TNF-α-associated signaling pathway in ***,pharmacokinetics and toxicity parameters of these phytochemicals were within acceptable limits according to ADMET *** The binding potential of phytoconstituents targeting TNF-αshowed promising ***,it encourages the traditional use of *** and provides vital information on drug development and clinical treatment.

关键词： Rheumatoid arthritis Ehretia laevis In silico Molecular docking Pharmacokinetics Tumor necrosis factor-α(TNF-α) lupeol α-Amyrin

Notes for genera:Ascomycota

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Fungal Diversity 2017年第5期86卷 1-594页

作者： Nalin N.Wijayawardene Kevin D.Hyde Kunhiraman C.Rajeshkumar David l.Hawksworth Hugo Madrid Paul M.Kirk Uwe Braun Rajshree V.Singh Pedro W.Crous Martin Kukwa Robert lücking Cletus P.Kurtzman Andrey Yurkov Danny Haelewaters Andre´Aptroot H.Thorsten lumbsch Einar Timdal Damien Ertz Javier Etayo Alan J.l.Phillips Johannes Z.Groenewald Moslem Papizadeh laura Selbmann Monika C.Dayarathne Gothamie Weerakoon E.B.Gareth Jones Satinee Suetrong Qing Tian Rafael F.Castanda-Ruiz Ali H.Bahkali Ka-lai Pang Kazuaki Tanaka Dong Qin Dai Jariya Sakayaroj Martina Hujslová lorenzo lombard Belle D.Shenoy Ave Suija Sajeewa S.N.Maharachchikumbura Kasun M.Thambugala Dhanushka N.Wanasinghe Bharati O.Sharma subhash Gaikwad Gargee Pandit laura Zucconi Silvano Onofri Eleonora Egidi Huzefa A.Raja Rampai Kodsueb Marcela E.S.Caceres Sergio Perez-Ortega Patrícia O.Fiuza Josiane Santana Monteiro larissa N.Vasilyeva Roger G.Shivas Maria Prieto Mats Wedin Ibai Olariaga Adebola Azeez lateef Yamini Agrawal Seyed Abolhassan Shahzadeh Fazeli Mohammad Ali Amoozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan Sharma Magdalena Oset Mohamed A.Abdel-Wahab Susumu Takamatsu Konstanze Bensch Nimali Indeewari de Silva AndréDe Kesel Anuruddha Karunarathna Saranyaphat Boonmee Donald H.Pfister Yong-Zhong lu Zong-long luo Nattawut Boonyuen Dinushani A.Daranagama Indunil C.Senanayake Subashini C.Jayasiri Milan C.Samarakoon Xiang-Yu Zeng Mingkwan Doilom luis Quijada Sillma Rampadarath Gabriela Heredia Asha J.Dissanayake Ruvishika S.Jayawardana Rekhani H.Perera li Zhou Tang Chayanard Phukhamsakda Margarita Hernańdez-Restrepo Xiaoya Ma Saowaluck Tibpromma luis F.P.Gusmao Darshani Weerahewa Samantha C.Karunarathna Key laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Royal Botanic Gardens KewRichmondSurrey TW93DSUK Department of life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin Agricultural University Changchun 130118JilinPeople’s Republic of China Centro de Geno´mica y Bioinforma´tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile Martin-luther-Universita¨t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland Botanic Garden and Botanical Museum Königin-Luise-Str.6-814195 BerlinGermany Mycotoxin Prevention and Applied Microbiology Research Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures Inhoffenstraße 7B38124 BrunswickGermany Farlow Reference library and Herbarium of Cryptogamic Botany Harvard University22 Divinity AvenueCambridgeMA 02138USA Department of Organismic and Evolutionary Biology Harvard University22 Divinity AvenueCambridgeMA 02138USA ABl Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Science&Education The Field Museum1400

Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to *** genera have been found to be polyphyletic,and their generic concepts have subsequently been *** names have thus been introduced for species which are phylogenetically distinct from the type species of particular *** ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic *** order to facilitate access to all important changes,it was desirable to compile these in a single *** present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are *** and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the Fungi’in 2008 are *** notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since *** work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of Fungi"published in 2013,which will be developed into a list of protected generic *** will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for Fungi(NCF).The previously invalidly published generic names Barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and *** species of lalaria,which were invalidly published are trans

关键词： Article 59 Classification One name Pleomorphic fungi Taxonomy

西澳Mulga Rock煤与稀土的成矿关系研究

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地质论评 2016年第B11期62卷 409-410页

作者：吴西顺黄文斌李莉吕鹏中国地质调查局地学文献中心北京100083 中国地质图书馆北京100083

2016年，美国能源部启动了10个项目研究从煤炭和煤炭副产品中提取稀土元素。在澳大利亚，西部的Mulga Rock矿区是典型的煤-铀-稀土多矿种共生岩体，具有重要的科学研究价值。该矿区的总稀土资源量虽然目前尚未公布，但前景十分广阔。与... 详细信息

2016年，美国能源部启动了10个项目研究从煤炭和煤炭副产品中提取稀土元素。在澳大利亚，西部的Mulga Rock矿区是典型的煤-铀-稀土多矿种共生岩体，具有重要的科学研究价值。该矿区的总稀土资源量虽然目前尚未公布，但前景十分广阔。与世界上的许多矿床相似，subhash Jaireth等（2014）的最新研究成果认为，该矿区的稀土元素也与褐煤有关。

关键词：稀土成矿成矿关系煤层澳大利亚