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MMP-2 Inhibitory Activity of PBS Extract of Guava Leaves

American Journal of Plant Sciences 2021年第12期12卷 1761-1767页

作者： Atanu mondal Ramanuj Mukherjee subhajit mondal Amitava Chatterjee Ramakrishna Mission Vivekananda Educational & Research Institute Kolkata India R G Kar Medical College Kolkata India

PBS (Phosphate Buffed Saline), pH 7.4 extract of Guava leaves (Psidium guajava L.) inhibits the active MMP-2 like molecule both of plant origin as well as active MMP-2 of human (breast cancer patients’ saliva) origin. The zymogram and ELISA were developed of different samples following standard methods. The isolation and identification of the new MMP-2 inhibitor(s) for its molecular characterization is under investigation.

关键词： MMP-2 Inhibitor Guava Leaves Cancer

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Salivary Active MMP-2 of Breast Cancer Patients Is Inhibited by Guava Leaves PBS Extract

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American Journal of Plant Sciences 2022年第5期13卷 650-658页

作者： Ramanuj Mukherjee Syandan Sinha Ray subhajit mondal Amitava Chatterjee R G Kar Medical College Kolkata India Ramakrishna Mission Vivekananda Educational & Research Institute Kolkata India

Matrixmetalloproteinase-2 (MMP-2), also called gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a zinc binding protein, responsible for the degradation of Extra Cellular Matrix (ECM) in normal physiological as well as disease processes like arthritis and cancer. It has a specific role in the cancer development and angiogenesis. MMP-2 contributes to cell migration. MMPs are the key to normal development as well as in the pathology of cancer and other inflammatory diseases. The inhibitors of MMP-2 activity are very important in maintaining the normal activity of MMP-2 and have an important role in the management of cancer. Regulation of MMP-2 activity is done by inhibitors like, TIMPs. In this report, we are discussing about a possible inhibitor(s) present in the PBS extract of guava leaves, inhibiting the active MMP-2 present in the saliva of breast cancer patients.

关键词： MMP-2 Inhibitor Saliva Breast Cancer

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Effect of Black Tea Polyphenol on Cell-ECM Interaction and MMP

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American Journal of Plant Sciences 2017年第4期8卷 856-866页

作者： Nabanita Bhattacharyya subhajit mondal Shuvojit Moulik Sathi Paul Shreoshi Bhattacharrya Alok Kumar Hazra Md. Nasim Ali Anjan Adhikari Amitava Chatterjee Ramakrishna Mission Vivekananda University IRDM Kolkata India B.C.K.V Kalyani India R.G. Kar Medical College Kolkata India

Tea is one of the most widely consumed beverages in the world. Black tea, obtained from the leaves of Camellia sinensis is the preferred beverage in India and in most western countries. Epidemiological studies on black tea and cancer are limited. However, preliminary studies indicate a positive correlation between black tea consumption and a lower incidence of breast and ovarian cancer. In the present communication, we wanted to see the effect of black tea extract and the polyphenol theaflavin on cell-ECM interaction, MMP activity etc. to strengthen the anti-cancer effect of black tea.

关键词： Black Tea Polyphenol MMP ECM Cancer

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Electron-capture Process Induced by Bare Ion Impact on Biological Targets

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Journal of Energy and Power Engineering 2019年第11期13卷 413-426页

作者： subhajit Samaddar Karunamoy Purkait Saheb Halder Abhoy mondal Chittaranjan Mandal Malay Purkait Department of Physics Ramakrishna Mission Residential CollegeNarendrapurKolkata 700103India Department of Physics Ramsaday CollegeAmtaHowrah 711401India

Within the framework of independent electron approach,the prior form of boundary corrected continuum intermediate state(BCCIS)approximation is employed to calculate the cross sections for total single electron capture in collision of bare ions(H^+,He^2+ and Li^3+)with biological molecules in the intermediate to high energy *** a suitable choice of the distorting potential,the boundary condition is satisfied with a proper account of the intermediate continuum *** cross sections have been calculated from 25 keV/amu to 10 MeV/*** have approximated the cross sections for molecular targets by the linear combination of atomic cross sections weighted by the effective occupation electron ***,the multi-electronic problem is reduced to a mono-electronic one using a version of the independent electron approximation.A detailed analysis on the contributions from different molecular orbitals to total cross sections is *** the present investigation,we observe clearly the importance of the core contribution in the change of slope of the TCS ***,analysis has been made on the cross section per target electron resulting in achievement of a‘universal'cross ***,some negligible discrepancies are observed for the case of the CH4 *** present computed results in prior from of BCCIS method have been compared with the available theoretical and experimental *** found that our computed results are in good agreement with the experimental findings.

关键词： Collision capture cross sections

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