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Anomalous scaling of flexural phonon damping in nanoresonators with confined fluid

Microsystems & Nanoengineering 2019年第1期5卷 682-694页

作者： subhadeep de Narayana R.Aluru department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Various one and two-dimensional(1D and 2D)nanomaterials and their combinations are emerging as next-generation sensors because of their unique opto-electro-mechanical properties accompanied by large surface-to-volume ratio and high quality *** numerous studies have demonstrated an unparalleled sensitivity of these materials as resonant nanomechanical sensors under vacuum isolation,an assessment of their performance in the presence of an interacting medium like fluid environment is ***,we report the mechanical damping behavior of a 1D singlewalled carbon nanotube(SWCNT)resonator operating in the fundamental flexural mode and interacting with a fluid environment,where the fluid is placed either inside or outside of the SWCNT.A scaling study of dissipation shows an anomalous behavior in case of interior fluid where the dissipation is found to be extremely low and scaling inversely with the fluid *** the sources of dissipation reveals that(i)the phonon dissipation remains unaltered with fluid density and(ii)the anomalous dissipation scaling in the fluid interior case is solely a characteristic of the fluid response under *** linear response theory,we construct a fluid damping kernel which characterizes the hydrodynamic force response due to the resonant *** damping kernel-based analysis shows that the unexpected behavior stems from time dependence of the hydrodynamic response under *** systematic dissipation analysis helps us to infer the origin of the intrinsic *** also emphasize on the difference in dissipative response of the fluid under nanoconfinement when compared to a fluid exterior *** finding highlights a unique feature of confined fluid–structure interaction and evaluates its effect on the performance of high-frequency nanoresonators.

关键词： scaling dissipation flexural

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Cellular interplay to 3D in vitro microphysiological disease model:cell patterning microbiota-gut-brain axis

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Bio-design and Manufacturing 2024年第3期7卷 320-357页

作者： Kamare Alam Lakshmi Nair Souvik Mukherjee Kulwinder Kaur Manjari Singh Santanu Kaity Velayutham Ravichandiran Sugato Banerjee subhadeep Roy department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India department of Pharmaceutical Sciences Assam UniversitySilchar 788011India department of Pharmaceutical Sciences Guru Ghasidas UniversityKoniBilaspur 495009C.G.India School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublin D02 YN77Ireland Tissue Engineering Research Group Department of Anatomy and Regenerative MedicineRCSI University of Medicine and Health SciencesDublin D02 YN77Ireland department of Pharmaceutics National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India department of Natural Products National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India

The microbiota-gut-brain axis(MGBA)has emerged as a key prospect in the bidirectional communication between two major organ systems:the brain and the *** between the two organ systems allows the body to function without disease,whereas dysbiosis has long-standing evidence of etiopathological *** most common communication paths are the microbial release of metabolites,soluble neurotransmitters,and immune ***,each pathway is intertwined with a complex *** the emergence of in vitro models and the popularity of three-dimensional(3D)cultures and Transwells,engineering has become easier for the scientific understanding of neurodegenerative *** paper briefly retraces the possible communication pathways between the gut microbiome and the *** further elaborates on three major diseases:autism spectrum disorder,Parkinson’s disease,and Alzheimer’s disease,which are prevalent in children and the *** diseases also decrease patients’quality of ***,understanding them more deeply with respect to current advances in in vitro modeling is crucial for understanding the *** of MGBA in the laboratory uses many molecular technologies and biomaterial *** and organoids provide a more realistic picture of the cell and tissue structure than *** them with the Transwell system offers the advantage of compartmentalizing the two systems(apical and basal)while allowing physical and chemical cues between ***-edge technologies,such as bioprinting and microfluidic chips,might be the future of in vitro modeling,as they provide dynamicity.

关键词： Microbiota-gut-brain axis Neurodegeneration 3D disease model Organoid Transwell system

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Viability of a concentrated solar power system in a low sun belt prefecture

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Frontiers in Energy 2020年第4期14卷 850-866页

作者： Rahul BHATTACHARJEE subhadeep BHATTACHARJEE department of Electrical Engineering National Institute of Technology(NIT)AgartalaTripura Pin-799046India

Concentrating solar power(CSP)is considered as a comparatively economical,more efficient,and large capacity type of renewable energy ***,CSP generation is found restricted only to high solar radiation belt and installed where high direct normal irradiance is *** paper examines the viability of the adoption of the CSP system in a low sun belt region with a lower direct normal irradiance(DNI).Various critical analyses and plant economics have been evaluated with a lesser DNI *** obtained results out of the designed system,subjected to low DNI are not found below par,but comparable to some extent with the performance results of such CSP plants at a higher *** analysis indicates that incorporation of the thermal energy storage reduces the levelized cost of energy(LCOE)and augments the plant capacity *** capacity factor,the plant efficiency,and the LCOE are found to be 32.50%,17.56%,and 0.1952$/kWh,respectively.

关键词： concentrated solar power direct normal irradiance plant performance plant economics thermal energy storage

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An HESS Based on a Modified MMCC-TSBC Converter Integrating Energy Storages

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CSEE Journal of Power and Energy Systems 2023年第5期9卷 1698-1709页

作者： Prabir Ranjan Kasari subhadeep Bhattacharjee the department of Electrical Engineering of National Institute of Technology Agartala AgartalaTripura 799046India

This paper presents a modified modular multilevel cascaded converter based on a triple star bridge cell(MMCCTSBC)for integrating different types of energy storage to form a hybrid energy storage system(HESS).The proposed HESS comprises battery energy storage,supercapacitor energy storage and a doubly-fed induction machine(DFIM)based variable speed pump storage(VSPS).Different low-rated energy storage units can be intermixed in this converter to form an *** is possible due to the modular structure of the modified converter and provides an advantage in a high-power energy storage *** validate the performance of HESS,real-time power variation data is accumulated from online sources and a weighted median filter(WMF)is employed for generating appropriate references for battery energy storage system(BESS)and supercapacitor storage to mitigate both low frequency and high-frequency power ***,the control approach permits independent regulation of grid current and DFIM current through the modified MMCC-TSBC *** simulation and experimental results validate the effectiveness of the control scheme for the proposed HESS.

关键词： BESS DFIM MMCC supercapacitor storage,TSBC converter VSPS

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Chicken collagen hydrolysates differentially mediate anti-inflammatory activity and type I collagen synthesis on human dermal fibroblasts

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Food Science and Human Wellness 2018年第2期7卷 138-147页

作者： Marina Offengenden subhadeep Chakrabarti Jianping Wu department of Agricultural Food&Nutritional Science and the Cardiovascular Research CentreUniversity of AlbertaEdmontonABCanada

Collagen is a major extracellular matrix *** the potential anti-inflammatory and antioxidant profiles of these bioactive compounds,there has been increasing interest in using collagen derived peptides and peptide-rich collagen hydrolysates for skin health,due to their immunomodulatory,antioxidant and proliferative effects on dermal ***,all hydrolysates are not equally effective in exerting the beneficial effects;hence,further research is needed to determine the factors that improve the therapeutic applicability of such *** used different enzymatic conditions to generate a number of different collagen hydrolysates with distinct peptide *** found that the use of two rather than one enzyme for hydrolysis generates a greater abundance of low molecular weight peptides with consequent improvement in bioactive *** these hydrolysates on human dermal fibroblasts showed distinct actions on inflammatory changes,oxidative stress,type I collagen synthesis and cellular *** findings suggest that different enzymatic conditions affect the peptide profile of hydrolysates and differentially regulate their biological activities and potential protective responses on dermal fibroblasts.

关键词： Chicken collagen Collagen peptides Antioxidant activity Anti-inflammatory activity Human dermal fibroblasts

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Tailoring in fungi for next generation cellulase production with special reference to CRISPR/CAS system

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Systems Microbiology and Biomanufacturing 2022年第1期2卷 113-129页

作者： subhadeep Mondal Suman Kumar Halder Keshab Chandra Mondal Center for Life Sciences Vidyasagar UniversityMidnapore 721102West BengalIndia department of Microbiology Vidyasagar UniversityMidnapore 721102West BengalIndia

Cellulose is the utmost plenteous source of biopolymer in our earth,and fungi are the most efcient and ubiquitous organism in degrading the cellulosic biomass by synthesizing *** through genetic manipulation has played a substantial role in constructing novel fungal strains towards improved cellulase production of desired ***,the traditional methods of genetic manipulation of fungi are time-consuming and *** the availability of the full-genome sequences of several industrially relevant flamentous fungi,CRISPR-CAS(clustered regularly interspaced short palindromic repeats/CRISPR-associated protein)technology has come into the focus for the profcient development of manipulated strains of flamentous *** review summarizes the mode of action of cellulases,transcription level regulation for cellulase expression,various traditional strategies of genetic manipulation with CRISPR-CAS technology to develop modifed fungal strains for a preferred level of cellulase production,and the futuristic trend in this arena of research.

关键词： Cellulose Cellulase Fungi Genetic manipulation CRISPR CAS

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Bioactive peptides on endothelial function

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Food Science and Human Wellness 2016年第1期5卷 1-7页

作者： subhadeep Chakrabarti Jianping Wu department of Agricultural Food&Nutritional Science and the Cardiovascular Research CentreUniversity of AlbertaEdmontonABCanada

Cardiovascular diseases(CVD)such as myocardial infarction and stroke are a major cause of morbidity and mortality *** of the normal vasorelaxant functions of the vascular endothelium,termed endothelial dysfunction;appear to underlie the pathogenesis of *** dysfunction is often secondary to abnormal increases in oxidative stress,inflammation and overactivity of the renin–angiotensin system(RAS),which makes these pathways attractive targets for therapeutic *** the side-effects associated with synthetic pharmaceutical agents,there is growing interest in using natural products such as bioactive peptides for treating chronic diseases like *** this review,we discuss the potential for bioactive peptides with antioxidant,anti-inflammatory and RAS modulating properties for treating endothelial dysfunction and preventing CVD.

关键词： diseases mortality inflammation

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IL-15 temporally reorients IL-10 biased B-la cells toward I L- 12 expression

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Cellular & Molecular Immunology 2016年第2期13卷 229-239页

作者： Amlan Kanti Ghosh debolina Sinha subhadeep Mukherjee Ratna Biswas Tapas Biswas Division of Immunology National Institute of Cholera and Enteric Diseases Kolkata India

Interleukin （IL）-15 is known to strongly modulate T-cell function; however, its role in controlling mucosal immunity, including its ability to modulate B-la cell activity, remains to be elucidated. Here, we show that IL-15 upregulates activation molecules and the costimulatory molecule CD80 on viable B-la cells. Cell activation was accompanied by the depletion of sialic acid-binding immunoglobulin-like lectin （Siglec）-G, an inhibitor of cell activation that is present on B-la cells. The IL-15 receptor CD122 was stimulated on B-la cells by the cytokine showing its direct involvement in IL-15-mediated responses. IL-IO is responsible for the long term survival of B-la cells in culture, which is initially promoted by IL-15. The upregulation of IL-IO was followed by the appearance of suppressor of cytokine signaling （SOCS）I in the presence of IL-15 and the loss of IL-IO. This resulted in the cells switching to IL-12 expression. This anti-inflammatory to pro-inflammatory shift in the B-la cell character was independent of the cell-specific marker CD5, which remained highly expressed throughout the in vitro life of the cells. The presence of the immunosuppressive receptor programmed cell death （PD）-I and its ligand PD-L2 were features of a predominantly IL-IO response. PD-1 and PD-L2 can mediate juxtacrine signaling. However, the abrogation of PD-1 and its ligand was observed when the cells expressed IL-12. This demonstrates an inverse relationship between the receptor and ligand and the pro-inflammatory cytokine. The induction of IgM and IgA, which can play pivotal roles in mucosal immunity, was promoted in the presence of IL-15. Collectively, the data implicate IL-15 as the master cytokine that induces B-la cells to mount a mucosal immune response.

关键词： B-la cells IgM innate immunity interleukin-12 generation interleukin-15

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An Intelligent Transportation System Application for Smartphones Based on Vehicle Position Advertising and Route Sharing in Vehicular Ad-Hoc Networks

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Journal of Computer Science & Technology 2018年第2期33卷 249-262页

作者： Seilendria A. Hadiwardoyo subhadeep Patra Carlos T. Calafate Juan-Carlos Cano Pietro Manzoni deptartment of Computer Engineering Universitat Politecnica de Valencia Valencia 46022 Spain

Alerting drivers about incoming emergency vehicles and their routes can greatly improve their travel time in congested cities, while reducing the risk of accidents due to distractions. This paper contributes to this goal by proposing Messiah, an Android application capable of informing regular vehicles about incoming emergency vehicles like ambulances, police cars and fire brigades. This is made possible by creating a network of vehicles capable of directly communicating between them. The user can, therefore, take driving decisions in a timely manner by considering incoming alerts. Using the support of our GRCBox hardware, the application can rely on vehicular ad-hoc network communications in the 5 GHz band, being V2V （vehicle-to-vehicle） communication provided through a combination of Android-based smartphone and our GRCBox device. The application was tested in three different scenarios with different levels of obstruction, showing that it is capable of providing alerts up to 300 meters, and notifying vehicles within less than one second.

关键词： intelligent transportation systems (ITS) vehicular ad-hoc network (VANET) mobile application Android,navigation ad-hoc network

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Friction characteristics of confined inflatable structures

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Friction 2014年第4期2卷 365-390页

作者： Eduardo M.SOSA Gregory J.THOMPSON Ever J.BARBERO subhadeep GHOSH Kevin L.PEIL department of Civil and Environmental Engineering West Virginia UniversityMorgantownWV 26506-6103USA department of Mechanical and Aerospace Engineering West Virginia UniversityMorgantownWV 26506-6106USA

The availability of high‐strength fabrics and progress in the development of large‐scale inflatable technology made possible the creation of temporary and quickly deployable structures for protection of underground *** structures are relatively lightweight and portable,and can maintain the required rigidity while in *** benefits have prompted the development of inflatable structures for use in confined spaces,such as tunnels and large‐diameter pipes to act as barriers for containing flooding with minimal infrastructure *** work presents experimental results obtained from the evaluation of frictional characteristics of the fabric material that constitute the structural membrane of confined inflatable structures developed for protection of underground transportation tunnels and other large *** tests at coupon level and slippage tests in a reduced‐scale inflatable structure were performed in order to evaluate the frictional characteristics of Vectran *** at coupon level were performed to determine the friction coefficient for different surface types and *** with the reduced‐scale inflatable structure contributed to the understanding of the friction characteristics at system level when subjected to different pressurization or depressurization sequences designed to induce *** results indicate that friction coefficient values at coupon level are about 29 percent higher than values derived from reduced‐scale tests.

关键词： friction fabric materials inflatable structures slippage Vectran

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