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Mediastinal and Pericardial Hydatidosis—A Case Report and Review of Literature

Open Journal of Clinical Diagnostics 2016年第2期6卷 13-17页

作者： subha narayan panda Department of Cardiology Queens NRI Hospital Visakhapatnam Andhra Pradesh India

Hydatid disease caused by Echinococcus granulosus is endemic in Indian subcontinent and a common surgical problem. Although occurrence of hydatid cyst is common in liver and lungs, it can be encountered in almost every part of the body. Combined mediastinal and pericardial hydatid disease is a rare occurrence and only a few cases have been reported in the literature. Patients with hydatid cysts are usually asymptomatic. Our case report demonstrates a 57-year-old female patient who presented with chest pain and dyspnea on exertion for few months duration. Detailed imaging and laboratory investigation revealed a pericardial and mediastinal hydatid cyst. The patient underwent operation for curative excision. After surgery, the patient’s symptoms resolved and his clinical status improved.

关键词： Hydatid Disease Echinococcus granulosus Parasitic Infection Zoonotic Disease

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Adjuvant role of a T-type calcium channel blocker, TTA-A2, in lung cancer treatment with paclitaxel

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Cancer Drug Resistance 2021年第4期4卷 996-1007页

作者： Neema Kumari Pravin Shankar Giri subha narayan Rath Department of Biomedical Engineering Indian Institute of Technology HyderabadHyderabad 502285India Department of Biotechnology Indian Institute of Technology HyderabadHyderabad 502285India

Aim:Chemoresistance is a prevalent issue in cancer ***(PTX)is a microtubule-binding anticancer drug used in various cancer ***,cancer cells often show chemoresistance against PTX with the help of P-glycoprotein(Pgp)-a drug efflux *** has also been observed that overexpressed T-type calcium channels(TTCCs)maintain calcium homeostasis in cancer cells,and calcium has a role in ***,the aim of this study was to test the adjuvant role of TTA-A2,a TTCC blocker,in enhancing the anticancer effect of PTX on the A549 lung adenocarcinoma cell ***:Morphology assay,calcium imaging assay,clonogenic assay,apoptosis assay,and real-time polymerase chain reaction(real-time PCR)were performed to find the adjuvant role of *** were treated with PTX at 10 nM concentration and TTA-A2 at 50 and 100 nM *** and TTA-A2 were used in the combination treatment at 10 and 100 nM concentrations,***:Immunocytochemistry confirmed the expression of TTCC in A549 *** assay showed altered morphology of A549 *** adjuvant role of TTA-A2 was observed in the calcium imaging assay in spheroids,in the clonogenic assay in monolayers,and in the apoptosis assay in both *** real-time PCR,it was observed that,even though cells express the mRNA of Pgp,it is non-significant upon treatment with PTX and ***:TTA-A2 can be used as an adjuvant to reduce chemoresistance in cancer cells as well as to enhance the anticancer effect of the standard anticancer drug *** a potent TTCC inhibitor,TTA-A2 may also enhance the anticancer effects of other anticancer drugs.

关键词： TTA-A2 paclitaxel adjuvant lung adenocarcinoma T-type calcium channel blocker

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Evaluation of a Direct Rapid Immunohistochemical Test (dRIT) for Rapid Diagnosis of Rabies in Animals and Humans

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Virologica Sinica 2012年第5期27卷 299-302页

作者： Shampur narayan Madhusudana Sundaramurthy subha Ullas Thankappan Yajaman Belludi Ashwin Department of Neurovirology National Institute of Mental health and Neurosciences(NIMHANS)

Presently the gold standard diagnostic technique for rabies is the direct immunofluorescence assay （dFA） which is very expensive and requires a high level of expertise. There is a need for more economical and user friendly tests, particularly for use in developing countries. We have established one such test called the direct rapid immunohistochemical test （dRIT） for diagnosis of rabies using brain tissue. The test is based on capture of rabies nucleoprotein （N） antigen in brain smears using a cocktail of biotinylated monoclonal antibodies specific for the N protein and color development by streptavidin peroxidase-amino ethyl carbazole and counter staining with haematoxollin. The test was done in parallel with standard FAT dFA using 400 brain samples from different animals and humans. The rabies virus N protein appears under fight microscope as reddish brown particles against a light blue background. There was 100 % correlation between the results obtained by the two tests. Also, interpretation of results by dRIT was easier and only required a light microscope. To conclude, this newly developed dRIT technique promises to be a simple, cost effective diagnostic tool for rabies and will have applicability in field conditions prevalent in developing countries.

关键词： Rabies, Post-mortem diagnosis Fluorescent antibody technique Immunohistochemistry Direct rapid immunohistochemical test(dRIT)

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