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Sodium channel mutation SCN1A T875M,D188V and associated dysfunction with drug resistant epilepsy

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World Journal of Psychiatry 2025年第2期15卷 41-47页

作者： Pradeep Kumar Dabla Swapan Gupta Swati Singh Aroop Viswas Manisha Yadav subash chandra Sonkar Bidhan chandra Koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education&ResearchNew Delhi 110002DelhiIndia Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education&ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACKGROUND The NaV1.1 sodium channel alpha subunit,encoded by SCN1A,is crucial for initiating and propagating action potentials in ***1A gene has long been an established target in the etiology and therapy of ***,very few studies have investigated the relevance of genetic variations in epilepsy and anti-epileptic drug *** To investigate associations between polymorphisms,rs121917953 T/A and rs121918623 C/T,and drug resistance in epilepsy patients in the north Indian *** A total of 100 age-and sex-matched epilepsy patients(50 drug responsive and 50 drug resistant subjects)were recruited and SCN1A rs121918623 C/T*and rs121917953 T/A*polymorphisms were analyzed by the allele specific-PCR technique.χ^(2)and Fisher’s exact test were used to estimate differences between the distribution of SCN1A rs121918623 and rs121917953 gene polymorphisms among various *** association between distinct rs121917953 genotypes and drug resistance was analyzed using logistic regression *** For the SCN1A rs121917953 T/A*(D188V)polymorphism,a significantly higher proportion of individuals with AT genotype were observed in the drug-resistant group as compared to the drug-responsive ***,a higher risk association was exhibited by AT genotype for drug resistance with an odds ratio of 3.51 and P value=*** the SCN1A rs121918623 C/T*(T875M)polymorphism,no significant difference in genotype distribution was observed between the drug-resistant and drug-sensitive *** Our findings indicate that the SCN1A polymorphism D188V is associated with a higher risk of drug resistance for the AT variant as compared to the homozygous TT *** research is needed at the functional level and in larger cohorts to determine the potential of these genes as a therapeutic target in epilepsy subjects.

关键词： Epilepsy Single nucleotide polymorphisms Drug-resistant epilepsy SCN1A receptor SCN1A rs121918623 and SCN1A rs121917953 gene polymorphism

Disentangling the contributing components of stream water by using environmental tracers

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Journal of Mountain Science 2025年第1期22卷 260-277页

作者： Abul Amir KHAN Naresh chandra PANT Amity Centre for Air Pollution Control(ACAPC)&Amity Centre for Ocean Atmospheric Science and Technology(ACOAST) Amity University Haryana(AUH)Gurugram-122413India Department of Geology University of DelhiNorth CampusDelhi-11007India

Identifying the various components contributing to river discharge can be *** study relies on stable isotopes and electrical conductivity(EC)of water as tracers to distinguish the different components contributing to total river ***,we have made an effort to comprehend the processes that may influence glacier ice melt as well as the limits of oxygen-based hydrograph *** distinct geographic domains in terms of climates and topographies were *** first study site represents the upper Ganga catchment(central Himalaya),while the second site is located in the chandra sub-basin in western *** in estimating the proportion of glacier melt in isotope mixing model are likely if end-member isotopic compositions,are not well defined,particularly for *** separation results indicate that snowmelt is the largest contributor to total river flow in both *** contribution of snowmelt to the total runoff of the upper Ganga ranged from~60%to 70%.The estimated contributions of glacier melt varied from 36%to 63%in upper Ganga headwater to 6%to 15%at Devprayag and~8%at *** the Hamtah River,glacier and snowmelt contributions,quantified using a two-component mixing model,ranged from 10%to 14%during the pre-and postmonsoon seasons of *** significant spatial and temporal variability,coupled with overlapping isotopic signatures,suggests complex glacio-fluvial interactions in these *** slow-moving air masses with whirling motion closer to the study area irrespective of the direction,and air parcels coming through Bay of Bengal branch are characterized by depleted isotopic rainfall compared to air masses originating from the Arabian Sea.

关键词： Snowmelt Glacier melt Oxygen isotopes Bhagirathi River Alaknanda River Hamtah

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Assessing tectonic influence on landscape evolution:case study of the Nandakini Watershed,Western Himalaya

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Journal of Mountain Science 2025年第2期22卷 666-680页

作者： Rakesh SINGH Pranati sahu Shalini KUMARI Vishal CHAUHAN Department of Petroleum Engineering and Earth Sciences Graphic Era(Deemed to be University)Dehradun 248002India School of Basic and Applied Sciences SGRR UniversityDehradun 248001India Graphic Era Hill University Dehradun 248002India

Understanding the active tectonic processes in the Nandakini Watershed is imperative for evaluating geological hazards and seismic risks,as well as for informing land-use planning and natural resource management strategies in the *** geomorphology serves as a vital tool for characterizing recent tectonic *** research employs GIS techniques to elucidate tectonic activity and its influence on drainage patterns in the Nandakini Watershed,utilizing morphometric parameters derived from SRTM DEM *** indices are employed to assess the tectonic movement within drainage basins,capturing both areal and linear factors such as drainage density,texture,circulatory and bifurcation ratios,and stream length *** linear and areal morphometric indices are categorized into three classes representing varying degrees of active tectonic *** classifications are then utilized to compute the relative active tectonic index(IRAT).In addition,geomorphic parameters include hypsometric integral,stream length-gradient index,normalized steepness index,chi gradient index,and swath *** majority of the studied region is in an extremely high to moderately active tectonic ***-scale faults and thrusts within the basins are closely correlated with these zones that have been *** integrated methodology of GIS-based morphometric analysis and geomorphic study enables the identification of deformed landforms associated with ongoing tectonic ***,these results offer valuable insights for informing watershed management strategies and promoting sustainable land use planning initiatives.

关键词： Nandakini Watershed Morphotectonic indices Steepness indices Active tectonics Relative active tectonic index(IRAT)

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Graphene derivatives as efficient hole transport materials for lead-free double perovskite（Cs2SnI6） solar cells: a numerical study

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Optoelectronics Letters 2025年第3期21卷 155-159页

作者： Sarita YADAV Saral K.GUPTA chandra Mohan Singh NEGI Department of Physical Science Banasthali Vidyapith

The double perovskite Cs2SnI6has notable optical and electrical characteristics, rendering it a highly prospective candidate for deployment as the absorber layer in perovskite solar cells （PSCs）. We simulated the performance of PSCs using lead-free Cs2SnI6double perovskite absorber layer and graphene derivatives, namely graphene oxide （GO） and reduced graphene oxide （rGO）, as hole transport layers （HTLs）. Our findings show that r GO offers an excellent hole extraction property with minimal interfacial recombination compared to GO.

关键词： A

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QM/MM Based Study of Electronic Structure of Platinum Dihalides

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Open Journal of Applied Sciences 2025年第1期15卷 305-328页

作者： Anil Kumar Soni Swati Vishnu Kumar sahu Department of Chemistry Shia Post Graduate College Lucknow India Academy of Scientific and Innovative Research NPL Chemical and Food BND Division CSIR-National Physical Laboratory New Delhi India Department of Chemistry Maharani Lal Kunwari Post Graduate College Balrmpur India

In this research work, atomic and molecular orbitals based analysis has been made to see electronic structure of platinum halides (platinum dichloride, platinum dibromide, platinum diiodide and platinum difluride). The geometry optimization and three dimensional (3D) modeling of the above mentioned species have been made on CAChe pro software. The results show: (i) The involvement of three p atomic orbitals is negligible as their summation values are very low in comparison to d orbital and considerably low with respect to s orbital. (ii) The study well support the Landis concepts of sdn-hybridation (here n = 1) as bond angle and contributions of s-orbital and d-orbital of Pt(II) are maximum with negligible contribution of p-orbitals. (iii) These halides also support the cloud-expanding effect with experimental data and also follow the nephelauxetic effect. The result is in good agreement with experiment results that covalent character increases in the order: PtI2 > PtBr2 > PtCl2 > PtF2. (iv) And thus the study will help to fine tune the existing complexes of these halides.

关键词： Platinum Dhalides Mulliken Population Analysis sd-Hybridization Molecular Orbital Diagram

Perioperative neurocognitive dysfunction and role of dexmedetomidine in radical colon cancer surgery in elderly patients

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 6-13页

作者： chandra K Pandey Abhishek Kumar Department of Anaesthesiology Medanta Hospital LucknowLucknow 226030Uttar PradeshIndia Department of Anaesthesia King George Medical UniversityLucknow 226003Uttar PradeshIndia

This article explored the application of dexmedetomidine(Dex),a highly selective alpha-2 agonist,in managing postoperative cognitive dysfunction(POCD)in elderly patients undergoing radical colon cancer *** is associated with a progressive decline in physiological functions and an increased risk of adverse surgical outcomes,including POCD,which encompasses many neurocognitive disorders that manifest during the perioperative *** aging population is at a higher risk for POCD,which can lead to prolonged hospital stays,delayed recovery,and increased healthcare *** has neuroprotective,opioid-sparing,and sympatholytic properties,which reduces the incidence and severity of *** was introduced for sedation in patients receiving mechanical ventilation but has since been adopted in anesthesia due to its multifaceted *** appli-cation extends to sedation,analgesia,maintenance of anesthesia,and controlling *** neuroprotective and anti-inflammatory effects have been explored in managing *** article discussed the broad range of patient and procedure-related risk factors for *** identification and intervention are crucial to prevent the progression of POCD,which can have severe physical,psychological,and economic *** article underscored the importance of a mul-tidisciplinary approach in managing POCD,involving the optimization of comor-bidities,depth of anesthesia monitoring,hemodynamic stability,and cerebral oxygenation monitoring.

关键词： Colon cancer Dexmedetomidine General anesthesia Elderly Radical colon cancer surgery Cognitive function

Influence of local stiffeners and cutout shapes on the vibration and stability characteristics of quasi-isotropic laminates under hygro-thermo-mechanical loadings

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Defence Technology（防务技术） 2022年第12期18卷 2107-2124页

作者： T.Rajanna K.S.subash chandra K.Venkata Rao Department of Civil Engineering B.M.S College of EngineeringBengaluru560019India Research Scholar B.M.S College of EngineeringBengaluru560019India Department of Mechanical Engineering B.M.S Evening College of EngineeringBengaluru560019India Department of Mechanical Engineering Government PolytechnicBagepalli561207India

The perforated stiffened panel is generally found as a sub-component of sophisticated *** fundamental purpose of this panel is to withstand against buckling under complicated loading and environmental ***,an accurate knowledge of critical buckling behaviour of stiffened panels is very much essential for a reliable and lightweight structural *** this paper,the focus is on quasi-laminated panels with different cutout shapes of various sizes and their responses to hygrothermal environments under nonlinearly varying edge loads and is compared with the locally stiffened *** this,the modelling of the panel and stiffener is done by adopting nine-noded heterosis plate elements and three noded beam elements *** stiffener formulation is suitably modified in order to take the torsional effect also into consideration along with the effect of shear ***,the plate and the stiffener elements are treated separately,and then the displacement compatibility is maintained between them by using the transformation *** a given loading and geometric discontinuity,the stress distribution within the perforated panel is highly non-uniform in nature and hence a dynamic approach has been used to calculate buckling loads by adopting two sets of boundary conditions,one set for pre-buckling stress analysis and the second set for buckling *** different quasi-isotropic stacking sequences are deliberated in this work by varying different ply-orientation in each *** study also addresses the effect of various parameters such as nonlinear loads,hygro-thermal loads,cutout size and shapes,position of cutout,stiffener parameters,stacking sequences,thickness of plate and boundary conditions.

关键词： Locally stiffened panels Buckling Vibration Cutouts Heterosis Hygrothermal environment

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Alcohol and alcoholism associated neurological disorders:Current updates in a global perspective and recent recommendations

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World Journal of Experimental Medicine 2025年第1期15卷 24-40页

作者： Prashanti sahu Henu Kumar Verma LVKS Bhaskar Department of Zoology GGU BilaspurBilaspur 495009ChhattīsgarhIndia Department of Lung Health and Immunity Helmholtz Zentrum MunichMunich 85764BayrenGermany Department of Zoology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattīsgarhIndia

Alcohol use disorder(AUD)is a medical condition that impairs a person's ability to stop or manage their drinking in the face of negative social,occupational,or health *** is defined by the National Institute on Alcohol Abuse and Alcoholism as a"severe problem".The central nervous system is the primary target of alcohol's adverse *** is crucial to identify various neurological disorders associated with AUD,including alcohol withdrawal syndrome,Wernicke-Korsakoff syndrome,Marchiafava-Bignami disease,dementia,and *** gain a better understanding of the neurological environment of alcoholism and to shed light on the role of various neurotransmitters in the phenomenon of alcoholism.A comprehensive search of online databases,including PubMed,EMBASE,Web of Science,and Google Scholar,was conducted to identify relevant *** neurotransmitters(dopamine,gammaaminobutyric acid,serotonin,and glutamate)have been linked to alcoholism due to a brain *** appears to be a complex genetic disorder,with variations in many genes influencing *** of these genes have been identified,including two alcohol metabolism genes,alcohol dehydrogenase 1B gene and aldehyde dehydrogenase 2 gene,which have the most potent known effects on the risk of *** degeneration and demyelination in people with AUD may be caused by neuronal damage,nutrient deficiencies,and blood brain barrier dysfunction;however,the underlying mechanism is *** review will provide a detailed overview of the neurobiology of alcohol addiction,followed by recent studies published in the genetics of alcohol addiction,molecular mechanism and detailed information on the various acute and chronic neurological manifestations of alcoholism for the Future research.

关键词： Alcohol Alcoholism Neurotransmitter Neurological disorders Alcohol metabolism

A Computational Modeling on Flow Bifurcation and Energy Distribution through a Loosely Bent Rectangular Duct with Vortex Structure

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Frontiers in Heat and Mass Transfer 2025年第1期23卷 249-278页

作者： Rabindra Nath Mondal Giulio Lorenzini Sidhartha Bhowmick Sreedham chandra Adhikari Department of Mathematics Jagannath University Dhaka 1100 Bangladesh Department of Industrial Systems and Technologies Engineering University of Parma Parma 43124 Italy Department of Mechanical and Aerospace Engineering Monash University Melbourne VIC 3800 Australia

The present study investigates the non-isothermal flow and energy distribution through a loosely bent rectangular duct using a spectral-based numerical approach over a wide range of the Dean number 0 < D n ≤ 3000 . Unlike previous research, this work offers novel insights by conducting a grid-point-specific velocity analysis and identifying new bifurcation structures. The study reveals how centrifugal and buoyancy forces interact to produce steady, periodic, and chaotic flow regimes significantly influencing heat transfer performance. The Newton-Raphson method is employed to explore four asymmetric steady branches, with vortex solutions ranging from 2- to 12 vortices. Unsteady flow characteristics are analyzed exquisitely by performing time-advancement of the solutions and the flow regimes are shown as a percentage of total flow with longitudinal vortex generation. Axial flow, secondary flow, and temperature profiles have been depicted in accordance with Dn to wander the flow pattern, and it is predicted that the time-dependent flow (TDF) consists of asymmetric 2- to 10-vortex solutions. The significant findings of this study include the axial displacement of the circulations due to the influence of the time-varying temperature dispersal applied along the wall. Chaotic flows, which dominate the higher Dean number range, are shown to enhance heat convection due to increased fluid mixing. A detailed comparison with prior research demonstrates the advantages of this approach, particularly in capturing complex non-linear behaviors. The findings of this study provide practical guidelines for optimizing duct designs to maximize heat transfer and suggest future research directions, such as using nanofluids or studying Magneto-hydrodynamics in the same configuration.

关键词： Bending duct steady solutions time-advancement energy distribution vortex