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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan sub.ash c.chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas center of Excellence in cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a cAF-like phenotype,which may be due to regulation of ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAc tumors,thus imply feasibility of developing a novel personalized medicine for PDAc patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

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Origami multi-layer space shield for cylindrical space structure

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chinese Journal of Aeronautics 2024年第10期37卷 294-312页

作者： Ji-Hun cHA Ji-sub NOH Sarath Kumar SATHISH KUMAR Dohyeon JIN Dae-Young LEE chun-Gon KIM Department of Aerospace Engineering Chosun UniversityGwangju 61452Republic of Korea Department of Aerospace and Software Engineering Gyeongsang National UniversityGyeongsangnam-do 52828Republic of Korea Department of Aerospace Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Aerospace Engineering KAISTDaejeon 34141Republic of Korea

The multidisciplinary space environment,encompassing orbital debris,cosmic radiation,and solar radiative heat,poses significant risks to spacecraft and astronauts,necessitating efficient and effective shielding solutions.A multi-layer shield with wide spacing has been proven to be an effective way to shield the spacecraft from space debris impact;however,due to the limited volume of the payload fairing,it was not feasible to apply a multi-layer shield to the spacecraft *** the origami design,the shield maintains a compact form during launch and subsequently expands in outer space to enhance *** geometric analysis,it has been confirmed that the deployable multi-layer space shield can occupy less space than conventional space shield structures while expanding into wider shield intervals and multiple *** hypervelocity impact experiments,it was confirmed that as the bumper spacing of the multi-layer space shield expands,its ballistic performance becomes superior to conventional space *** deployable multi-layer space shield can reduce not only hypervelocity impacts but also solar radiative heat using the same mechanism as multi-layer *** cosmic radiation dose analysis,it has been confirmed that the multi-layer space shield is effective in cosmic radiation shielding compared to conventional space structures.

关键词： Hybrid composite Origami Hypervelocity impact Space environment Space debris cosmic radiation

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Solar Driven 15.7% Hydrogen conversion by Harmony of Light Harvesting,Electron Transporting Bridge,and S-Defection in a Self-Assembled Microscale cuS/rGO/cP Photoanode

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Energy & Environmental Materials 2024年第3期7卷 190-201页

作者： Sujeong Kim Boseok Seo Hyerim Park Younghwan Im Jeong Yeon Do Byung sub Kwak Namgyu Son Minkyu Kim Misook Kang Department of chemistry College of Natural SciencesYeungnam UniversityGyeongsan Gyeongbuk 38541Korea School of chemical Engineering Yeungnam UniversityGyeongsan Gyeongbuk 38541Korea Department of Energy and Hydrocarbon chemistry Graduate School of EngineeringKyoto UniversityKyoto 615-8510Japan Korea Evaluation Institute of Industrial Technology(Keit) Cheomdan-Ro 8-GilDong-GuDaegu 41069Korea Korea Electric Power Research Institute(KEPRI)105 Munji-ro Yooseong-guDaejeon 34056Korea

cuS is an encouraging photoelectrode candidate that meets the essential requirements for efficient solar-to-hydrogen production,but it has not been thoroughly studied.A cuS light absorber layer is grown by the self-assembly of copper and sulfur precursors on a carbon paper(cP)***,rGO is introduced as a buffer layer to control the optical and electrical properties of the *** well-ordered microstructural arrangement suppresses the recombination loss of electrons and holes owing to enhanced charge-carrier generation,separation,and *** potential reaching 10 mA cm^(-2)in 1.0 M KOH solution is significantly lowered to 0.87 V,and the photocurrent density at 1.23 V is 94.7 mA cm^(-2).The computational result reveals that the potential-determining step is sensitive to O^(*)stability;the lower stability of O^(*)in the thin layer of cuS/rGO decreases the free-energy gap between the initial and final states of the potential-determining step,resulting in a lowering of the onset *** faradaic efficiency for the photoelectrochemical oxygen evolution reaction in the optimized 2cuS/1rGO/cP photoanode is 98.60%,and the applied bias photon-to-current and the solar-to-hydrogen efficiencies are 11.2%and 15.7%,respectively,and its ultra-high performance is maintained for 250 *** record-breaking achievement indices may be a trigger for establishing a green hydrogen economy.

关键词： 15.7%-solar to hydrogen density functional theory lower photopotential p-cuS/rGO/cP photoanode photoelectrochemical oxygen evolution

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Maximizing Resource Efficiency in cloud Data centers through Knowledge-Based Flower Pollination Algorithm (KB-FPA)

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computers, Materials & continua 2024年第6期79卷 3757-3782页

作者： Nidhika chauhan Navneet Kaur Kamaljit Singh Saini Sahil Verma Kavita Ruba Abu Khurma Pedro A.castillo University Institute of computing Department Chandigarh UniversityPunjab140413India Department of computer Science and Engineering Chandigarh UniversityPunjab140413India Universidade Federal do Piauí TeresinaPiauí64049-550Brazil MEU Research Unit Faculty of Information TechnologyMiddle East UniversityAmman11831Jordan Applied Science Research center Applied Science Private UniversityAmman11931Jordan Department of computer Engineering Automatics and RoboticsUniversity of GranadaGranada18071Spain

cloud computing is a dynamic and rapidly evolving field,where the demand for resources fluctuates *** paper delves into the imperative need for adaptability in the allocation of resources to applications and services within cloud computing *** motivation stems from the pressing issue of accommodating fluctuating levels of user demand *** adhering to the proposed resource allocation method,we aim to achieve a substantial reduction in energy *** reduction hinges on the precise and efficient allocation of resources to the tasks that require those most,aligning with the broader goal of sustainable and eco-friendly cloud computing *** enhance the resource allocation process,we introduce a novel knowledge-based optimization *** this study,we rigorously evaluate its efficacy by comparing it to existing algorithms,including the Flower Pollination Algorithm(FPA),Spark Lion Whale Optimization(SLWO),and Firefly *** findings reveal that our proposed algorithm,Knowledge Based Flower Pollination Algorithm(KB-FPA),consistently outperforms these conventional methods in both resource allocation efficiency and energy consumption *** paper underscores the profound significance of resource allocation in the realm of cloud *** addressing the critical issue of adaptability and energy efficiency,it lays the groundwork for a more sustainable future in cloud computing *** contribution to the field lies in the introduction of a new resource allocation strategy,offering the potential for significantly improved efficiency and sustainability within cloud computing infrastructures.

关键词： cloud computing resource allocation energy consumption optimization algorithm flower pollination algorithm

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Anneal-free ultra-low loss silicon nitride integrated photonics

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Light(Science & Applications) 2024年第8期13卷 1565-1577页

作者： Debapam Bose Mark W.Harrington Andrei Isichenko Kaikai Liu Jiawei Wang Nitesh chauhan Zachary L.Newman Daniel J.Blumenthal Department of Electrical and computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA Octave Photonics LouisvilleCO 80027USA

Heterogeneous and monolithic integration of the versatile low-loss silicon nitride platform with low-temperature materials such as silicon electronics and photonics,III–V compound semiconductors,lithium niobate,organics,and glasses has been inhibited by the need for high-temperature annealing as well as the need for different process flows for thin and thick *** techniques are needed to maintain the state-of-the-art losses,nonlinear properties,and cMOS-compatible processes while enabling this next generation of 3D silicon nitride *** report a significant advance in silicon nitride integrated photonics,demonstrating the lowest losses to date for an anneal-free process at a maximum temperature 250℃,with the same deuterated silane based fabrication flow,for nitride and oxide,for an order of magnitude range in nitride thickness without requiring stress mitigation or *** report record low anneal-free losses for both nitride core and oxide cladding,enabling 1.77 dBm^(-1) loss and 14.9 million Q for 80 nm nitride core waveguides,more than half an order magnitude lower loss than previously reported sub 300℃ *** 800 nm-thick nitride,we achieve as good as 8.66 dBm^(-1) loss and 4.03 million Q,the highest reported Q for a low temperature processed resonator with equivalent device area,with a median of loss and Q of 13.9 dBm^(-1) and 2.59 million each *** demonstrate laser stabilization with over 4 orders of magnitude frequency noise reduction using a thin nitride reference cavity,and using a thick nitride micro-resonator we demonstrate OPO,over two octave supercontinuum generation,and four-wave mixing and parametric gain with the lowest reported optical parametric oscillation threshold per unit resonator *** results represent a significant step towards a uniform ultra-low loss silicon nitride homogeneous and heterogeneous platform for both thin and thick waveguides capable of linear and nonlinear photonic circuits and

关键词： resonator thick free

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Milk exosomes:Nature’s abundant nanoplatform for theranostic applications

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Bioactive Materials 2021年第8期6卷 2479-2490页

作者： Benilde Adriano Nycol M.cotto Neeraj chauhan Meena Jaggi sub.ash c.chauhan Murali M.Yallapu Department of Immunology and Microbiology School of MedicineThe University of Texas Rio Grande ValleyMcAllenTX78504USA South Texas center of Excellence in cancer Research School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX78504USA

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle *** have proven to be excellent nanocarriers for carrying lipids,proteins,mRNAs,non-coding RNAs,and DNAs,and disseminating long-distance intercellular communications in various biological *** various cell-line or biological fluid derived exosomes,milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic *** be an effective delivery carrier for their clinical translation,exosomes must inbuilt loading,release,targeting,and imaging/tracking *** the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging *** review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery *** is emphasized on possible modifications of exosomes towards increasing the stability and delivery of *** article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle.

关键词： Milk exosomes Extracellular vesicles Drug delivery Imaging agents Theranostic applications

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Bioactive nanotherapeutic trends to combat triple negative breast cancer

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Bioactive Materials 2021年第10期6卷 3269-3287页

作者： Pallabita chowdhury Upasana Ghosh Kamalika Samanta Meena Jaggi sub.ash c.chauhan Murali M.Yallapu Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTNUSA Department of Biomedical Engineering School of EngineeringRutgers UniversityThe State University of New JerseyPiscatawayNJ08854USA Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTXUSA South Texas center of Excellence in cancer Research School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTXUSA

The management of aggressive breast cancer,particularly,triple negative breast cancer(TNBc)remains a formidable challenge,despite treatment *** newer therapies such as atezolizumab,olaparib,and sacituzumab can tackle the breast cancer prognosis and/or progression,but achieved limited survival benefit(s).The current research efforts are aimed to develop and implement strategies for improved bioavailability,targetability,reduce systemic toxicity,and enhance therapeutic outcome of FDA-approved treatment *** review presents various nanoparticle technology mediated delivery of chemotherapeutic agent(s)for breast cancer *** article also documents novel strategies to employ cellular and cell membrane cloaked(biomimetic)nanoparticles for effective clinical *** technologies offer a safe and active targeting nanomedicine for effective management of breast cancer,especially TNBc.

关键词： Breast cancer treatment Triple negative breast cancer chemotherapy Nanoparticles Membrane cloaked nanoparticles Nanomedicine Biomimetic nanoparticles

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Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer

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Acta Pharmaceutica Sinica B 2018年第4期8卷 602-614页

作者： Pallabita chowdhury Prashanth K.B.Nagesh Sheema Khan Bilal B.Hafeez sub.ash c.chauhan Meena Jaggi Murali M.Yallapu Department of Pharmaceutical Sciences and center for cancer Research University of Tennessee Health Science Center

The goal of this investigation was to develop and demonstrate a polymer/paclitaxel selfassembly(PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone(PVP)-based PTX-SAs(PVP/PTX-SAs) had superior cellular internalization capability in McF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTXSAs exhibited less toxicity to human red blood cells indicating a suitable formulation for reducing systemic toxicity. The formation of PVP and PTX self-assemblies was confirmed using fluorescence quenching and transmission electron microscopy which indicated that the PVP/PTX-SAs were spherical in shape with an average size range of 53.81 nm as detected by transmission electron microscopy(TEM).FTIR spectral analysis demonstrates incorporation of polymer and paclitaxel functional groups in PVP/PTX-SAs. Both proliferation(MTS) and clonogenic(colony formation) assays were used to validate superior anticancer activity of PVP/PTX-SAs in breast cancer cells over paclitaxel. Such superior anticancer activity was also demonstrated by downregulation of the expression of pro-survival protein(Bcl-x L), upregulation of apoptosis-associated proteins(Bid, Bax, cleaved caspase 7, and cleaved PARP)and β-tubulin stabilization. These results support the hypothesis that PVP/PTX-SAs improved paclitaxel delivery to cancer cells.

关键词： Drug delivery Nanoparticles Self-assemblies Polymer cancer therapeutics Breast cancer

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A Systematic Literature Review on Task Allocation and Performance Management Techniques in cloud Data center

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computer Systems Science & Engineering 2024年第3期48卷 571-608页

作者： Nidhika chauhan Navneet Kaur Kamaljit Singh Saini Sahil Verma Abdulatif Alabdulatif Ruba Abu Khurma Maribel Garcia-Arenas Pedro A.castillo University Institute of computing Chandigarh UniversityPunjab143001India Department of computer Science and Engineering Chandigarh UniversityPunjab143001India Department of computer Science and Engineering Uttaranchal UniversityUttarakhand248007India Department of computer Science College of Computer Qassim UniversityBuraydah52571Saudi Arabia MEU Research Unit Faculty of Information TechnologyMiddle East UniversityAmman11831Jordan Department of computer Engineering Automatics and RoboticsUniversity of GranadaGranada18071Spain Applied Science Research center Applied Science Private UniversityAmman11931Jordan

As cloud computing usage grows,cloud data centers play an increasingly important *** maximize resource utilization,ensure service quality,and enhance system performance,it is crucial to allocate tasks and manage performance *** purpose of this study is to provide an extensive analysis of task allocation and performance management techniques employed in cloud data *** aim is to systematically categorize and organize previous research by identifying the cloud computing methodologies,categories,and gaps.A literature review was conducted,which included the analysis of 463 task allocations and 480 performance management *** review revealed three task allocation research topics and seven performance management *** allocation research areas are resource allocation,load-Balancing,and *** management includes monitoring and control,power and energy management,resource utilization optimization,quality of service management,fault management,virtual machine management,and network *** study proposes new techniques to enhance cloud computing work allocation and performance ***-comings in each approach can guide future *** research’s findings on cloud data center task allocation and performance management can assist academics,practitioners,and cloud service providers in optimizing their systems for dependability,cost-effectiveness,and *** methodologies can steer future research to fill gaps in the literature.

关键词： cloud computing data centre task allocation performance management resource utilization

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Bi3+assisted luminescence in SrMoO_(4):Sm^(3+) red phosphors

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Journal of Rare Earths 2021年第11期39卷 1336-1343,I0002页

作者： Vaibhav chauhan Prashant Dixit Praveen c.Pandey Department of Physics Indian Institute of Technology(Banaras Hindu University)Varanasi221005UPIndia

In this paper,we report synthesis of pure SrMoO_(4),Sm^(3+)(1 at%-5 at%)doped SrMoO_(4)and Bi^(3+)(1 at%-3 at%)co-doped in 4 at%Sm^(3+)doped SrMoO_(4)(SrMoO_(4):4 Sm^(3+))phosphors by solution combustion *** X-ray diffraction(XRD)analysis reveals the tetragonal phase of all samples,also Bi^(3+)co-doping supports crystallite size growth and reduces lattice *** analysis of Sm^(3+)doped SrMoO_(4)ascertains a decrease in band gap and Bi^(3+)co-doping confirms the emergence of an absorbance peak at around 308 nm attributed to Bi^(3+)energy ***(PL)analysis ascertains an increase in emission peaks for Sm^(3+)doped SrMoO_(4)up to 4%concentration,which are attributed to an electron transition from 4 G5/2 to 6 HJ(J=5/2,7/2,9/2,and 11/2)energy levels of Sm^(3+)*** have explained the effects of Bi^(3+)co-doping on the luminescence of Sm^(3+)doped SrMoO_(4).The reduced microstrain and increased crystallinity of the phosphors as a result of Bi^(3+)co-doping and their correlation with the luminescence of Sm^(3+)ions are discussed.

关键词： SrMoO_(4):Sm^(3+) Bismuth ion Photoluminescence Absorption study crystallinity Microstrain

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