检索结果-南通市图书馆

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan sub.ash c.chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas center of Excellence in cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a cAF-like phenotype,which may be due to regulation of ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAc tumors,thus imply feasibility of developing a novel personalized medicine for PDAc patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Maximizing Resource Efficiency in cloud Data centers through Knowledge-Based Flower Pollination Algorithm (KB-FPA)

引用

computers, Materials & continua 2024年第6期79卷 3757-3782页

作者： Nidhika chauhan Navneet Kaur Kamaljit Singh Saini Sahil Verma Kavita Ruba Abu Khurma Pedro A.castillo University Institute of computing Department Chandigarh UniversityPunjab140413India Department of computer Science and Engineering Chandigarh UniversityPunjab140413India Universidade Federal do Piauí TeresinaPiauí64049-550Brazil MEU Research Unit Faculty of Information TechnologyMiddle East UniversityAmman11831Jordan Applied Science Research center Applied Science Private UniversityAmman11931Jordan Department of computer Engineering Automatics and RoboticsUniversity of GranadaGranada18071Spain

cloud computing is a dynamic and rapidly evolving field,where the demand for resources fluctuates *** paper delves into the imperative need for adaptability in the allocation of resources to applications and services within cloud computing *** motivation stems from the pressing issue of accommodating fluctuating levels of user demand *** adhering to the proposed resource allocation method,we aim to achieve a substantial reduction in energy *** reduction hinges on the precise and efficient allocation of resources to the tasks that require those most,aligning with the broader goal of sustainable and eco-friendly cloud computing *** enhance the resource allocation process,we introduce a novel knowledge-based optimization *** this study,we rigorously evaluate its efficacy by comparing it to existing algorithms,including the Flower Pollination Algorithm(FPA),Spark Lion Whale Optimization(SLWO),and Firefly *** findings reveal that our proposed algorithm,Knowledge Based Flower Pollination Algorithm(KB-FPA),consistently outperforms these conventional methods in both resource allocation efficiency and energy consumption *** paper underscores the profound significance of resource allocation in the realm of cloud *** addressing the critical issue of adaptability and energy efficiency,it lays the groundwork for a more sustainable future in cloud computing *** contribution to the field lies in the introduction of a new resource allocation strategy,offering the potential for significantly improved efficiency and sustainability within cloud computing infrastructures.

关键词： cloud computing resource allocation energy consumption optimization algorithm flower pollination algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Systematic Literature Review on Task Allocation and Performance Management Techniques in cloud Data center

引用

computer Systems Science & Engineering 2024年第3期48卷 571-608页

作者： Nidhika chauhan Navneet Kaur Kamaljit Singh Saini Sahil Verma Abdulatif Alabdulatif Ruba Abu Khurma Maribel Garcia-Arenas Pedro A.castillo University Institute of computing Chandigarh UniversityPunjab143001India Department of computer Science and Engineering Chandigarh UniversityPunjab143001India Department of computer Science and Engineering Uttaranchal UniversityUttarakhand248007India Department of computer Science College of Computer Qassim UniversityBuraydah52571Saudi Arabia MEU Research Unit Faculty of Information TechnologyMiddle East UniversityAmman11831Jordan Department of computer Engineering Automatics and RoboticsUniversity of GranadaGranada18071Spain Applied Science Research center Applied Science Private UniversityAmman11931Jordan

As cloud computing usage grows,cloud data centers play an increasingly important *** maximize resource utilization,ensure service quality,and enhance system performance,it is crucial to allocate tasks and manage performance *** purpose of this study is to provide an extensive analysis of task allocation and performance management techniques employed in cloud data *** aim is to systematically categorize and organize previous research by identifying the cloud computing methodologies,categories,and gaps.A literature review was conducted,which included the analysis of 463 task allocations and 480 performance management *** review revealed three task allocation research topics and seven performance management *** allocation research areas are resource allocation,load-Balancing,and *** management includes monitoring and control,power and energy management,resource utilization optimization,quality of service management,fault management,virtual machine management,and network *** study proposes new techniques to enhance cloud computing work allocation and performance ***-comings in each approach can guide future *** research’s findings on cloud data center task allocation and performance management can assist academics,practitioners,and cloud service providers in optimizing their systems for dependability,cost-effectiveness,and *** methodologies can steer future research to fill gaps in the literature.

关键词： cloud computing data centre task allocation performance management resource utilization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Milk exosomes:Nature’s abundant nanoplatform for theranostic applications

引用

Bioactive Materials 2021年第8期6卷 2479-2490页

作者： Benilde Adriano Nycol M.cotto Neeraj chauhan Meena Jaggi sub.ash c.chauhan Murali M.Yallapu Department of Immunology and Microbiology School of MedicineThe University of Texas Rio Grande ValleyMcAllenTX78504USA South Texas center of Excellence in cancer Research School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX78504USA

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle *** have proven to be excellent nanocarriers for carrying lipids,proteins,mRNAs,non-coding RNAs,and DNAs,and disseminating long-distance intercellular communications in various biological *** various cell-line or biological fluid derived exosomes,milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic *** be an effective delivery carrier for their clinical translation,exosomes must inbuilt loading,release,targeting,and imaging/tracking *** the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging *** review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery *** is emphasized on possible modifications of exosomes towards increasing the stability and delivery of *** article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle.

关键词： Milk exosomes Extracellular vesicles Drug delivery Imaging agents Theranostic applications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive nanotherapeutic trends to combat triple negative breast cancer

引用

Bioactive Materials 2021年第10期6卷 3269-3287页

作者： Pallabita chowdhury Upasana Ghosh Kamalika Samanta Meena Jaggi sub.ash c.chauhan Murali M.Yallapu Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTNUSA Department of Biomedical Engineering School of EngineeringRutgers UniversityThe State University of New JerseyPiscatawayNJ08854USA Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTXUSA South Texas center of Excellence in cancer Research School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTXUSA

The management of aggressive breast cancer,particularly,triple negative breast cancer(TNBc)remains a formidable challenge,despite treatment *** newer therapies such as atezolizumab,olaparib,and sacituzumab can tackle the breast cancer prognosis and/or progression,but achieved limited survival benefit(s).The current research efforts are aimed to develop and implement strategies for improved bioavailability,targetability,reduce systemic toxicity,and enhance therapeutic outcome of FDA-approved treatment *** review presents various nanoparticle technology mediated delivery of chemotherapeutic agent(s)for breast cancer *** article also documents novel strategies to employ cellular and cell membrane cloaked(biomimetic)nanoparticles for effective clinical *** technologies offer a safe and active targeting nanomedicine for effective management of breast cancer,especially TNBc.

关键词： Breast cancer treatment Triple negative breast cancer chemotherapy Nanoparticles Membrane cloaked nanoparticles Nanomedicine Biomimetic nanoparticles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer

引用

Acta Pharmaceutica Sinica B 2018年第4期8卷 602-614页

作者： Pallabita chowdhury Prashanth K.B.Nagesh Sheema Khan Bilal B.Hafeez sub.ash c.chauhan Meena Jaggi Murali M.Yallapu Department of Pharmaceutical Sciences and center for cancer Research University of Tennessee Health Science Center

The goal of this investigation was to develop and demonstrate a polymer/paclitaxel selfassembly(PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone(PVP)-based PTX-SAs(PVP/PTX-SAs) had superior cellular internalization capability in McF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTXSAs exhibited less toxicity to human red blood cells indicating a suitable formulation for reducing systemic toxicity. The formation of PVP and PTX self-assemblies was confirmed using fluorescence quenching and transmission electron microscopy which indicated that the PVP/PTX-SAs were spherical in shape with an average size range of 53.81 nm as detected by transmission electron microscopy(TEM).FTIR spectral analysis demonstrates incorporation of polymer and paclitaxel functional groups in PVP/PTX-SAs. Both proliferation(MTS) and clonogenic(colony formation) assays were used to validate superior anticancer activity of PVP/PTX-SAs in breast cancer cells over paclitaxel. Such superior anticancer activity was also demonstrated by downregulation of the expression of pro-survival protein(Bcl-x L), upregulation of apoptosis-associated proteins(Bid, Bax, cleaved caspase 7, and cleaved PARP)and β-tubulin stabilization. These results support the hypothesis that PVP/PTX-SAs improved paclitaxel delivery to cancer cells.

关键词： Drug delivery Nanoparticles Self-assemblies Polymer cancer therapeutics Breast cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photoionisation detection of a single Er3+ ion with sub-100-ns time resolution

引用

National Science Review 2024年第4期11卷 38-45页

作者： Yangbo Zhang Wenda Fan Jiliang Yang Hao Guan Qi Zhang Xi Qin changkui Duan Gabriele G.de Boo Brett c.Johnson Jeffrey c.Mc callum Matthew J.Sellars Sven Rogge chunming Yin Jiangfeng Du cAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of China cAS center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China centre of Excellence for Quantum computation and communication Technology School of Physics University of New South Wales centre of Excellence for Quantum computation and communication Technology School of Engineering RMIT University centre of Excellence for Quantum computation and communication Technology School of Physics University of Melbourne centre of Excellence for Quantum computation and communication Technology Research School of Physics and Engineering Australian National University

Efficient detection of single optical centres in solids is essential for quantum information processing, sensing and single-photon generation *** this work,we use radio-frequency（RF） reflectometry to electrically detect the photoionisation induced by a single Er3+ion in *** high bandwidth and sensitivity of the RF reflectometry provide sub-100-ns time resolution for the photoionisation *** this technique,the optically excited state lifetime of a single Er3+ion in a Si nano-transistor is measured for the first time to be 0.49±0.04μ*** results demonstrate an efficient approach for detecting a charge state change induced by Er excitation and *** approach could be used for fast readout of other single optical centres in solids and is attractive for large-scale integrated optical quantum systems thanks to the multi-channel RF reflectometry demonstrated with frequency multiplexing techniques.

关键词： single optical centres erbium ions RF reflectometry photoionisation detection

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Non-linear dynamic state-space network modeling for decoding neurodegeneration

引用

Neural Regeneration Research 2024年第9期19卷 1879-1880页

作者： Venkata c.chirumamilla chi Wang Ip Martin Reich Robert Peach Jens Volkmann Bahman Nasseroleslami Muthuraman Muthuraman Prenatal Pediatrics Institute Children’s National HospitalWashingtonDCUSA Neural Engineering with Signal Analytics and Artificial Intelligence Department of NeurologyUniversity of WürzburgWürzburgGermany Academic Unit of Neurology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Neurodegenerative disorders represent a pervasive global health challenge,yet therapeutic options remain conspicuously *** disorders are inherently dynamic processes within the central nervous system,unfolding across distinct sub-stages:initial structural neuronal alterations(sub-stage 1),functional impairment(sub-stage 2),and culminating in neuronal death(sub-stage 3).

关键词： alterations impairment dynamic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Luminescence Dating and Bracketing Time of the Youngest Toba Tuff Deposits in the Quaternary Sediments of Purna Alluvial Basin,central India

引用

Journal of Earth Science 2022年第4期33卷 1007-1016页

作者： Singh Ajab K.Srivastava ashok chauhan Naveen Department of Geology Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Department of Geology SGB Amravati UniversityAmravati 444602India Physical Research Laboratory Ahmedabad 380009India

Light gray to yellowish brown youngest Toba tuff(YTT)ash,preserved in the Quaternary sediments of India,have been used as a tool to know depositional and bracketing time period of the same in the sediments through applications of luminescence dating to interpret age connotation of various geological ***-and post-tephra sediments of YTT ash beds from Hudki and Sukali areas of Purna alluvial basin,central India have been optically dated to interpret the depositional age and bracketing time of the tephra within sedimentary *** sediments are yellowish brown,thinly bedded,laminated,silty clay and host laterally extend discontinued beds of 0.15–0.20 m *** ash is light gray,fine grained and powdery in nature,massive to structureless and lacks any sign of retransportation and redeposition,hence,considered as primary in *** four sediment samples,one each from pre-and post-tephra lithounits of both the localities have been dated through optically stimulated luminescence technique(OSL)equipped with single aliquot regenerative(SAR)procedure on the feldspar *** shows pre-and post-tephra ages of 57±5 and 70±4 ka respectively for Hudki and 66±5 and 67±4 ka for Sukali *** depositional ages suggest that the ash was bracketed within sediments thousands years after YTT *** is correlatable with the previously reported depositional and absolute ages for the YTT ash from the localities of Ghoghara and Khuntheli,Son Valley;Tejpur,Madhumati River Basin and Jwalapuram,Jurreru *** ages also provide an idea about the period of existence of biological communities represented by the remains of faunal and vegetational activities before and during settlement of the YTT ash in the basin area.

关键词： youngest Toba tuff Tephra optically stimulated luminescence Quaternary sediments depositional age

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deformable microlaser force sensing

引用

Light(Science & Applications) 2024年第6期13卷 1196-1209页

作者： Eleni Dalaka Joseph SHill Jonathan H.H.Booth Anna Popczyk Stefan R.Pulver Malte c.Gather Marcel Schubert centre of Biophotonics SUPASchool of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsUK Humboldt centre for Nano-and Biophotonics Department of ChemistryUniversity of CologneKölnGermany School of Psychology and Neuroscience University of St AndrewsSt Mary’s QuadSouth StreetSt AndrewsUK Institute for Bioengineering of catalonia BarcelonaSpain

Mechanical forces are key regulators of cellular behavior and function,affecting many fundamental biological processes such as cell migration,embryogenesis,immunological responses,and pathological *** force sensors and imaging techniques have been developed to quantify these otherwise invisible forces in single cells and in ***,current techniques rely heavily on high-resolution microscopy and do not allow interrogation of optically dense tissue,reducing their application to 2D cell cultures and highly transparent biological ***,we introduce DEFORM,deformable microlaser force sensing,a spectroscopic technique that detects sub-nanonewton forces with unprecedented spatio-temporal *** is based on the spectral analysis of laser emission from dye-doped oil microdroplets and uses the force-induced lifting of laser mode degeneracy in these droplets to detect nanometer *** validation by atomic force microscopy and development of a model that links changes in laser spectrum to applied force,DEFORM is used to measure forces in 3D and at depths of hundreds of microns within tumor spheroids and late-stage Drosophila *** furthermore show continuous force sensing with single-cell spatial and millisecond temporal resolution,thus paving the way for non-invasive studies of biomechanical forces in advanced stages of embryogenesis,tissue remodeling,and tumor invasion.

关键词： invasion otherwise hundreds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：