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Chinese Journal of Chemistry 2021年第11期39卷 2995-3003页

作者： Xing-yang Chen su-yang yao Li-Ping Li Bao-Hui Ye MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhouGuangdong510275 China Department of Chemistry Guangdong University of EducationGuangzhouGuangdong510303 China

The diastereoselective photoreactions of Ir(III)-amine and Ir(III)-diamine complexes are observed in the presence of ***Ʌ-[Ir(pq)_(2)(R-mapy)](PF_(6))(pq is 2-phenylquinoline and mapy is 2-(1-aminoethyl)pyridine)diastereomer is dehydrogenatively oxidized into imine complexɅ-[Ir(pq)_(2)(mapy-2H)](PF_(6))at room temperature,while theɅ-[Ir(pq)_(2)(S-mapy)](PF_(6))diastereomer occurs interligand C—N cross-coupling reaction at 60℃,affording a new tetradentate complexɅ-[Ir(pq)(S-pqpe)](PF_(6))(pqpe is 2-phenyl-N-(1-pyridin-2-yl)ethyl-quinolin-8-amine).The identical cases are also observed in diamine complexesɅ-[Ir(pq)_(2)(R,R-chda)](PF_(6))(chda is 1,2-diaminocyclohexane),Ʌ-[Ir(pq)_(2)(R,S-chda)](PF_(6)),andɅ-[Ir(pq)_(2)(S,S-chda)](PF_(6)),where the R configuration ligand is dehydrogenatively oxidized into imine,while the S configuration is retentive and the bound nitrogen atom is coupling to the C8 of pq ligand,affordingɅ-[Ir(pq)_(2)(chdi)](PF_(6))(chdi is 1,2-diiminocyclohexane),Ʌ-[Ir(pq)(S-pqchim)](PF_(6))(pqchim is N-(2-iminocyclohexyl)-2-phenyl-quinolin-8-amine),andɅ-[Ir(S,S-pqchda)](PF_(6))(pqchda is N',N”-bis(2-phenylquinolin-8-yl)cyclohexane-1,2-diamine),*** provide a new and useful protocol for the synthesis of multidentate ligands in situ via the postcoordinated interligand-coupling strategy under mild conditions.

关键词： Ir(III)complexes Interligand-Coupling Reaction/n-s/fu Photochemistry Diastereoselectivity

Thermodynamic Resolution of Pharmaceutical Precursor Modafinil Acid on the Basis of Chiral-at-Metal Strategy

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Chinese Journal of Chemistry 2021年第6期39卷 1483-1490页

作者： Man-Li Cao Jun-Ling Zhu Zhong-Lan Zhi Bao-Hui Ye su-yang yao Xiu-Lian Zhang Department of Chemistry Guangdong University of EducationGuangzhouGuangdong 510303China MOE Key Laboratory of Bioinorgonic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhouGuangdong 510275China

Chiral-at-metal strategy was developed to resolve the essential sulfoxide pharmaceutical intermediates R-modafinil acid and its ana-logues with high yields and ee *** efficient resolution process was achieved based on the diastereoselective discrimination caused by hydrogen bond and intramolecular π-π interaction between chiral-at-metal center and the coordinated chiral sulfoxide ***,the chiral Ir(lll)receptor can be reused with complete retention of their configurations and without the loss of reaction activity and *** work provides a new access to synthesize R-modafinil acid as well as its analogues and develops the application of chiral-at-metal strategy in chiral resolution.

关键词： Chiral resolution Chiral-at-metal complexes Modafinil acid Chiral pharmaceutical Ir(III)complexes

Chiral Dynamic Thermodynamic Resolution of sulfoxide Enantiomers by Chiral Iridium(Ⅲ) Complexes

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Chiral Dynamic Thermodynamic Resolution of Sulfoxide Enantio...

Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

中国化学会第八届全国分子手性学术研讨会

作者： su-yang yao Bao-Hui Ye School of Chemistry Sun Yat-Sen University

Chiral octahedral Ir(Ⅲ) complexes have been widely employed in many areas such as asymmetric conjugate additions of α,β-unsaturated 2-acyl imidazole as well as the discrimination and determination of the enantiopurity of varied amines and amine alcohol owing to theirs stability [1,2].Here we present an approach to the resolution of sulfoxide enantiomers with high enantiomeric *** shown in figure 1,the chiral Ir(Ⅲ) complex Λ-[Ir(ppy)(MeCN)](PF)(ppy is 2-phenylpyridine) was prefer to bind(R)-2-(alkylsulfinyl)phenol(HLO-R,R = Me,Et,i Pr,and Bn) rather than(S)-HLO-R under thermodynamic *** coupling 2 eq rac-HLO-R with 1 eq Λ-[Ir(ppy)(MeCN)](PF6),we obtained Λ-[Ir(ppy)2(S-HLO-R)] and the uncoordinated(S)-***(R)-HLO-R was obtained by the protonation of Λ-[Ir(ppy)(S-HLO-R)] with trifluoroacetic acid(TFA) in *** can also apply the methods to separate the pharmaceutical agent precursor(R)-modafinil acid(MA) from(S)-modafinil acid as shown in figure *** yield and optical purity of products were listed in table 1.

关键词： Chiral Octahedral Ir(Ⅲ) Complexes Chiral Resolution

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You Wu Lijie yang Wanrong Jiang Xinyuan Zhang Zhaohui yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing yang Jinghui Chen Xingyue Xiao Xiayin yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Solid-State Batteries

Bilevel Optimal Scheduling of Island Integrated Energy System Considering Multifactor Pricing

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Energy Engineering 2025年第1期122卷 349-378页

作者： Xin Zhang Mingming yao Daiwen He Jihong Zhang Peihong yang Xiaoming Zhang School of Automation and Electrical Engineering Inner Mongolia University of Science and TechnologyBaotou014010China

In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load *** to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption *** price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption *** benefits and win-win situations are achieved between the upper and lower ***,CPLEX is used to iteratively solve the bilevel optimization *** optimal solution is selected according to the joint optimal discrimination *** results indicate that the sourceload coordinate operation can reduce the upper and lower operation *** the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified.

关键词： Bilevel optimal scheduling load aggregator integrated energy operator carbon emission dynamic pricing mechanism

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing yang Lilingxuan yao Xinyue Xu yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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蛋白质的甲基化研究进展

微生物学报 2017年第11期57卷 1698-1707页

作者：刘舒婷苏杨姚玉峰上海交通大学医学院上海200025

蛋白质翻译后修饰是调控蛋白质生物学功能的重要步骤之一。甲基化修饰作为蛋白质翻译后修饰的一种重要形式,参与了真核生物和原核生物的多种细胞进程。本文综述了目前蛋白质甲基化的研究进展,包括真核生物、原核生物,组蛋白和非组蛋白,... 详细信息

蛋白质翻译后修饰是调控蛋白质生物学功能的重要步骤之一。甲基化修饰作为蛋白质翻译后修饰的一种重要形式,参与了真核生物和原核生物的多种细胞进程。本文综述了目前蛋白质甲基化的研究进展,包括真核生物、原核生物,组蛋白和非组蛋白,以及多种氨基酸位点的甲基化修饰。这些发现丰富了人们对蛋白质甲基化修饰的认识,对深入了解蛋白质翻译后修饰的功能具有重要意义。

关键词：甲基化修饰 O-甲基化 N-甲基化

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling Li Xiaoyao Yu Yingjie Zhou yao Lin Ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration