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Modified Xiaochaihu Decoction for gastroesophageal reflux disease:A randomized double-simulation controlled trial

World Journal of Gastroenterology 2021年第28期27卷 4710-4721页

作者： Zhe Li Lin Tao Sheng-Sheng Zhang Xiao-Hong sun su-ning chen Jing Wu The Digestive Center Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Department of Digestive Peking Union Medical College HospitalBeijing 100730China Department of Digestive Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Digestive Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Gastroesophageal reflux disease(GERD)has a high prevalence worldwide,and its incidence is increasing *** Xiaochaihu Decoction(MXD)could relieve the symptoms of GERD,but the effects of MXD on GERD manifestations and relapse prevention need to be further ***,we performed a prospective,double-blind,and double-simulation *** To verify the efficacy of MXD for GERD and its effect on esophageal *** Using randomization,double-blinding,and a simulation design,288 participants with GERD were randomized to the treatment group and control group and received herbs(MXD)plus omeprazole simulation and omeprazole plus herbs simulation,respectively,for 4 *** GERD-Q scale score and esophageal manometry were measured at baseline,after treatment,and at 1 mo and 3 mo follow-up visits when medication was complete to evaluate recurrence *** The GERD-Q scale score in both groups decreased significantly compared to those before treatment(P0.05).Esophageal manometry showed that participants with lower esophageal sphincter pressure reduction and the proportion of ineffective swallowing(more than 50%)improved in both groups from baseline(P0.05).There was no significant difference between the groups after treatment(P>0.05).The percentage of weak esophageal contractility(distal contractile integral0.05).The relapse rate in the treatment group was lower than that in the control group at the 1 mo(P<0.01)and 3 mo follow-up(P<0.05).CONCLUS

关键词： Gastroesophageal reflux disease Traditional Chinese medicine Esophageal sphincter pressure Gastroesophageal reflux disease-Q scale score Modified Xiaochaihu Decoction

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Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors:a Case Report and Literature Review

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Chinese Medical Sciences Journal 2013年第1期28卷 58-60页

作者： Bao-zhi Fang Guang-sheng He Hai-xia Zhou Hui-rong Chang De-pei Wu Ai-ning sun su-ning chen Jiangsu Institute of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of HealthThe First Affiliated Hospital of Soochow University The Affiliated suzhou Hospital of Nanjing Medical University(suzhou Municipal Hospital)

APLASTIC anemia （AA） is a bone marrow failure disease caused by abnormal activation of T lymphocytes, resulting in the apoptosis of he- matopoietic cells and bone marrow failure.

关键词： aplastic anemia granulocyte transfusion spontaneous remission related donor

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聚苯乙烯模块墙体空腔简易模块化装配式建筑应用

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施工技术 2017年第16期46卷 40-43页

作者：苏云辉陈宁新疆建筑科学研究院有限责任公司新疆乌鲁木齐830054

根据新疆地区的气候条件和实际情况,通过模拟计算、现场检测、实地调研、理论分析等手段,对聚苯乙烯模块墙体空腔简易模块化装配式建筑的安全性、节能性、保温性及经济性等开展研究,结合实际案例分析对比实际效果,探讨聚苯乙烯模块墙体... 详细信息

根据新疆地区的气候条件和实际情况,通过模拟计算、现场检测、实地调研、理论分析等手段,对聚苯乙烯模块墙体空腔简易模块化装配式建筑的安全性、节能性、保温性及经济性等开展研究,结合实际案例分析对比实际效果,探讨聚苯乙烯模块墙体空腔简易模块化装配式建筑在新疆巴州富民安居房和农村住房建设中的应用前景。

关键词：装配式聚苯乙烯空腔模块安全性保温节能经济性

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Study on correlation between carotid atherosclerotic plaques by carotid sonography and coronary artery disease

Study on correlation between carotid atherosclerotic plaques...

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第二届长三角超声医学论坛暨2009年浙江省超声医学学术年会

作者： Department of Ultrasonics,Tongji Hospital,Tongji University,Shanghai 200065,China Yuan LI su-ning chen

Objective To investigate whether carotid atherosclerotic plaque is associated with coronary artery disease (CAD) and evaluate the predictive value of carotid ultrasonography in the clinical assessment of myocardial infarction. Methods Eighty-nine patients with suspected coronary artery disease were divided into CAD group(52

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Characterizing the Molecular Abnormalities in Rare De Novo Ph^＋ Acute Myeloid Leukemia

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Chinese Medical Journal 2018年第10期131卷 1246-1248页

作者： Hong-Ying Chao Guang-Ying Sheng Xiu-Wen Zhang Min Zhou Hong-Jie Shen su-ning chen Jian-Nong Cen Yi-Wu sun Tao chen Xu-Zhang Lu Ri Zhang Department of Hematology Affiliated Changzhou Second Hospital of Nanjing Medical University Changzhou Jiangsu 213003 China Department of Hematology The First Affiliated Hospital of Suzhou University Jiangsu Institute of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Suzhou Jiangsu 215006 China

To the Editor：The t（9;22）（q34;q 11）（Philadelphia chromosome [Ph]） balanced translocation results in fusion of the BCR gene at 22q11 with cytoplasmic tyrosine kinase gene ABL1 and plays an essential role in leukemic *** Ph is an infrequent finding in de novo acute myeloid leukemia （AML）,approximately 0.5-3% of newly diagnosed patients. The World Health Organization （WHO） recently released a revised version of the Classification of Hematopoietic and Lymphoid Malignancies,a new provisional category of AM L with BCR-ABL1 was added to recognize these rare Ph AML cases that could benefit from tyrosine-kinase inhibitor （TKI） therapy. It is required to enlarge the sample size and research the molecular or genomic features to increase the argument in favor ofPh AML as a real entity.

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The NOTCH1 regulation of DEPTOR promotes acute T-cell lymphoblastic leukemia via AKT activation

The NOTCH1 regulation of DEPTOR promotes acute T-cell lympho...

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第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议

作者： Yu-feng Hu He-xiu su Qi Ye Zhao-jing Wang Liang Huang Qian Wang su-ning chen Jian-feng Zhou Guo-liang Qing Hu-dan Liu Huazhong University of Science and Technology Jiangsu Institute of Hematology

＜正＞Objective DEP Domain Containing mTOR-Interacting Protein（DEPTOR）is *** in multiple myeloma cells and required for their ***,its implications in other hematological malignancies and the mechanism of

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胃痛消痞方对脾胃虚寒型功能性消化不良大鼠胃肠动力和胃动素的影响

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世界华人消化杂志 2010年第7期18卷 699-702页

作者：陈苏宁梁靓靓史业东中国医科大学附属盛京医院中医科辽宁省沈阳市110004

目的:观察胃痛消痞方对功能性消化不良(FD)大鼠胃肠动力、血浆胃动素(MOT)的影响.方法:将66只大鼠以食醋灌胃建立FD模型,随机分为空白组、模型组、中药(低、中、高)剂量组、多潘立酮组;分别用生理盐水、不同浓度的胃痛消痞方、多潘立酮... 详细信息

目的:观察胃痛消痞方对功能性消化不良(FD)大鼠胃肠动力、血浆胃动素(MOT)的影响.方法:将66只大鼠以食醋灌胃建立FD模型,随机分为空白组、模型组、中药(低、中、高)剂量组、多潘立酮组;分别用生理盐水、不同浓度的胃痛消痞方、多潘立酮,每日2次灌胃治疗14d;观测各组大鼠血浆MOT水平、小肠推进比、胃内排空率.结果:与模型组比较,各浓度胃痛消痞方均能明显提高血浆MOT含量、提高小肠推进比,差异有统计学意义(MOT含量:104.57pmol/L±14.05pmol/L,124.90pmol/L±15.21pmol/L,125.84pmol/L±27.67pmol/Lvs81.95pmol/L±12.02pmol/L,P0.05),但均高于多潘立酮组(P0.05).结论:胃痛消痞方能通过提高血浆中MOT水平,从而促进脾胃虚寒型FD大鼠的胃肠动力.

关键词：胃痛消痞方功能性消化不良胃肠动力胃动素

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong chen ning sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo chen Shengpeng su Yanfang Huang Bingbing Liu Hu sun Shuzhen Yang Guihong Han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

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