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热诱导白蛋白与壳聚糖在溶液中的自组装

高分子学报 2016年第1期26卷 61-69页

作者：何乃普潘素娟王荣民西北师范大学化学化工学院生态环境相关高分子材料教育部重点实验室兰州730070 兰州交通大学化学与生物工程学院兰州730070

80℃热诱导牛血清白蛋白（BSA）变性,BSA疏水残基暴露在分子表面,并进一步凝胶化.采用紫外-可见光光度仪（UV-Vis）和动态激光光散射仪（DLS）考察了热处理时间、溶液p H值、壳聚糖（CS）与BSA配比等因素对CS与BSA自组装行为的影响.加... 详细信息

80℃热诱导牛血清白蛋白（BSA）变性,BSA疏水残基暴露在分子表面,并进一步凝胶化.采用紫外-可见光光度仪（UV-Vis）和动态激光光散射仪（DLS）考察了热处理时间、溶液p H值、壳聚糖（CS）与BSA配比等因素对CS与BSA自组装行为的影响.加热时间介于15-20 min,BSA与CS发生自组装;BSA/CS混合体系pH大于BSA等电点（p I=4.7）时,BSA与壳聚糖静电作用增强,随着p H增大,出现沉淀.BSA浓度过高,变性BSA之间聚集作用增强,导致体系出现沉淀.研究结果显示,CS阻碍了BSA自身凝胶化进程,并与BSA发生自组装.在p H=5.4的溶液中制备了BSA-CS自组装体.采用透射电镜（TEM）观察了自组装体的形态,采用DLS对其粒径及其分布进行了测试.自组装体是以BSA聚集体为核、CS分子链为壳的核壳纳米结构.制备的自组装体室温贮存40天后,其粒径和分布无明显变化.

关键词：热诱导蛋白质壳聚糖自组装机理

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao pan juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang juan Yang Kailimai su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： su-Ye Hu Meng-Can Li Zi-Jia Hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying Xu pan-pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** suMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

前期东北大西洋-地中海西部海温异常影响河南省干热风的可能途径

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高原气象 2025年第1期44卷 150-162页

作者：竹磊磊苏晓乐潘攀吴璐杨婷中国气象局•河南省农业气象保障与应用技术重点开放实验室河南郑州450003 河南省气候中心河南郑州450003

河南省是中国冬小麦的主产区,也是较易受干热风影响的地区。目前对干热风的研究和预报多在天气尺度,从气候的角度研究干热风是否具有可预报性,具有非常重要的意义。本文基于河南省干热风资料、NCEP/NCAR再分析资料和哈得莱环流中心海温... 详细信息

河南省是中国冬小麦的主产区,也是较易受干热风影响的地区。目前对干热风的研究和预报多在天气尺度,从气候的角度研究干热风是否具有可预报性,具有非常重要的意义。本文基于河南省干热风资料、NCEP/NCAR再分析资料和哈得莱环流中心海温资料,分析了1980-2022年前期海温异常与河南省干热风日数的关系,及其可能影响途径。结果表明:(1)豫北、豫西北和豫中多年平均干热风日数较多,其他地区则相对较少。日干热风出现的概率由南向北、由5月下旬至6月上旬逐渐增加。全省平均干热风日数有显著增加趋势。(2)河南省干热风日数与当年3-4月东北大西洋-地中海西部(关键区)海温在年代际和年际尺度上均存在着密切相关,两者与干热风发生时段500 hPa高度场在去趋势前和去趋势后的显著正相关区在东亚中纬度地区位于新疆北部至贝加尔湖尔湖北部,显著负相关区位于我国东北至日本群岛附近,与850 hPa风场在去趋势前和去趋势后的相关在上述正、负显著相关区分别呈反气旋和气旋分布,气旋后部呈偏北风的显著相关,即3-4月关键区高海温年,出现的蒙古高压脊和东亚大槽造成了河南省的干热风天气。海温与环流场的相关在去趋势前和去趋势后在中纬度地区呈现出一个更明显的由东北大西洋经欧亚大陆至东北亚的纬向遥相关波列。(3)西太平洋副热带高压(以下简称副高)偏南(北)时,干热风日数易偏多(少),而3-4月关键区高(低)海温则可以导致副高偏南(北)。(4)干热风偏多年和偏少年、3-4月关键区高海温年和低海温的干热风发生时段30°N-55°N经向平均的涡度差值,及高、低海温年的干热风发生时段500 hPa准地转流函数距平和波作用通量均显示在中纬度地区存在自东北大西洋至东北亚的纬向波列。也即表明,3-4月关键区海温可以激发出一个后期干热风发生时段的类似波列,经欧亚大陆传至东北亚,而高海温年在东亚中纬度地区的环流分布造成了河南省的干热风天气。

关键词：干热风东北大西洋地中海西部海温遥相关波列

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New approach for improving throughput in multi-channel packet radio systems

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Journal of Systems Engineering and Electronics 2010年第2期21卷 180-185页

作者： su pan Shengmei Liu College of Telecommunications and Information Engineering Nanjing University of Posts and Telecommunications Nanjing 210003 P. R. China

A new approach for improving the throughputs of multi- channel packet radio systems is proposed. Based on the charac- teristics of multi-code CDMA technology, the scheme factitiously improves the transmission bit rate of a terminal by compressing the packet transmission time and thereby increases the number of the orthogonal spreading codes used by the terminal. By this means, the average interference level of the system is reduced and the system capacity is improved. Simulation results show that the proposed scheme exhibits larger throughput compared with the traditional multi-code CDMA slotted Aloha systems.

关键词： packet radio multi-channel throughput MAC

Three-dimensional porous electrodes for direct formate fuel cells

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Science China(Technological Sciences) 2021年第4期64卷 705-718页

作者： su XiangYu pan ZheFei AN Liang Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SAR 999077China

The dual-layer electrode for fuel cells is typically prepared by binding discrete catalyst nanoparticles onto a diffusion *** a random packing forms a dense catalyst layer and thus creates a barrier for mass/ion transport,particularly for direct liquid fuel ***-dimensional porous electrodes,a thin nano-porous catalyst layer uniformly distributed on the matrix surface of a foam-like structure,are typically employed to improve the mass/ion *** a three-dimensional porous structure brings two critical advantages:(i)reduced mass/ion transport resistance for the delivery of the reactants via shortening the transport distance and(ii)enlarged electrochemical surface area,via reducing the dead pores,isolated particles and severe aggregations,for interfacial ***,the three-dimensional design is capable of fabricating binder-free electrodes,thereby eliminating the use of ionomers/binders and simplifying the fabrication *** this work,three types of three-dimensional porous electrode are fabricated,via different preparation methods,for direct formate fuel cells:(i)Pd/C nanoparticles coating on the nickel foam matrix surface(Pd-C/NF)via a dip-coating method,(ii)Pd nanoparticles depositing on the nickel foam matrix surface(Pd/NF)via reduction reaction deposition,and(iii)Pd nanoparticles embedding in the nickel foam matrix(Pd/(in)NF)via replacement reaction *** latter two are binder-free three-dimensional porous *** a comparison,a conventional dual-layer design,Pd/C nanoparticles painting on the nickel foam layer(Pd-C//NF),is also prepared via direct painting *** is shown that the use of the three-dimensional Pd-C/NF electrode as the anode in a direct formate fuel cell results in a peak power density of 45.0 mW cm^(-2)at 60℃,which is two times of that achieved by using a conventional dual-layer design(19.5 mW cm^(-2)).This performance improvement is mainly attributed to the unique three-dimensional structure

关键词： direct formate fuel cells dual-layer structure three-dimensional porous structure binder-free mass/ion transport electrochemical surface area

A Time-Domain Numerical Simulation for Free Motion Responses of Two Ships Advancing in Head Waves

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China Ocean Engineering 2024年第3期38卷 519-530页

作者： pan su-yong CHENG Yong School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

The constant panel method within the framework of potential flow theory in the time domain is developed for solving the hydrodynamic interactions between two parallel ships with forward *** solving problems within a time domain framework,the free water surface needs to simultaneously satisfy both the kinematic and dynamic boundary conditions of the free water *** provides conditions for adding artificial damping *** the Runge−Kutta method to solve equations related to *** upwind differential scheme is used in the present method to deal with the convection terms on the free surface to prevent waves *** the comparison with the available experimental data and other numerical methods,the present method is proved to have good mesh convergence,and satisfactory results can be *** constant panel method is applied to calculate the hydrodynamic interaction responses of two parallel ships advancing in head *** simulations are conducted on the effects of forward speed,different longitudinal and lateral distances on the motion response of two modified Wigley ships in head *** further investigations are conducted on the effects of different ship types on the motion response.

关键词： ship motions time domain simulation forward speed different distances wave loads

Service Migration Algorithm Based on Markov Decision Process with Multiple Service Types and Multiple System Factors

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Chinese Journal of Electronics 2024年第6期33卷 1515-1525页

作者： Anhua MA su pan Weiwei ZHOU Broadband Wireless Communication College Nanjing University of Posts and Telecommunications School of Computer Science and Technology Nanjing Tech University

This paper proposes a Markov decision process based service migration algorithm to satisfy quality of service(QoS) requirements when the terminals leave the original server. Services were divided into real-time services and non-real-time services, each type of them has different requirements on transmission bandwidth and latency,which were considered in the revenue function. Different values were assigned to the weight coefficients of QoS parameters for different service types in the revenue and cost functions so as to distinguish the differences between the two service types. The overall revenue was used for migration decisions, rather than fixed threshold or instant *** Markov decision process was used to maximize the overall revenue of the system. Simulation results show that the proposed algorithm obtained more revenue compared with the existing works.

关键词： Energy consumption Costs Markov decision processes Simulation Quality of service Market research Cost function Real-time systems Energy efficiency Servers