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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun jeong Lee su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： Md Ahasan Habib Shusen Lin Mehedi Hasan Joni sumiya Akter Dristy Rutuja Mandavkar Jae-Hun jeong Jihoon Lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Advanced electrocatalyst High current Corrosion resistance Industrial requirement

Influence of the molecular structure of metal-phthalocyanine on electrocatalytic reactions

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Science China Materials 2022年第12期65卷 3324-3333页

作者： Da Sol jeong hyeon suk Shin Jieun Yang Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)50 UNIST-gilUlsan 44919Republic of Korea Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University26 Kyungheedae-roDongdaemun-guSeoul 02447Republic of Korea

The demand for new catalysts for renewable energy production has become *** an alternative to metal catalysts for electrocatalysis to produce energy sources,metal-phthalocyanine(MPc)electrocatalysts have shown *** physicochemical and electrochemical properties depend on the chemical structure of the MPc and the central metal *** reviews of MPcs focused on their electrochemical performance in specific catalytic reactions,such as oxygen reduction reaction and CO_(2)reduction ***,understanding the structure of MPcs in depth is important,since their electrochemical catalytic activity is affected by structural modifications of ***,this minireview focuses on how the molecular structure of MPcs affects electrochemical catalysis.

关键词： metal-phthalocyanine oxygen reduction reaction carbon dioxide reduction reaction hydrogen evolution reaction oxygen evolution reaction electrocatalytic activities

Unveiling anomalous lattice shrinkage induced by Pi-backbonding in Prussian blue analogues

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Journal of Energy Chemistry 2022年第7期31卷 121-128,I0004页

作者： Ju-hyeon Lee Jin-Gyu Bae hyeon jeong Lee Ji Hoon Lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials University of OxfordOxford OX13PHUnited Kingdom

Transition-metal(TM)-based Prussian blue and its analogues(TM-PBAs) have attracted considerable attention as cathode materials owing to their versatile ion storage capability with tunable working voltages. TM-PBAs with different crystal structures, morphologies, and TM combinations can exhibit excellent electrochemical properties because of their unique and robust host frameworks with well-defined ionic diffusion channels. Nonetheless, there is still a lack of understanding regarding the performance dependence of TM-PBAs on structural changes during charging/discharging processes. In this study, in situ X-ray diffraction and X-ray absorption fine structure analyses elucidate the TMdependent structural changes in a series of TM-PBAs during the charging and discharging *** the discharging process, the lattice volume of Fe-PBA increased while those of Ni-and Cu-PBAs decreased. This discrepancy is attributed to the extent of size reduction of the cyanometallate complex([Fe(CN)_(6)]) via pi-backbonding from Fe to C due to redox flips of the low-spin Fe^(3+/2+) ion. This study presents a comprehensive understanding of how TM selection affects capacity acquisition and phase transition in TM-PBAs, a promising class of cathode materials.

关键词： Prussian blue analogues X-ray diffraction X-ray absorption fine structure Pi-backdonation Cyanides

Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports

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World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： Jin-Bok Hwang Hyo-jeong Jang Department of Pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** suMMARY Seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

Protective Effect of Brassica napus *** against Inflammation Response in RAW 264.7 Cells

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Chinese Journal of Integrative Medicine 2021年第4期27卷 273-279页

作者： su-hyeon Cho Song Rae Kim Myeong Seon jeong Miri Choi SeonJu Park Kil-Nam Kim Chuncheon Center Korea Basic Science InstituteChuncheon(24341)Republic of Korea

Objective:To demonstrate the anti-inflammatory activity of Brassica napus ***(BNH)in lipopolysaccharide(LPS)-stimulated RAW 264.7 ***:Composition analysis of BNH was conducted via gas chromatography-mass spectrometry after BNH were *** nitric oxide(NO)production was measured using the Griess *** E2(PGE2)production was evaluated with enzyme-linked immunosorbent *** effects of BNH on LPS-induced pro-inflammatory enzymes including inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)were evaluated using Western blot ***,phosphorylation of nuclear factor-kappa B(N F-k B)and nuclear translocation of N F-k B p65 were evaluated with Western blot analysis and immunofluorescence staining,***:Compared with LPS-stimulated cells,BNH markedly decreased the generation of NO and PGE_(2)in LPS-stimulated RAW 264.7 cells(P<0.01 or P<0.05).Moreover,BNH inhibited protein levels of iNOS and COX-2(P<0.01).Phosphorylation of NF-k B and nuclear translocation of NF-k B p65 was significantly inhibited by BNH(P<0.01 or P<0.05).Conclusion:The anti-inflammatory activities of BNH were mediated via blockage of the N F-k B signaling pathways in LPS-stimulated RAW 264.7 cells.

关键词： Brassica napus L. inflammation lipopolysaccharide RAW 264.7 cells hydrosols

Identification and comparison of the local physicochemical structures of transition metal-based layered double hydroxides for high performance electrochemical oxygen evolution reactions

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Journal of Energy Chemistry 2023年第12期87卷 89-97,I0004页

作者： Min sung Kim Bipin Lamichhane Ju-hyeon Lee Jin-Gyu Bae jeong Yeon Heo hyeon jeong Lee Shyam Kattel Ji Hoon Lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea KNU Advanced Material Research Institute Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Department of Physics Florida A&M UniversityTallahasseeFlorida 32307United States

Layered double hydroxides(LDHs) have attracted considerable attention as a cost effective alternative to the precious iridium-and ruthenium-based electrocatalysts for an oxygen evolution reaction(OER),a bottleneck of water electrolysis for sustainable hydrogen *** their excellent OER performance,the structural and electronic properties of LDHs,particularly during the OER process,remain to be poorly *** this study,a series of LDH catalysts is investigated through in situ X-ray absorption fine structure analyses and density functional theory(DFT) *** experimental results reveal that the LDH catalyst with equal amounts of Ni and Fe(NF-LDH) exhibits the highest OER activity and catalytic life span when compared with its counterparts having equal amounts of Ni and Co(NC-LDH)and Ni only(Ni-LDH).The NF-LDH shows a markedly enhanced OER kinetics compared to the NC-LDH and the Ni-LDH,as proven by the lower overpotentials of 180,240,and 310 mV,respectively,and the Tafel slopes of 35.1,43.4,and 62.7 mV dec^(-1),*** DFT calculations demonstrate that the lowest overpotential of the NF-LDH is associated with the active sites located at the edge planes of NF-LDH in contrast to those located at the basal planes of Ni-LDH and *** current study pinpoints the active sites on various LDHs and presents strategies for optimizing the OER performance of the LDH catalysts.

关键词： Layered double hydroxides Oxygen evolution reaction In situ X-ray analyses Density functional theory Catalytic active sites

Acute lower extremity arterial thrombosis after intraocular foreign body removal under general anesthesia: A case report and review of literature

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World Journal of Clinical Cases 2021年第27期9卷 8232-8241页

作者： Soeun Jeon jeong-Min Hong hyeon jeong Lee Eunsoo Kim Hyunju Lee Yesul Kim Hyun-su Ri Jae Jung Lee Department of Anesthesia and Pain Medicine Pusan National UniversitySchool of MedicineBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Anesthesia and Pain Medicine Kyungpook National UniversitySchool of MedicineDaegu 41944South Korea Department of Ophthalmology College of MedicinePusan National UniversitySchool of MedicineYangsan 50612South Korea

BACKGROUND surgery,which is a major risk factor for venous thrombosis,has rarely been considered a risk factor for arterial *** studies have suggested that venous and arterial thromboses share common risk factors and have a bidirectional ***,there is a growing interest in the risk of arterial thrombosis after *** report a case of acute bilateral lower extremity arterial thromboses that developed after a prolonged *** suMMARY A 59-year-old man was hospitalized for intraocular foreign body removal *** was a heavy-drinking smoker and had untreated hypertension and varicose veins in both *** operation was unexpectedly prolonged,lasting 4 h and 45 *** after emergence from general anesthesia,the patient complained of extreme pain in both *** the surgical drape was removed,cyanosis was evident in both feet of the *** pulse was not palpable,and continuous-wave Doppler signals were inaudible in the bilateral dorsalis pedis and posterior tibial *** tomography angiography confirmed acute bilateral thrombotic occlusion of the popliteal arteries,proximal anterior tibial arteries,and tibioperoneal *** pulse returned in both lower limbs after 6 h of heparin *** patient was discharged on postoperative day 26 without any *** Acute lower extremity arterial thrombosis can occur after *** should pay particular attention to patients with risk factors for thrombosis.

关键词： Thromboembolism Thrombosis Arterial thrombosis Arterial occlusive diseases Peripheral occlusive artery disease Case report

Strategies to overcome resistance to epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer

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World Journal of Gastroenterology 2014年第29期20卷 9862-9871页

作者： Woo-jeong jeong Pu-hyeon Cha Kang-Yell Choi Translational Research Center for Protein Function Control Department of BiotechnologyCollege of Life Science and BiotechnologyYonsei University

Administration of monoclonal antibodies(mAbs)against epidermal growth factor receptor(EGFR)such as cetuximab and panitumumab in combination with conventional chemotherapy substantially prolongs survival of patients with metastatic colorectal cancer(mCRC).However,the efficacy of these mAbs is limited due to genetic variation among patients,in particular K-ras *** discovery of K-ras mutation as a predictor of non-responsiveness to EGFR mAb therapy has caused a major change in the treatment of *** that inhibit transformation caused by oncogenic alterations of Ras and its downstream components such as BRAF,MEK and AKT seem to be promising cancer therapeutics as single agents or when given with EGFR *** multiple therapeutic strategies to overcome EGFR mAb-resistance are under investigation,our understanding of their mode of action is *** drug development based on stringent preclinical data,biomarker validation,and proper selection of patients is of paramount importance in the treatment of *** this review,we will discuss diverse approaches to overcome the problem of resistance to existing anti-EGFR therapies and potential future directions for cancer therapies related to the mutational status of genes associated with EGFRRas-ERK and PI3K signalings.

关键词： Colorectal cancer Epidermal growth factor receptor Resistance K-ras mutation Combinational therapy