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World Journal of Clinical Cases 2022年第17期10卷 5861-5868页

作者： Long Tang Zhen Cai su-xia wang Wen-Jing Zhao Department of Nephrology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Laboratory of Electron Microscopy Pathological CenterPeking University First HospitalPeking University Institute of NephrologyBeijing 100034China

BACKGROUND Although minimal change disease(MCD)and focal segmental glomerulosclerosis(FSGS)have been described as two separate forms of nephrotic syndrome(NS),they are not completely *** report a case of a patient transitioning from MCD to FSGS,review the literature,and explore the relationship between the two *** suMMARY A 42-year-old male welder,presenting with lower extremity edema and elevated serum creatinine,was diagnosed with NS and end-stage kidney disease(ESKD)based on laboratory test *** patient had undergone a kidney biopsy for NS 20 years previously,which indicated MCD,and a second recent kidney biopsy suggested *** patient was an electric welder with excessive levels of cadmium and lead in his ***,we suspect that his aggravated pathology and occurrence of ESKD were related to metal *** patient eventually received kidney replacement therapy and quit his job which involved long-term exposure to *** the 1-year follow-up period,the patient was negative for metal elements in the blood and urine and recovered partial kidney *** MCD and FSGS may be different stages of the same *** transition from MCD to FSGS in this case indicates disease progression,which may be related to excessive metal contaminants caused by the patient’s occupation.

关键词： Minimal change disease Focal segmental glomerulosclerosis Occupational exposure Cadmium Lead Case report

Early reoccurrence of traumatic posterior atlantoaxial dislocation without fracture:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1461-1468页

作者： Ying-Hua sun Li wang Jin-Ting Ren su-xia wang Zhao-De Jiao Jun Fang Department of Orthopedics Yidu Central HospitalWeifang Medical UniversityQingzhou 262500Shandong ProvinceChina

BACKGROUND In general,atlantoaxial dislocation is rare due to the stability of the C1-C2 *** atlantoaxial dislocations are usually anterior and accompanied by odontoid *** atlantoaxial dislocations are rare,and complete posterior dislocation without associated fracture is even more rare.A case of early recurrence of posterior atlantoaxial dislocation without fracture being in therapy of first closed reduction and then open reduction has not been previously *** suMMARY A 45-year-old female presented with traumatic posterior atlantoaxial dislocation(TPAD)of C1-C2 without associated fractures,and Frankel Grade B spinal cord *** was successfully managed by immediate closed reduction under skull ***,17 d later,re-dislocation was *** day 28,closed reduction was performed as before but ***,open reduction and posterior internal fixation with autologous iliac bone grafts was *** 6 mo after surgery,atlantoaxial joint fusion was achieved,and neurological function had recovered to Frankel Grade *** 12 mo follow-up,she had lost only 15°of cervical rotation,and atlantoaxial complex instability in joint flexing and extending were no longer observed under *** Early assessment of transverse ligament is critical for TPAD without fracture avoiding re-dislocation after closed reduction.

关键词： Reoccurrence Traumatic posterior atlantoaxial dislocation Without fracture Transverse ligament Case report

Clinicopathological and immunological features of new onset kidney disease: a rare event after SARS-CoV-2 vaccination

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National Science Review 2023年第5期10卷 112-123页

作者： Yue-Miao Zhang Xing-Zi Liu Zhao Zhang Tai-Cheng Zhou Xin Zhang Hong-Yu Yang Meng Tan Nan Hu su-Fang Shi Fang wang Rong Xu Li-Jun Liu su-xia wang Gang Liu Fu-De Zhou Ming-Hui Zhao Hong Zhang Ji-Cheng Lv Ya-Ping Zhang Zi-Jie Zhang Li Yang Renal Division Department of MedicinePeking University First Hospital Renal Pathology Center Institute of NephrologyPeking University Key Laboratory of Renal Disease Ministry of Health of China Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases Chinese Academy of Medical Sciences State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Central Laboratory and Liver Disease Research Center The Affiliated Hospital of Yunnan University Laboratory of Electron Microscopy Pathological CentrePeking University First Hospital State Key Laboratory for Conservation and Utilization of Bio-Resource and School of Life Sciences Yunnan University

The onset of various kidney diseases has been reported after severe acute respiratory syndrome coronavirus2(SARS-CoV-2) ***,detailed clinical and pathological features are *** screened and analyzed patients with newly diagnosed kidney diseases after inactivated SARS-CoV-2 vaccination in Peking University First Hospital from January 2021 to August 2021,and compared them with the reported cases in the *** obtained samples of blood,urine and renal biopsy *** and laboratory information,as well as light microscopy,immunostaining and ultrastructural observations,were *** SARS-CoV-2 spike protein and nucle oprotein were stained using the immunofluorescence technique in the kidney biopsy ***-CoV-2 specific antibodies were tested using magnetic particle chemiluminescence *** study group included 17 patients with a range of conditions including immune-complex-mediated kidney diseases(IgA nephropathy,membranous nephropathy and lupus nephritis),podocytopathy(minimal change disease and focal segmental glomerulosclerosis) and others(antineutrophil-cytoplasmic-antibody-associated vasculitis,anti-glomerular basement membrane nephritis,acute tubulointerstitial nephritis and thrombotic micro angiopathy).Seven patients(41.18%)developed renal disease after the first dose and ten(58.82%) after the second *** kidney disease spectrum as well as clinicopathological features are similar across different types of SARS-CoV-2 *** found no definitive evidence of SARS-CoV-2 spike protein or nucleoprotein deposition in the kidney biopsy *** markers implicated abnormal immune responses in predisposed *** and follow-up(median=86 days) showed that biopsy diagnosis informed treatment and prognosis in all *** conclusion,we observed various kidney diseases following SARS-CoV-2 vaccine administration,which show a high consistency across different types of SARS-CoV-2 vaccin

关键词： kidney disease SARS-CoV-2 vaccination abnormal immune response

Lactobacillus crispatus Modulates Vaginal Epithelial Cell Innate Response to Candida albicans

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Chinese Medical Journal 2017年第3期130卷 273-279页

作者： xiao-Xi Niu Ting Li Xu Zhang su-xia wang Zhao-Hui Liu Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China Laboratory of Electron Microscopy Ultrastructural Pathology Center Peking University First Hospital Beijing 100034 China

Background： Vulvovaginal candidiasis is caused by Candida albicans. The vaginal epithelium, as the first site of the initial stage of infection by pathogens, plays an important role in resisting genital tract infections. Moreover, lactobacilli are predominant members of the vaginal microbiota that help to maintain a normal vaginal microenvironment. Therefore, Lactobacillus crispatus was explored for its capacity to intervene in the immune response of vaginal epithelial cells VK2/E6E7 to C. albicans. Methods： We examined the interleukin-2 （IL-2）, 4, 6, 8, and 17 produced by VK2/E6E7 cells infected with C. albicans and treated with L. crispatus in vitro. The capacity ofL. crispatus to adhere to VK2/E6E7 and inhibit C. albicans growth was also tested by scanning electron microscopy （SEM） and adhesion experiments. Results： Compared with group VK2/E6E7 with C. albicans, when treated with L. crispatus, the adhesion of C. albicans to VK2/E6E7 cells decreased significantly by 52.87 ± 1.22%, 47.03 ± 1.35%, and 42.20 ± 1.55% under competition, exclusion, and displacement conditions, respectively. SEM revealed that the invasion of C. albicans into VK2/E6E7 cells was caused by induced endocytosis and active penetration. L. crispatus could effectively protect the cells from the virulence ofhyphae and spores of C. albicans and enhance the local immune function of the VK2/E6E7 cells. The concentrations of IL-2, 6, and 17 were upregulated significantly （P 〈 0.0 1） and that of IL-8 were downregulated significantly （P 〈 0.0 1） in infected VK2/E6E7 cells treated with L. crispatus. The concentration of IL-4 was similar to that of the group VK2/ E6E7 with C. albicans （24.10 ± 0.97 vs. 23.12 ±0.76 pg/ml, P= 0.221）. Conclusions： L. crispatus can attenuate the virulence of C. albicans, modulate the secretion of cytokines and chemokines, and enhance the immune response of VK2/E6E7 cells in vitro. The vaginal mucosa has a potential function in the local immune responses against pathogens tha

关键词： Candida albicans Cytokines Immunity Lactobacillus crispatus Scanning Electron Microscope Vaginal Epithelial Cells

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma xiaoping Gu Tianjiao xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑xia su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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地下水环境影响评价若干关键问题浅谈

中小企业管理与科技 2019年第20期3卷 43-43,45页

作者：苏旺霞河南金秋环保技术咨询有限公司

地下水作为重要的水资源,其环境评估有助于人们了解地下水环境的现状,也有利于评估区域开发和项目建设对地下水环境造成的影响.我国大部分地区的地下水环境都存在一系列问题,同时也处于不断恶化的状态,因此,论文分析了地下水质量评估方... 详细信息

地下水作为重要的水资源,其环境评估有助于人们了解地下水环境的现状,也有利于评估区域开发和项目建设对地下水环境造成的影响.我国大部分地区的地下水环境都存在一系列问题,同时也处于不断恶化的状态,因此,论文分析了地下水质量评估方法,为我国地下水环境的评估工作提供一些依据.

关键词：地下水环境影响评价关键问题采集数据

养殖水中孔雀石绿、隐色孔雀石绿、结晶紫、隐色结晶紫、亚甲基蓝残留量的测定

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食品安全质量检测学报 2018年第5期9卷 1122-1129页

作者：曾思瑜蒲红夏苏捷王柯上海市食品药品检验所上海201203

目的建立一种高效液相色谱-串联质谱同时测定养殖水体中孔雀石绿、结晶紫及其代谢物和亚甲基蓝残留量的方法。方法将水样用盐酸羟胺-对甲苯磺酸溶液和乙腈提取,二氯甲烷萃取2次后浓缩,用1 mL乙腈-5 mmol/L乙酸铵(1:1,V:V)定容。以乙腈-5... 详细信息

目的建立一种高效液相色谱-串联质谱同时测定养殖水体中孔雀石绿、结晶紫及其代谢物和亚甲基蓝残留量的方法。方法将水样用盐酸羟胺-对甲苯磺酸溶液和乙腈提取,二氯甲烷萃取2次后浓缩,用1 mL乙腈-5 mmol/L乙酸铵(1:1,V:V)定容。以乙腈-5 mmol/L乙酸铵(85:15,V:V)混合溶液为流动相进行色谱分离,然后进入串联质谱仪,选用电喷雾离子源,在正离子、多反应监测扫描模式下进行定性,孔雀石绿和结晶紫通过内标法定量,亚甲基蓝通过外标法定量。结果在优化条件下,孔雀石绿、隐色孔雀石绿、结晶紫、隐色结晶紫在0.025~0.600 ng/mL浓度范围内,亚甲基蓝在0.05~1 ng/mL浓度范围内均满足线性关系,相关系数r>0.99,方法检出限为0.2 ng/mL。加标浓度在0.2~2.0 ng/mL时,孔雀石绿、隐色孔雀石绿、结晶紫、隐色结晶紫和亚甲基蓝的平均回收率均在70%~110%之间,相对标准偏差均在10%以内。结论该方法简单快速、灵敏度高、前处理成本低、重现性好、回收率高,适用于同时检测养殖水体中孔雀石绿、隐色孔雀石绿、结晶紫、隐色结晶紫、亚甲基蓝残留量。

关键词：养殖水体孔雀石绿结晶紫亚甲基蓝液相色谱-质谱联用法

SiO_x/PET复合薄膜的力学性能及阻隔性能

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包装工程 2017年第19期38卷 57-62页

作者：贝荣华黄崇杏陈强李志嘉苏红霞王健广西大学南宁530004 北京印刷学院北京102600

目的基于氧化硅(SiO_x)镀层优异的性能,研究不同厚度的SiO_x层对SiO_x/PET复合薄膜力学性能和阻隔性能的影响,以期得到性能较优的SiO_x/PET复合薄膜。方法以自制的聚对苯二甲酸乙二醇酯(PET)薄膜为基材,采用等离子体增强化学气相沉积法... 详细信息

目的基于氧化硅(SiO_x)镀层优异的性能,研究不同厚度的SiO_x层对SiO_x/PET复合薄膜力学性能和阻隔性能的影响,以期得到性能较优的SiO_x/PET复合薄膜。方法以自制的聚对苯二甲酸乙二醇酯(PET)薄膜为基材,采用等离子体增强化学气相沉积法沉积得到SiO_x层厚度分别为40,150,230,320 nm的SiO_x/PET复合薄膜,并进行傅里叶变换红外线光谱分析、力学性能和阻隔性能测试,以及薄膜表观形貌分析。结果沉积SiO_x层后,SiO_x/PET复合薄膜拉伸强度和断裂伸长率随SiO_x层厚度的增大先增大后减小,氧气透过率和水蒸气透过率则出现明显衰减而后逐渐平缓的趋势。SiO_x层厚度达150~230 nm时,复合薄膜的力学性能和阻隔性能表现较优,拉伸强度、断裂伸长率、氧气透过率以及水蒸气透过率分别提高了约25.0%,20.9%,79.3%,77.3%。结论适宜厚度的SiO_x层可以使得SiO_x/PET复合薄膜同时具备较优的力学性能和阻隔性能。

关键词： SiOx层结构成分力学性能阻隔性能

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卫星导航星基增强系统及信号体制的比较

空间电子技术 2016年第5期13卷 52-57页

作者：周昀陶晓霞苏哲王瑛梁曦中国空间技术研究院西安分院西安710000

概述了美国广域增强系统(WAAS)、俄罗斯的差分校正和监测系统(SDCM)、欧洲的地球静止导航重叠服务(EGNOS)、日本的多功能卫星星基增强系统(MSAS)以及印度的GPS辅助静地轨道增强系统(GAGAN)的基本工作原理、现状及技术发展趋势。研究了SB... 详细信息

概述了美国广域增强系统(WAAS)、俄罗斯的差分校正和监测系统(SDCM)、欧洲的地球静止导航重叠服务(EGNOS)、日本的多功能卫星星基增强系统(MSAS)以及印度的GPS辅助静地轨道增强系统(GAGAN)的基本工作原理、现状及技术发展趋势。研究了SBAS L5、L1频点的信号体制,包括调制方式、扩频码生成方法、电文类型、电文编码方式等,并对信号体制进行了比较。为国内卫星导航星基增强系统的研究提供参考,同时给出了增强载荷信号体制的设计建议。

关键词：星基增强系统 SBAS L5、L1信号体制卫星信号