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Drug utilization of clarithromycin for gastrointestinal disease treatment

World Journal of Gastroenterology 2008年第39期14卷 6065-6071页

作者： Quan Zhou Ling-Ling zhu Xiao-Feng Yan wen-Sheng Pan su Zeng Department of Clinical Pharmacy the 2nd Affiliated Hospital School of Medicine Zhejiang University Zhejiang Province 310009 China Geriatric Ward the 2nd Affiliated Hospital School of Medicine Zhejiang University Zhejiang Province 310009 China Department of gastroenterology the 2nd Affiliated Hospital School of Medicine Zhejiang University Zhejiang Province 310009 China Department of Pharmaceutical Analysis & Drug Metabolism College of Pharmaceutical Sciences Zhejiang University Zhejiang Province 310058 China

AIM： To evaluate the patterns of use of clarithromycin for gastrointestinal disease treatment and promote its rational use.METHODS： Using a structured pro forma, we conducted a two-month survey of the electronic prescriptions containing immediate-release （IR） or sustained-release （SR） product of clarithromycin for outpatients with gastrointestinal diseases in a 2200-bed general hospital. suitability of the prescription was audited retrospectively. REsuLTS： One hundred and sixty-four prescriptions of SR product and 110 prescriptions of IR product were prescribed for gastrointestinal disease treatment. Among prescriptions for anti-Helicobacter pylori （H pylori） therapy, triple therapy take the dominant position （91.8%）, followed by quadruple therapy （4.3%） and dual therapy （3.9%）. Amoxicillin was the most frequently co-prescribed *** and levofloxacin are used more widely than metronidazole or tinidazole. Clarithromycin SR was administered at inappropriate time points in all prescriptions. Fifty percent of all prescriptions of clarithromycin SR, and 6.4% of prescriptions of clarithromycin IR, were prescribed at inappropriate dosing intervals. surprisingly, disconcordance between diagnoses and indications was observed in all prescriptions of clarithromycin SR which has not been approved for treating Hpy/ori infection although off-label use for this purpose was reported in literature. On the contrary, only one prescription （0.9%） of clarithromycin IR was prescribed for unapproved indication （i.e. gastro-oesophageal reflux disease）. 1.4% of prescriptions for chronic gastritis or peptic ulcer treatment were irrational in that clarithromycin was not co-prescribed with gastric acid inhibitors. Clinical significant CYP3A based drug interactions with clarithromycin were identified. CONCLUSION： There is a great scope to improve the quality of clarithromycin prescribing in patients with gastrointestinal disease, especially with regard to administration

关键词： Clarithromycin Drug utilization Prescriptions Helicobacter pylori Gastrointestinal Diseases Drug administration schedule Drug interactions Polypharmacy

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A New Solution to Detectable Byzantine Agreement Problem

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Communications in Theoretical Physics 2009年第12期52卷 1013-1015页

作者： QIN su-Juan wen Qiao-Yan MENG Luo-Ming zhu Fu-Chen State key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China State Key Laboratory of Integrated Service Networks Xidian University Xi＇an 710071 China National Laboratory for Modern Communications P.O. Box 810 Chengdu 610041 China

We present a new quantum protocol for solving detectable Byzantine agreement problem between threeparties by employing one quantum key distribution *** protocol is suggested by a special four-qubit entangledstate inst... 详细信息

关键词： quantum protocol detectable Byzantine agreement entangled state

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前期东北大西洋-地中海西部海温异常影响河南省干热风的可能途径

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高原气象 2025年第1期44卷 150-162页

作者：竹磊磊苏晓乐潘攀吴璐杨婷中国气象局•河南省农业气象保障与应用技术重点开放实验室河南郑州450003 河南省气候中心河南郑州450003

河南省是中国冬小麦的主产区,也是较易受干热风影响的地区。目前对干热风的研究和预报多在天气尺度,从气候的角度研究干热风是否具有可预报性,具有非常重要的意义。本文基于河南省干热风资料、NCEP/NCAR再分析资料和哈得莱环流中心海温... 详细信息

河南省是中国冬小麦的主产区,也是较易受干热风影响的地区。目前对干热风的研究和预报多在天气尺度,从气候的角度研究干热风是否具有可预报性,具有非常重要的意义。本文基于河南省干热风资料、NCEP/NCAR再分析资料和哈得莱环流中心海温资料,分析了1980-2022年前期海温异常与河南省干热风日数的关系,及其可能影响途径。结果表明:(1)豫北、豫西北和豫中多年平均干热风日数较多,其他地区则相对较少。日干热风出现的概率由南向北、由5月下旬至6月上旬逐渐增加。全省平均干热风日数有显著增加趋势。(2)河南省干热风日数与当年3-4月东北大西洋-地中海西部(关键区)海温在年代际和年际尺度上均存在着密切相关,两者与干热风发生时段500 hPa高度场在去趋势前和去趋势后的显著正相关区在东亚中纬度地区位于新疆北部至贝加尔湖尔湖北部,显著负相关区位于我国东北至日本群岛附近,与850 hPa风场在去趋势前和去趋势后的相关在上述正、负显著相关区分别呈反气旋和气旋分布,气旋后部呈偏北风的显著相关,即3-4月关键区高海温年,出现的蒙古高压脊和东亚大槽造成了河南省的干热风天气。海温与环流场的相关在去趋势前和去趋势后在中纬度地区呈现出一个更明显的由东北大西洋经欧亚大陆至东北亚的纬向遥相关波列。(3)西太平洋副热带高压(以下简称副高)偏南(北)时,干热风日数易偏多(少),而3-4月关键区高(低)海温则可以导致副高偏南(北)。(4)干热风偏多年和偏少年、3-4月关键区高海温年和低海温的干热风发生时段30°N-55°N经向平均的涡度差值,及高、低海温年的干热风发生时段500 hPa准地转流函数距平和波作用通量均显示在中纬度地区存在自东北大西洋至东北亚的纬向波列。也即表明,3-4月关键区海温可以激发出一个后期干热风发生时段的类似波列,经欧亚大陆传至东北亚,而高海温年在东亚中纬度地区的环流分布造成了河南省的干热风天气。

关键词：干热风东北大西洋地中海西部海温遥相关波列

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Acute generalized exanthematous pustulosis as a manifestation of Kawasaki disease

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World Journal of Pediatrics 2021年第5期17卷 557-559页

作者： wen-Jie Wu wen-Qun Zhang Dao-zhu Si Yong-Chun su Qin Xie Department of Pediatrics Chongqing Youyoubaobei Women and Children's HospitalNo.999Jiarong RoadYubei DistrictChongqing 401147China

Kawasaki disease(KD)is the leading cause of acquired heart disease in children *** patients with an onset of lymph node enlargement had a high incidence of coronary artery complications[1].It is important to recognize... 详细信息

关键词： Kawasaki enlargement diagnostic

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling sun Xiaodan Qin Lin zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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Influence of sperm morphology on pregnancy outcome and offspring in in vitro fertilization and intracytoplasmic sperm injection:a matched case-control study

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Asian Journal of Andrology 2021年第4期23卷 421-428页

作者： wen-Jun Zhou Chuan Huang su-Hua Jiang Xi-Ren Ji Fei Gong Li-Qing Fan wen-Bing zhu Institute of Reproductive and Stem Cell Engineering Basic Medicine CollegeCentral South UniversityChangsha 410008China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410008China Clinical Research Center for Reproduction and Genetics in Hunan Province Changsha 410008China

Sperm morphology was once believed as one of the most predictive indicators of pregnancy outcome in assisted reproductive technology(ART).However,the impact of teratozoospermia on in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI)outcomes and its offspring remains *** order to evaluate the influence of teratozoospermia on pregnancy outcome and newborn status after IVF and ICSI,a retrospective study was *** was a matched case-control study that included 2202 IVF cycles and 2574 ICSI cycles and was conducted at the Reproductive and Genetic Hospital of CITIC-Xiangya in Changsha,China,from June 2013 to June *** were divided into two groups based on sperm morphology:teratozoospermia and normal sperm *** pregnancy outcome and newborn outcome were *** results indicated that couples with teratozoospermia had a significantly lower optimal embryo rate compared to those with normal sperm morphology in IVF(P=0.007),while there were no statistically significant differences between the two groups in terms of the fertilization rate,cleavage rate,implantation rate,and pregnancy rate(all P>0.05).Additionally,teratozoospermia was associated with lower infant birth weight in multiple births after *** regard to ICSI,there was no significant difference in both pregnancy outcome and newborn outcome between the teratozoospermia and normal groups(both P>0.05).Furthermore,no increase in the risk of birth defects occurred in the teratozoospermia group after IVF/***,we believe that teratozoospermia has limited predictive value for pregnancy outcomes in IVF/ICSI,and has little impact on the resulting offspring if multiple pregnancy is avoided.

关键词： in vitro fertilization intracytoplasmic sperm injection newborn outcome pregnancy outcome teratozoospermia

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Association between T174M polymorphism in the angiotensinogen gene and risk of coronary artery disease: a meta-analysis

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Journal of Geriatric Cardiology 2013年第1期10卷 59-65页

作者： wen-zhu Wang Department of Neurology Saint Petersburg Pavlov State Medical University St. Petersburg 197022 Russia

Background Angiotensinogen (AGT) T174M gene polymorphism has been suggested to be linked to risk of coronary artery disease, however, results from studies of this association have been inconsistent. In this study, we assess the relationship between AGT T174Mgene polymorphism and coronary artery disease. Methods We conducted a meta-analysis of 18 case-control studies with 8,147 coronary artery disease cases and 5,344 controls in Google scholar, PubMed, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases to identify eligible studies published by July, 2012. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated from these studies. Results Overall, a significant association was found between angiotensinogen T174M polymorphism and coronary artery disease risk when all studies were pooled into the meta-analysis (TT vs. MM:OR = 0.53, 95%CI = 0.40–0.71; dominantmodel: OR = 1.16,95% CI = 1.01–1.35; recessive model: OR = 0.54, 95% CI = 0.40–0.72). In a stratified analysis, the results indicate a significant association in Caucasians suffering from coronary stenosis (TT vs. MM: OR = 0.38, 95% CI = 0.23–0.63; recessive model: OR = 0.39, 95% CI =0.23–0.64). No significant increased risk for coronary artery disease was found in Asians. Conclusions The meta-analysis indicate a significant association of T174Mpolymorphism with coronary stenosis risk in Caucasians.

关键词： Angiotensinogen Coronary artery disease Meta-analysis Polymorphism

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Dynamic characteristics of multi-span spinning beams with elastic constraints under an axial compressive force

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 295-310页

作者： Xiaodong GUO zhu su Lifeng WANG State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

A theoretical model for the multi-span spinning beams with elastic constraints under an axial compressive force is *** displacement and bending angle functions are represented through an improved Fourier series,which ensures the continuity of the derivative at the boundary and enhances the *** exact characteristic equations of the multi-span spinning beams with elastic constraints under an axial compressive force are derived by the Lagrange *** efficiency and accuracy of the present method are validated in comparison with the finite element method(FEM)and other *** effects of the boundary spring stiffness,the number of spans,the spinning velocity,and the axial compressive force on the dynamic characteristics of the multi-span spinning beams are *** results show that the present method can freely simulate any boundary constraints without modifying the solution *** elastic range of linear springs is larger than that of torsion springs,and it is not affected by the number of *** an increase in the axial compressive force,the attenuation rate of the natural frequency of a spinning beam with a large number of spans becomes larger,while the attenuation rate with an elastic boundary is lower than that under a classic simply supported boundary.

关键词： multi-span spinning beam elastic constraint improved Fourier series free vibration semi-analytical solution

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Recent advances in preparation of metallic superhydrophobic surface by chemical etching and its applications

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Chinese Journal of Chemical Engineering 2023年第9期61卷 221-236页

作者： Shitong zhu wenyi Deng Yaxin su College of Environmental Science and Engineering Donghua UniversityShanghai 201620China

In the past few decades,inspired by the superhydrophobic surfaces(SHPS)of animals and plants such as lotus leaves,rose petals,legs of water striders,and wings of butterflies,preparing metal materials with metallic SHPS(MSHPS)have attracted great research interest,due to the great prospect in practical *** obtain SHPS on conventional metal materials,it is necessary to construct rough surface,followed by modification with low surface energy *** this paper,the action mechanism and the current research status of MSHPS were reviewed through the following ***,the model of wetting theory was presented,and then the progress in MSHPS preparation through chemical etching method was ***,the applications of MSHPS in self-cleaning,anti-icing,corrosion resistance,drag reduction,oil-water separation,and other aspects were ***,the challenges encountered in the present application of MSHPS were summarized,and the future research interests were discussed.

关键词： Metal superhydrophobic surface Chemical etching Low adhesion Self-cleaning

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Advances in in-situ characterizations of electrode materials for better supercapacitors

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Journal of Energy Chemistry 2021年第3期30卷 242-253页

作者： Xiaoli su Jianglin Ye Yanwu zhu Hefei National Research Center for Physical Sciences at the Microscale &Department of Materials Science and Engineering&CAS Key Laboratory of Materials for Energy ConversionIf i-ChEMUniversity of Science and Technology of ChinaHefei 230026AnhuiChina

In past decades,the performance of supercapacitors has been greatly improved by rationalizing the electrode materials at the ***,there is still a lack of understanding on how the charges are efficiently stored in the electrodes or transported across the electrolyte/electrode *** it is very challenging to investigate the ion-involved physical and chemical processes with single experiment or computation,combining advanced analytic techniques with electrochemical measurements,i.e.,developing in-situ characterizations,have shown considerable prospect for the better understanding of behaviors of ions in electrodes for ***,we briefly review several typical in-situ techniques and the mechanisms these techniques reveal in charge storage mechanisms specifically in *** strategies for designing better electrode materials are also discussed.

关键词： Electric double layer capacitor Pseudocapacitor In-situ technique Charge storage mechanism

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