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Expression of interferon inducible protein-10 in pancreas of mice

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World Journal of Gastroenterology 2005年第30期11卷 4750-4752页

作者： Dong Li su-wen zhu Dong-Juan Liu Guo-Liang Liu Department of Infectious Disease the First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China Department of Histology and Embryology the College of Basic Science China Medical University Shenyang 110001 Liaoning Province China Department of Endocrinology the First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China

AIM: To investigate the expression of interferon inducible protein-10 (IP-10) in pancreas of mice and to discuss its possible role in the pathogenesis of type 1 ***: Non-obese diabetic (NOD) mice were used as experiment group and BALB/c mice as non-diabetic prone model. Immunohistochemistry method was used to evaluate the expression of IP-10 in the pancreas of NOD mice and BALB/c mice. Immunoelectron microscope was used to show the location of IP-10 in pancreatic islet β ***: Pancreatic islets were positively stained in all the NOD mice. Insulitis could be found in mice at the age of 4 wk. The weakly positive results were found in control group with no insulitis. Immunoelectron microscopy further demonstrated that IP-10 was produced by pancreatic β cells and stored in cytoplasm of the ***: IP-10 can be largely produced in pancreatic islets of NOD mice at the age of 2 wk when there is no significant insulitis, and may play an important part in the pathogenesis of type 1 diabetes by attracting immune cells to infiltrate the pancreatic islets.

关键词： Interferon inducible Protein-10 Type 1 diabetes Insulitis

Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang zhu Chenxi Ding Zhe sui Hong su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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习斋研究三百余年之回顾

河北师范大学学报（教育科学版） 2009年第7期11卷 48-51页

作者：苏文珠河北省图书馆河北石家庄050011

对颜元的研究从颜元在世已经开始,至今已经三百余年。其中,清初期、清晚期以及民国初期、建国初期是颜元研究的几个高峰期。改革开放以后,其学术思想的研究进入了新时代,呈现出百花齐放的景象。在这一过程中,颜元的研究也逐渐走向国际化... 详细信息

对颜元的研究从颜元在世已经开始,至今已经三百余年。其中,清初期、清晚期以及民国初期、建国初期是颜元研究的几个高峰期。改革开放以后,其学术思想的研究进入了新时代,呈现出百花齐放的景象。在这一过程中,颜元的研究也逐渐走向国际化,从欧美到日本、韩国,均有学者对颜元思想进行研究。

关键词：颜元研究三百余年综述

从物象到易象——兼论中国古代哲学思想的萌芽

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中国石油大学胜利学院学报 2010年第4期24卷 38-41页

作者：苏祝文中国石油大学胜利学院中文系山东东营257000

从物象到易象的思维过程,被古人称为"观物取象",其实就是中国古代最初的哲学抽象过程。中国古代思想产生与发展的史实表明,原始社会后期八卦的创立是中国最初完整系统的哲学抽象的思想活动,是古人认识水平与思维水平的跃迁,是中国古代... 详细信息

从物象到易象的思维过程,被古人称为"观物取象",其实就是中国古代最初的哲学抽象过程。中国古代思想产生与发展的史实表明,原始社会后期八卦的创立是中国最初完整系统的哲学抽象的思想活动,是古人认识水平与思维水平的跃迁,是中国古代哲学思想的萌芽。

关键词：物象易象古代哲学

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古籍数字化所面临的问题及对策

河北科技图苑 2007年第3期20卷 19-21页

作者：苏文珠河北省图书馆古籍与地方文献部河北省石家庄市050011

古籍的不可再生性与人们对古籍需求的不断增长,使古籍数字化已成大势所趋。由于缺乏统一管理,制作单位各行其是,致使古籍数字化市场上出现了产品严重重复、质量参差不齐等问题,对此提出了改进的建议。

关键词：古籍古籍数字化数字化古籍

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《金瓶梅》中的西门府住宅建筑初探

河北经贸大学学报（综合版） 2007年第2期7卷 50-53页

作者：苏文珠河北省图书馆古籍与地方文献部河北石家庄050011

对“四大奇书”之一《金瓶梅》的研究,历来以其文意、历史、名物、方言等为重,鲜及建筑。依据张竹坡评本及词话本二书,初步论证了西门住宅的位置、建筑规模、平面布局,以及其中的更道、人流交叉路线等,并纠正了“张评本”关于该书建筑... 详细信息

对“四大奇书”之一《金瓶梅》的研究,历来以其文意、历史、名物、方言等为重,鲜及建筑。依据张竹坡评本及词话本二书,初步论证了西门住宅的位置、建筑规模、平面布局,以及其中的更道、人流交叉路线等,并纠正了“张评本”关于该书建筑的个别错误。

关键词：金瓶梅西门府住宅建筑

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地方灰色文献征集中的问题及其对策

河北科技图苑 2007年第5期20卷 69-71,45页

作者：苏文珠河北省图书馆古籍与地方文献部河北省石家庄市050011

目前,地方灰色文献的收藏价值和服务作用越来越显著,随着灰色文献的大量产生,其征集的难度也越来越大,针对地方灰色文献征集中存在的信息不畅、出版单位分散、印行数量少、发行范围小等问题,结合工作实践提出了相应对策。

关键词：灰色文献地方灰色文献文献征集

观物取象与托物言志——论《易经》观象系辞与《诗经》比兴之异同

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中国石油大学胜利学院学报 2007年第3期21卷 25-27页

作者：苏祝文中国石油大学胜利学院中文系山东东营257000

《易经》与《诗经》同是我国先秦时期出现的两部经典文献。《易经》的观物取象系辞与《诗经》的比兴既有相同相近之处,又有明显差别。相同时代里相同的思维方式、语言表达方式和文学象征手法的运用使《易经》观物取象系辞与《诗经》比... 详细信息

《易经》与《诗经》同是我国先秦时期出现的两部经典文献。《易经》的观物取象系辞与《诗经》的比兴既有相同相近之处,又有明显差别。相同时代里相同的思维方式、语言表达方式和文学象征手法的运用使《易经》观物取象系辞与《诗经》比兴有相同相近之处;而不同的功用、不同的目的不同的内涵又使二者有明显差别,这种差别归根结底就是观物取象系辞与托物言志抒情的差别。

关键词：《易经》观象系辞《诗经》比兴

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin wenzhen zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor