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The Effect of Basalt Fiber on Concrete Performance under a sulfate Attack Environment

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Journal of Renewable Materials 2023年第1期11卷 233-244页

作者： Qiang su Jinming xu Department of Civil Engineering Shanghai UniversityShanghai200444China

To enhance the sulfate attack resistance performance of concrete,sulfate erosion test was carried out on basalt fiber concrete with different contents,selecting a concentration of 5%sulfate solution and using a dry−wet cycle mechanism attack of basalt fiber-reinforced concrete(BFRC).Every 15 dry−wet cycles,the mass,compressive strength,splitting tensile strength,and relative dynamic elastic modulus of BFRC were tested,and the SO_(4)^(2−)con-centration was *** work demonstrates that the mass,relative dynamic elastic modulus,compressive and splitting tensile strength of BFRC reveal a trend of climb up and then decline with the process of the dry−wet *** fiber can enhance the sulfate corrosion resistance of concrete by delaying the erosion of concrete induced by SO_(4)^(2−)and increasing the bearing and anti-deformation capacities of concrete by improving its inter-nal ***,when mixing 0.2%basalt fiber into concrete,the strength deterioration rate will be reduced when the peak values of splitting tensile and compressive strength appear at 60 and 75 times the alter-nating dry−wet cycles,*** effects will occur when the fiber volume fraction exceeds 0.2%.The research in this paper can provide a foundation for the engineering applications of basalt fiber concrete.

关键词： Concrete basalt fiber dry−wet cycle compressive strength splitting tensile strength

Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong xu Shoumin xuan Shuai Chen Dan Liu Qian Xiao Jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

Growth Control of High-Performance In As/Ga Sb Type-Ⅱ superlattices via Optimizing the In/Ga Beam-Equivalent Pressure Ratio

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Chinese Physics Letters 2020年第3期37卷 60-63页

作者： Da-Hong su Yun xu wen-Xin Wang Guo-Feng Song Institute of Semiconductors Chinese Academy of SciencesBeijing 100083 College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049 Beijing Key Laboratory of Inorganic Stretchable and Flexible Information Technology Beijing 100083 Institute of Physics Chinese Academy of SciencesBeijing 100190

The performance of type-Ⅱ superlattice(T2 SL) long-wavelength infrared devices is limited by crystalline quality of T2 SLs. We optimize the process of growing molecular beam epitaxy deposition T2 SL epi-layers on Ga Sb(100)to improve the material properties. Samples with identical structure but diverse In/Ga beam-equivalent pressure(BEP) ratio are studied by various methods, including high-resolution x-ray diffraction, atomic force microscopy and high-resolution transmission electron microscopy. We find that appropriately increasing the In/Ga BEP ratio contributes to improving the quality of T2 SLs, but too large In BEP will much more easily cause a local strain,which can lead to more In Sb islands in the In Sb interfaces. The In Sb islands melt in the In Sb interfaces caused by the change of chemical potential of In atoms may result in the "nail" defects covering the whole T2 SLs, especially the interfaces of Ga Sb-on-In As. When the In/Ga BEP ratio is about 1, the T2 SL material possesses a lower full width at half maximum of +1 first-order satellite peak, much smoother surface and excellently larger area uniformity.

关键词： properties. beam identical

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Polymer-derived SiBCN ceramic pressure sensor with excellent sensing performance

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Journal of Advanced Ceramics 2020年第3期9卷 374-379页

作者： Gang SHAO Junpeng JIANG Mingjie JIANG Jie su wen LIU Hailong WANG Hongliang xu Hongxia LU Rui ZHANG School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Provincial Key Laboratory of Aviation Materials and Application Technology Zhengzhou University of AeronauticsZhengzhou 450046China

Pressure measurement with excellent stability and long time durability is highly desired,especially at high temperature and harsh environments.A polymer-derived silicoboron carbonitride(SiBCN)ceramic pressure sensor with excellent stability,accuracy,and repeatability is designed based on the giant piezoresistivity of SiBCN *** SiBCN ceramic sensor was packaged in a stainless steel case and tested using half Wheatstone bridge with the uniaxial pressure up to 10 *** SiBCN ceramic showed a remarkable piezoresistive effect with the gauge factor(K)as high as *** output voltage of packed SiBCN ceramic sensor changes monotonically and smoothly versus external *** as received SiBCN pressure sensor possesses features of short response time,excellent repeatability,stability,sensitivity,and *** the excellent high temperature thermo-mechanical properties of polymer-derived SiBCN ceramics(e.g.,high temperature stability,oxidation/corrosion resistance)into account,SiBCN ceramic sensor has significant potential for pressure measurement at high temperature and harsh environments.

关键词： polymer-derived ceramics(PDCs) silicoboron carbonitride(SiBCN)ceramic pressure sensor,piezoresistivity high termperature and harsh environment sensor

Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong Dan Zou Zhijun Yang Lili Guo Ruxiang xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

Three New Sesquiterpenoids from Agrocybe sp.

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Chemical Research in Chinese Universities 2012年第6期28卷 976-979页

作者： ZHENG Yong-biao LU Chun-hua xu Li su wen-jin SHEN Yue-mao Engineering Research Center of Industrial Microbiology Ministry of Education Engineering Research Center of Fujian Modern Fermentation Technology College of Life Sciences Fujian Normal University Fuzhou 350108 P. R. China School of Pharmaceutical Sciences Shandong University Jinan 250012 P. R. China School of Life Sciences Xiamen University Xiamen 361005 P. R. China

Two new marasmone derivatives,1α,2β-dihydroxymarasmone（1） and 2β,3α-dihydroxymarasmone（2）,and one new norsesquiterpenoid,14-hydroxyoreadone（3）,were obtained from the fermentation broth of Agrocybe sp.,together with three known sesquiterpenes,agrocybolacton（4）,marasmene（5） and 14-hydroxymarasmene（6）.Their structures were elucidated by spectroscopic analyses,including 1D-and 2D-NMR experiments,high resolution electron spray ionization quadrupole time of flight（HR-ESI-Q-TOF） mass spectrometry,chemical correlation,X-ray single crystal diffraction and also compared with reported data.

关键词： Sesquiterpenoid Agrocybe sp. Marasmone derivative

Topology: a unique dimension in protein engineering

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Science China Chemistry 2018年第1期61卷 3-16页

作者： Lianjie xu wen-Bin Zhang Key Laboratory of Polymer Chemistry & Physics of Ministry of Education Center for Soft Matter Science and EngineeringCollege of Chemistry and Molecular Engineering Peking University

Controlling protein topology has been a long standing challenge to go beyond their linear configuration defined by the translation mechanism of cellular machinery. In this mini-review, we focus on the topological diversity in proteins and review the major categories of protein topologies known to date, including branched/star proteins, circular proteins, lasso proteins, knotted proteins, and protein catenanes. The discovery of these topologically complex natural proteins and their synthetic pathways, the rational design and recombinant synthesis of artificial topological proteins and their biophysical studies, are summarized and discussed with regard to their general features and broad implications. The complexity of protein topology is recognized and the routes to diverse protein topologies are illustrated. We believe that topology engineering is an important way to modify protein properties without altemating their native sequences and shall bring in valuable dynamic features central to the creation of artificial protein machinery.

关键词： protein topology protein engineering catenane rotaxane knot lasso peptide

Numerical study on wave loads and motions of two ships advancing in waves by using three-dimensional translating-pulsating source

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Acta Mechanica Sinica 2013年第4期29卷 494-502页

作者： Yong xu wen-Cai Dong Department of Naval Architecture Naval University of Engineering

A frequency domain analysis method based on the three-dimensional translating-pulsating （3DTP） source Green function is developed to investigate wave loads and free motions of two ships advancing on parallel course in waves. Two experiments are carried out respectively to mea- sure the wave loads and the free motions for a pair of side-by- side arranged ship models advancing with an identical speed in head regular waves. For comparison, each model is also tested alone. Predictions obtained by the present solution are found in favorable agreement with the model tests and are more accurate than the traditional method based on the three dimensional pulsating （3DP） source Green function. Numer- ical resonances and peak shift can be found in the 3DP pre- dictions, which result from the wave energy trapped in the gap between two ships and the extremely inhomogeneous wave load distribution on each hull. However, they can be eliminated by 3DTP, in which the speed affects the free sur- face and most of the wave energy can be escaped from the gap. Both the experiment and the present prediction show that hydrodynamic interaction effects on wave loads and free motions are significant. The present solver may serve as a validated tool to predict wave loads and motions of two ves- sels under replenishment at sea, and may help to evaluate the hydrodynamic interaction effects on the ships safety in replenishment operation.

关键词： Hydrodynamic interaction - Wave loads ~Ship motions ~ Model test ~ Three-dimensional translating-pulsating source ~ Underway replenishment