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Science China Chemistry 2021年第12期64卷 2125-2133页

作者： Ming xu Jia Liu Xianlong su Qianwen Zhou Hang Yuan Yue wen Yihang Cheng Fuyou Li Department of Chemistry&State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200433China Shanghai Taywell Biotechnology Co. Ltd.Shanghai200438China

Lanthanide-containing persistent luminescence materials are promising candidates for a wide range of applications by virtue of splendid superiorities in afterglow ***,it is a crucial challenge to achieve high-quality afterglow materials at the attractive nanoscale,with uniform size,controllable morphology,and satisfying ***,a bottom-up approach was developed to construct the high-quality afterglow nanoparticles,incorporating luminescent lanthanide complex and organic molecular ingredients under mild *** nanoparticles exhibited intrinsic lanthanide luminescence with superbright red afterglow(>10 cd m^(−2))in a homogeneous *** afterglow solution with excellent processability can serve as ideal building blocks for the on-demand fabrication of functional ***-dispersible afterglow nanoparticles with state-of-the-art high brightness were uniformly constructed to perform whole-blood lateral flow assay of procalcitonin with a naked-eye detection limit of 0.5 ng mL^(−1),promoting the point-of-care testing development.

关键词： persistent luminescence lanthanide photochemical afterglow solution processing point-of-care testing

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Caution in building a Burgers circuit for studying secondary dislocations

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Journal of Materials Science & Technology 2019年第6期35卷 1192-1197页

作者： wen-Sheng xu wen-Zheng Zhang Key Laboratory of Advanced Materials (MOE) School of Materials Science and EngineeringTsinghua University

As the Burgers vector of a secondary dislocation may not conform to the translation vectors in the periodic pattern in a high-resolution transmission electron microscope(HRTEM) image, a Burgers circuit directly constructed according to an HRTEM image may render a wrong Burgers vector. The HRTEM images of the habit plane(HP) of δ precipitate in an Inconel 718 alloy were re-examined by using different Burgers circuits, as an example. Evidence is found for predicted secondary dislocation associated with a down step. The Burgers vector of the dislocation is 1/6[112]/1/3[001]δ, determined with the Burgers circuit built on the reference of the displacement shift completely lattice(DSCL). It is consistent with both the calculated and the measured result of the major defects in the habit plane. Different Burgers vectors due to different Burgers circuits were explained quantitatively. The present study has a general implication for the determination of the Burgers vectors of secondary interfacial dislocations in other systems.

关键词： Dislocation Burgers vector Burgers circuit Coincidence site lattice (CSL) Displacement shift completely lattice (DSCL) Lattice correspondence

Optimal control data scheduling with limited controller-plant communication

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Science China(Information Sciences) 2018年第1期61卷 204-218页

作者： Jiapeng xu Chenglin wen Daxing xu Institute of Systems Science and Control Engineering School of AutomationHangzhou Dianzi University College of Electrical and Information Engineering Quzhou University

This paper considers optimal control data scheduling for finite-horizon linear quadratic regulation(LQR) control of scalar systems with limited controller-plant communication. Both the single-system and multiple-system scenarios are studied. For the first scenario, we derive the necessary and sufficient condition for a comparison function to be positive. Using this condition, the optimality of an explicit schedule is extended from unstable systems in the existing work to general systems. For the second scenario, we are able to construct explicit optimal scheduling policies for three particular classes of problems. Numerical examples are provided to illustrate the proposed results.

关键词： control data scheduling LQR control optimal schedule limited transmission energy multiple systems

Lithium cobaltate:a novel host material enables high-rate and stable lithium-sulfur batteries

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Rare Metals 2018年第11期37卷 929-935页

作者： wen Ma Qing xu GRINM Bohan (Beijing) Publisher Co. Ltd.GRINM Group Co.Ltd. subinstitute of Standardization Theory and Strategy China National Institute of Standardization

Element sulfur is highly attractive due to their potentially low cost and environmental ***, polysulfides dissolution hinders the lithiumsulfur(Li-S) batteries toward commercialization. To overcome these issues, in this work, lithium cobaltate as a commercial material, for the first time, was devoted to engineering the electrode structure and composition to improve the performance. When incorporated with 80% sulfur powder, the synergetic effects of cobalt atoms and interlayer spaces effectively enable the production of Li-S batteries with a relatively high discharge capacity of 1420 mAh·g-1at the low surface current density of 1 mA·cm-2and stable capacity retention of 650 mAh·g-1at high surface current density of 6 mA·cm-2. The introduction of lithium cobaltate is a viable approach for successfully developing practical Li-S batteries.

关键词： Lithium cobaltate Polysulfides dissolution Electrochemical properties Lithium-sulfur batteries

Sediment supply mechanism and its influence on hydrocarbon accumulation in the Paleogene of the northern Huanghekou Sag,Bohai Bay Basin,China

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Journal of Palaeogeography 2023年第2期12卷 229-245页

作者： Hai-Feng Yang Geng Qian Meng Zhao Yan-Fei Gao wen su Yao-Hui xu China National Offshore Oil Corporation Tianjin Branch Tianjin300450China

Tectonic activity and sediment supply have significantly affected the rifted basin fillings and hydrocarbon *** Huanghekou Sag in the southeastern Bohai Bay Basin is a hydrocarbon rich sag and was bounded by the Bonan Uplift to the north in the Paleogene,which strongly affected sediment disribution and hydrocarbon accumulation in this *** sediment supply mechanism of the Paleogene parent rocks in this area has not been revealed ***,the Huanghekou Sag is a natural laboratory to reveal the relationship between the tectonic activties and hydrcoarbon accumulations in a rifted *** this study,the tectonic evolution characteristics of the Bonan Uplift in different geological periods are revealed during the main fault depression ***,the direction of the provenance and distribution of the depositional system of the Bonan Uplift are analyzed based on the sedimentary system and mineralogy ***,the sediment supply in the Bonan Uplift in different geological periods has been systematically *** results indicated that sediment supply is the dominant factor of hydrocarbon accumulation in the Paleogene in the Huanghekou *** the Paleocene-Middle Eocene,extensive denudation occurred in the Bonan Uplift,sediments were mainly sourced from the Bonan Uplift in the northern margin of the Huanghekou *** the Late Eocene to Early Oligocene,the Bonan Uplift had a large angle rotation and subsidence due to the strong rifting of the Bozhong Sag in the north,and the sand supply capacity was seriously *** to the different sediment supply in different geological periods,high quality reservoir and cap conditions were formed in the Paleogene in the central and northern parts of the Huanghekou Sag,which is conducive to the accumulation and preservation of oil and gas.

关键词： Huanghekou Sag Tectonic evolution Fault depression period Recovery of parent rock area Reservoir-cap combination

Development characteristics of the fault system and its control on basin structure, Bodong Sag, East China

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Petroleum Science 2013年第4期10卷 450-457页

作者： Wu Zhiping Cheng Yanjun Yan Shiyong su wen Wang Xin xu Changgui Zhou Xinhuai China University of Petroleum Tianjin Technical Department CNOOC

The Bodong Sag,located in the Bohai Sea,offshore China,is one of the most petroliferous basins in *** on three dimensional seismic reflection data and time slice data,we analyze the fault system of the Bodong area in detail,establish the fault structure pattern of different types and summarize the distribution of the fault *** is concluded that the development characteristics of the Cenozoic fault system are in accordance with the dextral stress field of the Tanlu Fault,which displayed a brush structure with NNE strike-slip faults as its principal faults,NE-trending extensional faults as secondary faults and EW-trending faults as minor *** can be divided into （1） strike-slip type,（2） extensional type,（3） strike-slip extensional type and （4） extensional strike-slip *** spatial structures of different faults have obvious differences because of the fault properties and activity *** fault system at different stages shows tremendous differences because of the transition of the Tanlu Fault from sinistral strike-slip to dextral strike-slip,the transition between extension and strike-slip,and the transition from mantle upwelling to thermal *** to the controlling effect of faults on basin structure,the Cenozoic basin experienced four evolutionary stages,（a） transition stage from sinistral strike-slip to dextral strike-slip,（b） strike-slip extensional faulted stage,（c） extensional strike-slip faulted stage and （d） strike-slip depression *** identification of temporal and spatial differences of faults could be used as a significant guideline for oil and gas exploration in the Bodong area.

关键词： Fault system basin structure Bodong area

Valuable clinical indicators for identifying infantile-onset inflammatory bowel disease patients with monogenic diseases

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World Journal of Gastroenterology 2021年第1期27卷 92-106页

作者： wen su Yi Yu xu xu Xin-Qiong Wang Jie-Bin Huang Chun-Di xu Yuan Xiao Department of Pediatrics Ruijin HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China

BACKGROUND Infantile-onset inflammatory bowel disease(IO-IBD)occurs in very young children and causes severe clinical manifestations,which has poor responses to traditional inflammatory bowel disease(IBD)*** present,there are no simple and reliable laboratory indicators for early screening IO-IBD patients,especially those in whom the disease is caused by monogenic *** To search for valuable indicators for early identifying IO-IBD patients,especially those in whom the disease is caused by monogenic *** A retrospective analysis was performed in 73 patients with IO-IBD admitted to our hospital in the past 5 *** on the next-generation sequencing results,they were divided into a monogenic IBD group(M-IBD)and a non-monogenic IBD group(NM-IBD).Forty age-matched patients with allergic proctocolitis(AP)were included in a control *** clinical manifestations and the inflammatory factors in peripheral blood were *** regression analysis and receiver operating characteristic(ROC)curve analysis were used to identify the screening factors and cut-off values of IO-IBD as well as monogenic IO-IBD,*** Among the 44 M-IBD patients,35 carried IL-10RA mutations,and the most common mutations were c.301C>T(p.R101W,30/70)and the c.537G>A(p.T179T,17/70).Patients with higher serum tumor necrosis factor(TNF)-αvalue were more likely to have IBD[odds ratio(OR)=1.25,95%confidence interval(CI):1.05-1.50,P=0.013],while higher serum albumin level was associated with lower risk of IBD(OR=0.86,95%CI:0.74-1.00,P=0.048).The cut-off values of TNF-αand albumin were 17.40 pg/mL(sensitivity:0.78;specificity:0.88)and 36.50 g/L(sensitivity:0.80;specificity:0.90),*** increased ferritin level was indicative of a genetic mutation in IO-IBD *** cut-off value was 28.20 ng/mL(sensitivity:0.93;specificity:0.92).When interleukin(IL)-10 level was higher than 33.05 pg/mL(sensitivity:1.00;specificity:0.84),or the onset age

关键词： Infantile-onset inflammatory bowel disease Immunodeficiency Clinical indicators Interleukin 10 Ferritin IL10RA

Overview of global monthly surface temperature data in the past century and preliminary integration

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Advances in Climate Change Research 2014年第3期5卷 111-117页

作者： xu wen-Hui LI Qing-Xiang YANG su xu Yan National Meteorological Information Center China Meteorological Administration

This paper analyzes the status of existing resources through extensive research and international cooperation on the basis of four typical global monthly surface temperature datasets including the climate research dataset of the University of East Anglia(CRUTEM3), the dataset of the U.S. National Climatic Data Center(GHCN-V3), the dataset of the U.S. National Aeronautics and Space Administration(GISSTMP), and the Berkeley Earth surface temperature dataset(Berkeley). China's first global monthly temperature dataset over land was developed by integrating the four aforementioned global temperature datasets and several regional datasets from major countries or regions. This dataset contains information from 9,519 stations worldwide of at least 20 years for monthly mean temperature, 7,073 for maximum temperature, and 6,587 for minimum temperature. Compared with CRUTEM3 and GHCN-V3, the station density is much higher particularly for South America, Africa,and Asia. Moreover, data from significantly more stations were available after the year 1990 which dramatically reduced the uncertainty of the estimated global temperature trend during 1990e2011. The integrated dataset can serve as a reliable data source for global climate change research.

关键词： Global monthly surface temperature dataset Integration of multi-source data Climate change

Regression of intervertebral disc calcification combined with ossification of the posterior longitudinal ligament:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7285-7291页

作者： xu-Dong Wang Xian-Jun su Yao-Kun Chen wen-Gang Wang Department of Orthopaedic surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Intervertebral disc calcification(IDC)combined with ossification of the posterior longitudinal ligament(OPLL)in cervical discs is rarely *** case study presents a rare case of IDC combined with OPLL in the C2-C3 *** suMMARY Here,we present a case of a 6-year-old Asian boy with severe neck pain and *** examination showed no neurological or other *** radiography and computed tomography(CT)revealed a calcified intervertebral disc and OPLL at the C2-C3 *** spinal canal compromise at C2-C3 was approximately 50%on magnetic resonance *** final diagnosis was IDC combined with *** applied a neck brace for the patient to protect the *** patient's neck pain and stiffness recovered significantly within approximately 3 *** the 3 mo follow-up,the follow-up CT showed resolution of the ossified intervertebral disc herniation,and a small amount of calcification and slight OPLL remained at the involved *** IDC combined with OPLL is a relatively rare condition in ***,the majority of patients could have a favorable outcome,and the ossified mass in the canal would be spontaneously resolved with conservative therapy.

关键词： Intervertebral disc calcification Ossification of the posterior longitudinal ligament Diagnosis Treatment Case report