检索结果-南通市图书馆

Long noncoding RNA HOXA11-AS promotes gastric cancer cell proliferation and invasion via SRSF1 and functions as a biomarker in gastric cancer

引用

World Journal of Gastroenterology 2019年第22期25卷 2763-2775页

作者： Yun Liu Yu-Mei Zhang Feng-Bo Ma su-rong pan Bao-Zhen Liu Department of Operating Room Binzhou People's HospitalBinzhou 256610Shandong ProvinceChina Department of Return Visit Binzhou People's HospitalBinzhou 256610Shandong ProvinceChina Department of Gastroenterology Binzhou People's HospitalBinzhou 256610Shandong ProvinceChina

BACKGROUND Gastric cancer (GC) is the fourth most frequent malignancy all over the world. The diagnosis of GC is challenging and the prognosis of GC is very unfavorable. Accumulating evidence reveals that serum long noncoding RNAs (lncRNAs) can function as biomarkers in various types of cancers, including GC. AIM To explore the level and molecular mechanism of the lncRNA HOXA11-AS in GC and the diagnostic and prognostic significance of serum HOXA11-AS in GC. METHODS HOXA11-AS levels in GC tissue, cell lines, and serum samples were measured. The correlation between HOXA11-AS expression and clinicopathological characteristics was analyzed. The role of HOXA11-AS in the diagnosis and prognosis of GC was evaluated. Cell function assays were performed for exploration of the roles of HOXA11-AS in GC cells. Moreover, Western blot was performed to explore the target regulated by HOXA11-AS in GC cells. REsuLTS Up-regulation of HOXA11-AS was found in GC tissues, cell lines, and serum samples. In GC patients, decreased serum HOXA11-AS levels were negatively related with tumor size, TNM stage, and lymph node metastasis. The area under the receiver operating characteristic curve of serum HOXA11-AS in the diagnosis of GC was 0.924 (95%CI: 0.881-0.967;sensitivity, 0.787;specificity 0.978). Results of the Kaplan-Meier survival curves suggested the GC patients with a lower HOXA11-AS level having a better overall survival rate. HOXA11-AS promoted GC cell proliferation and invasion. SRSF1 may be the target regulated by HOXA11-AS in GC cells. CONCLUSION HOXA11-AS promotes GC cell proliferation and invasion via SRSF1 and may function as a promising marker in GC.

关键词： Long noncoding RNA HOXA11-AS SRSF1 Gastric cancer Biomarker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Time-Domain Numerical Simulation for Free Motion Responses of Two Ships Advancing in Head Waves

引用

China Ocean Engineering 2024年第3期38卷 519-530页

作者： pan su-yong CHENG Yong School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

The constant panel method within the framework of potential flow theory in the time domain is developed for solving the hydrodynamic interactions between two parallel ships with forward *** solving problems within a time domain framework,the free water surface needs to simultaneously satisfy both the kinematic and dynamic boundary conditions of the free water *** provides conditions for adding artificial damping *** the Runge−Kutta method to solve equations related to *** upwind differential scheme is used in the present method to deal with the convection terms on the free surface to prevent waves *** the comparison with the available experimental data and other numerical methods,the present method is proved to have good mesh convergence,and satisfactory results can be *** constant panel method is applied to calculate the hydrodynamic interaction responses of two parallel ships advancing in head *** simulations are conducted on the effects of forward speed,different longitudinal and lateral distances on the motion response of two modified Wigley ships in head *** further investigations are conducted on the effects of different ship types on the motion response.

关键词： ship motions time domain simulation forward speed different distances wave loads

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental Investigation of the Operating Characteristics of a Pulsating Heat Pipe with Ultra-Pure Water and Micro Encapsulated Phase Change Material suspension

引用

Journal of Thermal Science 2024年第2期33卷 457-468页

作者： SHI Weixiu su Xiaoyang CHEN Hongdi pan Lisheng Beijing Engineering Research Center of sustainable Energy and Buildings Beijing University of Civil Engineering and ArchitectureBeijing100044China School of Environment and Energy Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China State Key Laboratory of High Temperature Gas Dynamics Institute of MechanicsChinese Academy of SciencesBeijing100190China

The specific heat capacity of working fluid is an important influence factor on heat transfer characteristic of the pulsating heat pipe(PHP).Due to the relatively large specific heat capacity of micro encapsulated phase change material(MEPCM) suspension,a heat transfer performance experimental facility of the PHP was *** heat transfer characteristic with MEPCM suspension of different mass concentrations(0.5% and 1.0%) and ultra-pure water were compared *** was found that when the PHP uses MEPCM suspension as its working fluid,operating stability is impoverished under lower heating power and the operating stability is better under higher heating *** the inclination angle of 90°,the temperature at heating side decreases compared to ultra-pure water and the temperature at heating side decreases with the raising of MEPCM suspension mass *** heat transfer characteristic of the PHP is positively correlated with the inclination angle and the 90° is *** unfavorable effect of the inclination angle decreases with heating power *** the inclination angle is 90°,the PHP with MEPCM suspension at 1.0% of mass concentration has the lowest thermal transfer resistance and followed by ultra-pure water and MEPCM suspension at 0.5% of mass concentration has the highest thermal transfer *** the inclination angles are 60° and30°,the effect of gravity on the flow direction is reduced to 86.6% and 50% of that on the inclination angle of 90°,respectively,and the promoting effect of gravity on the working fluid is further weakened as the inclination angle further *** to the high viscosity of MEPCM suspension,the PHP with ultra-pure water has the lowest heat transfer *** the inclination angles is 60°,the thermal resistance with MEPCM suspension at0.5% of the mass concentration is lower than that at 1.0% at the heating power below 230 *** thermal resistance of MEPCM suspension tends to be simila

关键词： pulsating heat pipe(PHP) micro encapsulated phase change material(MEPCM) heat transfer characteristic inclination angle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synergistic precipitant powered self-assembly of papain for cross-linked enzyme crystals preparation

引用

Particuology 2024年第2期85卷 102-112页

作者： Qi Hao pan Guo Honghai Wang Min su Chunli Li Yuqi Hu Weiyi su School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300130China National-Local Joint Engineering Laboratory for Energy Conservation of Chemical Process Integration and Resources Utilization Tianjin300130China

In this study,we prepared cross-linked enzyme crystals(CLECs)of papain to further broaden the application of the enzyme with high activity in extreme ***,papain crystals were successfully obtained based on the micro-batch,batch,and expanded batch crystallization ***,ammonium sulfate and polyethylene glycol 6000(PEG6000)were synergistically used as the precipitants,while L-cysteine was applied to enhance the activity of ***,the interaction between L-cysteine and papain was modeled by molecular docking *** was found that L-cysteine could form a hydrogen bond with aspartic acid residue(Asp)at site 158,and the electrostatic attraction with lysine residue(Lys)at site 156 was also quite *** the enzyme crystals were cross-linked by glutaraldehyde at optimized *** papain CLECs were identified by various methods,and it was found that the thermal stability and enzymatic activity both increased compared to the raw *** importantly,it could be applied at more rigorous conditions,for example,pH of 4.

关键词： Papain Cross-linked enzyme crystals L-cysteine Molecular docking Crystallization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A star-like photodetector for angle-based light sensing in 3D space

引用

Nano Research 2024年第8期17卷 7567-7573页

作者： Qi pan Sisi Chen Hongfei Xie Qiling Xu Meng su Yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450051China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The development of three-dimensional(3D)space light angle detection is vital in optical technology for applications such as 3D imaging,computer vision,and augmented *** methods involve advanced sensors and algorithms,including time-offlight cameras,which need multiple cameras and light sources to improve ***,it is a great challenge to integrate these complex components into compact *** semiconductor structures offer optical resonance characteristics,enabling precise light–matter interaction regulation.A 3D star-like photodetector,fabricated using a template assistant printing strategy,demonstrates optical resonances of the subwavelength facade and the shielding effect of spatial *** achieves light angle detection with the resolution of 10°in vertical space and the resolution of 36°in horizontal space,making it a promising prototype for various applications.

关键词： photodetector light angle detection printing subwavelength structure shielding effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Overview of coals as carbon anode materials for sodium-ion batteries

引用

Clean Energy 2024年第4期8卷 197-218页

作者： Junli Kong Zhijiang su Chunwei Dong Quanbin Chen Guanghong pan National Institute of Clean-and-Low-Carbon Energy Beijing 102211China

Energy storage is an important technology in achieving carbon-neutrality *** with lithium-ion batteries,the raw materials of sodium-ion batteries are abundant,low-cost,and highly ***,their costs are expected to be further reduced as large-scale applications take off,making them viable for energy storage *** primary anode material for sodium-ion batteries is hard carbon,which has a high sodium-ion storage capacity but is relatively expensive,limiting its applications in energy *** order to widen the applications of sodium-ion batteries in energy storage and other fields,it is particularly important to develop anode materials that have both high performance and low ***,with abundant reserves and worldwide availability,can serve as low-cost carbon sources for anode ***,coals of different grades of metamorphism have different structural characteristics that can be tailored for the structural characteristics of coal-based anode materials for sodium-ion bat*** research on tailoring coals as the anode materials for sodium-ion batteries is summarized and the recent progress made towards mitigating the existing issues is analysed in this ***,the impacts of different grades of metamorphism on the sodium-ion storage performance of coal-based anode materials prepared using direct carbonization are discussed in *** on improving the electrochemical performances of coal-based anode materials through pore and microcrystalline structure controls and surface as well as interface modifications are ***,the advantages and disadvantages of different preparation methods are *** make the industrial applications of coal-based anode materials for sodium-ion batteries more viable,the importance of the de-ashing process is introduced.

关键词： coals sodium-ion batteries anodes structure controls de-ashing process

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deformation characteristics and damage ontologies of soft and hard composite rock masses under impact loading

引用

Journal of Mountain Science 2024年第5期21卷 1715-1727页

作者： LI Jinhua ZHANG Tianyu WU Baolin su Peili YANG Yang WANG pan Architectural and Civil Engineering College Xi’an University of Science and TechnologyXi’an 710054China

As one of the most common occurring geological landforms in deep rock formations, the dynamic mechanical properties of layered composite rock bodies under impact loading have been widely studied by scholars. To study the dynamic properties of soft and hard composite rocks with different thickness ratios, this paper utilizes cement, quartz sand and gypsum powder to construct soft and hard composite rock specimens and utilizes a combination of indoor tests, numerical calculations, and theoretical analyses to investigate the mechanical properties of soft and hard composite rock bodies. The test results reveal that:(1) When the proportion of hard rock increases from 20% to 50%, the strength of the combined rock body increases by 69.14 MPa and 87 MPa when the hard rock face and soft rock face are loaded, respectively;however, when the proportion of hard rock is the same, the compressive strength of the hard rock face impact is 9%-17% greater than that of the soft rock face impact;(2) When a specimen of soft and hard combined rock body is subjected to impact loading, the damage mode involves mixed tension and shear damage, and the cracks generally first appear at the ends of the specimen, then develop on the laminar surface from the impact surface, and finally end in the overall damage of the soft rock part. The development rate and the total number of cracks in the same specimen when the hard rock face is impacted are significantly greater than those when the soft rock face is impacted;(3) By introducing Weibull’s statistical strength theory to establish the damage variables of soft-hard combined rock bodies, combined with the DP strength criterion, the damage model and the Kelvin body are concatenated to obtain a statistical damage constitutive model, which can better fit the full stress-strain curve of soft-hard combined rock body specimens under a single impact load.

关键词： Soft and hard composite rock mass Dynamic properties Split Hopkinson pressure bar(SHPB) Numerical simulation Intrinsic damage model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Generative deep-learning-embedded asynchronous structured light for three-dimensional imaging

引用

Advanced Photonics 2024年第4期6卷 45-58页

作者： Lei Lu Chenhao Bu Zhilong su Banglei Guan Qifeng Yu Wei pan Qinghui Zhang Henan University of Technology College of Information Science and EngineeringZhengzhouChina Shanghai University Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai Key Laboratory of Mechanics in Energy EngineeringShanghaiChina Shaoxing Research Institute of Shanghai University ShaoxingChina National University of Defense Technology College of Aerospace Science and EngineeringChangshaChina OPT Machine Vision Tech Co. Ltd.Department of Research and DevelopmentDongguanChina

Three-dimensional(3D)imaging with structured light is crucial in diverse scenarios,ranging from intelligent manufacturing and medicine to ***,current structured light methods rely on projector-camera synchronization,limiting the use of affordable imaging devices and their consumer *** this work,we introduce an asynchronous structured light imaging approach based on generative deep neural networks to relax the synchronization constraint,accomplishing the challenges of fringe pattern aliasing,without relying on any a priori constraint of the projection *** overcome this need,we propose a generative deep neural network with U-Net-like encoder-decoder architecture to learn the underlying fringe features directly by exploring the intrinsic prior principles in the fringe pattern *** train within an adversarial learning framework and supervise the network training via a statisticsinformed loss *** demonstrate that by evaluating the performance on fields of intensity,phase,and 3D *** is shown that the trained network can separate aliased fringe patterns for producing comparable results with the synchronous one:the absolute error is no greater than 8μm,and the standard deviation does not exceed 3μ*** results on multiple objects and pattern types show it could be generalized for any asynchronous structured light scene.

关键词： structured light fringe pattern projection asynchrony deep learning generative neural networks three-dimensional imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In situ atomic-scale tracking of unusual interface reaction circulation and phase reversibility in(de)potassiated alloy-typed anode

引用

Journal of Energy Chemistry 2024年第8期95卷 241-249,I0006页

作者： Lin su Ruining Fu Shuangying Lei Yuchen pan Chongyang Zhu Pengcheng Liu Feng Xu SEU-FEI Nano-Pico Center Key Laboratory of MEMS of the Ministry of EducationSoutheast UniversityNanjing210096China

Alloy-typed anode materials,endowed innately with high theoretical specific capacity,hold great promise as an alternative to intercalation-typed counterparts for alkali-ion *** tremendous efforts devoted to addressing drastic volume change and severe pulverization issues of such anodes,the underlying mechanisms involving dynamic phase evolutions and reaction kinetics have not yet been fully ***,taking antimony(Sb)anode as a representative paradigm,its microscopic operating mechanisms down to the atomic scale during live(de)potassiation cycling are systematically unraveled using in situ transmission electron *** reversible phase transformations at single-particle level,that are Sb←→KSb_(2)←→KSb←→K_5Sb_(4)←→K_(3)Sb,were revealed during ***,multiple phase interfaces associated with different reaction kinetics coexisted and this phenomenon was properly elucidated in the context of density functional theory ***,previously unexplored unidirectional circulation of reaction interfaces within individual Sb particle is confirmed for both potassiation and *** on the empirical results,the surface diffusion-mediated potassiation-depotassiation pathways at single-particle level are *** work affords new insights into energy storage mechanisms of Sb anode and valuable guidance for targeted optimization of alloy-typed anodes(not limited to Sb)toward advanced potassium-ion batteries.

关键词： Alloy-typed anode Potassium storage mechanism In situ transmission electron microscopy Reaction interface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Acupotomy on Immobilization-Induced Gastrocnemius Contracture and Fibrosis in Rats via Wnt/β-Catenin Signaling

引用

Chinese Journal of Integrative Medicine 2024年第7期30卷 633-642页

作者： HU Rui pan Jun-kang LI Jia-hui ZHANG Han LI Shao-rong ZHANG Yi School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing100029China Acupuncture Department Kunming Municipal Hospital of Traditional Chinese MedicineKunming650500China

Objective To determine whether acupotomy ameliorates immobilization-induced muscle contracture and fibrosis via Wnt/β-catenin signaling *** Thirty Wistar rats were randomly divided into 5 groups(n=6)by a random number table,including control,immobilization,passive stretching,acupotomy,and acupotomy 3 weeks(3-w)*** rat model of gastrocnemius contracture was established by immobilizing the right hind limb in plantar flexion for 4 *** in the passive stretching group received passive stretching at gastrocnemius,a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive *** in the acupotomy and acupotomy 3-w groups received acupotomy once and combined with passive stretching at gastrocnemius a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive ***,rats in the acupotomy 3-w group were allowed to walk freely for 3 weeks after 10-day *** treatment,range of motion(ROM),gait analysis[i.e.,paw area,stance/swing and maximum ratio of paw area to paw area duration(Max dA/dT)],gastrocnemius wet weight and the ratio of muscle wet weight to body weight(MWW/BW)were *** morphometric and muscle fiber cross-sectional area(CSA)were assessed by hematoxylin-eosin ***-related mRNA expressions(i.e.,Wnt 1,β-catenin,axin-2,α-smooth muscle actin,fibronectin,and types I and III collagen)were measured using real-time quantitative polymerase chain *** 1,β-catenin and fibronectin concentrations were measured by enzyme-linked immunosorbent *** I and III collagen in the perimysium and endomysium were analyzed using *** Compared with the control group,ROM,gait function,muscle weight,MWW/BW and CSA were significantly decreased in the immobilization group(all P<0.01),while protein levels of types I and III collagen,Wnt 1,β-catenin,fibronectin and mRNA levels of fibrosis-related genes were obviously increased(all P<0.01).Tr

关键词： acupotomy immobilization muscle contracture muscle fibrosis Wnt/β-catenin signaling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：