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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1430-1432页

作者： Tian-Wei Qian su-qin yu Xun Xu Department of Ophthalmology Shanghai General HospitalShanghai 200080 China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080 China

Dear Editor,I am ***-Wei Qian,from Shanghai General Hospital,Shanghai,China.I write to present one case report of tuberculosis（TB）-associated uveitis after corticosteroid treatment for Vogt-Koyanagi-Harada（VKH）dis... 详细信息

关键词： A challenging case of tuberculosis-associated uveitis corticosteroid treatment for Vogt-Koyanagi-Harada disease

Quantitative analysis of retinal intermediate and deep capillary plexus in patients with retinal deep vascular complex ischemia

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 1025-1033页

作者： Xin-Xin Li Tian-Wei Qian Ya-Nan Lyu Xun Xu su-qin yu Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseaseShanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China

AIM: To quantitatively analyze the retinal intermediate and deep capillary plexus(ICP and DCP) in patients with retinal deep vascular complex ischemia(RDVCI), using 3D projection artifacts removal(3D PAR) optical coherence tomography angiography(OCTA).METHODS: RDVCI patients and gender-and agematched healthy controls were assessed and underwent OCTA examinations. The parafoveal vessel density(PFVD) of retinal deep vascular complex(DVC), ICP, and DCP were analyzed, and the percentage of reduction(PR) of PFVD was ***: Twenty-four eyes in 22 RDVCI patients(20 in acute phase and 4 in chronic phase) and 24 eyes of 22 healthy subjects were enrolled as the control group. Significant reduction of PFVD in DVC, ICP, and DCP was observed in comparison with the controls(DVC: acute: 43.59%±6.58% vs 49.92%±5.49%, PR=12.69%;chronic: 43.50%±3.33% vs 51.20%±3.80%, PR=15.04%. ICP: acute: 40.28%±7.91% vs 46.97%±7.14%, PR=14.23%;chronic: 41.48%±2.87% vs 46.43%±3.29%, PR=10.66%. DCP: acute: 45.44%±8.27% vs 51.51%±9.97%, PR=11.79%;chronic: 37.78%±3.48% vs 51.73%±5.17%, PR=26.97%;all Psubsequent DCP impairment is uncovered and can be explained by ischemia-reperfusion damage.

关键词： intermediate and deep capillary plexus 3D projection artifacts removal optical coherence tomography angiography retinal deep vascular complex ischemia

Comprehensive assessment of growth factors,inflammatory mediators, and cytokines in vitreous from patients with proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1736-1742页

作者： Qiao-yun Gong Guang-Yi Hu su-qin yu Tian-Wei Qian Xun Xu Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China National Clinical Research Center for Eye Diseases Shanghai 200080China Shanghai Key Laboratoryof Ocular Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease Shanghai 200080China

AIM: To assess alterations in growth factors, inflammatory mediators, and cytokines associated with vitreous-retinal diseases in vitreous humor from patients with proliferative diabetic retinopathy(PDR), and to identify potential new treatment targets and ***: Control vitreous samples were collected from patients with macular hole, epiretinal membranes, or rhegmatogenous retinal detachments, and PDR samples from patients with complications of PDR, who required pars plana vitrectomy. Specimens were stored at-80℃ and then investigated by Luminex multi-factor assay. Parametric and nonparametric analyses of demographic characteristics and cytokine expression levels were conducted using ***: There were no significant differences in demographic characteristics between patients with and without PDR. Expression levels of growth factors [plateletderived growth factor(PDGF)-AA, glial cell line-derived neurotrophic factor(GDNF), and vascular endothelial growth factor A(VEGFA)], inflammatory mediators [interleukin(IL)-8, IL-11, and tumor necrosis factor-α(TNF-α)] and cytokines [chemokine C-X-C ligand(CXCL)10, interferon-γ(IFN-γ), and granulocyte macrophage-colony stimulating factor(GM-CSF)] were significantly elevated in vitreous humor from patients with PDR compared with those in the control group(all P0.05).CONCLUSION: This proof-of-concept study demonstrates the potential for combinational therapeutic strategies to ameliorate diabetic retinopathy progression by targeting growth factors, inflammatory factors, and cytokines, in addition to VEGFA.

关键词： vitreous proliferative diabetic retinopathy growth factors inflammation cytokines

Segmentation of retinal fluid based on deep learning:application of three-dimensional fully convolutional neural networks in optical coherence tomography images

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 1012-1020页

作者： Meng-Xiao Li su-qin yu Wei Zhang Hao Zhou Xun Xu Tian-Wei Qian Yong-Jing Wan School of Information Science and Engineering East China University of Science and TechnologyShanghai 200237China Department of Ophthalmology Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai Key Laboratory of Ocular Fundus DiseasesShanghai 200080China

AIM: To explore a segmentation algorithm based on deep learning to achieve accurate diagnosis and treatment of patients with retinal ***: A two-dimensional(2D) fully convolutional network for retinal segmentation was employed. In order to solve the category imbalance in retinal optical coherence tomography(OCT) images, the network parameters and loss function based on the 2D fully convolutional network were modified. For this network, the correlations of corresponding positions among adjacent images in space are ignored. Thus, we proposed a three-dimensional(3D) fully convolutional network for segmentation in the retinal OCT ***: The algorithm was evaluated according to segmentation accuracy, Kappa coefficient, and F1 score. For the 3D fully convolutional network proposed in this paper, the overall segmentation accuracy rate is 99.56%, Kappa coefficient is 98.47%, and F1 score of retinal fluid is 95.50%. CONCLUSION: The OCT image segmentation algorithm based on deep learning is primarily founded on the 2D convolutional network. The 3D network architecture proposed in this paper reduces the influence of category imbalance, realizes end-to-end segmentation of volume images, and achieves optimal segmentation results. The segmentation maps are practically the same as the manual annotations of doctors, and can provide doctors with more accurate diagnostic data.

关键词： optical coherence tomography images fluid segmentation 2D fully convolutional network 3D fully convolutional network

Study on viscosity mechanism of caffeine crystallization solutions Author links open overlay panel

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Particuology 2024年第8期91卷 341-350页

作者： Linjing yu Min su School of Chemical Engineering Hebei University of TechnologyTianjin300130China

The solid-liquid viscous system formed by high viscosity crystallization solution impacts the flow and separation ***,it is very important to study the viscosity mechanism to improve viscosity and regulate crystallization,ensuring a seamless production ***,the viscosity of crystallization solution was taken as the measurement parameter of caffeine as a model *** investigated the viscosity mechanism of caffeine crystallization solutions by combining experiment and *** results indicated that the weak interactions between caffeine and water result in increased viscosity of the caffeine crystallization ***,caffeine crystals possess elongated needle-like shapes,featuring a substantial specific surface ***,there isπ-πstacking occurring between the(200)crystal face and(110)crystal face,effectively fostering coalescence of the crystals towards the radial side of the crystal along its elongated axis,resulting in a more viscous crystallization *** results contribute to comprehending the viscosity mechanism of crystal systems and provide theoretical foundation to enhance engineering efficiency in crystallization.

关键词： Crystallization Caffeine Viscosity mechanism Molecular simulation

Role of catalyst surface-active sites in the hydrogenation ofα,β-unsaturated aldehyde

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 41-69页

作者： Haixiang Shi Tongming su Zuzeng qin Hongbing Ji School of Chemistry and Chemical Engineering Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification TechnologyGuangxi UniversityNanning 530004China Zhejiang Green Petrochemical and Light Hydrocarbon Transformation Research Institute Zhejiang University of TechnologyHangzhou 310014China

As an important technology in fine chemical production,the selective hydrogenation ofα,β-unsaturated aldehydes has attracted much attention in recent *** the process ofα,β-unsaturated aldehyde hydrogenation,a conjugated system is formed between>C=CC=O,leading to hydrogenation at both ends of the conjugated system,which competes with each other and results in more complex ***,improving the reaction selectivity is also difficult in industrial ***,many researchers have reported that surface-active sites on catalysts play a crucial role inα,β-unsaturated aldehyde *** review attempts to summarize recent advances in understanding the effects of surface-active sites(SASs)over metal catalysts for enhancing the process of *** construction strategies and roles of SASs for hydrogenation catalysts are *** attention has been given to the adsorption configuration and transformation mechanism ofα,β-unsaturated aldehydes on catalysts,which contributes to understanding the relationship between SASs and hydrogenation *** addition,recent advances in metal-supported catalysts for the selective hydrogenation ofα,β-unsaturated aldehydes to understand the role of SASs in hydrogenation are briefly ***,the opportunities and challenges will be highlighted for the future development of the precise construction of SASs.

关键词： α,β-unsaturatedd aldehydes hydrogenation active site cinnamaldehyde

A quantitative comparison of five optical coherence tomography angiography systems in clinical performance

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1784-1795页

作者： Xin-Xin Li Wei Wu Hao Zhou Jun-Jie Deng Meng-Ya Zhao Tian-Wei Qian Chen Yan Xun Xu su-qin yu Department of Ophthalmology Shanghai General Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Disease Shanghai 200080 China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080 China Department of Mathematics Eidgenossische Technische Hochschule Zurich Zurich 8092 Switzerland

AIM： To compare the clinical performance of 4 spectraldomain（SD） optical coherence tomography angiography（OCTA） systems： AngioVueTM, AngioPlexTM, Spectralis？ OCTA, AngioScan, and 1 swept-source（SS） OCTA SS OCT AngioTM. METHODS： Twenty-seven undilated right eyes of 27 participants underwent OCTA examination using five different systems respectively for both 3×3 and 6×6 mm^2 scan pattern（Spectralis OCTA for 3×3 mm^2 scan only）. Image quality, including vessel valid visibility and the number of motion artifacts, and acquisition time were evaluated. Repeated measures analysis of variance（ANOVA） with Bonferroni＇s post-test and Friedman test with Dunn＇s posttest were used to compare ***： The age of the subjects was 28.19±5.55 y（range, 23-49 y）. The spherical equivalent refraction was-2.55±1.84 D（range, 0.00 to-5.25 D）. Significant difference was observed in the evaluation of vessel valid visibility（Angio Vue the highest： 0.111±0.031 for 3×3 mm^2 scan and 0.128±0.020 for 6×6 mm^2 scan）, number of motion artifacts（AngioVue the fewest： 0.778±1.086 for 3×3 mm^2 scan and 0.333±0.620 for 6×6 mm^2 scan） and acquisition time（AngioPlex the shortest： 8.537±1.921 s for 3×3 mm^2 scan and 8.298±1.741 s for 6×6 mm^2 scan; all P〈0.001）. CONCLUSION： There is poor agreement of measurements among systems. AngioVue provides images with the highest vessel valid visibility and the fewest motion artifacts. AngioPlex achieves the shortest acquisition.

关键词： optical coherence tomography angiography devices vessel valid visibility motion artifacts acquisition time

Learning in games:a systematic review

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Science China(Information Sciences) 2024年第7期67卷 133-159页

作者： Rong-Jun qin Yang yu National Key Laboratory for Novel Software Technology Nanjing University Polixir Technologies

Game theory studies the mathematical models for self-interested individuals. Nash equilibrium is arguably the most central solution in game theory. While finding the Nash equilibrium in general is known as polynomial parity arguments on directed graphs(PPAD)-complete, learning in games provides an alternative to approximate Nash equilibrium, which iteratively updates the player's strategy through interactions with other players. Rules and models have been developed for learning in games, such as fictitious play and no-regret learning. Particularly, with recent advances in online learning and deep reinforcement learning,techniques from these fields greatly boost the breakthroughs in learning in games from theory to *** a result, we have witnessed many superhuman game AI systems. The techniques used in these systems evolve from conventional search and learning to purely reinforcement learning(RL)-style learning methods,gradually getting rid of the domain knowledge. In this article, we systematically review the above techniques,discuss the trend of basic learning rules towards a unified framework, and recap applications in large ***, we discuss some future directions and make the prospect of future game AI systems. We hope this article will give some insights into designing novel approaches.

关键词： non-cooperative games learning in games no-regret learning reinforcement learning superhuman AI

Multiscale observation in wide-spatial radar surveillance based on coherent FDA design

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Science China(Information Sciences) 2024年第2期67卷 232-252页

作者： Lei yu Feng HE Yi su College of Electronics Science National University of Defense Technology

Wide-spatial radar surveillance missions are challenging tasks, requiring an increased power budget and agility in transmission aimed at extracting information from multiple targets in different environments. These requirements necessitate high transmitting degrees of freedom(DOF) to achieve the objective of multiscale observation for specific tasks in specialized regions of interest. Herein, we exploit the multiscale observation ability in wide-spatial radar surveillance based on frequency diverse array(FDA)radar. The proposed method facilitates spatial anisotropic control of multiple radar resources, including the transmitting waveforms, beampattern, and bandwidth. By utilizing a coherent FDA radar, we offer principles for the selection of baseband waveforms, in addition to the quantitative design of the beampattern gain and optimal bandwidth from the perspective of detection. The feasibility of the proposed method is validated through numerical experiments, thus indicating the potential in wide-spatial radar surveillance. Moreover,this work can be regarded as a preliminary attempt to gauge the efficacy of the computational array, a novel academic concept.

关键词： multi-scale observation wide-spatial surveillance frequency diverse array (FDA) beampattern synthesis frequency diversity gain computational array

Ligand-controlled electrochemiluminescence generation from CdSe/CdS/ZnS core/shell/shell quantum dots

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Nano Research 2024年第8期17卷 7776-7785页

作者： Hui sun Zhiyuan Cao Haiyan qin Xiaogang Peng Bin su Key Laboratory of Excited-State Materials of Zhejiang Province Department of ChemistryZhejiang UniversityHangzhou 310058China

The CdSe/CdS/ZnS core/shell/shell quantum dots(QDs)with strong exciton confinement have manifested themselves as competitive light-emitting materials in electrochemiluminescence(ECL).However,cathodic ECL generation by these QDs requires the injection of electron and hole from solid electrode and electrogenerated radicals(for example SO_(4)•^(−)),which is inevitably influenced by not only the inorganic structure of QDs but also the organic ligands on the *** this work we aimed at studying the impact of surface organic ligands on ECL performance of CdSe/CdS/ZnS *** changing the surface ligand from oleate to acetate,we phenomenologically observed the positive shift of ECL onset potential by ca.200 mV and the increase of ECL intensity by~100 times,suggesting that a short ligand is more favorable for ECL *** further comprehend the ligand effect,we measured the charge injection kinetics using potential-modulated,time-resolved photoluminescence,and thinlayer spectroelectrochemistry *** electron and hole injection into QDs were found to be accelerated by 2–20 times if shortening the ligand from oleate to acetate,confirming the significant impact of surface ligands on ECL performance of *** study is expected to provide guidance on how to design surface functionalized QDs for specific applications such as ECL immunodiagnosis,photocatalysis,and photovoltaics.

关键词： electrochemiluminescence quantum dots spectroelectrochemistry surface ligands charge injection charge transfer