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A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery

Microsystems & Nanoengineering 2021年第4期7卷 169-179页

作者： yoo Na Kang Namsun Chou Jae-Won Jang Han Kyoung Choe Sohee Kim Department of Medical Assistant Robot Korea Institute of Machinery&Materials(KIMM)DaeguRepublic of Korea Center for BioMicrosystems Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Brain&Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea

The demand for multifunctional neural interfaces has grown due to the need to provide a better understanding of biological mechanisms related to neurological diseases and neural *** intracerebral drug injection using microfluidic neural interfaces is an effective way to deliver drugs to the brain,and it expands the utility of drugs by bypassing the blood-brain barrier(BBB).In addition,uses of implantable neural interfacing devices have been challenging due to inevitable acute and chronic tissue responses around the electrodes,pointing to a critical issue still to be *** neural interfaces comprised of a collection of microneedles in an array have been used for various applications,it has been challenging to integrate microfluidic channels with them due to their characteristic three-dimensional structures,which differ from two-dimensionally fabricated shank-type neural *** we present a method to provide such three-dimensional needle-type arrays with chemical delivery *** fabricated a microfluidic interconnection cable(pFIC)and integrated it with a flexible penetrating microelectrode array(FPMA)that has a 3-dimensional structure comprised of silicon microneedle electrodes supported by a flexible array *** successfully demonstrated chemical delivery through the developed device by recording neural signals acutely from in vivo brains before and after KCl *** suggests the potential of the developed microfluidic neural interface to contribute to neuroscience research by providing simultaneous signal recording and chemical delivery capabilities.

关键词： neural recording needle

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Understanding of the Relationship between the Properties of Cu(In,Ga)Se_(2) Solar Cells and the Structure of Ag Network Electrodes

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Energy & Environmental Materials 2024年第6期7卷 246-253页

作者： Hyesun yoo Hoang Van Quy Inpyo Lee Seung Taek Jo Tae Ei Hong JunHo Kim Dae-Hwang yoo Jinwook Shin Walter Commerell Dae-Hwan Kim Jong Wook Roh Regional Leading Research Center(RLRC)of Smart Energy System Kyungpook National UniversityGyeongsangbuk-do 37224Korea Division of Energy Technology DaeguGyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 47922Korea Nano Photoelectronic Device Lab Department of PhysicsIncheon National UniversityIncheon 22012Korea Institute for Energy and Drive Technology Technische Hochschule Ulm(THU)Ulm 89081Germany Department of Nano&Advanced Materials Science and Engineering Kyungpook National UniversityGyeongsangbuk-do 37224Korea

The relation between the structure of the silver network electrodes and the properties of Cu(In,Ga)Se_(2)(CIGS)solar cells is systemically *** Ag network electrode is deposited onto an Al:ZnO(AZO)thin film,employing a self-forming cracked *** control over the cracked template's structure is achieved through careful adjustment of temperature and *** Ag network electrodes with different coverage areas and network densities are systemically applied to the CIGS solar *** is revealed that predominant fill factor(FF)is influenced by the figure of merit of transparent conducting electrodes,rather than sheet resistance,particularly when the coverage area falls within the range of 1.3–5%.Furthermore,a higher network density corresponds to an enhanced FF when the coverage areas of the Ag networks are *** utilizing a thinner AZO film,CIGS solar cells with a surface area of 1.0609 cm^(2)exhibit a notable performance improvement,with efficiency increasing from 10.48%to 11.63%.This enhancement is primarily attributed to the increase in FF from 45%to 65%.These findings underscore the considerable potential for reducing the thickness of the transparent conductive oxide(TCO)in CIGS modules with implications for practical applications in photovoltaic technology.

关键词： CIGS large-area solar cell metal mesh metallic network transparent electrode

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Glehnia fittoralis Extract Promotes Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Mouse through Increasing Expressions of Brain-Derived Neurotrophic Factor and Tropomyosin-Related Kinase B

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Chinese Medical Journal 2018年第6期131卷 689-695页

作者： Joon Ha Park Bich Na Shin Ji Hyeon Ahn Jeong Hwi Cho Tae-Kyeong Lee Jae-Chul Lee Yong Hwan Jeon II Jun Kang Ki-Yeon yoo In Koo Hwang Choong hyun Lee yoo Hun Noh sung-su Kim Moo-Ho Won Jong Dai Kim Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Chuncheon 24252 Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Radiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Food Science and Nutrition Hallym University Chuncheon 24252 Korea epartment of Oral Anatomy College of Dentistry and Research Institute of Oral Biology Gangneung-Wonju National University Gangneung 25457 Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seou108826 Korea Department of Pharmacy College of Pharmacy Dankook University Cheonan 31116 Korea Famenity Biomedical Research Center Famenity Inc. Gyeonggi 13837 Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 24341 Korea

Background： Glehnia littoralis has been used for traditional Asian medicine, which has diverse therapeutic activities. However, studies regarding neurogenic effects of G. littoralis have not yet been considered. Therefore, in this study, we examined effects of G. littoralis extract on cell proliferation, neuroblast differentiation, and the maturation of newborn neurons in the hippocampus of adult mice. Methods： A total of 39 male ICR mice （12 weeks old） were randomly assigned to vehicle-treated and 100 and 200 mg/kg G. littoralis extract-treated groups （n = 13 in each group）. Vehicle and G. littoralis extract were orally administrated for 28 days. To examine neurogenic effects ofG. litmralis extract, we performed immunohistochemistry tbr 5-bromo-2-deoxyuridine （BrdU, an indicator for cell proliferation） and doublecortin （DCX, an immature neuronal marker） and double immunofluorescence staining for BrdU and neuronal nuclear antigen （NeuN, a mature neuronal marker）. In addition, we examined expressional changes of brain-derived neurotrophic factor （BDNF） and its major receptor tropomyosin-related kinase B （TrkB） using Western blotting analysis. Results： Treatment with 200 mg/kg, not 100 mg/kg, significantly increased number of BrdU-immunoreactive （＋） and DCX＋ cells （48.0 ±3.1and 72.0 ± 3.8 cells/section, respectively） in the subgranular zone （SGZ） of the dentate gyrus （DG） and BrdU＊/NeuN＋ cells （17.0 ±1.5 cells/section） in the granule cell layer as well as in the SGZ. In addition, protein levels of BDNF and YrkB （about 232% and 244% of the vehicle-treated group, respectively） were significantly increased in the DG of the mice treated with 200 mg/kg ofG. littoralis extract. Conclusion： G. littoralis extract promots cell proliferation, neuroblast differentiation, and neuronal maturation in the hippocampal DG, and neurogenic effects might be closely related to increases ofBDN F and TrkB proteins by G. littoralis extract treatment.

关键词： Brain-Derived Neurotrophic Factor CellProliferation Glehnia littoralis Neuroblast Differentiation Tropomyosin-Related Kinase B

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Ultrasonographic evaluation of the effect of extracorporeal shock wave therapy on calcific tendinopathy of the rectus femoris tendon:A case report

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World Journal of Clinical Cases 2019年第22期7卷 3772-3777页

作者： Chang Han Lee Min-Kyun Oh Jun-Il yoo Department of Rehabilitation Medicine Gyeongsang National University School of Medicine and Gyeongsang National University HospitalJinju 52727South Korea Department of Orthopaedic surgery School of MedicineGyeongsang National University90 ChilamdongGyeongsangnam-doJinju 52727South Korea

BACKGROUND Calcific tendinopathy denotes calcific deposits in a specific *** is also known as calcifying tendinitis,calcifying periarticulitis,or periarticular apatite deposition ***,extracorporeal shock wave therapy(ESWT)has been reported to be effective in relieving and treating pain in calcific *** suMMARY A 36-year-old female patient suffered from left hip joint pain for six *** pain was increased during abduction of the hip,waking,and jumping.B-mode ultrasonography was performed by a physiatrist with an L12-5 linear transducer.A single session of ESWT was given in the marking area under ultrasound guidance at 4 Hz,2500 shots with intensity of stimulation using energy of 0.1 mJ/*** hip pain of the patient slowly decreased within 4 wk after starting the *** six weeks of ESWT,her hip pain was completely ***,the size of calcification showed almost no reduction in simple radiography at the final *** Ultrasonography is a very good modality not only for diagnosing calcified tendinitis by classical appearance,but also for evaluating the effect of ESWT during the follow-up period.

关键词： Rectus femoris Calcific tendinopathy Extracorporeal shock wave therapy Ultrasonography Hip Joint Case report

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Management of obstructive colon cancer:Current status,obstacles,and future directions

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1850-1862页

作者： Ri-Na yoo Hyeon-Min Cho Bong-Hyeon Kye Division of Colorectal surgery Department of SurgerySt.Vincent’s HospitalThe Catholic University of KoreaSuwon 442-723South Korea

Approximately 10%–18%of patients with colon cancer present with obstruction at the initial *** active screening efforts,the incidence of obstructive colon cancer remains ***,emergency surgery has been indicated to treat patients with obstructive colon ***,compared to patients undergoing elective surgery,the morbidity and mortality rates of patients requiring emergency surgery for obstructive colon cancer are *** the advancement of colonoscopic techniques and equipment,a self-expandable metal stent(SEMS)was introduced to relieve obstructive symptoms,allowing the patient’s general condition to be restored and for them undergo elective *** the use of SEMS placement is growing,controversies about its application in potentially curable diseases have been *** this review,the short-and longterm outcomes of different treatment strategies,particularly emergency surgery vs SEMS placement followed by elective surgery in resectable,locally advanced obstructive colon cancer,are described based on the location of the obstructive cancer *** regarding each treatment strategy are *** overcome current obstacles,a potential diagnostic method using circulating tumor DNA and further research directions incorporating neoadjuvant chemotherapy are introduced.

关键词： Colonic neoplasms Self-expandable metallic stents Intestinal obstruction survival rate Morbidity Mortality

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Amputation stump management:A narrative review

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World Journal of Clinical Cases 2022年第13期10卷 3981-3988页

作者： yoo Jin Choo Du Hwan Kim Min Cheol Chang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaegu 705-717South Korea Department of Physical Medicine and Rehabilitation College of MedicineChung-Ang UniversitySeoul 06973South Korea Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityTaegu 705-717South Korea

In this review intended for medical staff involved in patient rehabilitation,we provided an overview of the basic methods for managing amputation *** the amputation surgery,it is imperative to optimize the remaining physical abilities of the amputee through rehabilitation processes,including postoperative rehabilitation,desensitization,and continuous application of soft or rigid dressings for pain reduction and shaping of the *** on the situation,a prosthesis may be worn in the early stage of recovery or an immediate postoperative prosthesis may be applied to promote stump ***,to maintain the range of motion of the stump and to prevent deformation,the remaining portion of the limb should be positioned to prevent *** exercises should also be performed to improve muscle strength to ensure that the amputee is able to perform activities of daily living,***,clean wound or edema management of the stump is necessary to prevent problems associated with wearing the *** review is expected to contribute to the establishment of basic protocols that will be useful for stump management from the time of completion of amputation surgery to the fitting of a prosthesis to optimize patient recovery.

关键词： Amputation Amputee Management Rehabilitation Stump Review

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An updated diced cartilage fascia technique for dorsal augmentation in rhinoplasty

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Plastic and Aesthetic Research 2019年第3期6卷 1-9页

作者： Jinli Wu Donald B.yoo Private practice Facial Plastic&Reconstructive SurgeryBeverly HillsCA 90212USA Division of Facial Plastic&Reconstructive surgery Department of Otolaryngology-Head&Neck SurgeryUniversity of Southern CaliforniaLos AngelesCA 90033USA Division of Facial Plastic&Reconstructive surgery Department of Otolaryngology-Head&Neck SurgeryUniversity of California-Los AngelesLos AngelesCA 90095USA

The aim of this paper is to discuss an updated technique for dorsal augmentation during rhinoplasty using diced cartilage wrapped in fascia. The usage of diced cartilage has been variously described in the literature with consistently satisfactory results. Herein, we present our experience with patients undergoing dorsal augmentation during rhinoplasty using an updated method of diced cartilage wrapped in fascia. Diced cartilage fascia techniques have become the technique of choice for dorsal augmentation for an ever-increasing number of rhinoplasty surgeons. The term is broadly descriptive and there remains a wide-range of ways to execute. Updating and enhancing the technique with greater attention to precision, and creating an aesthetically optimal and predictable result, may result in even improved outcomes for future patients.

关键词： Rhinoplasty revision rhinoplasty dorsal augmentation costal cartilage diced cartilage asian rhinoplasty DCF diced cartilage fascia

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Neural network reactive force field for C,H,N,and O systems

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npj Computational Materials 2021年第1期7卷 69-78页

作者： Pilsun yoo Michael Sakano Saaketh Desai Md Mahbubul Islam Peilin Liao Alejandro Strachan School of Materials Engineering and Birck Nanotechnology Center Purdue UniversityWest LafayetteIN 47907USA Department of Mechanical Engineering Wayne State UniversityDetroitMI 48202USA

Reactive force fields have enabled an atomic level description of a wide range of phenomena,from chemistry at extreme conditions to the operation of electrochemical devices and *** significant insight and semi-quantitative understanding have been drawn from such work,the accuracy of reactive force fields limits quantitative *** developed a neural network reactive force field(NNRF)for CHNO systems to describe the decomposition and reaction of the high-energy nitramine 1,3,5-trinitroperhydro-1,3,5-triazine(RDX).NNRF was trained using energies and forces of a total of 3100 molecules(11,941 geometries)and 15 condensed matter systems(32,973 geometries)obtained from density functional theory calculations with semi-empirical corrections to dispersion *** training set is generated via a semi-automated iterative procedure that enables refinement of the NNRF until a desired accuracy is *** root mean square(RMS)error of NNRF on a testing set of configurations describing the reaction of RDX is one order of magnitude lower than current state of the art potentials.

关键词： network field reactive

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Proton therapy for hepatocellular carcinoma:Current knowledges and future perspectives

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World Journal of Gastroenterology 2018年第28期24卷 3090-3100页

作者： Gyu Sang yoo Jeong Il Yu Hee Chul Park Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of Medicine Department of Medical Device Management and Research Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University

Hepatocellular carcinoma(HCC) is the second leading cause of cancer-related death, as few patients can be treated with currently available curative local modalities. In patients with HCC where curative modalities are not feasible, radiation therapy(RT) has emerged as an alternative or combination therapy. With the development of various technologies, RT has been increasingly used for the management of HCC. Among these advances, proton beam therapy(PBT) has several unique physical properties that give it a finite range in a distal direction, and thus no exit dose along the beam path. Therefore, PBT has dosimetric advantages compared with X-ray therapy for the treatment of HCC. Indeed, various reports in the literature have described the favorable clinical outcomes and improved safety of PBT for HCC patients compared with X-ray therapy. However, there are some technical issues regarding the use of PBT in HCC, including uncertainty of organ motion and inaccuracy during calculation of tissue density and beam range, all of which may reduce the robustness of a PBT treatment plan. In this review, we discuss the physical properties, current clinical data, technical issues, and future perspectives on PBT for the treatment of HCC.

关键词： radiation therapy hepatocellular carcinoma proton beam therapy X-ray therapy

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Extracorporeal membrane oxygenation for lung cancer-related life-threatening hypoxia:A case report

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World Journal of Clinical Cases 2022年第25期10卷 8974-8979页

作者： Seung Soo yoo Shin Yup Lee sun Ha Choi Department of Internal Medicine Kyungpook National UniversityDaegu 41404South Korea Lung Cancer Center Kyungpook National University Chilgok HospitalDaegu 41404South Korea

BACKGROUND Life-threatening hypoxia can occur in patients with lung cancer due to bronchial *** membrane oxygenation(ECMO)can be used as a bridge therapy for patients with severe hypoxia not relieved by conventional mechanical ***,the usefulness of chemotherapy in patients with lung cancer receiving ECMO therapy is not well *** suMMARY A 53-year-old man visited the emergency room with worsening dyspnea for 1 mo.A series of imaging and diagnostic tests were performed,and stageⅢB(cT4N2M0)lung cancer was eventually *** hospital day 3,he experienced dyspnea and hypoxia that was not relieved with oxygen support via a high-flow nasal *** was initiated because his respiratory condition did not improve even with mechanical *** patient then underwent gemcitabine/cisplatin chemotherapy without dose reduction while on *** two cycles of chemotherapy,there was a decrease in the size of the primary tumor in the right main *** the completion of concurrent chemoradiotherapy,a computed tomography scan revealed further improvement in the right main bronchus *** months after a lung cancer diagnosis,the patient did well without any *** ECMO is a potential bridge therapy for respiratory failure in patients with central airway obstruction secondary to lung cancer.

关键词： Extracorporeal membrane oxygen Lung cancer Hypoxia Respiratory failure Chemoradiotherapy Case report

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