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CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain

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Neuroscience Bulletin 2023年第6期39卷 947-961页

作者： Ting Xu Zhen-Yu Li Meng Liu su-bo zhang Huan-Huan Ding Jia-Yan Wu su-Yan Lin Jun Liu Jia-You Wei Xue-Qin zhang Wen-Jun Xin Neuroscience Program of Zhongshan School of Medicine and the Fifth Affiliated Hospital Sun Yat-sen UniversityGuangzhou510080China Guangdong Province Key Laboratory of Brain Function and Disease Sun Yat-sen UniversityGuangzhou510120China Department of Anesthesia and Pain Medicine Guangzhou First People’s HospitalGuangzhou510000China Department of Physiology Xuzhou Medical UniversityXuzhou221004China Department of Neurology The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou510000China Guangdong Provincial Engineering Research Center of Molecular Imaging Guangdong Provincial Key Laboratory of Biomedical Imagingand Department of Interventional MedicineThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai519000China The Affiliated Brain Hospital(Guangzhou Huiai Hospital)and School of Health Management Guangzhou Medical UniversityGuangzhou510182China Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Guangzhou510000China

Effective treatments for neuropathic pain are lacking due to our limited understanding of the *** circRNAs are mainly enriched in the central nervous ***,their function in various physiological and pathological conditions have yet to be ***,we identified circFhit,an exon-intron circRNA expressed in GABAergic neurons,which reduced the inhibitory synaptic transmission in the spinal dorsal horn to mediate spared nerve injury-induced neuropathic ***,we found that circFhit decreased the expression of GAD65 and induced hyperexcitation in NK1R^(+) neurons by promoting the expression of its parental gene Fhit in ***,circFhit was directly bound to the intronic region of Fhit,and formed a circFhit/HNRNPK complex to promote Pol II phosphorylation and H2B monoubiquitination by recruiting CDK9 and RNF40 to the Fhit *** summary,we revealed that the exon-intron circFhit contributes to GABAergic neuron-mediated NK1R^(+) neuronal hyperexcitation and neuropathic pain via regulating Fhit in cis.

关键词： Chronic pain Neuropathic pain CircRNA Inhibitory transmission Epigenetic regulation

Progress and prospects of Mg-based amorphous alloys in azo dye wastewater treatment

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Journal of Magnesium and Alloys 2024年第3期12卷 873-889页

作者： Yanan Chen Fengchun Chen Liang Li Chen su bo Song Hongju zhang Shengfeng Guo Fusheng Pan School of Materials and Energy Southwest UniversityChongqing 400715China Analytical and Testing Center Southwest UniversityChongqing 400715China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Mg-based amorphous alloys exhibit efficient catalytic performance and excellent biocompatibility with a promising application probability,specifically in the field of azo dye wastewater ***,the problems like difficulty in preparation and poor cycling stability need to be *** present,Mg-based amorphous alloys applied in wastewater degradation are available in powder and *** amorphous alloy powder fabricated by ball milling has a high specific surface area,and its reactivity is thousands of times better than that of gas atomized alloy *** the development is limited due to the high energy consumption,difficult and costly process of powder *** single roller melt-spinning method is a new manufacturing process of amorphous alloy *** to amorphous powder,the specific surface area of amorphous ribbon is relatively lower,therefore,it is necessary to carry out surface modification to enhance *** is a way that can form a pore structure on the surface of the amorphous alloys,increasing the specific surface area and providing more reactive sites,which all contribute to the catalytic *** the optimal conditions for Mg-based amorphous alloys in wastewater degradation by adjusting amorphous alloy composition,choosing suitable method to preparation and surface modification,reducing cost,expanding the pH range will advance the steps to put Mg-based amorphous alloys in industrial environments into practice.

关键词： Mg-based amorphous alloys Azo dyes Dealloying surface modification Wastewater degradation.

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Impact Analysis of Microscopic Defect Types on the Macroscopic Crack Propagation in Sintered Silver Nanoparticles

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 441-458页

作者： Zhongqing zhang bo Wan Guicui Fu Yutai su Zhaoxi Wu Xiangfen Wang Xu Long School of Reliability and Systems Engineering Beihang UniversityBeijing100191China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China China Aerospace Components Engineering Center Beijing100098China

Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional ***,the material reliability is significantly affected by various microscopic *** this work,the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified,categorized,and *** dynamics(MD)simulations are employed to observe the failure evolution of different microscopic *** dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation *** the same time,this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by defining key strain *** impact of defect types on the failure process is also ***,traction-separation curves extracted from microscopic defect evolutions serve as a bridge to connect the macro-scale *** validity of the crack propagation model is confirmed through tensile ***,we thoroughly analyze how micro-defect types influence macro-crack propagation and attempt to find supporting evidence from the MD *** findings provide a multi-perspective reference for the reliability analysis of sintered AgNPs.

关键词： Sintered silver nanoparticles defect types microscopic defect evolution macroscopic crack propagation molecular dynamics simulation cohesive zone model

Exceptional electrostrain with minimal hysteresis and superior temperature stability under low electric field in KNN-based lead-free piezoceramics

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Journal of Advanced Ceramics 2024年第3期13卷 364-372页

作者： Huan Liu Yijin Hao Ziqi Yang Tianyi Feng Bin su Xin zhang Mengping Xue bo-Ping zhang Jing-Feng Li Beijing Municipal Key Laboratory of New Energy Materials and Technologies School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Over the past two decades,(K_(0.5)Na_(0.5))Nbo_(3)(KNN)-based lead-free piezoelectric ceramics have made significant ***,attaining a high electrostrain with remarkable temperature stability and minimal hysteresis under low electric fields has remained a significant *** address this long-standing issue,we have employed a collaborative approach that combines defect engineering,phase engineering,and relaxation *** LKNNS-6BZH ceramic,when sintered at T_(sint)=1170℃,demonstrates an impressive electrostrain with a d_(33) value of 0.276%and 1379 pm·V^(-1)under 20 kV·cm^(-1),which is comparable to or even surpasses that of other lead-free and Pb(Zr,Ti)O_(3)***,the electrostrain performance of this ceramic remains stable up to a temperature of 125℃,with the lowest hysteresis observed at 9.73%under 40 kV·cm^(-1).These excellent overall performances are attributed to the presence of defect dipoles involving V′_(A)-V∙∙_(O) and B′_(Nb)-V∙∙O,the coexistence of R-O-T multiphase,and the tuning of the trade-off between long-range ordering and local *** work provides a lead-free alternative for piezoelectric actuators and a paradigm for designing piezoelectric materials with outstanding comprehensive performance under low electric fields.

关键词： lead-free piezoelectric ceramics temperature stability electrostrain potassium sodium niobate low hysteresis

A variable structure passivity control method for elastic joint robots based on cascaded high-order state estimation

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Science China(Technological Sciences) 2024年第2期67卷 395-407页

作者： zhang JieXin NIE PingYun zhang bo State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240China

Passivity-based controllers are widely used to facilitate physical interaction between humans and elastic joint robots,as they enhance the stability of the interaction ***,the joint position tracking performance can be limited by the structures of these controllers when the system is faced with uncertainties and rough high-order system state measurements(such as joint accelerations and jerks).This study presents a variable structure passivity(VSP)control method for joint position tracking of elastic joint robots,which combines the advantages of passive control and variable structure *** method ensures the tracking error converges in a finite time,even when the system faces *** method also preserves the passivity of the ***,a cascaded observer,called CHOSSO,is also proposed to accurately estimate high-order system states,relying only on position and velocity *** observer allows independent implementation of disturbance compensation in the acceleration and jerk estimation *** particular,the observer has an enhanced ability to handle fast time-varying disturbances in physical human-robot *** effectiveness of the proposed method is verified through simulations and experiments on a lower limb rehabilitation robot equipped with elastic joints.

关键词： motion control elastic joint robot finite-time convergence high-order system state estimation physical human-robot interaction

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Automated regression test method for scientific computing libraries:Illustration with SPHinXsys

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Journal of Hydrodynamics 2024年第3期36卷 466-478页

作者： bo zhang Chi zhang Xiangyu Hu TUM School of Engineering and Design Technical University of MunichMunichGermany

Scientific computing libraries,whether in-house or open-source,have witnessed enormous progress in both engineering and scientific ***,it is important to ensure that modifications to the source code,prompted by bug fixing or new feature development,do not compromise the accuracy and functionality that have been already validated and *** paper introduces a method for establishing and implementing an automatic regression test environment,using the open-source multi-physics library SPHinXsys as an illustrative ***,a reference database for each benchmark test is generated from observed data across multiple *** comprehensive database encapsulates the maximum variation range of metrics for different strategies,including the time-averaged,ensemble-averaged,and dynamic time warping *** accounts for uncertainties arising from parallel computing,particle relaxation,physical instabilities,and ***,new results obtained after source code modifications undergo testing based on a curve-similarity comparison against the reference *** the source code is updated,the regression test is automatically executed for all test cases,providing a comprehensive assessment of the validity of the current *** regression test environment has been successfully implemented in all dynamic test cases within SPHinXsys,including fluid dynamics,solid mechanics,fluid-structure interaction,thermal and mass diffusion,reaction-diffusion,and their multi-physics couplings,and demonstrates robust capabilities in testing different *** is noted that while the current test environment is built and implemented for a particular scientific computing library,its underlying principles are generic and can be easily adapted for use with other libraries,achieving equal effectiveness.

关键词： Scientific computing open-source library verification and validation regression test automatic test environment curve similarity comparison smoothed particle hydrodynamics

Osteology of Leptobrachella bijie(Anura,Megophryidae)

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Asian Herpetological Research 2024年第2期15卷 90-103页

作者： Wei LI Meihua zhang Zhonghao LUO Jing LIU Tuo SHEN bo CHEN Haijun su Bin WANG College of Forestry Guizhou UniversityGuiyang 550025GuizhouChina Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041SichuanChina

The Asian leaf litter toad genus Leptobrachella contains more than 100 species widely distributed in southwestern ***,the systematic profiles of this group remain *** morphology is important for taxonomic and phylogenetic ***,few studies have focused on the osteology of the ***,we comprehensively described the osteological features of a representative species *** based on micro-CT scanning and double-staining *** results show that the skull of adult *** is well-ossified,exhibiting sexual dimorphism and minimal intraspecific *** skull length is slightly greater than the width,with the maxilla slightly overlapping with the *** nasal connects with the sphenethmoid in males,but only part or not connects with the sphenethmoid in *** transverse processes of the sacrum are robust and symmetrically butterfly-shaped,and the presacral vertebrae are *** pectoral girdle is *** phalangeal formula is 2-2-3-3 for the hand,and 2-2-3-4-3 for the *** study provides the first detailed and comprehensive osteological accounts of the genus Leptobrachella.

关键词： sexual dimorphism skeleton taxonomy

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UNIFORM ERROR boUNDS OF A CONSERVATIVE COMPACT FINITE DIFFERENCE METHOD FOR THE QUANTUM ZAKHAROV SYSTEM IN THE suBSONIC LIMIT REGIME

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Journal of Computational Mathematics 2024年第1期42卷 289-312页

作者： Gengen zhang Chunmei su School of Mathematics and Statistics Yunnan UniversityKunming 650504China Yau Mathematical Sciences Center Tsinghua UniversityBeijing 100084China

In this paper,we consider a uniformly accurate compact finite difference method to solve the quantum Zakharov system(QZS)with a dimensionless parameter 0<ε≤1,which is inversely proportional to the acoustic *** the s... 详细信息

In this paper,we consider a uniformly accurate compact finite difference method to solve the quantum Zakharov system(QZS)with a dimensionless parameter 0subsonic limit regime,i.e.,when 0both time and space forε∈(0,1]and optimal at the fourth order in *** results are reported to verify the error behavior.

关键词： Quantum Zakharov system subsonic limit Compact finite difference method Uniformly accurate Error estimate

Processing,microstructure,and properties of porous ceramic composites with directional channels

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Journal of Materials Science & Technology 2024年第1期168卷 1-15页

作者： bo zhang Yang Yang Xueling Fan Key Laboratory of Service Performance and Protection Technology in Extreme Environments Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China

Porous ceramic composites with directional microchannels from micrometer to dozens of micrometer levels have attracted more and more attention in various fields including aerospace,biomedicines,and thermal insulation due to their excellent fluid permeability,mechanical properties,*** this article,we summarize the recent directional porous ceramics developments including their main processing routes and respective ***,the properties get from different processing routes have been com-pared and analyzed in terms of microstructures,mechanical properties,and *** has been given to the deeper understanding which can allow one to control the microstructural features of these porous ceramic composites to obtain the desired *** work can provide a useful reference for the development and application of porous ceramic composites with directional microchan-nels.

关键词： Porous ceramic composites Directional microchannels Processing routes Permeability