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Relationships among KRAS mutation status, expression of RAS pathway signaling molecules, and clinicopathological features and prognosis of patients with colorectal cancer

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World Journal of Gastroenterology 2019年第7期25卷 808-823页

作者： xiang-Bin Wan Ai-Qin Wang Jian Cao Zhi-Chuang Dong Ning Li Sen Yang Miao-Miao sun Zhi Li su-xia luo Department of General surgery the Affiliated Tumor Hospital of Zhengzhou University Department of Pharmacy The Second Affiliated Hospital of Xinxiang Medical University Department of Medical Oncology the Affiliated Tumor Hospital of Zhengzhou University China-US (Henan) Hormel Cancer Institute Department of Pathology the Affiliated Tumor Hospital of Zhengzhou University

BACKGROUND The RAS/RAF/MEK/ERK and PI3 K/AKT/mTOR signaling pathways all belong to mitogen-activated protein kinase(MAPK) signaling pathways, Mutations in any one of the upstream genes(such as the RAS gene or the BRAF gene) may be transmitted to the protein through transcription or translation, resulting in abnormal activation of the signaling pathway. This study investigated the relationship between the KRAS gene mutation and the clinicopathological features and prognosis of colorectal cancer(CRC), and the effect of KRAS mutations on its associated proteins in CRC, with an aim to clarify the cause of tumor progression and drug resistance caused by mutation of the KRAS *** To investigate the KRAS gene and RAS pathway signaling molecules in CRC and to analyze their relationship with clinicopathological features and prognosis METHODS Colorectal cancer tissue specimens from 196 patients were analyzed for KRAS mutations using quantitative polymerase chain reaction and for KRAS, BRAF,MEK, and ERK protein expression levels using immunohistochemistry of tumor microarrays. To analyze differences of RAS pathway signaling molecule expression levels in different KRAS gene status, the relationships between these parameters and clinicopathological features, 4-year progression-free survival, and overall survival were analyzed by independent sample t test, Kaplan-Meier plots,and the log-rank test. Predictors of overall and disease-free survival were assessed using a Cox proportional hazards *** Of the 196 patients, 62(32%) carried mutations in codon 12(53/62) or codon 13(9/62) in exon 2 of the KRAS gene. KRAS, BRAF, ERK, and MEK protein expression was detected in 71.4%, 78.8%, 64.3%, and 50.8% of CRC tissues,respectively. There were no significant differences between KRAS mutation status and KRAS, BRAF, MEK, or ERK protein levels. Positive expression of KRAS and ERK was associated with poor tumor differentiation, and KRAS expression was also associated with age < 56

关键词： Colorectal cancer KRAS gene KRAS protein BRAF protein MEK protein ERK protein

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Recent advances in transition-metal catalyzed nitrene transfer reactions with carbamates

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Chinese Chemical Letters 2024年第3期35卷 76-86页

作者： Yanshu luo Xinyu Zhang Yuanzhi xia College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China

Nitrene transfer reactions are powerful tools in synthetic organic *** recent years,transitionmetal catalyzed nitrene transfer reactions with carbamates as the nitrene precursors have been widely *** species undergoes facile C-H amination,aziridination,and bifunctionalization of alkenes under the catalysis of different transition metals including Rh,Fe,Ru and others,enabling the efficient construction of various nitrogen-containing *** this review,the recent developments in nitrene transfer reactions with carbamates via N-O bond cleavage were introduced based on different types of reaction,and the key mechanistic information and synthetic applications of the methodologies were discussed.

关键词： Transition-metal catalysis Nitrene transfer Carbamate C—H amination Aziridination Bifunctionalization

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Stochastic and Distributed Optimal Energy Management of Active Distribution Networks Within Integrated Office Buildings

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 504-517页

作者： Zening Li su su xiaolong Jin Mingchao xia Qifang Chen Koji Yamashita National Active Distribution Network Technology Research Center Beijing Jiaotong UniversityBeijing 100044China Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China Electrical and Computer Engineering University of California RiversideCA92521USA.

This paper proposes a stochastic and distributed optimal energy management approach for active distribution networks(ADNs)within office *** proposed approach aims at scheduling office buildings fitted with heating ventilation and air conditioning(HVAC)systems,and electric vehicle(EV)charging piles,to participate in the ADN ***,an energy management approach for the ADN with aggregated office buildings is *** the ADN optimization model is formulated considering the detailed building thermal dynamics and the mobile behaviors of ***,to consider un-certainties of photovoltaic(PV)power,scenario-based stochastic programming is integrated into the ADN optimization *** further realize the stochastic energy management of the ADN within office buildings in a distributed manner,the alternating direction method of multipliers(ADMM)is used to solve the ADN optimization *** original ADN optimization problem is divided into the network-side and the building-side sub-problems to effectively protect the privacy of the ADN and the office ***,the ADN optimization model incorporating office buildings is validated in the winter by numerical *** addition,the impacts of comfort temperature range and expected state of charge(SOC)at departure are *** Terms—ADN,EV,HVAC system,Office building,Stochastic and distributed energy management.

关键词： ADN EV HVAC system Office building Stochastic and distributed energy management

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Security-Enhanced Directional Modulation Based on Two-Dimensional M-WFRFT

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China Communications 2024年第5期21卷 229-248页

作者： Zhou Zhuang luo Junshan Wang Shilian xia Guojiang School of Electronic Science National University of Defense TechnologyChangsha 410073China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

Directional modulation(DM)is one of the most promising secure communication ***,when the eavesdropper is co-located with the legitimate receiver,the conventional DM has the disadvantages of weak anti-scanning capability,anti-deciphering capability,and low secrecy *** response to these problems,we propose a twodimensional multi-term weighted fractional Fourier transform aided DM scheme,in which the legitimate receiver and the transmitter use different transform terms and transform orders to encrypt and decrypt the confidential *** order to further lower the probability of being deciphered by an eavesdropper,we use the subblock partition method to convert the one-dimensional modulated signal vector into a twodimensional signal matrix,increasing the confusion of the useful *** results demonstrate that the proposed DM scheme not only provides stronger anti-deciphering and anti-scanning capabilities but also improves the secrecy rate performance of the system.

关键词： bit error rate directional modulation phased array secrecy rate weighted fractional Fourier transform

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High-Order Two-Scale Asymptotic Paradigm for the Elastodynamic Homogenization of Periodic Composites

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Acta Mechanica Solida Sinica 2024年第1期37卷 124-138页

作者： Wei-Zhi luo Mu He Liang xia Qi-Chang He State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Laboratoire Modélisation et Simulation Multi-Echelle MSME UMR 8208 CNRSUniversite Gustave Eiffel77454 Marne-la-ValléeFrance

The classical two-scale asymptotic paradigm provides macroscopic and microscopic analyses for the elastodynamic homogenization of periodic composites based on the spatial or/and temporal variable,which offers an approximate framework for the asymptotic homogenization analysis of the motion ***,in this framework,the growing complexity of the homogenization formulation gradually becomes an obstacle as the asymptotic order *** such a context,a compact,fast,and accurate asymptotic paradigm is *** work reviews the high-order spatial two-scale asymptotic paradigm with the effective displacement field representation and optimizes the implementation by symmetrizing the tensor to be ***,the modified implementation gets rid of the excessive memory consumption required for computing the high-order tensor,which is demonstrated by representative one-and two-dimensional *** numerical results show that(1)the contrast of the material parameters between media in composites directly affects the convergence rate of the asymptotic results for the homogenization of periodic composites,(2)the convergence error of the asymptotic results mainly comes from the truncation error of the modified asymptotic homogenized motion equation,and(3)the excessive norm of the normalized wavenumber vector in the two-dimensional inclusion case may lead to a non-convergence of the asymptotic results.

关键词： Composites Homogenization Asymptotic analysis Dynamics Dispersion

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Effect of Bimodal Quasicrystal Phase on the Dynamic Recrystallization of Mg–Zn–Gd Alloy during High-Pressure Torsion

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1128-1134页

作者： Ping Li Shuangwu xia Junfu Dong Liangwei Dai Zhicheng luo Kemin Xue School of Material Science and Engineering Hefei University of TechnologyHefei230009China

The Mg–Zn–Gd alloy with quasicrystal icosahedral phase was processed by high-pressure torsion (HPT). The effect of bimodal I-phase on the dynamic recrystallization was analyzed by transmission electron microscopy. The results showed that the block I-phase can stimulate obvious particle-stimulated nucleation and dynamic recrystallization (DRX) grains were preferentially formed after HPT for 5 turns, while the granular I-phase only promoted the generation of sub-grains. The orientation relationship was determined as twofold//[1210] and fivefold//(0002)_(Mg). Moreover, after HPT for 9 turns, the DRX grains induced by block I-phase appeared to grow up and coarsened. Compared with block I-phase, the grains induced by granular I-phase presented much smaller size and distributed more homogeneous due to the strong pinning effect.

关键词： High-pressure torsion(HPT)-Quasicrystal phase Dynamic recrystallization Particle-stimulated nucleation Orientation relationship

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Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

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Journal of Environmental Sciences 2024年第3期137卷 172-180页

作者： Zhiyu Chen Fang Li Lei Fu Yu xia Ying luo Ang Guo xiaona Zhu Huifang Zhong Qian luo Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Rheumatology&Immunology Department of Shenzhen Children’s Hospital Shenzhen 518038China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the *** have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)*** PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,***,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as ***-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and *** results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants Childhood asthma Lipid and fatty acid metabolism Machine-learning random forest model Chronic airway infammation

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Parameter Estimation of a Valve-Controlled Cylinder System Model Based on Bench Test and Operating Data Fusion

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 247-263页

作者： Deying su Shaojie Wang Haojing Lin xiaosong xia Yubing Xu Liang Hou Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361102China Xuzhou XCMG Excavation Machinery Co. LtdXuzhou 221000China

The accurate estimation of parameters is the premise for establishing a high-fidelity simulation model of a valve-controlled cylinder *** test data are easily obtained,but it is challenging to emulate actual loads in the research on parameter estimation of valve-controlled cylinder *** the actual load information contained in the operating data of the control valve,its acquisition remains *** paper proposes a method that fuses bench test and operating data for parameter estimation to address the aforementioned *** proposed method is based on Bayesian theory,and its core is a pool fusion of prior information from bench test and operating ***,a system model is established,and the parameters in the model are ***,the bench and operating data of the system are ***,the model parameters and weight coefficients are estimated using the data fusion ***,the estimated effects of the data fusion method,Bayesian method,and particle swarm optimisation(PSO)algorithm on system model parameters are *** research shows that the weight coefficient represents the contribution of different prior information to the parameter estimation *** effect of parameter estimation based on the data fusion method is better than that of the Bayesian method and the PSO *** load complexity leads to a decrease in model accuracy,highlighting the crucial role of the data fusion method in parameter estimation studies.

关键词： Valve-controlled cylinder system Parameter estimation The Bayesian theory Data fusion method Weight coefficients

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Experimental Study on the Electrochemical Performance of PEMFC under Different Assembly Forces

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 265-274页

作者： Tongze su Jiaran Liu Yanqiang Wei Yihuizi Li Weichao luo Jinzhu Tan Nanjing Tech University Nanjing 211816China

Proton exchange membrane fuel cell(PEMFC)is of paramount significance to the development of clean *** components of PEMFC are assembled using many pairs of nuts and *** assembly champing bolt torque is critical to the electrochemical performance and mechanical stability of *** this paper,a PEMFC with the threechannel serpentine flow field was used and *** different assembly clamping bolt torques were applied to the PEMFC in three uniform assembly bolt torque and six non-uniform assembly bolt torque conditions,*** then,the electrochemical performance experiments were performed to study the effect of the assembly bolt torque on the electrochemical *** test results show that the assembly bolt torque significantly affected the electrochemical performance of the *** uniform assembly bolt torque conditions,the maximal power density increased initially as the assembly bolt torque increased,and then decreased on further increasing the assembly *** existed the optimum assembly torque which was found to be 3.0 N·m in this *** non-uniform assembly clamping bolt torque conditions,the optimum electrochemical performance appeared in the condition where the assembly torque of each bolt was closer to be 3.0 N·*** could be due to the change of the contact resistance between the gas diffusion layer and bipolar plate and mass transport resistance for the hydrogen and oxygen towards the catalyst *** work could optimize the assembly force conditions and provide useful information for the practical PEMFC stack assembly.

关键词： Proton exchange membrane fuel cell Assembly force Experiment Electrochemical performance

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Unlocking the potential of bispecific ADCs for targeted cancer therapy

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Frontiers of Medicine 2024年第4期18卷 597-621页

作者： Hongye Zeng Wenjing Ning Xue Liu Wenxin luo Ningshao xia State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsNational Innovation Platform for Industry-Education Integration in Vaccine Researchthe Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical SciencesXiamen UniversityXiamen361102China

Antibody–drug conjugates(ADCs)are biologically targeted drugs composed of antibodies and cytotoxic drugs connected by *** innovative compounds enable precise drug delivery to tumor cells,minimizing harm to normal tissues and offering excellent prospects for cancer ***,monoclonal antibody-based ADCs still present challenges,especially in terms of balancing efficacy and *** antibodies are alternatives to monoclonal antibodies and exhibit superior internalization and selectivity,producing ADCs with increased safety and therapeutic *** this review,we present available evidence and future prospects regarding the use of bispecific ADCs for cancer treatment,including a comprehensive overview of bispecific ADCs that are currently in clinical *** offer insights into the future development of bispecific ADCs to provide novel strategies for cancer treatment.

关键词： antibody-drug conjugate bispecific antibody bispecific ADC cancer

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